Details for: GPR35

Gene ID: 2859

Symbol: GPR35

Ensembl ID: ENSG00000178623

Description: G protein-coupled receptor 35

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 26.0374
    Cell Significance Index: -4.0500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 15.6125
    Cell Significance Index: -3.9600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 10.5106
    Cell Significance Index: -4.2700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 9.8370
    Cell Significance Index: -5.0600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 6.6317
    Cell Significance Index: -4.4500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 3.2929
    Cell Significance Index: -4.0600
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 3.0014
    Cell Significance Index: 22.7600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.4828
    Cell Significance Index: 71.5400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.8205
    Cell Significance Index: 39.4400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.7462
    Cell Significance Index: 79.1500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.4970
    Cell Significance Index: 243.4700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1497
    Cell Significance Index: 125.0500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.0057
    Cell Significance Index: 15.0700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6814
    Cell Significance Index: 47.1300
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.6723
    Cell Significance Index: 5.5600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.5489
    Cell Significance Index: 11.6900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.4918
    Cell Significance Index: 9.0900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.4249
    Cell Significance Index: 14.9300
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.4243
    Cell Significance Index: 5.9600
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.3451
    Cell Significance Index: 3.7400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 0.3173
    Cell Significance Index: -0.8500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.3059
    Cell Significance Index: 6.3500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2592
    Cell Significance Index: 6.4800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2445
    Cell Significance Index: 7.8300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.2137
    Cell Significance Index: 3.0600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1914
    Cell Significance Index: 18.9300
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.1249
    Cell Significance Index: 1.2600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0813
    Cell Significance Index: 16.3000
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.0786
    Cell Significance Index: 1.0900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0758
    Cell Significance Index: 2.0300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0646
    Cell Significance Index: 12.2900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0638
    Cell Significance Index: 0.6600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0523
    Cell Significance Index: 10.3800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0407
    Cell Significance Index: 1.0900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0344
    Cell Significance Index: 12.3400
  • Cell Name: colonocyte (CL1000347)
    Fold Change: 0.0210
    Cell Significance Index: 0.1300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0189
    Cell Significance Index: 1.4500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0053
    Cell Significance Index: 4.8100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0017
    Cell Significance Index: 3.2400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0004
    Cell Significance Index: 0.2100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0010
    Cell Significance Index: -1.8000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0016
    Cell Significance Index: -2.5200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0021
    Cell Significance Index: -0.3700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0023
    Cell Significance Index: -3.1700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0031
    Cell Significance Index: -1.3900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0040
    Cell Significance Index: -2.5600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0046
    Cell Significance Index: -0.2400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0050
    Cell Significance Index: -3.7900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0057
    Cell Significance Index: -4.2200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0057
    Cell Significance Index: -4.2100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0069
    Cell Significance Index: -0.3100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0073
    Cell Significance Index: -4.1000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0075
    Cell Significance Index: -3.4200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0088
    Cell Significance Index: -1.1300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0107
    Cell Significance Index: -3.0700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0126
    Cell Significance Index: -0.8500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0138
    Cell Significance Index: -1.7000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0146
    Cell Significance Index: -1.7000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0155
    Cell Significance Index: -1.5800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0179
    Cell Significance Index: -2.4600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0185
    Cell Significance Index: -2.6900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0192
    Cell Significance Index: -1.2100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0197
    Cell Significance Index: -3.3700
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0201
    Cell Significance Index: -0.1300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0215
    Cell Significance Index: -4.5200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0227
    Cell Significance Index: -0.8600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0232
    Cell Significance Index: -0.3300
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.0251
    Cell Significance Index: -0.2600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0260
    Cell Significance Index: -2.9800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0272
    Cell Significance Index: -0.7600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0296
    Cell Significance Index: -1.5000
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.0309
    Cell Significance Index: -0.2500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0339
    Cell Significance Index: -3.5300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0341
    Cell Significance Index: -2.2000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0351
    Cell Significance Index: -4.5300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0358
    Cell Significance Index: -1.6700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0379
    Cell Significance Index: -2.6800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0410
    Cell Significance Index: -4.8400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0478
    Cell Significance Index: -1.9600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0483
    Cell Significance Index: -2.2700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0485
    Cell Significance Index: -1.2400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0534
    Cell Significance Index: -3.2800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0540
    Cell Significance Index: -3.3100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0614
    Cell Significance Index: -4.8600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0635
    Cell Significance Index: -4.7300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0638
    Cell Significance Index: -1.6400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0662
    Cell Significance Index: -3.7200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0662
    Cell Significance Index: -1.8900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0671
    Cell Significance Index: -1.4700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0695
    Cell Significance Index: -2.0400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0763
    Cell Significance Index: -2.4300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0789
    Cell Significance Index: -4.1400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0800
    Cell Significance Index: -2.6200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0802
    Cell Significance Index: -2.8100
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0812
    Cell Significance Index: -0.5900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0826
    Cell Significance Index: -4.3000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0846
    Cell Significance Index: -3.6800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0862
    Cell Significance Index: -2.1500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0919
    Cell Significance Index: -1.9500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0998
    Cell Significance Index: -2.0900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GPR35 is a seven-transmembrane GPCR that belongs to the class A/1 rhodopsin-like receptors. It is characterized by its high expression levels in various tissues, including the enterocyte, cardiac muscle myoblast, colon epithelial cells, and the brain. GPR35 exhibits a unique ligand-binding profile, with a high affinity for certain endogenous ligands, such as quinolinic acid and 3-hydroxyquinolinic acid. These ligands are known to play a critical role in regulating neuronal excitability and immune responses. **Pathways and Functions:** GPR35 is involved in various signaling pathways, including: 1. **C-x-c chemokine receptor activity**: GPR35 can interact with chemokines, such as CXCL12, to regulate immune cell migration and recruitment. 2. **Chemokine-mediated signaling pathway**: GPR35 can modulate chemokine signaling, influencing the production of pro-inflammatory cytokines and chemokines. 3. **G protein-coupled receptor activity**: GPR35 can activate G-proteins, leading to the modulation of downstream signaling pathways, including calcium ion signaling and rho protein signaling. 4. **Negative regulation of neuronal action potential**: GPR35 can inhibit neuronal excitability by reducing the release of neurotransmitters and modulating ion channels. **Clinical Significance:** GPR35 has been implicated in various human diseases, including: 1. **Inflammatory bowel disease (IBD)**: GPR35 has been shown to regulate immune responses in the gut, and its dysregulation may contribute to the development of IBD. 2. **Neurodegenerative disorders**: GPR35 has been linked to the pathogenesis of neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease, where it may play a role in regulating neuronal excitability and immune responses. 3. **Cardiovascular disease**: GPR35 has been implicated in the regulation of cardiac function and may play a role in the development of cardiovascular disease. In conclusion, GPR35 is a multifaceted GPCR that plays a crucial role in regulating immune responses, neuronal excitability, and cellular signaling. Further research is needed to fully understand the mechanisms by which GPR35 regulates these processes and its implications in human diseases.

Genular Protein ID: 3627639304

Symbol: GPR35_HUMAN

Name: G-protein coupled receptor 35

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9479505

Title: Discovery of three novel G-protein-coupled receptor genes.

PubMed ID: 9479505

DOI: 10.1006/geno.1998.5095

PubMed ID: 11017071

Title: Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus.

PubMed ID: 11017071

DOI: 10.1038/79876

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16754668

Title: Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35.

PubMed ID: 16754668

DOI: 10.1074/jbc.m603503200

PubMed ID: 20361937

Title: GPR35 is a novel lysophosphatidic acid receptor.

PubMed ID: 20361937

DOI: 10.1016/j.bbrc.2010.03.169

PubMed ID: 35148838

Title: GPR35 promotes neutrophil recruitment in response to serotonin metabolite 5-HIAA.

PubMed ID: 35148838

DOI: 10.1016/j.cell.2022.01.010

PubMed ID: 35101446

Title: Agonist-induced phosphorylation of orthologues of the orphan receptor GPR35 functions as an activation sensor.

PubMed ID: 35101446

DOI: 10.1016/j.jbc.2022.101655

PubMed ID: 37660910

Title: G protein-receptor kinases 5/6 are the key regulators of G protein-coupled receptor 35-arrestin interactions.

PubMed ID: 37660910

DOI: 10.1016/j.jbc.2023.105218

PubMed ID: 36543774

Title: Insights into divalent cation regulation and G13-coupling of orphan receptor GPR35.

PubMed ID: 36543774

DOI: 10.1038/s41421-022-00499-8

Sequence Information:

  • Length: 309
  • Mass: 34072
  • Checksum: 97734FB7231B26F0
  • Sequence:
  • MNGTYNTCGS SDLTWPPAIK LGFYAYLGVL LVLGLLLNSL ALWVFCCRMQ QWTETRIYMT 
    NLAVADLCLL CTLPFVLHSL RDTSDTPLCQ LSQGIYLTNR YMSISLVTAI AVDRYVAVRH 
    PLRARGLRSP RQAAAVCAVL WVLVIGSLVA RWLLGIQEGG FCFRSTRHNF NSMAFPLLGF 
    YLPLAVVVFC SLKVVTALAQ RPPTDVGQAE ATRKAARMVW ANLLVFVVCF LPLHVGLTVR 
    LAVGWNACAL LETIRRALYI TSKLSDANCC LDAICYYYMA KEFQEASALA VAPSAKAHKS 
    QDSLCVTLA

Genular Protein ID: 3993932683

Symbol: A8K2J1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 340
  • Mass: 37463
  • Checksum: 4EF3FC3F3AEAB714
  • Sequence:
  • MLSGSRAVPT PHHGSEELLK YMLHSPCVSL TMNGTYNTCG SSDLTWPPAI KLGFYAYLGV 
    LLVLGLLLNS LALWVFCCRM QQWTETRIYM TNLAVADLCL LCTLPFVLHS LRDTSDTPLC 
    QLSQGIYLTN RYMSISLVMA IAVDRYVAVR HPLRARGLRS PRQAAAVCAV LWVLVIGSLV 
    ARWLLGIQEG GFCFRSTRHN FNSMAFPLLG FYLPLAVVVF CSLKVVTALA QRPPTDVGQA 
    EATRKAARMV WANLLVFVVC FLPLHVGLTV RLAVGWNACA LLETIRRALY ITSKLSDANC 
    CLDAICYYYM AKEFQEASAL AVAPSAKAHK SQDSLCVTLA

Genular Protein ID: 2306372971

Symbol: B2RA17_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 309
  • Mass: 34056
  • Checksum: 33335EF23BDFF371
  • Sequence:
  • MNGTYNTCGS SDLTWPPAIK LGFYAYLGVL LVLGLLLNSL ALWVFCCRMQ QWTETRIYMT 
    NLAVADLCLL CTLPFVLHSL RDTSDTPLCQ LSQGIYLTNR YMSISLVTAI AVDRYVAVRH 
    PLRARGLRSP RQAAAVCAVL WVLVIGSLVA RWPLGIQEGG FCFRSTRHNF NSMAFPLLGF 
    YLPLAVVVFC SLKVVTALAQ RPPTDVGQAE ATRKAARMVW ANLLVFVVCF LPLHVGLTVR 
    LAVGWNACAL LETIRRALYI TSKLSDANCC LDAICYYYMA KEFQEASALA VAPSAKAHKS 
    QDSLCVTLA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.