Details for: ANGPT2

Gene ID: 285

Symbol: ANGPT2

Ensembl ID: ENSG00000091879

Description: angiopoietin 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 158.7320
    Cell Significance Index: -24.6900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 97.6568
    Cell Significance Index: -24.7700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 54.9898
    Cell Significance Index: -22.3400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 23.4932
    Cell Significance Index: -22.4300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 20.3981
    Cell Significance Index: -25.1500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.7840
    Cell Significance Index: -26.2100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.4758
    Cell Significance Index: -18.5500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.4064
    Cell Significance Index: -25.2800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 6.1925
    Cell Significance Index: 109.4300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 4.5549
    Cell Significance Index: 27.5200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.5386
    Cell Significance Index: -13.9400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 4.2996
    Cell Significance Index: 110.5200
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 3.9251
    Cell Significance Index: 28.1900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 2.1293
    Cell Significance Index: 44.1700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0257
    Cell Significance Index: 203.5500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.9314
    Cell Significance Index: 57.2500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.7509
    Cell Significance Index: 10.8000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6420
    Cell Significance Index: 444.0600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.5951
    Cell Significance Index: 86.5100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.5896
    Cell Significance Index: 14.1400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.5821
    Cell Significance Index: 11.3600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.5793
    Cell Significance Index: 3.9300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5350
    Cell Significance Index: 107.3200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5086
    Cell Significance Index: 39.0300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3819
    Cell Significance Index: 344.8700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3272
    Cell Significance Index: 32.3700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.3214
    Cell Significance Index: 16.7400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2482
    Cell Significance Index: 89.0200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2445
    Cell Significance Index: 39.7700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2252
    Cell Significance Index: 24.5000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2170
    Cell Significance Index: 41.3100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.2030
    Cell Significance Index: 312.4900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2017
    Cell Significance Index: 12.1100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1680
    Cell Significance Index: 4.2000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1580
    Cell Significance Index: 28.4900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1345
    Cell Significance Index: 5.9500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1266
    Cell Significance Index: 233.4200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1191
    Cell Significance Index: 4.5100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1167
    Cell Significance Index: 2.4900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.1160
    Cell Significance Index: 2.4800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0950
    Cell Significance Index: 1.4700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0869
    Cell Significance Index: 10.1300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0840
    Cell Significance Index: 114.2300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0700
    Cell Significance Index: 131.7900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0683
    Cell Significance Index: 8.4000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0491
    Cell Significance Index: 3.4000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0337
    Cell Significance Index: 1.8900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0243
    Cell Significance Index: 15.4500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0215
    Cell Significance Index: 0.6200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0183
    Cell Significance Index: 10.0200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0153
    Cell Significance Index: 6.7800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0093
    Cell Significance Index: 4.2100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0023
    Cell Significance Index: 0.0400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0037
    Cell Significance Index: -0.1300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0108
    Cell Significance Index: -7.9800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0127
    Cell Significance Index: -0.3400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0146
    Cell Significance Index: -9.1200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0173
    Cell Significance Index: -9.7700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0249
    Cell Significance Index: -1.1300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0332
    Cell Significance Index: -24.3400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0357
    Cell Significance Index: -27.0300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0512
    Cell Significance Index: -1.1100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0634
    Cell Significance Index: -18.2300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0666
    Cell Significance Index: -14.0200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0710
    Cell Significance Index: -4.7800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0732
    Cell Significance Index: -9.3900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0751
    Cell Significance Index: -12.8300
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.0786
    Cell Significance Index: -0.9900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0851
    Cell Significance Index: -11.6800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0949
    Cell Significance Index: -5.8200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1138
    Cell Significance Index: -3.1800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1224
    Cell Significance Index: -7.9000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.1333
    Cell Significance Index: -1.1200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1392
    Cell Significance Index: -15.9500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1504
    Cell Significance Index: -10.6400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1533
    Cell Significance Index: -4.9100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1604
    Cell Significance Index: -20.7200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1703
    Cell Significance Index: -17.7300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1869
    Cell Significance Index: -19.0900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2077
    Cell Significance Index: -23.7100
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.2085
    Cell Significance Index: -2.6000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2177
    Cell Significance Index: -25.6700
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: -0.2179
    Cell Significance Index: -1.5700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.2246
    Cell Significance Index: -3.2300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2645
    Cell Significance Index: -12.3300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2790
    Cell Significance Index: -20.8000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.3037
    Cell Significance Index: -7.4100
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.3201
    Cell Significance Index: -4.0400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3550
    Cell Significance Index: -16.6900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3759
    Cell Significance Index: -23.6900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3831
    Cell Significance Index: -19.9000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4059
    Cell Significance Index: -21.3100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4261
    Cell Significance Index: -9.3300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4342
    Cell Significance Index: -6.4100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4408
    Cell Significance Index: -14.0400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4658
    Cell Significance Index: -15.2500
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.4743
    Cell Significance Index: -2.1900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4806
    Cell Significance Index: -10.2000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4865
    Cell Significance Index: -24.5800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4918
    Cell Significance Index: -17.2300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ANGPT2 is a member of the angiopoietin family, which consists of four proteins: Ang-1, Ang-2, Ang-3, and Ang-4. Ang-2 is the only member of this family that is not a ligand for the Tie2 receptor, but rather an antagonist that modulates the activity of Ang-1. ANGPT2 is primarily secreted by endothelial cells and has a dual role in angiogenesis: it can either inhibit or promote the formation of new blood vessels, depending on the context. **Pathways and Functions** ANGPT2 interacts with various signaling pathways that regulate angiogenesis, including: 1. **Tie2 signaling pathway**: ANGPT2 binds to the Tie2 receptor, inhibiting the activation of downstream signaling pathways that promote angiogenesis. 2. **Negative regulation of angiogenesis**: ANGPT2 inhibits the formation of new blood vessels by suppressing the expression of pro-angiogenic genes and promoting the expression of anti-angiogenic genes. 3. **Positive regulation of angiogenesis**: In contrast, ANGPT2 can also promote angiogenesis by stimulating the expression of pro-angiogenic genes and inhibiting the expression of anti-angiogenic genes. 4. **Cell surface interactions**: ANGPT2 interacts with cell surface receptors, such as the Tie2 receptor, to regulate cell adhesion, migration, and proliferation. **Clinical Significance** ANGPT2 has been implicated in various diseases and conditions, including: 1. **Cancer**: ANGPT2 has been shown to promote angiogenesis in various types of cancer, including breast, lung, and colon cancer. 2. **Cardiovascular disease**: ANGPT2 has been linked to the development of cardiovascular disease, including atherosclerosis and cardiac hypertrophy. 3. **Neurological disorders**: ANGPT2 has been implicated in the pathogenesis of neurological disorders, including Alzheimer's disease and multiple sclerosis. 4. **Pregnancy and parturition**: ANGPT2 plays a role in the regulation of angiogenesis during pregnancy and parturition. In conclusion, ANGPT2 is a multifunctional protein that plays a crucial role in the regulation of angiogenesis and has implications in various physiological and pathological processes. Further research is needed to fully understand the mechanisms by which ANGPT2 regulates angiogenesis and its role in human disease. **Significantly expressed cells** * Vascular lymphangioblast * Lens epithelial cell * Cerebral cortex endothelial cell * Renal interstitial pericyte * Skeletal muscle fiber * OFF retinal ganglion cell * Mural cell * Prostate gland microvascular endothelial cell * Trophoblast giant cell * Contractile cell **Proteins** * ANGP2_HUMAN (Angiopoietin-2) Note: The information provided is based on the given description and may not be comprehensive or up-to-date.

Genular Protein ID: 2732424518

Symbol: ANGP2_HUMAN

Name: Angiopoietin-2

UniProtKB Accession Codes:

O15123 A0AV38 A8K205 B7ZLM7 Q9NRR7 Q9P2Y7

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EMBL 9 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 26 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 1 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniLectin 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9204896

Title: Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis.

PubMed ID: 9204896

DOI: 10.1126/science.277.5322.55

PubMed ID: 9927494

Title: Biologic significance of angiopoietin-2 expression in human hepatocellular carcinoma.

PubMed ID: 9927494

DOI: 10.1172/jci4891

PubMed ID: 10766762

Title: Characterization and expression of a novel alternatively spliced human angiopoietin-2.

PubMed ID: 10766762

DOI: 10.1074/jbc.m910084199

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12427764

Title: Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats.

PubMed ID: 12427764

DOI: 10.1074/jbc.m208550200

PubMed ID: 15284220

Title: Biological characterization of angiopoietin-3 and angiopoietin-4.

PubMed ID: 15284220

DOI: 10.1096/fj.03-1466com

PubMed ID: 19116766

Title: Tyrosine phosphatase beta regulates angiopoietin-Tie2 signaling in human endothelial cells.

PubMed ID: 19116766

DOI: 10.1007/s10456-008-9126-0

PubMed ID: 19223473

Title: Angiopoietin 2 is a partial agonist/antagonist of Tie2 signaling in the endothelium.

PubMed ID: 19223473

DOI: 10.1128/mcb.01472-08

PubMed ID: 19234476

Title: Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system.

PubMed ID: 19234476

DOI: 10.1038/nrm2639

PubMed ID: 29323190

Title: Angiopoietins bind thrombomodulin and inhibit its function as a thrombin cofactor.

PubMed ID: 29323190

DOI: 10.1038/s41598-017-18912-8

PubMed ID: 15893672

Title: Structure of the angiopoietin-2 receptor binding domain and identification of surfaces involved in Tie2 recognition.

PubMed ID: 15893672

DOI: 10.1016/j.str.2005.03.009

PubMed ID: 16732286

Title: Crystal structures of the Tie2 receptor ectodomain and the angiopoietin-2-Tie2 complex.

PubMed ID: 16732286

DOI: 10.1038/nsmb1101

PubMed ID: 32908006

Title: Characterization of ANGPT2 mutations associated with primary lymphedema.

PubMed ID: 32908006

DOI: 10.1126/scitranslmed.aax8013

Sequence Information:

  • Length: 496
  • Mass: 56919
  • Checksum: 5642A58847A7385C
  • Sequence:
    • MWQIVFFTLS CDLVLAAAYN NFRKSMDSIG KKQYQVQHGS CSYTFLLPEM DNCRSSSSPY 
VSNAVQRDAP LEYDDSVQRL QVLENIMENN TQWLMKLENY IQDNMKKEMV EIQQNAVQNQ 
TAVMIEIGTN LLNQTAEQTR KLTDVEAQVL NQTTRLELQL LEHSLSTNKL EKQILDQTSE 
INKLQDKNSF LEKKVLAMED KHIIQLQSIK EEKDQLQVLV SKQNSIIEEL EKKIVTATVN 
NSVLQKQQHD LMETVNNLLT MMSTSNSAKD PTVAKEEQIS FRDCAEVFKS GHTTNGIYTL 
TFPNSTEEIK AYCDMEAGGG GWTIIQRRED GSVDFQRTWK EYKVGFGNPS GEYWLGNEFV 
SQLTNQQRYV LKIHLKDWEG NEAYSLYEHF YLSSEELNYR IHLKGLTGTA GKISSISQPG 
NDFSTKDGDN DKCICKCSQM LTGGWWFDAC GPSNLNGMYY PQRQNTNKFN GIKWYYWKGS 
GYSLKATTMM IRPADF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.