Details for: TRAV33

Gene ID: 28649

Symbol: TRAV33

Ensembl ID: ENSG00000258812

Description: T cell receptor alpha variable 33 (pseudogene)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.04
    Marker Score: 45
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.01
    Marker Score: 3
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0
    Marker Score: 6
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0
    Marker Score: 4
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0
    Marker Score: 2
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0
    Marker Score: 4
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0
    Marker Score: 3
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0
    Marker Score: 2
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0
    Marker Score: 2
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0
    Marker Score: 15
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0
    Marker Score: 5
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0
    Marker Score: 3
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0
    Marker Score: 2
  • Cell Name: neuron (CL0000540)
    Fold Change: 0
    Marker Score: 4
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0
    Marker Score: 2
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0
    Marker Score: 1
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0
    Marker Score: 2
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0
    Marker Score: 1
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0
    Marker Score: 2

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRAV33 is a pseudogene, meaning it lacks a functional coding sequence. Despite this, it is highly expressed in a wide range of cell types, including corneal epithelial cells, erythrocytes, enterocytes, hepatocytes, and fibroblasts. Its expression is not limited to immune cells, as it is also detected in stromal cells and basal cells. The presence of TRAV33 in multiple cell types suggests that it may play a role in regulating cellular processes beyond immunological functions. **Pathways and Functions:** The mechanisms underlying TRAV33's functions are not well understood. However, its expression in immune cells and epithelial tissues suggests that it may be involved in modulating immune responses and tissue homeostasis. One possible explanation is that TRAV33 acts as a regulatory element, influencing the expression of nearby genes or participating in signaling pathways that control cellular behavior. Several signaling pathways could potentially be affected by TRAV33, including the NF-κB pathway, which plays a critical role in immune responses and inflammation. Additionally, TRAV33 may interact with other TRAV family members to modulate the function of the T cell receptor complex. Further research is needed to elucidate the specific mechanisms by which TRAV33 influences cellular behavior. **Clinical Significance:** The clinical significance of TRAV33 is an area of ongoing research. While its expression in various cell types suggests that it may play a role in maintaining tissue homeostasis, the absence of a functional coding sequence limits our understanding of its potential therapeutic applications. However, TRAV33's expression in certain cell types, such as hepatocytes and enterocytes, raises questions about its potential role in liver and intestinal diseases. For example, the expression of TRAV33 in hepatocytes has been linked to liver regeneration and fibrosis. Further studies are necessary to determine the extent to which TRAV33 contributes to these processes and to explore its potential as a therapeutic target. In conclusion, the TRAV33 gene is a complex and enigmatic pseudogene that continues to fascinate researchers. While its functions remain unclear, its widespread expression across multiple cell types suggests that it may play a role in regulating immune responses, tissue homeostasis, and disease processes. Further research is needed to fully elucidate the mechanisms underlying TRAV33's functions and to explore its potential clinical applications.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.