Details for: ANGPT2

Gene ID: 285

Symbol: ANGPT2

Ensembl ID: ENSG00000091879

Description: angiopoietin 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.78
    Marker Score: 3014.5
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.74
    Marker Score: 2110
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.68
    Marker Score: 1005
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.58
    Marker Score: 1504
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.57
    Marker Score: 3928
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.51
    Marker Score: 632
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 169093
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.43
    Marker Score: 556
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: 1.39
    Marker Score: 449
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.37
    Marker Score: 742
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.24
    Marker Score: 727
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.22
    Marker Score: 1635
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.18
    Marker Score: 4209
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.15
    Marker Score: 315
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.11
    Marker Score: 2219
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.08
    Marker Score: 24180
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.08
    Marker Score: 1770
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.05
    Marker Score: 746
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251771
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.03
    Marker Score: 675
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1
    Marker Score: 2032
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71789
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48014
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30405
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.98
    Marker Score: 310
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.98
    Marker Score: 1508
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.97
    Marker Score: 15187
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.96
    Marker Score: 485
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 490
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2410
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.95
    Marker Score: 641
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.95
    Marker Score: 2075
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 445
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2729
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.9
    Marker Score: 374
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5133
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.9
    Marker Score: 359
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.88
    Marker Score: 419
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 312.5
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.86
    Marker Score: 253
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.83
    Marker Score: 482
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.82
    Marker Score: 1532
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.8
    Marker Score: 3357
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.8
    Marker Score: 4812
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 599.5
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.77
    Marker Score: 754
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1244
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.76
    Marker Score: 1786
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.76
    Marker Score: 391
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.75
    Marker Score: 470
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.75
    Marker Score: 2782
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.75
    Marker Score: 418
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 681
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.74
    Marker Score: 3116
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 381
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.71
    Marker Score: 493
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.71
    Marker Score: 6084
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.7
    Marker Score: 623
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.68
    Marker Score: 245
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.68
    Marker Score: 841
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.66
    Marker Score: 167
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.65
    Marker Score: 578
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.64
    Marker Score: 387
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.64
    Marker Score: 6048
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.6
    Marker Score: 190
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.59
    Marker Score: 729
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.59
    Marker Score: 859
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.58
    Marker Score: 2405
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.58
    Marker Score: 35482
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.58
    Marker Score: 5942
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.56
    Marker Score: 160
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 442
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.54
    Marker Score: 597
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.54
    Marker Score: 345
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.54
    Marker Score: 356
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.54
    Marker Score: 157
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.54
    Marker Score: 577
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.53
    Marker Score: 167
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.53
    Marker Score: 167
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.52
    Marker Score: 252
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.52
    Marker Score: 579
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.51
    Marker Score: 18853
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.51
    Marker Score: 957
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.5
    Marker Score: 501
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.5
    Marker Score: 140
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.5
    Marker Score: 100
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.49
    Marker Score: 166
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.49
    Marker Score: 1909
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.49
    Marker Score: 238
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.49
    Marker Score: 4578
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.48
    Marker Score: 512
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.48
    Marker Score: 313
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.46
    Marker Score: 175
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.46
    Marker Score: 191
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.46
    Marker Score: 225
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.45
    Marker Score: 153
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.45
    Marker Score: 859
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.44
    Marker Score: 549

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Other Information

**Key characteristics:** * Protein type: Protein * Ensembl ID: ENSG00000091879 * Protein length: 115 amino acids * Subcellular location: Extracellular * Expression: Highly expressed in vascular endothelial cells, but also expressed in other cell types such as lens epithelial cells, cerebral cortex endothelial cells, renal interstitial pericytes, skeletal muscle fibers, and OFF retinal ganglion cells. **Pathways and functions:** * AngPT2 is a key factor in the regulation of angiogenesis. It is essential for the migration and proliferation of endothelial cells and is involved in the formation of new blood vessels in a variety of tissues, including the skin, lungs, and brain. * AngPT2 is also involved in the regulation of cell-substrate adhesion and migration. It is a key factor in the formation of stable cell-substrate contacts between endothelial cells and other cell types. * AngPT2 is involved in the regulation of the blood-brain barrier (BBB). It is expressed in endothelial cells of blood-brain barrier vessels and helps to maintain the integrity of the BBB. * ANGPT2 is also involved in the regulation of inflammation. It is expressed in endothelial cells of blood vessels and is a key factor in the regulation of inflammation. **Clinical significance:** * Mutations in ANGPT2 have been linked to a number of human diseases, including cancer, heart disease, and stroke. * AngPT2 inhibitors are being investigated as a treatment for these diseases.

Genular Protein ID: 2732424518

Symbol: ANGP2_HUMAN

Name: Angiopoietin-2

UniProtKB Accession Codes:

O15123 A0AV38 A8K205 B7ZLM7 Q9NRR7 Q9P2Y7

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 9 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 26 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 5 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 1 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniLectin 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9204896

Title: Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis.

PubMed ID: 9204896

DOI: 10.1126/science.277.5322.55

PubMed ID: 9927494

Title: Biologic significance of angiopoietin-2 expression in human hepatocellular carcinoma.

PubMed ID: 9927494

DOI: 10.1172/jci4891

PubMed ID: 10766762

Title: Characterization and expression of a novel alternatively spliced human angiopoietin-2.

PubMed ID: 10766762

DOI: 10.1074/jbc.m910084199

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12427764

Title: Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats.

PubMed ID: 12427764

DOI: 10.1074/jbc.m208550200

PubMed ID: 15284220

Title: Biological characterization of angiopoietin-3 and angiopoietin-4.

PubMed ID: 15284220

DOI: 10.1096/fj.03-1466com

PubMed ID: 19116766

Title: Tyrosine phosphatase beta regulates angiopoietin-Tie2 signaling in human endothelial cells.

PubMed ID: 19116766

DOI: 10.1007/s10456-008-9126-0

PubMed ID: 19223473

Title: Angiopoietin 2 is a partial agonist/antagonist of Tie2 signaling in the endothelium.

PubMed ID: 19223473

DOI: 10.1128/mcb.01472-08

PubMed ID: 19234476

Title: Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system.

PubMed ID: 19234476

DOI: 10.1038/nrm2639

PubMed ID: 15893672

Title: Structure of the angiopoietin-2 receptor binding domain and identification of surfaces involved in Tie2 recognition.

PubMed ID: 15893672

DOI: 10.1016/j.str.2005.03.009

PubMed ID: 16732286

Title: Crystal structures of the Tie2 receptor ectodomain and the angiopoietin-2-Tie2 complex.

PubMed ID: 16732286

DOI: 10.1038/nsmb1101

PubMed ID: 32908006

Title: Characterization of ANGPT2 mutations associated with primary lymphedema.

PubMed ID: 32908006

DOI: 10.1126/scitranslmed.aax8013

Sequence Information:

  • Length: 496
  • Mass: 56919
  • Checksum: 5642A58847A7385C
  • Sequence:
    • MWQIVFFTLS CDLVLAAAYN NFRKSMDSIG KKQYQVQHGS CSYTFLLPEM DNCRSSSSPY 
VSNAVQRDAP LEYDDSVQRL QVLENIMENN TQWLMKLENY IQDNMKKEMV EIQQNAVQNQ 
TAVMIEIGTN LLNQTAEQTR KLTDVEAQVL NQTTRLELQL LEHSLSTNKL EKQILDQTSE 
INKLQDKNSF LEKKVLAMED KHIIQLQSIK EEKDQLQVLV SKQNSIIEEL EKKIVTATVN 
NSVLQKQQHD LMETVNNLLT MMSTSNSAKD PTVAKEEQIS FRDCAEVFKS GHTTNGIYTL 
TFPNSTEEIK AYCDMEAGGG GWTIIQRRED GSVDFQRTWK EYKVGFGNPS GEYWLGNEFV 
SQLTNQQRYV LKIHLKDWEG NEAYSLYEHF YLSSEELNYR IHLKGLTGTA GKISSISQPG 
NDFSTKDGDN DKCICKCSQM LTGGWWFDAC GPSNLNGMYY PQRQNTNKFN GIKWYYWKGS 
GYSLKATTMM IRPADF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.