Details for: GPR35

Gene ID: 2859

Symbol: GPR35

Ensembl ID: ENSG00000178623

Description: G protein-coupled receptor 35

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.16
    Marker Score: 5587
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.11
    Marker Score: 17336
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.04
    Marker Score: 3266
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71813
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48037
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 503
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 456
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.95
    Marker Score: 1803.5
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2734
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5181
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.9
    Marker Score: 539
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.89
    Marker Score: 1448
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 320
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5281
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.85
    Marker Score: 1312
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.81
    Marker Score: 1653
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 597
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.76
    Marker Score: 1815
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 391
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.73
    Marker Score: 293
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.72
    Marker Score: 2674
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.72
    Marker Score: 659
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.71
    Marker Score: 455
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.65
    Marker Score: 646
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.65
    Marker Score: 2706
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.63
    Marker Score: 600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6
    Marker Score: 148
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.59
    Marker Score: 3757
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.59
    Marker Score: 142
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.56
    Marker Score: 179
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 438
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.54
    Marker Score: 203
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.53
    Marker Score: 29732
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.52
    Marker Score: 1173
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.5
    Marker Score: 237
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.49
    Marker Score: 140
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.48
    Marker Score: 1139
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.46
    Marker Score: 1288
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.45
    Marker Score: 542
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.44
    Marker Score: 1100
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.44
    Marker Score: 849
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.42
    Marker Score: 430
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.41
    Marker Score: 273
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.38
    Marker Score: 229
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.37
    Marker Score: 82
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.35
    Marker Score: 155
  • Cell Name: basophil (CL0000767)
    Fold Change: 0.33
    Marker Score: 159
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.32
    Marker Score: 187
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.31
    Marker Score: 71
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.31
    Marker Score: 82
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 0.3
    Marker Score: 86
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.29
    Marker Score: 188
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.29
    Marker Score: 748
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.29
    Marker Score: 688.5
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.28
    Marker Score: 73
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.27
    Marker Score: 189
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.27
    Marker Score: 157
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.27
    Marker Score: 1123
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.26
    Marker Score: 175
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.26
    Marker Score: 83
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.26
    Marker Score: 128
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.26
    Marker Score: 2965
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.24
    Marker Score: 65
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.24
    Marker Score: 378
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.24
    Marker Score: 1429
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.24
    Marker Score: 80
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.23
    Marker Score: 355
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.22
    Marker Score: 156.5
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.22
    Marker Score: 66
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.22
    Marker Score: 90
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.21
    Marker Score: 110
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.21
    Marker Score: 56
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.21
    Marker Score: 60
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.21
    Marker Score: 1956
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.2
    Marker Score: 263
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.2
    Marker Score: 156
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.2
    Marker Score: 320
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: 0.2
    Marker Score: 60
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.2
    Marker Score: 137
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.2
    Marker Score: 338
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.2
    Marker Score: 4241
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.19
    Marker Score: 87
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.19
    Marker Score: 78
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.18
    Marker Score: 226
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.18
    Marker Score: 486
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.17
    Marker Score: 430
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.17
    Marker Score: 192
  • Cell Name: pre-conventional dendritic cell (CL0002010)
    Fold Change: 0.17
    Marker Score: 51
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.17
    Marker Score: 70
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.17
    Marker Score: 491
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.17
    Marker Score: 124
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.17
    Marker Score: 97
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.17
    Marker Score: 112
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.17
    Marker Score: 38
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.17
    Marker Score: 153

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Other Information

**Key characteristics:** * GPR35 is a single-pass transmembrane protein with a molecular weight of approximately 140 kDa. * It is expressed in high levels in the enterocyte, cardiac muscle myoblast, colon epithelial cell, cerebral cortex GABAergic interneuron, forebrain radial glial cell, absorptive cell, tuft cell of colon, and BEST4+ intestinal epithelial cell. * It is a highly conserved protein, with a similar sequence in mammals, birds, and fish. **Pathways and functions:** * GPR35 is a key regulator of epithelial cell migration and adhesion. * It is involved in the regulation of gastrointestinal inflammation and pain. * It is also involved in the regulation of neuronal function, and may play a role in schizophrenia and other neurological disorders. **Clinical significance:** * Mutations in GPR35 have been linked to a number of human diseases, including inflammatory bowel disease, schizophrenia, and pain. * Targeting GPR35 has been investigated as a therapeutic strategy for these diseases. **Other important points:** * GPR35 is a relatively new protein, with the first sequence being identified in 2005. * It is a member of the GPCR superfamily, which is a large family of receptors that are involved in a variety of cellular processes. * GPR35 is a highly conserved protein, with a similar sequence in mammals, birds, and fish.

Genular Protein ID: 3627639304

Symbol: GPR35_HUMAN

Name: G-protein coupled receptor 35

UniProtKB Accession Codes:

Q9HC97 J3KR30 O43495 Q17R58 Q4VBN5 Q4ZFV2 Q6FHI8 Q86UH4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EMBL 9 EMDB 1 Ensembl 5 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9479505

Title: Discovery of three novel G-protein-coupled receptor genes.

PubMed ID: 9479505

DOI: 10.1006/geno.1998.5095

PubMed ID: 11017071

Title: Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus.

PubMed ID: 11017071

DOI: 10.1038/79876

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16754668

Title: Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35.

PubMed ID: 16754668

DOI: 10.1074/jbc.m603503200

PubMed ID: 20361937

Title: GPR35 is a novel lysophosphatidic acid receptor.

PubMed ID: 20361937

DOI: 10.1016/j.bbrc.2010.03.169

PubMed ID: 35148838

Title: GPR35 promotes neutrophil recruitment in response to serotonin metabolite 5-HIAA.

PubMed ID: 35148838

DOI: 10.1016/j.cell.2022.01.010

PubMed ID: 35101446

Title: Agonist-induced phosphorylation of orthologues of the orphan receptor GPR35 functions as an activation sensor.

PubMed ID: 35101446

DOI: 10.1016/j.jbc.2022.101655

PubMed ID: 37660910

Title: G protein-receptor kinases 5/6 are the key regulators of G protein-coupled receptor 35-arrestin interactions.

PubMed ID: 37660910

DOI: 10.1016/j.jbc.2023.105218

PubMed ID: 36543774

Title: Insights into divalent cation regulation and G13-coupling of orphan receptor GPR35.

PubMed ID: 36543774

DOI: 10.1038/s41421-022-00499-8

Sequence Information:

  • Length: 309
  • Mass: 34072
  • Checksum: 97734FB7231B26F0
  • Sequence:
    • MNGTYNTCGS SDLTWPPAIK LGFYAYLGVL LVLGLLLNSL ALWVFCCRMQ QWTETRIYMT 
NLAVADLCLL CTLPFVLHSL RDTSDTPLCQ LSQGIYLTNR YMSISLVTAI AVDRYVAVRH 
PLRARGLRSP RQAAAVCAVL WVLVIGSLVA RWLLGIQEGG FCFRSTRHNF NSMAFPLLGF 
YLPLAVVVFC SLKVVTALAQ RPPTDVGQAE ATRKAARMVW ANLLVFVVCF LPLHVGLTVR 
LAVGWNACAL LETIRRALYI TSKLSDANCC LDAICYYYMA KEFQEASALA VAPSAKAHKS 
QDSLCVTLA

Genular Protein ID: 2306372971

Symbol: B2RA17_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2RA17

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 2 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 1 RefSeq 1 RuleBase 1 SAM 1 SUPFAM 1

Sequence Information:

  • Length: 309
  • Mass: 34056
  • Checksum: 33335EF23BDFF371
  • Sequence:
    • MNGTYNTCGS SDLTWPPAIK LGFYAYLGVL LVLGLLLNSL ALWVFCCRMQ QWTETRIYMT 
NLAVADLCLL CTLPFVLHSL RDTSDTPLCQ LSQGIYLTNR YMSISLVTAI AVDRYVAVRH 
PLRARGLRSP RQAAAVCAVL WVLVIGSLVA RWPLGIQEGG FCFRSTRHNF NSMAFPLLGF 
YLPLAVVVFC SLKVVTALAQ RPPTDVGQAE ATRKAARMVW ANLLVFVVCF LPLHVGLTVR 
LAVGWNACAL LETIRRALYI TSKLSDANCC LDAICYYYMA KEFQEASALA VAPSAKAHKS 
QDSLCVTLA

Genular Protein ID: 3993932683

Symbol: A8K2J1_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K2J1

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 2 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 1 RefSeq 2 RuleBase 1 SAM 1 SUPFAM 1

Sequence Information:

  • Length: 340
  • Mass: 37463
  • Checksum: 4EF3FC3F3AEAB714
  • Sequence:
    • MLSGSRAVPT PHHGSEELLK YMLHSPCVSL TMNGTYNTCG SSDLTWPPAI KLGFYAYLGV 
LLVLGLLLNS LALWVFCCRM QQWTETRIYM TNLAVADLCL LCTLPFVLHS LRDTSDTPLC 
QLSQGIYLTN RYMSISLVMA IAVDRYVAVR HPLRARGLRS PRQAAAVCAV LWVLVIGSLV 
ARWLLGIQEG GFCFRSTRHN FNSMAFPLLG FYLPLAVVVF CSLKVVTALA QRPPTDVGQA 
EATRKAARMV WANLLVFVVC FLPLHVGLTV RLAVGWNACA LLETIRRALY ITSKLSDANC 
CLDAICYYYM AKEFQEASAL AVAPSAKAHK SQDSLCVTLA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.