Details for: FFAR2

Gene ID: 2867

Symbol: FFAR2

Ensembl ID: ENSG00000126262

Description: free fatty acid receptor 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 21.4086
    Cell Significance Index: -3.3300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 13.2667
    Cell Significance Index: -3.3700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 8.0737
    Cell Significance Index: -3.2800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 7.4361
    Cell Significance Index: -3.8300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 5.0855
    Cell Significance Index: -3.4100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 4.1745
    Cell Significance Index: 255.9400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 3.7089
    Cell Significance Index: 118.7900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 2.7170
    Cell Significance Index: -3.3500
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 2.2028
    Cell Significance Index: 13.2000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.5062
    Cell Significance Index: 68.2700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 0.8578
    Cell Significance Index: -3.3900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6195
    Cell Significance Index: 559.3800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.5746
    Cell Significance Index: 8.8900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5214
    Cell Significance Index: 31.3000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5045
    Cell Significance Index: 54.8800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.4902
    Cell Significance Index: 9.0600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4771
    Cell Significance Index: 90.7900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3935
    Cell Significance Index: 64.0000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2787
    Cell Significance Index: 19.2800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.2404
    Cell Significance Index: 6.4300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.1738
    Cell Significance Index: 4.3400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0968
    Cell Significance Index: 9.5800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0877
    Cell Significance Index: 3.0800
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.0349
    Cell Significance Index: 0.2400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0222
    Cell Significance Index: 0.6400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0013
    Cell Significance Index: 0.0200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0014
    Cell Significance Index: -0.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0016
    Cell Significance Index: -3.0600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0026
    Cell Significance Index: -4.7800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0028
    Cell Significance Index: -0.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0028
    Cell Significance Index: -2.0600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0030
    Cell Significance Index: -4.6400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0034
    Cell Significance Index: -1.9200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0036
    Cell Significance Index: -4.8600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0043
    Cell Significance Index: -3.2700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0052
    Cell Significance Index: -2.8600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0054
    Cell Significance Index: -3.4100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0059
    Cell Significance Index: -3.6800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0080
    Cell Significance Index: -2.8700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0087
    Cell Significance Index: -3.9300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0097
    Cell Significance Index: -1.9200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0119
    Cell Significance Index: -3.4300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0140
    Cell Significance Index: -0.7100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0155
    Cell Significance Index: -0.6400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0168
    Cell Significance Index: -3.3700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0173
    Cell Significance Index: -3.1200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0179
    Cell Significance Index: -0.4600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0180
    Cell Significance Index: -3.7900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0189
    Cell Significance Index: -2.6000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0208
    Cell Significance Index: -3.0300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0209
    Cell Significance Index: -3.5700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0236
    Cell Significance Index: -0.4900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0243
    Cell Significance Index: -2.8300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0257
    Cell Significance Index: -3.1600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0271
    Cell Significance Index: -1.1800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0289
    Cell Significance Index: -3.7300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0307
    Cell Significance Index: -3.1300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0336
    Cell Significance Index: -0.9400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0337
    Cell Significance Index: -1.7500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0338
    Cell Significance Index: -3.8700
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.0355
    Cell Significance Index: -0.4500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0429
    Cell Significance Index: -0.3500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0438
    Cell Significance Index: -2.7600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0498
    Cell Significance Index: -3.8200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0501
    Cell Significance Index: -3.3700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0505
    Cell Significance Index: -3.7700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0542
    Cell Significance Index: -2.5500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0560
    Cell Significance Index: -3.6100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0590
    Cell Significance Index: -2.7500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0599
    Cell Significance Index: -3.6800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0607
    Cell Significance Index: -3.1600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0681
    Cell Significance Index: -3.8200
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0725
    Cell Significance Index: -0.7500
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0748
    Cell Significance Index: -0.8200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0750
    Cell Significance Index: -2.0100
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0771
    Cell Significance Index: -1.1200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0821
    Cell Significance Index: -2.0500
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.0827
    Cell Significance Index: -1.0000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0850
    Cell Significance Index: -3.1200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0891
    Cell Significance Index: -3.9400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0911
    Cell Significance Index: -3.1900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0919
    Cell Significance Index: -1.5500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0953
    Cell Significance Index: -1.5700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0975
    Cell Significance Index: -2.0400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1000
    Cell Significance Index: -2.5000
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1019
    Cell Significance Index: -1.4900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1020
    Cell Significance Index: -2.0000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1040
    Cell Significance Index: -3.9400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1049
    Cell Significance Index: -2.5400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1068
    Cell Significance Index: -3.7100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1068
    Cell Significance Index: -1.8300
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.1072
    Cell Significance Index: -1.1500
  • Cell Name: immature alpha-beta T cell (CL0000790)
    Fold Change: -0.1101
    Cell Significance Index: -0.8200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1122
    Cell Significance Index: -3.6800
  • Cell Name: eosinophil (CL0000771)
    Fold Change: -0.1122
    Cell Significance Index: -0.9900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1146
    Cell Significance Index: -3.6500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1175
    Cell Significance Index: -3.4600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1193
    Cell Significance Index: -3.4100
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.1204
    Cell Significance Index: -0.9800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1210
    Cell Significance Index: -0.8200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** FFAR2 is a member of the GPR40 family of GPCRs, which are activated by free fatty acids (FFAs) and other lipid ligands. The receptor is characterized by its high expression in tissues involved in lipid metabolism, such as the intestine, pancreas, and adipose tissue. FFAR2 is also known to be involved in the regulation of glucose homeostasis, insulin secretion, and inflammation. The receptor's ligand-binding site is distinct from other GPCRs, allowing it to interact with FFAs and other lipid molecules. **Pathways and Functions:** FFAR2 is involved in several signaling pathways, including: 1. **G-protein coupled receptor signaling pathway:** FFAR2 activates G proteins, which in turn regulate various cellular responses, including inflammation, insulin secretion, and lipid storage. 2. **Cell surface pattern recognition receptor signaling pathway:** FFAR2 recognizes FFAs and other lipid ligands, triggering a signaling cascade that regulates immune responses and metabolic homeostasis. 3. **Lipid binding:** FFAR2 binds to FFAs and other lipid molecules, regulating their uptake and storage in cells. 4. **Regulation of insulin secretion:** FFAR2 is involved in the regulation of insulin secretion, particularly in response to FFAs. 5. **Inflammation regulation:** FFAR2 modulates inflammatory responses, including the production of cytokines and chemokines. **Clinical Significance:** FFAR2 plays a crucial role in regulating immune responses and metabolic homeostasis. Dysregulation of FFAR2 has been implicated in various diseases, including: 1. **Type 2 diabetes:** FFAR2 is involved in the regulation of insulin secretion, and its dysregulation contributes to the development of type 2 diabetes. 2. **Atherosclerosis:** FFAR2 modulates inflammatory responses, which are essential for the development of atherosclerosis. 3. **Obesity:** FFAR2 is involved in lipid storage and metabolism, and its dysregulation contributes to the development of obesity. 4. **Inflammatory bowel disease:** FFAR2 is involved in the regulation of inflammation, and its dysregulation contributes to the development of inflammatory bowel disease. In conclusion, FFAR2 is a critical regulator of immune responses and metabolic homeostasis. Its dysregulation contributes to the development of various diseases, including type 2 diabetes, atherosclerosis, obesity, and inflammatory bowel disease. Further research is needed to fully understand the mechanisms of FFAR2 and its clinical significance in regulating immune responses and metabolic disorders.

Genular Protein ID: 310215910

Symbol: FFAR2_HUMAN

Name: Free fatty acid receptor 2

UniProtKB Accession Codes:

O15552 B0M0J9 Q4VAZ3 Q4VAZ5 Q4VBL5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EMBL 8 EMDB 4 Ensembl 2 ExpressionAtlas 1 GO 22 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 4 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9344866

Title: A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1.

PubMed ID: 9344866

DOI: 10.1006/bbrc.1997.7513

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12684041

Title: Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids.

PubMed ID: 12684041

DOI: 10.1016/s0006-291x(03)00488-1

PubMed ID: 12496283

Title: The orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids.

PubMed ID: 12496283

DOI: 10.1074/jbc.m211609200

PubMed ID: 12711604

Title: Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation.

PubMed ID: 12711604

DOI: 10.1074/jbc.m301403200

PubMed ID: 18801738

Title: Conserved polar residues in transmembrane domains V, VI, and VII of free fatty acid receptor 2 and free fatty acid receptor 3 are required for the binding and function of short chain fatty acids.

PubMed ID: 18801738

DOI: 10.1074/jbc.m805601200

PubMed ID: 20837008

Title: Allosteric rescuing of loss-of-function FFAR2 mutations.

PubMed ID: 20837008

DOI: 10.1016/j.febslet.2010.09.007

PubMed ID: 21037097

Title: Secreted M-ficolin anchors onto monocyte transmembrane G protein-coupled receptor 43 and cross talks with plasma C-reactive protein to mediate immune signaling and regulate host defense.

PubMed ID: 21037097

DOI: 10.4049/jimmunol.1001225

PubMed ID: 21216233

Title: Mutational analysis of G-protein coupled receptor--FFA2.

PubMed ID: 21216233

DOI: 10.1016/j.bbrc.2010.12.139

PubMed ID: 23066016

Title: Extracellular ionic locks determine variation in constitutive activity and ligand potency between species orthologs of the free fatty acid receptors FFA2 and FFA3.

PubMed ID: 23066016

DOI: 10.1074/jbc.m112.396259

PubMed ID: 23589301

Title: Defining the molecular basis for the first potent and selective orthosteric agonists of the FFA2 free fatty acid receptor.

PubMed ID: 23589301

DOI: 10.1074/jbc.m113.455337

Sequence Information:

  • Length: 330
  • Mass: 37144
  • Checksum: F4A8AC6AFBDF1E90
  • Sequence:
    • MLPDWKSSLI LMAYIIIFLT GLPANLLALR AFVGRIRQPQ PAPVHILLLS LTLADLLLLL 
LLPFKIIEAA SNFRWYLPKV VCALTSFGFY SSIYCSTWLL AGISIERYLG VAFPVQYKLS 
RRPLYGVIAA LVAWVMSFGH CTIVIIVQYL NTTEQVRSGN EITCYENFTD NQLDVVLPVR 
LELCLVLFFI PMAVTIFCYW RFVWIMLSQP LVGAQRRRRA VGLAVVTLLN FLVCFGPYNV 
SHLVGYHQRK SPWWRSIAVV FSSLNASLDP LLFYFSSSVV RRAFGRGLQV LRNQGSSLLG 
RRGKDTAEGT NEDRGVGQGE GMPSSDFTTE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.