Details for: FFAR2

Gene ID: 2867

Symbol: FFAR2

Ensembl ID: ENSG00000126262

Description: free fatty acid receptor 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2
    Marker Score: 1996
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 857
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4818
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.14
    Marker Score: 2318
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71830
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48055
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 511
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 464
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.96
    Marker Score: 400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.94
    Marker Score: 1779
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5335
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 327
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5288
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.86
    Marker Score: 660.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.78
    Marker Score: 279
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.77
    Marker Score: 308
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.71
    Marker Score: 11176
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.64
    Marker Score: 383
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.62
    Marker Score: 412
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6
    Marker Score: 381.5
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.6
    Marker Score: 33335
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.56
    Marker Score: 1356
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 147
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.48
    Marker Score: 943
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 278
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.4
    Marker Score: 388
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.4
    Marker Score: 163
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.4
    Marker Score: 241
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.35
    Marker Score: 628
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.33
    Marker Score: 107
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.31
    Marker Score: 369
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.3
    Marker Score: 306
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.3
    Marker Score: 143
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.26
    Marker Score: 98
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.26
    Marker Score: 256
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.25
    Marker Score: 129
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.25
    Marker Score: 113
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.24
    Marker Score: 380
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.24
    Marker Score: 729
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.23
    Marker Score: 98
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.22
    Marker Score: 186
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.22
    Marker Score: 919
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.21
    Marker Score: 72
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.2
    Marker Score: 79
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.19
    Marker Score: 52
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.19
    Marker Score: 190
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.18
    Marker Score: 116
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.18
    Marker Score: 471
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.18
    Marker Score: 233
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.17
    Marker Score: 38
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.16
    Marker Score: 70
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.16
    Marker Score: 1820
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.15
    Marker Score: 64
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.15
    Marker Score: 144
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.15
    Marker Score: 33
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.14
    Marker Score: 81
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.13
    Marker Score: 73
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.13
    Marker Score: 771
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.13
    Marker Score: 73
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.12
    Marker Score: 43
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.12
    Marker Score: 804
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.12
    Marker Score: 119
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.12
    Marker Score: 132
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.11
    Marker Score: 285
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.11
    Marker Score: 164
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.11
    Marker Score: 51
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.11
    Marker Score: 58
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.11
    Marker Score: 2816
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.11
    Marker Score: 45
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.11
    Marker Score: 100
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.11
    Marker Score: 118
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.11
    Marker Score: 108
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.1
    Marker Score: 46
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.1
    Marker Score: 93
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.1
    Marker Score: 114
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.1
    Marker Score: 67
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.09
    Marker Score: 32
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.09
    Marker Score: 41
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.09
    Marker Score: 70
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.09
    Marker Score: 21
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.09
    Marker Score: 45
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.09
    Marker Score: 46
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.09
    Marker Score: 81
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.08
    Marker Score: 1142
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.08
    Marker Score: 49
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.08
    Marker Score: 168
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.08
    Marker Score: 20
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.08
    Marker Score: 25
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.08
    Marker Score: 4135

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Other Information

**Key characteristics:** * FFAR2 is a single-pass transmembrane protein with a molecular weight of approximately 140 kDa. * It has seven extracellular domains, each of which is associated with a specific signaling pathway. * FFAR2 is a ligand-gated channel that is sensitive to fatty acids. * It is expressed in high levels in the enterocyte of the large intestine, where it is involved in maintaining intestinal homeostasis and preventing inflammation. * It is also expressed in immune cells, where it plays a role in regulating immune responses. **Pathways and functions:** * FFAR2 signaling is involved in the regulation of inflammation and immune responses in the gut. * It is expressed in epithelial cells of the small intestine, where it is crucial for maintaining mucosal integrity and preventing pathogen entry. * It is also expressed in immune cells, including dendritic cells, macrophages, and neutrophils. * FFAR2 signaling is activated by fatty acids released from dead or dying epithelial cells. * This activation leads to the opening of the channel, which allows calcium ions to enter the cell. * Calcium ions activate a variety of intracellular signaling pathways, including the MAPK pathway, which is involved in inflammation and cell growth. **Clinical significance:** * Mutations in FFAR2 have been linked to a number of inflammatory diseases, including Crohn's disease, ulcerative colitis, and obesity-related inflammation. * Overexpression of FFAR2 has been observed in cancer cells, where it promotes tumor growth and metastasis. * Thus, targeting FFAR2 signaling could be a potential therapeutic strategy for inflammatory diseases. **Additional notes:** * FFAR2 is a promising target for the development of novel therapeutic strategies for inflammatory diseases. * The development of inhibitors that block FFAR2 signaling has shown promise in preclinical models of inflammatory diseases. * Further research is needed to understand the role of FFAR2 in human health and disease.

Genular Protein ID: 310215910

Symbol: FFAR2_HUMAN

Name: Free fatty acid receptor 2

UniProtKB Accession Codes:

O15552 B0M0J9 Q4VAZ3 Q4VAZ5 Q4VBL5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EMBL 8 Ensembl 2 ExpressionAtlas 1 GO 22 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 4 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9344866

Title: A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1.

PubMed ID: 9344866

DOI: 10.1006/bbrc.1997.7513

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12684041

Title: Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids.

PubMed ID: 12684041

DOI: 10.1016/s0006-291x(03)00488-1

PubMed ID: 12496283

Title: The orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids.

PubMed ID: 12496283

DOI: 10.1074/jbc.m211609200

PubMed ID: 12711604

Title: Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation.

PubMed ID: 12711604

DOI: 10.1074/jbc.m301403200

PubMed ID: 18801738

Title: Conserved polar residues in transmembrane domains V, VI, and VII of free fatty acid receptor 2 and free fatty acid receptor 3 are required for the binding and function of short chain fatty acids.

PubMed ID: 18801738

DOI: 10.1074/jbc.m805601200

PubMed ID: 20837008

Title: Allosteric rescuing of loss-of-function FFAR2 mutations.

PubMed ID: 20837008

DOI: 10.1016/j.febslet.2010.09.007

PubMed ID: 21037097

Title: Secreted M-ficolin anchors onto monocyte transmembrane G protein-coupled receptor 43 and cross talks with plasma C-reactive protein to mediate immune signaling and regulate host defense.

PubMed ID: 21037097

DOI: 10.4049/jimmunol.1001225

PubMed ID: 21216233

Title: Mutational analysis of G-protein coupled receptor--FFA2.

PubMed ID: 21216233

DOI: 10.1016/j.bbrc.2010.12.139

PubMed ID: 23066016

Title: Extracellular ionic locks determine variation in constitutive activity and ligand potency between species orthologs of the free fatty acid receptors FFA2 and FFA3.

PubMed ID: 23066016

DOI: 10.1074/jbc.m112.396259

PubMed ID: 23589301

Title: Defining the molecular basis for the first potent and selective orthosteric agonists of the FFA2 free fatty acid receptor.

PubMed ID: 23589301

DOI: 10.1074/jbc.m113.455337

Sequence Information:

  • Length: 330
  • Mass: 37144
  • Checksum: F4A8AC6AFBDF1E90
  • Sequence:
    • MLPDWKSSLI LMAYIIIFLT GLPANLLALR AFVGRIRQPQ PAPVHILLLS LTLADLLLLL 
LLPFKIIEAA SNFRWYLPKV VCALTSFGFY SSIYCSTWLL AGISIERYLG VAFPVQYKLS 
RRPLYGVIAA LVAWVMSFGH CTIVIIVQYL NTTEQVRSGN EITCYENFTD NQLDVVLPVR 
LELCLVLFFI PMAVTIFCYW RFVWIMLSQP LVGAQRRRRA VGLAVVTLLN FLVCFGPYNV 
SHLVGYHQRK SPWWRSIAVV FSSLNASLDP LLFYFSSSVV RRAFGRGLQV LRNQGSSLLG 
RRGKDTAEGT NEDRGVGQGE GMPSSDFTTE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.