Details for: TRAJ49

Gene ID: 28706

Symbol: TRAJ49

Ensembl ID: ENSG00000211840

Description: T cell receptor alpha joining 49

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 9.0590
    Cell Significance Index: 177.1200
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 2.0071
    Cell Significance Index: 25.3600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.5704
    Cell Significance Index: 38.0400
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.3334
    Cell Significance Index: 4.3800
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.2449
    Cell Significance Index: 3.5700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.1377
    Cell Significance Index: 2.2300
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.1106
    Cell Significance Index: 1.2500
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.0459
    Cell Significance Index: 0.6300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0024
    Cell Significance Index: 0.1200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0004
    Cell Significance Index: -0.0200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0037
    Cell Significance Index: -1.3200
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0183
    Cell Significance Index: -0.2500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0342
    Cell Significance Index: -0.8700
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0343
    Cell Significance Index: -0.4400
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0437
    Cell Significance Index: -0.5300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0478
    Cell Significance Index: -0.8200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0528
    Cell Significance Index: -0.6300
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0534
    Cell Significance Index: -0.6300
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0546
    Cell Significance Index: -0.6200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0635
    Cell Significance Index: -1.3900
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0773
    Cell Significance Index: -0.8200
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0817
    Cell Significance Index: -1.0200
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0834
    Cell Significance Index: -1.0000
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0880
    Cell Significance Index: -1.1600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0898
    Cell Significance Index: -1.6600
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0916
    Cell Significance Index: -1.2600
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.0920
    Cell Significance Index: -0.8100
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0926
    Cell Significance Index: -1.1600
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0949
    Cell Significance Index: -1.2800
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0956
    Cell Significance Index: -1.2000
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1012
    Cell Significance Index: -1.1900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1017
    Cell Significance Index: -1.3200
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1023
    Cell Significance Index: -1.1800
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1034
    Cell Significance Index: -1.3100
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1044
    Cell Significance Index: -0.9900
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.1055
    Cell Significance Index: -1.2000
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.1057
    Cell Significance Index: -1.1400
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1058
    Cell Significance Index: -0.9900
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.1102
    Cell Significance Index: -0.9100
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.1114
    Cell Significance Index: -1.2800
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1121
    Cell Significance Index: -1.4900
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.1125
    Cell Significance Index: -1.2100
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1146
    Cell Significance Index: -1.4700
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1147
    Cell Significance Index: -1.2700
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1159
    Cell Significance Index: -1.3700
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.1164
    Cell Significance Index: -1.3000
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.1173
    Cell Significance Index: -1.0000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1239
    Cell Significance Index: -1.3500
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.1252
    Cell Significance Index: -1.3700
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.1340
    Cell Significance Index: -1.4200
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.1343
    Cell Significance Index: -1.3400
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1371
    Cell Significance Index: -1.7900
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.1374
    Cell Significance Index: -1.5600
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1376
    Cell Significance Index: -1.6900
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.1395
    Cell Significance Index: -1.3600
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.1444
    Cell Significance Index: -1.1900
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.1472
    Cell Significance Index: -1.3600
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.1481
    Cell Significance Index: -1.3700
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.1508
    Cell Significance Index: -1.1600
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.1516
    Cell Significance Index: -1.3500
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.1572
    Cell Significance Index: -1.2900
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.1593
    Cell Significance Index: -1.3700
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.1607
    Cell Significance Index: -1.6300
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1720
    Cell Significance Index: -2.0000
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.1761
    Cell Significance Index: -1.3700
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.1892
    Cell Significance Index: -1.6600
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.1950
    Cell Significance Index: -1.9700
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.2090
    Cell Significance Index: -1.6700
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.2256
    Cell Significance Index: -2.3800
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.2283
    Cell Significance Index: -1.9700
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.2329
    Cell Significance Index: -1.2700
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.2408
    Cell Significance Index: -1.9500
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.2432
    Cell Significance Index: -2.4500
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.2542
    Cell Significance Index: -2.1500
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.3078
    Cell Significance Index: -2.2900
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.6562
    Cell Significance Index: -2.0000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The TRAJ49 gene is an alpha chain of the TCR complex, specifically joining the alpha chain to the beta chain to form a functional TCR. This gene is characterized by its unique structure and expression pattern, which distinguishes it from other TCR alpha chains. Notably, TRAJ49 is highly expressed in cells of the intestinal epithelium, including goblet cells, absorptive cells, and intestinal crypt stem cells, suggesting a critical role in mucosal immunity and tissue homeostasis. **Pathways and Functions** The TRAJ49 gene is involved in the TCR signaling pathway, which is essential for the activation and regulation of immune cells, including T cells and natural killer cells. Upon antigen recognition, the TCR undergoes conformational changes that activate downstream signaling pathways, including the activation of transcription factors such as NF-κB and AP-1. These transcription factors regulate the expression of genes involved in immune function, including cytokines, chemokines, and adhesion molecules. The TRAJ49 gene also plays a role in maintaining tissue homeostasis and preventing excessive immune responses. For example, TRAJ49-expressing cells in the intestinal epithelium can regulate the production of anti-inflammatory cytokines and inhibit the activation of pro-inflammatory T cells. **Clinical Significance** Dysregulation of TRAJ49 expression has been implicated in various immune-related disorders, including autoimmune diseases, such as multiple sclerosis and type 1 diabetes. Additionally, aberrant TRAJ49 expression has been found in certain types of cancer, including colorectal cancer, where it may contribute to tumor progression and immune evasion. Furthermore, TRAJ49 has been identified as a potential therapeutic target for the treatment of autoimmune diseases. For example, modulation of TRAJ49 expression or signaling has been shown to reduce inflammation and improve immune function in animal models of autoimmune diseases. In conclusion, the TRAJ49 gene is a critical component of the TCR complex that plays a pivotal role in immune function and tissue homeostasis. Its dysregulation has been implicated in various immune-related disorders, and it holds promise as a therapeutic target for the treatment of autoimmune diseases. Further research is necessary to fully elucidate the mechanisms of TRAJ49 and its role in human health and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.