Details for: TRBV6 7

Gene ID: 28600

Symbol: TRBV6 7

Ensembl ID: ENSG00000253188

Description: T cell receptor beta variable 6-7 (non-functional)

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.9768
    Cell Significance Index: 23.6600
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.3684
    Cell Significance Index: 5.3700
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.3208
    Cell Significance Index: 4.2100
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.2130
    Cell Significance Index: 2.7800
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.1896
    Cell Significance Index: 3.0700
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0171
    Cell Significance Index: 0.2200
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.0094
    Cell Significance Index: 0.0400
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.0075
    Cell Significance Index: 0.0700
  • Cell Name: lung resident memory CD8-positive, alpha-beta T cell (CL4033039)
    Fold Change: 0.0062
    Cell Significance Index: 0.0600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0010
    Cell Significance Index: -0.2000
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0018
    Cell Significance Index: -0.0200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0021
    Cell Significance Index: -0.0200
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0040
    Cell Significance Index: -0.0500
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0068
    Cell Significance Index: -0.0700
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0084
    Cell Significance Index: -0.0900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0110
    Cell Significance Index: -0.1300
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0113
    Cell Significance Index: -0.1300
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0117
    Cell Significance Index: -0.1600
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0118
    Cell Significance Index: -0.1100
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0135
    Cell Significance Index: -0.1600
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0137
    Cell Significance Index: -0.1300
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.0144
    Cell Significance Index: -0.1500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0174
    Cell Significance Index: -0.3400
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0185
    Cell Significance Index: -0.1600
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0188
    Cell Significance Index: -0.1600
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0200
    Cell Significance Index: -0.2300
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: -0.0201
    Cell Significance Index: -0.0700
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0209
    Cell Significance Index: -0.1800
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0210
    Cell Significance Index: -0.1700
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0211
    Cell Significance Index: -0.2000
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0213
    Cell Significance Index: -0.2200
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0217
    Cell Significance Index: -0.2200
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0217
    Cell Significance Index: -0.2300
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0241
    Cell Significance Index: -0.2500
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0242
    Cell Significance Index: -0.2000
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: -0.0257
    Cell Significance Index: -0.2500
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: -0.0269
    Cell Significance Index: -0.0700
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0276
    Cell Significance Index: -0.3200
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0276
    Cell Significance Index: -0.3200
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0278
    Cell Significance Index: -0.3000
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.0278
    Cell Significance Index: -0.2300
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.0280
    Cell Significance Index: -0.2900
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0293
    Cell Significance Index: -0.1600
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0295
    Cell Significance Index: -0.3400
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0298
    Cell Significance Index: -0.2900
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.0313
    Cell Significance Index: -0.2500
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0318
    Cell Significance Index: -0.3200
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.0320
    Cell Significance Index: -0.2200
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0324
    Cell Significance Index: -0.3700
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.0329
    Cell Significance Index: -0.2800
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0330
    Cell Significance Index: -0.3900
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0331
    Cell Significance Index: -0.3300
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0332
    Cell Significance Index: -0.2900
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0333
    Cell Significance Index: -0.3200
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0334
    Cell Significance Index: -0.3700
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.0335
    Cell Significance Index: -0.3100
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0335
    Cell Significance Index: -0.3400
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.0339
    Cell Significance Index: -0.3100
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0340
    Cell Significance Index: -0.4200
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0344
    Cell Significance Index: -0.2900
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0351
    Cell Significance Index: -0.3700
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0352
    Cell Significance Index: -0.3900
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0359
    Cell Significance Index: -0.3200
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.0368
    Cell Significance Index: -0.3400
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0376
    Cell Significance Index: -0.4200
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0387
    Cell Significance Index: -0.3600
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.0390
    Cell Significance Index: -0.3200
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.0395
    Cell Significance Index: -0.3300
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.0399
    Cell Significance Index: -0.3700
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0403
    Cell Significance Index: -0.4300
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0437
    Cell Significance Index: -0.3400
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0442
    Cell Significance Index: -0.3400
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: -0.0446
    Cell Significance Index: -0.2200
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0470
    Cell Significance Index: -0.3500
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: -0.0520
    Cell Significance Index: -0.3600
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0777
    Cell Significance Index: -0.4200
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.1116
    Cell Significance Index: -0.3400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The TRBV6-7 gene is a non-functional variant of the T cell receptor beta variable region, which is a crucial component of the adaptive immune system. The non-functional nature of this gene suggests that it may not contribute to the diversity of the T cell receptor repertoire, potentially affecting the immune system's ability to recognize and respond to pathogens. The TRBV6-7 gene is significantly expressed in various cell types, including goblet cells, neoplastic cells, and intestinal epithelial cells, which highlights its potential role in tissue-specific immune responses. **Pathways and Functions:** The TRBV6-7 gene is involved in the adaptive immune response, specifically in the cell surface receptor signaling pathway. This pathway is crucial for the activation of T cells, which are central to the adaptive immune response. The TRBV6-7 gene's expression in intestinal epithelial cells suggests that it may play a role in the gut-associated lymphoid tissue (GALT) immune response. The gene's involvement in the plasma membrane and T cell receptor complex further supports its role in cell surface receptor signaling. **Functions:** The TRBV6-7 gene's functions are not fully understood, but its expression in various cell types suggests that it may have tissue-specific immune regulatory functions. The gene's involvement in the adaptive immune response and cell surface receptor signaling pathways implies that it may play a role in the activation and regulation of T cells. Additionally, the gene's expression in goblet cells and intestinal epithelial cells suggests that it may be involved in the maintenance of the gut barrier function and the regulation of immune responses in the gut. **Clinical Significance:** The TRBV6-7 gene's non-functional nature and its expression in various cell types have significant implications for our understanding of immune system dysfunction. The gene's involvement in the adaptive immune response and cell surface receptor signaling pathways suggests that it may contribute to autoimmune diseases, such as inflammatory bowel disease (IBD), which are characterized by dysregulated immune responses in the gut. Furthermore, the gene's expression in neoplastic cells and abnormal cells suggests that it may be involved in cancer development and progression. In conclusion, the TRBV6-7 gene is a non-functional variant of the T cell receptor beta variable region that is significantly expressed in various cell types, including goblet cells, neoplastic cells, and intestinal epithelial cells. Further research is needed to fully understand the gene's functions and its implications in immune system dysfunction, particularly in the context of autoimmune diseases and cancer. As an expert immunologist, I recommend further investigation into the TRBV6-7 gene to uncover its full potential and its role in the immune system.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.