Details for: TRAV33

Gene ID: 28649

Symbol: TRAV33

Ensembl ID: ENSG00000258812

Description: T cell receptor alpha variable 33 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.3809
    Cell Significance Index: 8.5800
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.2110
    Cell Significance Index: 2.5300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0717
    Cell Significance Index: 1.0200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.0560
    Cell Significance Index: 1.6500
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0334
    Cell Significance Index: 0.4100
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.0189
    Cell Significance Index: 0.2100
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.0086
    Cell Significance Index: 0.0900
  • Cell Name: adipocyte (CL0000136)
    Fold Change: 0.0008
    Cell Significance Index: 0.0100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0000
    Cell Significance Index: 0.0500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0000
    Cell Significance Index: 0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0001
    Cell Significance Index: -0.2100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0004
    Cell Significance Index: -0.0100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0005
    Cell Significance Index: -0.2500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0009
    Cell Significance Index: -0.0500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0010
    Cell Significance Index: -0.2000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0011
    Cell Significance Index: -0.0500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0022
    Cell Significance Index: -0.2700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0022
    Cell Significance Index: -0.2200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0022
    Cell Significance Index: -0.0500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0024
    Cell Significance Index: -0.0800
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0030
    Cell Significance Index: -0.0400
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0050
    Cell Significance Index: -0.0600
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0054
    Cell Significance Index: -0.0700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0055
    Cell Significance Index: -0.0900
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0059
    Cell Significance Index: -0.0700
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0061
    Cell Significance Index: -0.0700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0068
    Cell Significance Index: -0.1700
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0086
    Cell Significance Index: -0.1100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0087
    Cell Significance Index: -0.1900
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0089
    Cell Significance Index: -0.0900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0089
    Cell Significance Index: -0.1700
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0103
    Cell Significance Index: -0.1300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0116
    Cell Significance Index: -0.1200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0119
    Cell Significance Index: -0.1300
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0123
    Cell Significance Index: -0.1300
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0125
    Cell Significance Index: -0.1100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0130
    Cell Significance Index: -0.1800
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0133
    Cell Significance Index: -0.1300
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0143
    Cell Significance Index: -0.2400
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.0146
    Cell Significance Index: -0.2200
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0151
    Cell Significance Index: -0.1900
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.0156
    Cell Significance Index: -0.1400
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0156
    Cell Significance Index: -0.1800
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0162
    Cell Significance Index: -0.2100
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0168
    Cell Significance Index: -0.2000
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0168
    Cell Significance Index: -0.1500
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0173
    Cell Significance Index: -0.1800
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0177
    Cell Significance Index: -0.3000
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.0181
    Cell Significance Index: -0.1700
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0184
    Cell Significance Index: -0.2000
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0196
    Cell Significance Index: -0.2100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0200
    Cell Significance Index: -0.1900
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0202
    Cell Significance Index: -0.2800
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0207
    Cell Significance Index: -0.2200
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0208
    Cell Significance Index: -0.2100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0210
    Cell Significance Index: -0.2600
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0213
    Cell Significance Index: -0.2000
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0214
    Cell Significance Index: -0.2000
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0220
    Cell Significance Index: -0.2600
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: -0.0223
    Cell Significance Index: -0.2200
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: -0.0230
    Cell Significance Index: -0.2500
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0247
    Cell Significance Index: -0.2300
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0260
    Cell Significance Index: -0.2600
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0262
    Cell Significance Index: -0.2000
  • Cell Name: podocyte (CL0000653)
    Fold Change: -0.0262
    Cell Significance Index: -0.3000
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.0262
    Cell Significance Index: -0.2700
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.0263
    Cell Significance Index: -0.2400
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0267
    Cell Significance Index: -0.2300
  • Cell Name: kidney interstitial alternatively activated macrophage (CL1000695)
    Fold Change: -0.0274
    Cell Significance Index: -0.2800
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.0286
    Cell Significance Index: -0.3000
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0289
    Cell Significance Index: -0.2600
  • Cell Name: colonocyte (CL1000347)
    Fold Change: -0.0307
    Cell Significance Index: -0.1900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0315
    Cell Significance Index: -0.2900
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0315
    Cell Significance Index: -0.3000
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0351
    Cell Significance Index: -0.2600
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0355
    Cell Significance Index: -0.2200
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0398
    Cell Significance Index: -0.3100
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0405
    Cell Significance Index: -0.2600
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0437
    Cell Significance Index: -0.2300
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: -0.0440
    Cell Significance Index: -0.2600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRAV33 is a pseudogene, meaning it lacks a functional coding sequence. Despite this, it is highly expressed in a wide range of cell types, including corneal epithelial cells, erythrocytes, enterocytes, hepatocytes, and fibroblasts. Its expression is not limited to immune cells, as it is also detected in stromal cells and basal cells. The presence of TRAV33 in multiple cell types suggests that it may play a role in regulating cellular processes beyond immunological functions. **Pathways and Functions:** The mechanisms underlying TRAV33's functions are not well understood. However, its expression in immune cells and epithelial tissues suggests that it may be involved in modulating immune responses and tissue homeostasis. One possible explanation is that TRAV33 acts as a regulatory element, influencing the expression of nearby genes or participating in signaling pathways that control cellular behavior. Several signaling pathways could potentially be affected by TRAV33, including the NF-κB pathway, which plays a critical role in immune responses and inflammation. Additionally, TRAV33 may interact with other TRAV family members to modulate the function of the T cell receptor complex. Further research is needed to elucidate the specific mechanisms by which TRAV33 influences cellular behavior. **Clinical Significance:** The clinical significance of TRAV33 is an area of ongoing research. While its expression in various cell types suggests that it may play a role in maintaining tissue homeostasis, the absence of a functional coding sequence limits our understanding of its potential therapeutic applications. However, TRAV33's expression in certain cell types, such as hepatocytes and enterocytes, raises questions about its potential role in liver and intestinal diseases. For example, the expression of TRAV33 in hepatocytes has been linked to liver regeneration and fibrosis. Further studies are necessary to determine the extent to which TRAV33 contributes to these processes and to explore its potential as a therapeutic target. In conclusion, the TRAV33 gene is a complex and enigmatic pseudogene that continues to fascinate researchers. While its functions remain unclear, its widespread expression across multiple cell types suggests that it may play a role in regulating immune responses, tissue homeostasis, and disease processes. Further research is needed to fully elucidate the mechanisms underlying TRAV33's functions and to explore its potential clinical applications.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.