Details for: IGKJ1

Gene ID: 28950

Symbol: IGKJ1

Ensembl ID: ENSG00000211597

Description: immunoglobulin kappa joining 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 8.5568
    Cell Significance Index: 167.3000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.3603
    Cell Significance Index: 32.9500
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.2731
    Cell Significance Index: 3.9800
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.1662
    Cell Significance Index: 1.7500
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.0048
    Cell Significance Index: 0.0300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0045
    Cell Significance Index: -0.1200
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0104
    Cell Significance Index: -0.1000
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.0108
    Cell Significance Index: -0.1100
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0219
    Cell Significance Index: -0.3000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0258
    Cell Significance Index: -1.2000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0455
    Cell Significance Index: -1.6700
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.0470
    Cell Significance Index: -0.4200
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0535
    Cell Significance Index: -0.5000
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.0574
    Cell Significance Index: -0.6200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0616
    Cell Significance Index: -1.5700
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0662
    Cell Significance Index: -0.7400
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0733
    Cell Significance Index: -0.9400
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0945
    Cell Significance Index: -1.5300
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1084
    Cell Significance Index: -1.4400
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1094
    Cell Significance Index: -1.8700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1125
    Cell Significance Index: -2.0800
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.1169
    Cell Significance Index: -1.4600
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.1175
    Cell Significance Index: -0.7300
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: -0.1228
    Cell Significance Index: -1.1400
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1236
    Cell Significance Index: -1.4600
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1252
    Cell Significance Index: -1.6200
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1254
    Cell Significance Index: -1.6400
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.1284
    Cell Significance Index: -1.5500
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1292
    Cell Significance Index: -1.7000
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.1334
    Cell Significance Index: -1.6900
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1353
    Cell Significance Index: -1.5700
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1356
    Cell Significance Index: -1.4300
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.1382
    Cell Significance Index: -1.2500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1407
    Cell Significance Index: -1.9300
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1414
    Cell Significance Index: -1.6700
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.1414
    Cell Significance Index: -1.6300
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1417
    Cell Significance Index: -1.8500
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.1442
    Cell Significance Index: -1.5000
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.1446
    Cell Significance Index: -1.6800
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.1447
    Cell Significance Index: -1.7100
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1455
    Cell Significance Index: -1.9100
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1456
    Cell Significance Index: -1.7900
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.1462
    Cell Significance Index: -1.7200
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.1469
    Cell Significance Index: -1.5800
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.1488
    Cell Significance Index: -1.5900
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1504
    Cell Significance Index: -1.7900
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.1511
    Cell Significance Index: -1.4300
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.1547
    Cell Significance Index: -1.6400
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.1547
    Cell Significance Index: -1.8700
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.1565
    Cell Significance Index: -1.6600
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1623
    Cell Significance Index: -1.5600
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1651
    Cell Significance Index: -1.9000
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1655
    Cell Significance Index: -1.6900
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.1663
    Cell Significance Index: -1.6800
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: -0.1742
    Cell Significance Index: -1.4200
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1758
    Cell Significance Index: -1.6500
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.1760
    Cell Significance Index: -1.5700
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.1808
    Cell Significance Index: -1.9600
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: -0.1810
    Cell Significance Index: -1.6800
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.1811
    Cell Significance Index: -1.8500
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.1834
    Cell Significance Index: -1.9000
  • Cell Name: peptic cell (CL0000155)
    Fold Change: -0.1834
    Cell Significance Index: -1.6300
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.1859
    Cell Significance Index: -1.7000
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.1909
    Cell Significance Index: -1.7000
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.1922
    Cell Significance Index: -1.5900
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.1972
    Cell Significance Index: -2.0000
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1983
    Cell Significance Index: -1.8800
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.2111
    Cell Significance Index: -1.1300
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.2113
    Cell Significance Index: -2.3400
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.2232
    Cell Significance Index: -2.5300
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: -0.2309
    Cell Significance Index: -1.6600
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.2319
    Cell Significance Index: -1.9600
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.2406
    Cell Significance Index: -2.5600
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.2521
    Cell Significance Index: -2.3400
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.2532
    Cell Significance Index: -1.6800
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.2544
    Cell Significance Index: -2.3000
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.2632
    Cell Significance Index: -1.6800
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.2928
    Cell Significance Index: -1.9500
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.3132
    Cell Significance Index: -2.5700
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.4273
    Cell Significance Index: -2.3300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.4795
    Cell Significance Index: -11.9800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGKJ1 is a gene that encodes a protein essential for the proper assembly and secretion of immunoglobulins, specifically the kappa light chain. The kappa light chain is a critical component of the B-cell receptor complex, which recognizes and binds to specific antigens. IGKJ1's primary function is to facilitate the joining of the kappa light chain with the heavy chain, allowing for the proper formation of the immunoglobulin molecule. This process is crucial for the activation and differentiation of B cells, the primary effector cells of the adaptive immune system. **Pathways and Functions:** IGKJ1's signaling pathways are intricately linked to the adaptive immune response, particularly in the context of B-cell development and function. The gene's products participate in the following pathways: 1. **Adaptive Immune Response:** IGKJ1 plays a critical role in the adaptive immune response by facilitating the assembly and secretion of immunoglobulins. This process enables B cells to recognize and respond to specific antigens, thereby mediating immunity against pathogens and foreign substances. 2. **Extracellular Region:** IGKJ1's products are integral to the extracellular region of the immunoglobulin molecule, where they interact with antigens and other immune molecules. 3. **Immunoglobulin Complex:** IGKJ1's role in immunoglobulin formation is essential for the assembly of the immunoglobulin complex, which is the primary effector molecule of the immune system. 4. **Plasma Membrane:** IGKJ1's products also interact with the plasma membrane, where they participate in the signaling and activation of B cells. **Clinical Significance:** IGKJ1's clinical significance is multifaceted and far-reaching. Abnormalities in IGKJ1 have been linked to various diseases, including: 1. **Autoimmune Disorders:** Dysregulation of IGKJ1 has been implicated in autoimmune disorders, such as rheumatoid arthritis and lupus, where the immune system mistakenly targets self-antigens. 2. **Immunodeficiency Diseases:** IGKJ1 mutations have been associated with immunodeficiency diseases, such as X-linked agammaglobulinemia, where the immune system is severely impaired due to the lack of immunoglobulins. 3. **Cancer:** IGKJ1 has been identified as a potential oncogene, where its dysregulation can contribute to the development and progression of certain cancers, such as lymphoma and leukemia. 4. **Gastrointestinal Disorders:** IGKJ1's expression in intestinal epithelial cells has been linked to gastrointestinal disorders, such as inflammatory bowel disease and cancer. In conclusion, IGKJ1 is a critical component of the adaptive immune system, and its dysregulation can have far-reaching consequences for human health. Further research is necessary to fully elucidate IGKJ1's mechanisms of action and its clinical significance, with the ultimate goal of developing novel therapeutic strategies for the treatment of immune-related diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.