Details for: MRPS28

Gene ID: 28957

Symbol: MRPS28

Ensembl ID: ENSG00000147586

Description: mitochondrial ribosomal protein S28

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 193.8343
    Cell Significance Index: -30.1500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 123.3622
    Cell Significance Index: -31.2900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 88.3608
    Cell Significance Index: -36.4000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 75.9548
    Cell Significance Index: -35.8600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 65.9234
    Cell Significance Index: -33.9100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 27.6652
    Cell Significance Index: -34.1100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.2921
    Cell Significance Index: -30.2500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.2780
    Cell Significance Index: -34.6400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.8798
    Cell Significance Index: -35.0400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.8531
    Cell Significance Index: 111.2500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.6456
    Cell Significance Index: 44.1000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.3989
    Cell Significance Index: 78.5000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3699
    Cell Significance Index: 274.8000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.3047
    Cell Significance Index: 82.2300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2741
    Cell Significance Index: 1150.4000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.9406
    Cell Significance Index: 21.7300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8184
    Cell Significance Index: 133.1000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.7023
    Cell Significance Index: 31.0600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6913
    Cell Significance Index: 35.9100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.6634
    Cell Significance Index: 25.1200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6608
    Cell Significance Index: 119.1200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6298
    Cell Significance Index: 225.9000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5807
    Cell Significance Index: 71.4100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4809
    Cell Significance Index: 332.5900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.4756
    Cell Significance Index: 4.3800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4231
    Cell Significance Index: 32.4700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4207
    Cell Significance Index: 53.9300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3729
    Cell Significance Index: 164.8800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3726
    Cell Significance Index: 25.7700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3698
    Cell Significance Index: 22.7300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3328
    Cell Significance Index: 8.3200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3288
    Cell Significance Index: 179.5700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2995
    Cell Significance Index: 29.6300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2800
    Cell Significance Index: 3.8200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2659
    Cell Significance Index: 5.7600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.2498
    Cell Significance Index: 12.6300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2481
    Cell Significance Index: 11.6600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2305
    Cell Significance Index: 31.6500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2212
    Cell Significance Index: 6.0200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1748
    Cell Significance Index: 12.3600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1514
    Cell Significance Index: 1.8100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1336
    Cell Significance Index: 9.9600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1290
    Cell Significance Index: 24.5400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1285
    Cell Significance Index: 15.1500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1249
    Cell Significance Index: 5.6600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1007
    Cell Significance Index: 2.6900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0842
    Cell Significance Index: 3.9200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0338
    Cell Significance Index: 4.3700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0238
    Cell Significance Index: 0.6300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0020
    Cell Significance Index: -1.4700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0101
    Cell Significance Index: -7.6300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0134
    Cell Significance Index: -25.1600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0202
    Cell Significance Index: -0.7100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0208
    Cell Significance Index: -38.4200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0244
    Cell Significance Index: -37.5600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0247
    Cell Significance Index: -18.2700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0250
    Cell Significance Index: -0.8000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0295
    Cell Significance Index: -40.0800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0374
    Cell Significance Index: -3.8200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0432
    Cell Significance Index: -1.2700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0454
    Cell Significance Index: -28.8100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0501
    Cell Significance Index: -8.5500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0558
    Cell Significance Index: -31.4600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0627
    Cell Significance Index: -39.1300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0739
    Cell Significance Index: -33.5200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0772
    Cell Significance Index: -8.8400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.0833
    Cell Significance Index: -0.6600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1043
    Cell Significance Index: -0.6300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1045
    Cell Significance Index: -30.0800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1173
    Cell Significance Index: -23.2800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1311
    Cell Significance Index: -15.2800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1507
    Cell Significance Index: -7.9100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1717
    Cell Significance Index: -1.4000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1718
    Cell Significance Index: -36.1900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2124
    Cell Significance Index: -30.8700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2385
    Cell Significance Index: -5.7200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2613
    Cell Significance Index: -16.8600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2699
    Cell Significance Index: -5.7700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3010
    Cell Significance Index: -23.8400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3374
    Cell Significance Index: -35.1300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4116
    Cell Significance Index: -8.7700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4141
    Cell Significance Index: -10.5800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4584
    Cell Significance Index: -15.9300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5108
    Cell Significance Index: -13.6600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5287
    Cell Significance Index: -35.5500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5755
    Cell Significance Index: -35.2900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6042
    Cell Significance Index: -19.7800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6270
    Cell Significance Index: -19.9700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.6292
    Cell Significance Index: -10.5300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.6500
    Cell Significance Index: -9.7400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.7006
    Cell Significance Index: -14.8700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.7095
    Cell Significance Index: -5.9600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.7111
    Cell Significance Index: -8.8200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7378
    Cell Significance Index: -21.7300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.7650
    Cell Significance Index: -26.8000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.7707
    Cell Significance Index: -15.2400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.7776
    Cell Significance Index: -22.2900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.7882
    Cell Significance Index: -15.8300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.7931
    Cell Significance Index: -8.2100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.7960
    Cell Significance Index: -29.2200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Mitochondrial localization**: MRPS28 is a mitochondrial protein, which means it is specifically localized within the mitochondria. 2. **Ribosomal protein**: MRPS28 is a component of the small subunit of the mitochondrial ribosome, which is responsible for translating mitochondrial mRNAs into proteins. 3. **Conservation across species**: The MRPS28 gene is conserved across different species, including humans, suggesting its evolutionary importance. 4. **Expression in various cell types**: MRPS28 is expressed in a wide range of cell types, including germ cells, astrocytes, and neurons, highlighting its broad tissue-specific expression. **Pathways and Functions:** 1. **Mitochondrial translation**: MRPS28 plays a critical role in the translation of mitochondrial mRNAs into proteins, which are essential for mitochondrial function and overall cellular health. 2. **Mitochondrial inner membrane**: MRPS28 is localized within the inner membrane of the mitochondria, where it interacts with other mitochondrial proteins to regulate translation. 3. **Metabolism of proteins**: MRPS28 is involved in the metabolism of proteins, including the translation of mitochondrial proteins, which are essential for energy production and cellular homeostasis. 4. **RNA binding**: MRPS28 has RNA-binding capabilities, which allows it to interact with mitochondrial mRNAs and regulate translation. **Clinical Significance:** 1. **Mitochondrial diseases**: Mutations in the MRPS28 gene have been associated with various mitochondrial diseases, including neurodegenerative disorders, metabolic disorders, and cancer. 2. **Neurological disorders**: MRPS28 has been implicated in the pathogenesis of neurological disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 3. **Cancer**: MRPS28 has been shown to be overexpressed in certain types of cancer, including glioblastoma and hepatocellular carcinoma, suggesting its potential role in tumorigenesis. 4. **Neurodevelopmental disorders**: MRPS28 has been implicated in neurodevelopmental disorders, including autism spectrum disorder and schizophrenia, suggesting its potential role in brain development and function. In conclusion, MRPS28 is a critical component of mitochondrial translation, and its dysregulation has been implicated in various human diseases, including mitochondrial diseases, neurological disorders, cancer, and neurodevelopmental disorders. Further research is necessary to fully elucidate the molecular mechanisms underlying MRPS28 function and its role in human health and disease.

Genular Protein ID: 1741952921

Symbol: RT28_HUMAN

Name: 28S ribosomal protein S28, mitochondrial

UniProtKB Accession Codes:

Q9Y2Q9 B2RDZ7 Q96Q21

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EMDB 28 Ensembl 1 ExpressionAtlas 1 GO 5 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 42 PDBsum 42 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11543634

Title: The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders.

PubMed ID: 11543634

DOI: 10.1006/geno.2001.6622

PubMed ID: 10938081

Title: A proteomics approach to the identification of mammalian mitochondrial small subunit ribosomal proteins.

PubMed ID: 10938081

DOI: 10.1074/jbc.m003596200

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 30566640

Title: Mutations in the MRPS28 gene encoding the small mitoribosomal subunit protein bS1m in a patient with intrauterine growth retardation, craniofacial dysmorphism and multisystemic involvement.

PubMed ID: 30566640

DOI: 10.1093/hmg/ddy441

PubMed ID: 25838379

Title: Ribosome. The structure of the human mitochondrial ribosome.

PubMed ID: 25838379

DOI: 10.1126/science.aaa1193

Sequence Information:

  • Length: 187
  • Mass: 20843
  • Checksum: 2ED0EA43552B9B54
  • Sequence:
    • MAALCRTRAV AAESHFLRVF LFFRPFRGVG TESGSESGSS NAKEPKTRAG GFASALERHS 
ELLQKVEPLQ KGSPKNVESF ASMLRHSPLT QMGPAKDKLV IGRIFHIVEN DLYIDFGGKF 
HCVCRRPEVD GEKYQKGTRV RLRLLDLELT SRFLGATTDT TVLEANAVLL GIQESKDSRS 
KEEHHEK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.