Details for: DEXI

Gene ID: 28955

Symbol: DEXI

Ensembl ID: ENSG00000182108

Description: Dexi homolog

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 137.2591
    Cell Significance Index: -21.3500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 85.8686
    Cell Significance Index: -21.7800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 47.6147
    Cell Significance Index: -22.4800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 46.8176
    Cell Significance Index: -19.0200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 33.5607
    Cell Significance Index: -22.5200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.3218
    Cell Significance Index: -22.5900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.6185
    Cell Significance Index: -17.7300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 6.1480
    Cell Significance Index: 101.3100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.7779
    Cell Significance Index: -22.8000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.9911
    Cell Significance Index: -15.3300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.4223
    Cell Significance Index: -7.4900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.9066
    Cell Significance Index: 188.6100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.5956
    Cell Significance Index: 43.4300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.5487
    Cell Significance Index: 1398.3900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.5428
    Cell Significance Index: 92.6200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.3621
    Cell Significance Index: 148.1600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.0282
    Cell Significance Index: 119.8200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.9834
    Cell Significance Index: 8.2600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.9250
    Cell Significance Index: 24.7900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7164
    Cell Significance Index: 49.5400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.6327
    Cell Significance Index: 33.2200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6208
    Cell Significance Index: 85.2500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4558
    Cell Significance Index: 21.2500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4176
    Cell Significance Index: 228.0400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3804
    Cell Significance Index: 19.7600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3737
    Cell Significance Index: 165.2400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.3718
    Cell Significance Index: 12.9200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3169
    Cell Significance Index: 38.9600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3157
    Cell Significance Index: 23.5300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2924
    Cell Significance Index: 20.6800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2698
    Cell Significance Index: 48.6400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2692
    Cell Significance Index: 45.9600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2569
    Cell Significance Index: 51.5400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.2547
    Cell Significance Index: 159.0700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2515
    Cell Significance Index: 49.9100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2403
    Cell Significance Index: 30.8000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2340
    Cell Significance Index: 30.2300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2014
    Cell Significance Index: 9.4700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1841
    Cell Significance Index: 4.8400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1702
    Cell Significance Index: 4.8800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1366
    Cell Significance Index: 2.8600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1364
    Cell Significance Index: 22.1800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1207
    Cell Significance Index: 43.3000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.1093
    Cell Significance Index: 1.4000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0644
    Cell Significance Index: 12.2600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0282
    Cell Significance Index: 0.2300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0254
    Cell Significance Index: 0.5400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0123
    Cell Significance Index: 8.9900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0113
    Cell Significance Index: 21.3400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0001
    Cell Significance Index: -0.0700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0004
    Cell Significance Index: -0.0100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0061
    Cell Significance Index: -0.4000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0070
    Cell Significance Index: -5.1800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0115
    Cell Significance Index: -7.2800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0128
    Cell Significance Index: -0.2200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0136
    Cell Significance Index: -7.6900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0138
    Cell Significance Index: -25.3600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0155
    Cell Significance Index: -23.8500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0174
    Cell Significance Index: -23.7100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0333
    Cell Significance Index: -15.1300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0377
    Cell Significance Index: -3.8500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0399
    Cell Significance Index: -1.0200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0444
    Cell Significance Index: -1.1100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0488
    Cell Significance Index: -2.2100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0509
    Cell Significance Index: -10.7300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0585
    Cell Significance Index: -1.8800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0603
    Cell Significance Index: -6.9100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0612
    Cell Significance Index: -3.8600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0660
    Cell Significance Index: -19.0000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0823
    Cell Significance Index: -11.9700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0887
    Cell Significance Index: -10.4600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0899
    Cell Significance Index: -10.2600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1091
    Cell Significance Index: -1.0100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1104
    Cell Significance Index: -3.8800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1120
    Cell Significance Index: -3.1300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1160
    Cell Significance Index: -2.6800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1443
    Cell Significance Index: -8.8700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1450
    Cell Significance Index: -11.1300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1508
    Cell Significance Index: -10.1400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1585
    Cell Significance Index: -12.5500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1634
    Cell Significance Index: -3.5400
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.2045
    Cell Significance Index: -2.9300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2064
    Cell Significance Index: -10.7500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.2088
    Cell Significance Index: -3.6900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2088
    Cell Significance Index: -21.7400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2125
    Cell Significance Index: -1.4400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2717
    Cell Significance Index: -4.0100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2763
    Cell Significance Index: -16.9400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2939
    Cell Significance Index: -4.0100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3258
    Cell Significance Index: -16.4700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3406
    Cell Significance Index: -13.9600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3409
    Cell Significance Index: -19.1300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3435
    Cell Significance Index: -8.8300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3608
    Cell Significance Index: -15.9600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3627
    Cell Significance Index: -4.1200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.3700
    Cell Significance Index: -5.8700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3967
    Cell Significance Index: -8.4200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.4078
    Cell Significance Index: -7.0300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4441
    Cell Significance Index: -7.6100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4456
    Cell Significance Index: -11.9200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression profile:** DEXI_HUMAN is significantly expressed in cells involved in neurotransmission, hormone regulation, and immune response, including GABAergic amacrine cells, granulosa cells, mononuclear cells, and immature innate lymphoid cells. 2. **Protein binding:** DEXI_HUMAN is predicted to interact with various proteins, including transcription factors and signaling molecules, which may influence its downstream effects. 3. **Cellular localization:** The subcellular localization of DEXI_HUMAN is not specified, but its expression in cellular compartments such as the nucleus and cytoplasm suggests a role in regulating gene expression or protein-protein interactions. **Pathways and Functions:** 1. **Protein binding interactions:** DEXI_HUMAN may interact with various proteins involved in transcriptional regulation, signaling, and protein degradation, influencing gene expression, cell proliferation, and differentiation. 2. **Neurotransmission and hormone regulation:** The expression of DEXI_HUMAN in GABAergic amacrine cells and granulosa cells suggests a role in neurotransmission and hormone regulation, potentially modulating synaptic plasticity and reproductive functions. 3. **Immune response:** The presence of DEXI_HUMAN in mononuclear cells and immature innate lymphoid cells implies a potential role in modulating immune responses, possibly influencing inflammation and autoimmunity. **Clinical Significance:** 1. **Neurological disorders:** Abnormalities in DEXI_HUMAN expression may contribute to neurological disorders, such as epilepsy, anxiety, or depression, which are characterized by dysregulation of neurotransmission and hormone regulation. 2. **Reproductive disorders:** Altered DEXI_HUMAN expression in granulosa cells may be associated with reproductive disorders, such as polycystic ovary syndrome (PCOS) or infertility, which involve hormonal imbalances. 3. **Inflammatory diseases:** The involvement of DEXI_HUMAN in immune responses suggests a potential link to inflammatory diseases, such as rheumatoid arthritis or multiple sclerosis, which may be influenced by dysregulated immune cell function. In conclusion, while the functional significance of DEXI_HUMAN remains unclear, its widespread expression in various cell types and predicted protein binding interactions suggest a multifaceted role in regulating gene expression, neurotransmission, hormone regulation, and immune responses. Further research is necessary to elucidate the molecular mechanisms underlying DEXI_HUMAN's involvement in various diseases and disorders.

Genular Protein ID: 2606678179

Symbol: DEXI_HUMAN

Name: Dexamethasone-induced protein

UniProtKB Accession Codes:

O95424 B2RAA7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 3 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 2 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 11472984

Title: Cloning of dexamethasone-induced transcript: a novel glucocorticoid-induced gene that is upregulated in emphysema.

PubMed ID: 11472984

DOI: 10.1165/ajrcmb.25.1.4417

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 95
  • Mass: 10429
  • Checksum: F9F98DE2572D3F83
  • Sequence:
    • MLGARVAAHL DALGPLVPYV PPPLLPSMFY VGLFFVNVLI LYYAFLMEYI VLNVGLVFLP 
EDMDQALVDL GVLSDPGSGL YDADSELDVF DAYLE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.