Details for: TRBV6 7

Gene ID: 28600

Symbol: TRBV6 7

Ensembl ID: ENSG00000253188

Description: T cell receptor beta variable 6-7 (non-functional)

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.63
    Marker Score: 10,813
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.25
    Marker Score: 7,578
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.22
    Marker Score: 3,658
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.06
    Marker Score: 32,723
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.97
    Marker Score: 733
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,407
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,349
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.81
    Marker Score: 741
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,265
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.74
    Marker Score: 1,269
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 440
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.15
    Marker Score: 246
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.1
    Marker Score: 215
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.05
    Marker Score: 39
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.05
    Marker Score: 38
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.04
    Marker Score: 19
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.04
    Marker Score: 70
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.04
    Marker Score: 74
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.03
    Marker Score: 20
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.03
    Marker Score: 20
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.02
    Marker Score: 20
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.02
    Marker Score: 24
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.02
    Marker Score: 20
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.02
    Marker Score: 20
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.02
    Marker Score: 20
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.02
    Marker Score: 22
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.01
    Marker Score: 16
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.01
    Marker Score: 25
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.01
    Marker Score: 18
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.01
    Marker Score: 22
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.01
    Marker Score: 397
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.01
    Marker Score: 18
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0
    Marker Score: 12
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0
    Marker Score: 16
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0
    Marker Score: 35
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0
    Marker Score: 12
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0
    Marker Score: 19

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The TRBV6-7 gene is a non-functional variant of the T cell receptor beta variable region, which is a crucial component of the adaptive immune system. The non-functional nature of this gene suggests that it may not contribute to the diversity of the T cell receptor repertoire, potentially affecting the immune system's ability to recognize and respond to pathogens. The TRBV6-7 gene is significantly expressed in various cell types, including goblet cells, neoplastic cells, and intestinal epithelial cells, which highlights its potential role in tissue-specific immune responses. **Pathways and Functions:** The TRBV6-7 gene is involved in the adaptive immune response, specifically in the cell surface receptor signaling pathway. This pathway is crucial for the activation of T cells, which are central to the adaptive immune response. The TRBV6-7 gene's expression in intestinal epithelial cells suggests that it may play a role in the gut-associated lymphoid tissue (GALT) immune response. The gene's involvement in the plasma membrane and T cell receptor complex further supports its role in cell surface receptor signaling. **Functions:** The TRBV6-7 gene's functions are not fully understood, but its expression in various cell types suggests that it may have tissue-specific immune regulatory functions. The gene's involvement in the adaptive immune response and cell surface receptor signaling pathways implies that it may play a role in the activation and regulation of T cells. Additionally, the gene's expression in goblet cells and intestinal epithelial cells suggests that it may be involved in the maintenance of the gut barrier function and the regulation of immune responses in the gut. **Clinical Significance:** The TRBV6-7 gene's non-functional nature and its expression in various cell types have significant implications for our understanding of immune system dysfunction. The gene's involvement in the adaptive immune response and cell surface receptor signaling pathways suggests that it may contribute to autoimmune diseases, such as inflammatory bowel disease (IBD), which are characterized by dysregulated immune responses in the gut. Furthermore, the gene's expression in neoplastic cells and abnormal cells suggests that it may be involved in cancer development and progression. In conclusion, the TRBV6-7 gene is a non-functional variant of the T cell receptor beta variable region that is significantly expressed in various cell types, including goblet cells, neoplastic cells, and intestinal epithelial cells. Further research is needed to fully understand the gene's functions and its implications in immune system dysfunction, particularly in the context of autoimmune diseases and cancer. As an expert immunologist, I recommend further investigation into the TRBV6-7 gene to uncover its full potential and its role in the immune system.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.