Details for: RAPGEF1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 290.5907
Cell Significance Index: -45.2000 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 177.8876
Cell Significance Index: -45.1200 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 107.6593
Cell Significance Index: -44.3500 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 102.8546
Cell Significance Index: -48.5600 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 102.4105
Cell Significance Index: -41.6100 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 90.2436
Cell Significance Index: -46.4200 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 36.8059
Cell Significance Index: -45.3800 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 20.2733
Cell Significance Index: -44.3700 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 16.7833
Cell Significance Index: -44.9600 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 14.4427
Cell Significance Index: -44.3600 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 11.5964
Cell Significance Index: -45.7600 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 9.4604
Cell Significance Index: 136.0700 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 2.4433
Cell Significance Index: 65.2400 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 1.9383
Cell Significance Index: 73.4000 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 1.9301
Cell Significance Index: 85.3800 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.8509
Cell Significance Index: 371.2800 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.7913
Cell Significance Index: 355.4900 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.4102
Cell Significance Index: 505.8300 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 1.3951
Cell Significance Index: 35.8600 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 1.1910
Cell Significance Index: 66.8300 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.0276
Cell Significance Index: 78.8600 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.0095
Cell Significance Index: 181.9800 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.8856
Cell Significance Index: 23.7300 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.7764
Cell Significance Index: 536.9800 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.5852
Cell Significance Index: 95.1800 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.5645
Cell Significance Index: 61.4000 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.4802
Cell Significance Index: 433.5700 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.4625
Cell Significance Index: 11.5600 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.4468
Cell Significance Index: 27.4600 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.3801
Cell Significance Index: 46.7400 - Cell Name: preadipocyte (CL0002334)
Fold Change: 0.3771
Cell Significance Index: 7.3600 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.3746
Cell Significance Index: 22.4900 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.3318
Cell Significance Index: 9.5600 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.2832
Cell Significance Index: 19.0400 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.2773
Cell Significance Index: 3.4400 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.1972
Cell Significance Index: 3.3800 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.1947
Cell Significance Index: 22.9600 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.1899
Cell Significance Index: 13.1300 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.1885
Cell Significance Index: 355.0000 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.1832
Cell Significance Index: 83.1600 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.1758
Cell Significance Index: 3.8500 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.1750
Cell Significance Index: 111.1600 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.1705
Cell Significance Index: 1.0300 - Cell Name: type I muscle cell (CL0002211)
Fold Change: 0.1624
Cell Significance Index: 3.9600 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1299
Cell Significance Index: 24.7200 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.1142
Cell Significance Index: 7.3700 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1087
Cell Significance Index: 59.3500 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.0967
Cell Significance Index: 9.5700 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0757
Cell Significance Index: 2.6600 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0690
Cell Significance Index: 106.1900 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0631
Cell Significance Index: 10.7700 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0630
Cell Significance Index: 116.2400 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.0494
Cell Significance Index: 1.3800 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0210
Cell Significance Index: 9.3000 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0033
Cell Significance Index: -4.4600 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0212
Cell Significance Index: -13.2300 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0264
Cell Significance Index: -19.5800 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0386
Cell Significance Index: -28.2900 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.0547
Cell Significance Index: -1.1700 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0580
Cell Significance Index: -43.8800 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0608
Cell Significance Index: -34.3100 - Cell Name: extravillous trophoblast (CL0008036)
Fold Change: -0.1127
Cell Significance Index: -0.7000 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.1298
Cell Significance Index: -17.8200 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1333
Cell Significance Index: -13.6200 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1391
Cell Significance Index: -40.0100 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1433
Cell Significance Index: -30.1800 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1524
Cell Significance Index: -22.1600 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.1610
Cell Significance Index: -3.8600 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.1956
Cell Significance Index: -9.1200 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.2116
Cell Significance Index: -27.1300 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2512
Cell Significance Index: -29.2700 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2527
Cell Significance Index: -28.9500 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.2559
Cell Significance Index: -4.3100 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.2647
Cell Significance Index: -12.4400 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.2752
Cell Significance Index: -35.5500 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.2967
Cell Significance Index: -33.8700 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3189
Cell Significance Index: -33.2000 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.3963
Cell Significance Index: -11.3100 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.4853
Cell Significance Index: -25.2800 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.4958
Cell Significance Index: -36.9500 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.4997
Cell Significance Index: -25.9600 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.5126
Cell Significance Index: -40.6000 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.5377
Cell Significance Index: -11.6500 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.5520
Cell Significance Index: -8.1500 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.5542
Cell Significance Index: -34.9300 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: -0.5613
Cell Significance Index: -8.5400 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.5767
Cell Significance Index: -18.4700 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.5933
Cell Significance Index: -31.1500 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.6012
Cell Significance Index: -42.5200 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.6517
Cell Significance Index: -13.8800 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.6698
Cell Significance Index: -41.0700 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.6724
Cell Significance Index: -14.2700 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.7096
Cell Significance Index: -22.6000 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.7146
Cell Significance Index: -32.3900 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.7168
Cell Significance Index: -10.2700 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.7450
Cell Significance Index: -13.7700 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.7544
Cell Significance Index: -24.7000 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.7733
Cell Significance Index: -11.1100 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.7764
Cell Significance Index: -11.4600 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.7911
Cell Significance Index: -16.4100
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1410279526
Symbol: RPGF1_HUMAN
Name: Rap guanine nucleotide exchange factor 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7512734
Title: C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins.
PubMed ID: 7512734
PubMed ID: 7806500
Title: Four proline-rich sequences of the guanine-nucleotide exchange factor C3G bind with unique specificity to the first Src homology 3 domain of Crk.
PubMed ID: 7806500
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 15164053
Title: DNA sequence and analysis of human chromosome 9.
PubMed ID: 15164053
DOI: 10.1038/nature02465
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8662907
Title: Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins.
PubMed ID: 8662907
PubMed ID: 12432078
Title: Novel function of Chat in controlling cell adhesion via Cas-Crk-C3G-pathway-mediated Rap1 activation.
PubMed ID: 12432078
DOI: 10.1242/jcs.00207
PubMed ID: 14551197
Title: Physical and functional interaction between Hck tyrosine kinase and guanine nucleotide exchange factor C3G results in apoptosis, which is independent of C3G catalytic domain.
PubMed ID: 14551197
PubMed ID: 15144186
Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.
PubMed ID: 15144186
DOI: 10.1021/ac035352d
PubMed ID: 17724123
Title: Rap1-PDZ-GEF1 interacts with a neurotrophin receptor at late endosomes, leading to sustained activation of Rap1 and ERK and neurite outgrowth.
PubMed ID: 17724123
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21840392
Title: Epac1 and PDZ-GEF cooperate in Rap1 mediated endothelial junction control.
PubMed ID: 21840392
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25218447
Title: Uncovering global SUMOylation signaling networks in a site-specific manner.
PubMed ID: 25218447
DOI: 10.1038/nsmb.2890
PubMed ID: 23033978
Title: Diagnostic exome sequencing in persons with severe intellectual disability.
PubMed ID: 23033978
Sequence Information:
- Length: 1077
- Mass: 120548
- Checksum: E700631A0EE76CA1
- Sequence:
MDTDSQRSHL SSFTMKLMDK FHSPKIKRTP SKKGKPAEVS VKIPEKPVNK EATDRFLPEG YPLPLDLEQQ AVEFMSTSAV ASRSQRQKNL SWLEEKEKEV VSALRYFKTI VDKMAIDKKV LEMLPGSASK VLEAILPLVQ NDPRIQHSSA LSSCYSRVYQ SLANLIRWSD QVMLEGVNSE DKEMVTTVKG VIKAVLDGVK ELVRLTIEKQ GRPSPTSPVK PSSPASKPDG PAELPLTDRE VEILNKTTGM SQSTELLPDA TDEEVAPPKP PLPGIRVVDN SPPPALPPKK RQSAPSPTRV AVVAPMSRAT SGSSLPVGIN RQDFDVDCYA QRRLSGGSHS YGGESPRLSP CSSIGKLSKS DEQLSSLDRD SGQCSRNTSC ETLDHYDPDY EFLQQDLSNA DQIPQQTAWN LSPLPESLGE SGSPFLGPPF QLPLGGHPQP DGPLAPGQQT DTPPALPEKK RRSAASQTAD GSGCRVSYER HPSQYDNISG EDLQSTAPIP SVPYAPFAAI LPFQHGGSSA PVEFVGDFTA PESTGDPEKP PPLPEKKNKH MLAYMQLLED YSEPQPSMFY QTPQNEHIYQ QKNKLLMEVY GFSDSFSGVD SVQELAPPPA LPPKQRQLEP PAGKDGHPRD PSAVSGVPGK DSRDGSERAP KSPDALESAQ SEEEVDELSL IDHNEIMSRL TLKQEGDDGP DVRGGSGDIL LVHATETDRK DLVLYCEAFL TTYRTFISPE ELIKKLQYRY EKFSPFADTF KKRVSKNTFF VLVRVVDELC LVELTEEILK LLMELVFRLV CNGELSLARV LRKNILDKVD QKKLLRCATS SQPLAARGVA ARPGTLHDFH SHEIAEQLTL LDAELFYKIE IPEVLLWAKE QNEEKSPNLT QFTEHFNNMS YWVRSIIMLQ EKAQDRERLL LKFIKIMKHL RKLNNFNSYL AILSALDSAP IRRLEWQKQT SEGLAEYCTL IDSSSSFRAY RAALSEVEPP CIPYLGLILQ DLTFVHLGNP DYIDGKVNFS KRWQQFNILD SMRCFQQAHY DMRRNDDIIN FFNDFSDHLA EEALWELSLK IKPRNITRRK TDREEKT
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.