Details for: RAPGEF1
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 2.67
Marker Score: 1,325 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 2.53
Marker Score: 1,508 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 2.44
Marker Score: 1,419 - Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 2.38
Marker Score: 1,952 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 2.17
Marker Score: 4,760 - Cell Name: mature microglial cell (CL0002629)
Fold Change: 2.13
Marker Score: 770 - Cell Name: stellate neuron (CL0000122)
Fold Change: 2.06
Marker Score: 11,059 - Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
Fold Change: 2.03
Marker Score: 10,628 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 1.98
Marker Score: 2,187 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 1.97
Marker Score: 72,556 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 1.95
Marker Score: 38,769 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 1.92
Marker Score: 34,134 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 1.92
Marker Score: 4,809 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 1.9
Marker Score: 595 - Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 1.87
Marker Score: 71,205 - Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 1.86
Marker Score: 2,705 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 1.84
Marker Score: 7,642 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 1.82
Marker Score: 13,921 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 1.82
Marker Score: 27,147 - Cell Name: neuron (CL0000540)
Fold Change: 1.8
Marker Score: 7,318 - Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.79
Marker Score: 6,931 - Cell Name: mononuclear cell (CL0000842)
Fold Change: 1.74
Marker Score: 562 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.73
Marker Score: 106,388 - Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 1.72
Marker Score: 1,985 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.72
Marker Score: 16,369 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 1.72
Marker Score: 16,181 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.69
Marker Score: 17,419 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 1.67
Marker Score: 56,315 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 1.63
Marker Score: 6,833 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.63
Marker Score: 13,960 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 1.61
Marker Score: 34,441 - Cell Name: A2 amacrine cell (CL0004219)
Fold Change: 1.58
Marker Score: 502 - Cell Name: granule cell (CL0000120)
Fold Change: 1.57
Marker Score: 11,844 - Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.57
Marker Score: 3,697 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 1.52
Marker Score: 445 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.49
Marker Score: 2,301 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 1.47
Marker Score: 881 - Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 1.45
Marker Score: 812 - Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 1.42
Marker Score: 1,527 - Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 1.41
Marker Score: 6,516 - Cell Name: lung goblet cell (CL1000143)
Fold Change: 1.39
Marker Score: 401 - Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 1.39
Marker Score: 2,674 - Cell Name: hepatoblast (CL0005026)
Fold Change: 1.38
Marker Score: 4,524 - Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 1.35
Marker Score: 567 - Cell Name: macroglial cell (CL0000126)
Fold Change: 1.35
Marker Score: 3,093 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.35
Marker Score: 2,736 - Cell Name: brainstem motor neuron (CL2000047)
Fold Change: 1.32
Marker Score: 767 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.31
Marker Score: 20,548 - Cell Name: IgG memory B cell (CL0000979)
Fold Change: 1.29
Marker Score: 777 - Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 1.24
Marker Score: 655 - Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 1.23
Marker Score: 336 - Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 1.22
Marker Score: 829 - Cell Name: podocyte (CL0000653)
Fold Change: 1.21
Marker Score: 447 - Cell Name: fat cell (CL0000136)
Fold Change: 1.19
Marker Score: 666 - Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 1.18
Marker Score: 575 - Cell Name: Kupffer cell (CL0000091)
Fold Change: 1.16
Marker Score: 1,161 - Cell Name: non-classical monocyte (CL0000875)
Fold Change: 1.13
Marker Score: 2,738 - Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
Fold Change: 1.12
Marker Score: 308 - Cell Name: transitional stage B cell (CL0000818)
Fold Change: 1.11
Marker Score: 394 - Cell Name: mesangial cell (CL0000650)
Fold Change: 1.1
Marker Score: 1,329 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 1.1
Marker Score: 1,476 - Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 1.1
Marker Score: 473 - Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 1.1
Marker Score: 279 - Cell Name: taste receptor cell (CL0000209)
Fold Change: 1.09
Marker Score: 940 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.09
Marker Score: 1,231 - Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 1.09
Marker Score: 344 - Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 1.08
Marker Score: 1,032 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 1.08
Marker Score: 24,091 - Cell Name: endothelial cell (CL0000115)
Fold Change: 1.07
Marker Score: 960 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 1.06
Marker Score: 407 - Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 1.05
Marker Score: 1,121 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 1.05
Marker Score: 1,266 - Cell Name: oligodendrocyte (CL0000128)
Fold Change: 1.05
Marker Score: 2,503 - Cell Name: melanocyte (CL0000148)
Fold Change: 1.03
Marker Score: 419 - Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 1.03
Marker Score: 1,463 - Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 1.02
Marker Score: 1,258 - Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 1.02
Marker Score: 933 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 1.01
Marker Score: 6,044 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 1
Marker Score: 6,433 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,635 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 0.99
Marker Score: 47,860 - Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 0.99
Marker Score: 4,287 - Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: 0.99
Marker Score: 414 - Cell Name: alveolar macrophage (CL0000583)
Fold Change: 0.99
Marker Score: 25,364 - Cell Name: cardiac neuron (CL0010022)
Fold Change: 0.99
Marker Score: 1,231 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 0.98
Marker Score: 310 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,381 - Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.98
Marker Score: 1,036 - Cell Name: astrocyte (CL0000127)
Fold Change: 0.97
Marker Score: 844 - Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 0.97
Marker Score: 2,772 - Cell Name: neuronal brush cell (CL0000555)
Fold Change: 0.97
Marker Score: 3,256 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.97
Marker Score: 477 - Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 0.97
Marker Score: 909 - Cell Name: pyramidal neuron (CL0000598)
Fold Change: 0.96
Marker Score: 1,613 - Cell Name: macrophage (CL0000235)
Fold Change: 0.95
Marker Score: 1,060 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.94
Marker Score: 2,391 - Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 0.94
Marker Score: 184 - Cell Name: mesenchymal lymphangioblast (CL0005021)
Fold Change: 0.93
Marker Score: 208 - Cell Name: lymphocyte (CL0000542)
Fold Change: 0.93
Marker Score: 468 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.93
Marker Score: 315
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1410279526
Symbol: RPGF1_HUMAN
Name: Rap guanine nucleotide exchange factor 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7512734
Title: C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins.
PubMed ID: 7512734
PubMed ID: 7806500
Title: Four proline-rich sequences of the guanine-nucleotide exchange factor C3G bind with unique specificity to the first Src homology 3 domain of Crk.
PubMed ID: 7806500
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 15164053
Title: DNA sequence and analysis of human chromosome 9.
PubMed ID: 15164053
DOI: 10.1038/nature02465
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8662907
Title: Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins.
PubMed ID: 8662907
PubMed ID: 12432078
Title: Novel function of Chat in controlling cell adhesion via Cas-Crk-C3G-pathway-mediated Rap1 activation.
PubMed ID: 12432078
DOI: 10.1242/jcs.00207
PubMed ID: 14551197
Title: Physical and functional interaction between Hck tyrosine kinase and guanine nucleotide exchange factor C3G results in apoptosis, which is independent of C3G catalytic domain.
PubMed ID: 14551197
PubMed ID: 15144186
Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.
PubMed ID: 15144186
DOI: 10.1021/ac035352d
PubMed ID: 17724123
Title: Rap1-PDZ-GEF1 interacts with a neurotrophin receptor at late endosomes, leading to sustained activation of Rap1 and ERK and neurite outgrowth.
PubMed ID: 17724123
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21840392
Title: Epac1 and PDZ-GEF cooperate in Rap1 mediated endothelial junction control.
PubMed ID: 21840392
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25218447
Title: Uncovering global SUMOylation signaling networks in a site-specific manner.
PubMed ID: 25218447
DOI: 10.1038/nsmb.2890
PubMed ID: 23033978
Title: Diagnostic exome sequencing in persons with severe intellectual disability.
PubMed ID: 23033978
Sequence Information:
- Length: 1077
- Mass: 120548
- Checksum: E700631A0EE76CA1
- Sequence:
MDTDSQRSHL SSFTMKLMDK FHSPKIKRTP SKKGKPAEVS VKIPEKPVNK EATDRFLPEG YPLPLDLEQQ AVEFMSTSAV ASRSQRQKNL SWLEEKEKEV VSALRYFKTI VDKMAIDKKV LEMLPGSASK VLEAILPLVQ NDPRIQHSSA LSSCYSRVYQ SLANLIRWSD QVMLEGVNSE DKEMVTTVKG VIKAVLDGVK ELVRLTIEKQ GRPSPTSPVK PSSPASKPDG PAELPLTDRE VEILNKTTGM SQSTELLPDA TDEEVAPPKP PLPGIRVVDN SPPPALPPKK RQSAPSPTRV AVVAPMSRAT SGSSLPVGIN RQDFDVDCYA QRRLSGGSHS YGGESPRLSP CSSIGKLSKS DEQLSSLDRD SGQCSRNTSC ETLDHYDPDY EFLQQDLSNA DQIPQQTAWN LSPLPESLGE SGSPFLGPPF QLPLGGHPQP DGPLAPGQQT DTPPALPEKK RRSAASQTAD GSGCRVSYER HPSQYDNISG EDLQSTAPIP SVPYAPFAAI LPFQHGGSSA PVEFVGDFTA PESTGDPEKP PPLPEKKNKH MLAYMQLLED YSEPQPSMFY QTPQNEHIYQ QKNKLLMEVY GFSDSFSGVD SVQELAPPPA LPPKQRQLEP PAGKDGHPRD PSAVSGVPGK DSRDGSERAP KSPDALESAQ SEEEVDELSL IDHNEIMSRL TLKQEGDDGP DVRGGSGDIL LVHATETDRK DLVLYCEAFL TTYRTFISPE ELIKKLQYRY EKFSPFADTF KKRVSKNTFF VLVRVVDELC LVELTEEILK LLMELVFRLV CNGELSLARV LRKNILDKVD QKKLLRCATS SQPLAARGVA ARPGTLHDFH SHEIAEQLTL LDAELFYKIE IPEVLLWAKE QNEEKSPNLT QFTEHFNNMS YWVRSIIMLQ EKAQDRERLL LKFIKIMKHL RKLNNFNSYL AILSALDSAP IRRLEWQKQT SEGLAEYCTL IDSSSSFRAY RAALSEVEPP CIPYLGLILQ DLTFVHLGNP DYIDGKVNFS KRWQQFNILD SMRCFQQAHY DMRRNDDIIN FFNDFSDHLA EEALWELSLK IKPRNITRRK TDREEKT
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.