Details for: GIT1

Gene ID: 28964

Symbol: GIT1

Ensembl ID: ENSG00000108262

Description: GIT ArfGAP 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 143.4310
    Cell Significance Index: -22.3100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 81.5318
    Cell Significance Index: -20.6800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 46.0792
    Cell Significance Index: -18.7200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 19.6912
    Cell Significance Index: -18.8000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.1596
    Cell Significance Index: -22.3900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.9773
    Cell Significance Index: -21.3700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.7158
    Cell Significance Index: -22.5600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.5869
    Cell Significance Index: -17.1600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.6788
    Cell Significance Index: -10.2400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 2.1058
    Cell Significance Index: 34.7000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.6709
    Cell Significance Index: 87.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9100
    Cell Significance Index: 182.5400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7928
    Cell Significance Index: 47.6000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7889
    Cell Significance Index: 128.3000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.6712
    Cell Significance Index: 19.1600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.6301
    Cell Significance Index: 17.6100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4720
    Cell Significance Index: 426.1700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.4291
    Cell Significance Index: 28.8600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4067
    Cell Significance Index: 28.1300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3919
    Cell Significance Index: 48.1900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3907
    Cell Significance Index: 140.1300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3302
    Cell Significance Index: 59.5300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2890
    Cell Significance Index: 127.7800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2802
    Cell Significance Index: 12.4000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2788
    Cell Significance Index: 17.9900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2756
    Cell Significance Index: 7.9400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1990
    Cell Significance Index: 9.0200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1962
    Cell Significance Index: 4.2500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1955
    Cell Significance Index: 106.7400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1913
    Cell Significance Index: 37.9700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1901
    Cell Significance Index: 26.1000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1898
    Cell Significance Index: 36.1200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1884
    Cell Significance Index: 18.6400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1830
    Cell Significance Index: 6.9300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1563
    Cell Significance Index: 8.1200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1236
    Cell Significance Index: 3.3700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1067
    Cell Significance Index: 6.5600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0956
    Cell Significance Index: 66.1400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0884
    Cell Significance Index: 4.1200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0728
    Cell Significance Index: 0.4400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0698
    Cell Significance Index: 10.1400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0529
    Cell Significance Index: 1.8600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0505
    Cell Significance Index: 3.5700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0272
    Cell Significance Index: 0.5900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0073
    Cell Significance Index: 0.4600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0003
    Cell Significance Index: 0.6100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0068
    Cell Significance Index: -12.5800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0076
    Cell Significance Index: -11.6400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0129
    Cell Significance Index: -17.5400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0160
    Cell Significance Index: -10.1900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0172
    Cell Significance Index: -0.4600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0194
    Cell Significance Index: -14.1900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0211
    Cell Significance Index: -15.6200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0228
    Cell Significance Index: -1.2800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0232
    Cell Significance Index: -17.5900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0238
    Cell Significance Index: -4.0600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0257
    Cell Significance Index: -1.2100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0270
    Cell Significance Index: -3.4600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0340
    Cell Significance Index: -19.1600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0355
    Cell Significance Index: -16.0900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0394
    Cell Significance Index: -24.6100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0424
    Cell Significance Index: -0.6100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0528
    Cell Significance Index: -4.0600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0649
    Cell Significance Index: -18.6600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0689
    Cell Significance Index: -8.1200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0721
    Cell Significance Index: -9.3200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0732
    Cell Significance Index: -8.5300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0735
    Cell Significance Index: -1.2600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0759
    Cell Significance Index: -7.7500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0777
    Cell Significance Index: -8.9000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0802
    Cell Significance Index: -2.3000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1143
    Cell Significance Index: -24.0700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1268
    Cell Significance Index: -2.7000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1366
    Cell Significance Index: -10.1800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1636
    Cell Significance Index: -8.5900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1653
    Cell Significance Index: -3.4300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1671
    Cell Significance Index: -2.2800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1824
    Cell Significance Index: -2.7700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1935
    Cell Significance Index: -4.6400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2061
    Cell Significance Index: -21.4600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2339
    Cell Significance Index: -18.5300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2482
    Cell Significance Index: -7.9500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2500
    Cell Significance Index: -15.3300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2622
    Cell Significance Index: -7.0000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2812
    Cell Significance Index: -9.7700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2885
    Cell Significance Index: -7.7300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3046
    Cell Significance Index: -8.0100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.3310
    Cell Significance Index: -5.3100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3565
    Cell Significance Index: -5.1100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3697
    Cell Significance Index: -4.2000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3733
    Cell Significance Index: -11.8900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3785
    Cell Significance Index: -9.6700
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.3859
    Cell Significance Index: -3.2800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4029
    Cell Significance Index: -13.1900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4066
    Cell Significance Index: -8.6300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.4149
    Cell Significance Index: -8.3300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4452
    Cell Significance Index: -11.1300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.4539
    Cell Significance Index: -6.8400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4767
    Cell Significance Index: -16.7000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4786
    Cell Significance Index: -8.0100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** GIT1 is a highly expressed gene in the nervous system, with significant expression in neurons, glial cells, and endothelial cells. Its expression is tightly regulated during development, and it plays a critical role in neuronal migration, axon guidance, and synaptic plasticity. GIT1 has been implicated in various signaling pathways, including the Eph-ephrin signaling pathway, which is essential for axon guidance and neuronal development. Additionally, GIT1 regulates the activity of Arf1, which is involved in membrane trafficking, endocytosis, and exocytosis. **Pathways and Functions** GIT1 is involved in several signaling pathways, including: 1. **Eph-ephrin signaling pathway**: GIT1 regulates the activity of Arf1, which is involved in axon guidance and neuronal development. 2. **Rac1 downstream of NMDARs**: GIT1 regulates the activity of Rac1, a small GTPase involved in cell signaling and cytoskeletal organization. 3. **Cdc42 GTPase cycle**: GIT1 regulates the activity of Cdc42, a small GTPase involved in cell signaling and cytoskeletal organization. 4. **Calxy of Held**: GIT1 regulates the activity of Arf1, which is involved in synaptic plasticity and neurotransmitter release. 5. **Axon guidance**: GIT1 regulates the activity of Eph-ephrin receptors, which are involved in axon guidance and neuronal development. GIT1 has several functions, including: 1. **Regulation of membrane trafficking**: GIT1 regulates the activity of Arf1, which is involved in membrane trafficking, endocytosis, and exocytosis. 2. **Regulation of cytoskeletal organization**: GIT1 regulates the activity of Rac1 and Cdc42, which are involved in cytoskeletal organization and cell signaling. 3. **Regulation of synaptic plasticity**: GIT1 regulates the activity of Arf1, which is involved in synaptic plasticity and neurotransmitter release. 4. **Regulation of axon guidance**: GIT1 regulates the activity of Eph-ephrin receptors, which are involved in axon guidance and neuronal development. **Clinical Significance** GIT1 has been implicated in several neurological disorders, including: 1. **Neurodevelopmental disorders**: GIT1 has been implicated in neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. 2. **Neurodegenerative disorders**: GIT1 has been implicated in neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Neuropsychiatric disorders**: GIT1 has been implicated in neuropsychiatric disorders, such as anxiety and depression. 4. **Cancer**: GIT1 has been implicated in cancer, particularly in glioblastoma and breast cancer. In conclusion, GIT1 is a critical gene involved in various cellular processes, including signaling pathways, axon guidance, and neuronal development. Its dysregulation has been implicated in several neurological disorders, highlighting the importance of GIT1 in maintaining cellular homeostasis and its potential as a therapeutic target.

Genular Protein ID: 2978562774

Symbol: GIT1_HUMAN

Name: ARF GTPase-activating protein GIT1

UniProtKB Accession Codes:

Q9Y2X7 B4DGU9 B4DSV3 Q86SS0 Q9BRJ4

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 2 ExpressionAtlas 1 GO 35 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 10 RefSeq 2 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10896954

Title: The GIT family of ADP-ribosylation factor GTPase-activating proteins. Functional diversity of GIT2 through alternative splicing.

PubMed ID: 10896954

DOI: 10.1074/jbc.275.29.22373

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10938112

Title: Coupling of PAK-interacting exchange factor PIX to GIT1 promotes focal complex disassembly.

PubMed ID: 10938112

DOI: 10.1128/mcb.20.17.6354-6363.2000

PubMed ID: 12153727

Title: Hic-5 interacts with GIT1 with a different binding mode from paxillin.

PubMed ID: 12153727

DOI: 10.1093/oxfordjournals.jbchem.a003222

PubMed ID: 11896197

Title: GIT1 functions in a motile, multi-molecular signaling complex that regulates protrusive activity and cell migration.

PubMed ID: 11896197

DOI: 10.1242/jcs.115.7.1497

PubMed ID: 12695502

Title: Synapse formation is regulated by the signaling adaptor GIT1.

PubMed ID: 12695502

DOI: 10.1083/jcb.200211002

PubMed ID: 15182672

Title: Mammalian Scribble forms a tight complex with the betaPIX exchange factor.

PubMed ID: 15182672

DOI: 10.1016/j.cub.2004.05.051

PubMed ID: 15923189

Title: GIT1 is a scaffold for ERK1/2 activation in focal adhesions.

PubMed ID: 15923189

DOI: 10.1074/jbc.m502271200

PubMed ID: 15800193

Title: A GIT1/PIX/Rac/PAK signaling module regulates spine morphogenesis and synapse formation through MLC.

PubMed ID: 15800193

DOI: 10.1523/jneurosci.3553-04.2005

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 19041750

Title: Deregulation of scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinoma.

PubMed ID: 19041750

DOI: 10.1016/j.cell.2008.09.045

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19273721

Title: G-protein-coupled receptor kinase interacting protein-1 is required for pulmonary vascular development.

PubMed ID: 19273721

DOI: 10.1161/circulationaha.108.823997

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23108400

Title: The serologically defined colon cancer antigen-3 interacts with the protein tyrosine phosphatase PTPN13 and is involved in the regulation of cytokinesis.

PubMed ID: 23108400

DOI: 10.1038/onc.2012.485

PubMed ID: 25284783

Title: GIT1 and betaPIX are essential for GABA(A) receptor synaptic stability and inhibitory neurotransmission.

PubMed ID: 25284783

DOI: 10.1016/j.celrep.2014.08.061

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27012601

Title: GIT1/betaPIX signaling proteins and PAK1 kinase regulate microtubule nucleation.

PubMed ID: 27012601

DOI: 10.1016/j.bbamcr.2016.03.016

PubMed ID: 31502302

Title: GIT1 regulates angiogenic factor secretion in bone marrow mesenchymal stem cells via NF-kappaB/Notch signalling to promote angiogenesis.

PubMed ID: 31502302

DOI: 10.1111/cpr.12689

Sequence Information:

  • Length: 761
  • Mass: 84341
  • Checksum: 702744942A796399
  • Sequence:
    • MSRKGPRAEV CADCSAPDPG WASISRGVLV CDECCSVHRS LGRHISIVKH LRHSAWPPTL 
LQMVHTLASN GANSIWEHSL LDPAQVQSGR RKANPQDKVH PIKSEFIRAK YQMLAFVHKL 
PCRDDDGVTA KDLSKQLHSS VRTGNLETCL RLLSLGAQAN FFHPEKGTTP LHVAAKAGQT 
LQAELLVVYG ADPGSPDVNG RTPIDYARQA GHHELAERLV ECQYELTDRL AFYLCGRKPD 
HKNGHYIIPQ MADSLDLSEL AKAAKKKLQA LSNRLFEELA MDVYDEVDRR ENDAVWLATQ 
NHSTLVTERS AVPFLPVNPE YSATRNQGRQ KLARFNAREF ATLIIDILSE AKRRQQGKSL 
SSPTDNLELS LRSQSDLDDQ HDYDSVASDE DTDQEPLRST GATRSNRARS MDSSDLSDGA 
VTLQEYLELK KALATSEAKV QQLMKVNSSL SDELRRLQRE IHKLQAENLQ LRQPPGPVPT 
PPLPSERAEH TPMAPGGSTH RRDRQAFSMY EPGSALKPFG GPPGDELTTR LQPFHSTELE 
DDAIYSVHVP AGLYRIRKGV SASAVPFTPS SPLLSCSQEG SRHTSKLSRH GSGADSDYEN 
TQSGDPLLGL EGKRFLELGK EEDFHPELES LDGDLDPGLP STEDVILKTE QVTKNIQELL 
RAAQEFKHDS FVPCSEKIHL AVTEMASLFP KRPALEPVRS SLRLLNASAY RLQSECRKTV 
PPEPGAPVDF QLLTQQVIQC AYDIAKAAKQ LVTITTREKK Q

Genular Protein ID: 1339609161

Symbol: Q59FC3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59FC3

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 12 Gene3D 4 IntAct 1 InterPro 9 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 4 PROSITE-ProRule 2 PeptideAtlas 1 Pfam 5 PharmGKB 1 RefSeq 1 SAM 1 SMART 3 SUPFAM 2

Sequence Information:

  • Length: 774
  • Mass: 85900
  • Checksum: A36C79B44ADA2F7C
  • Sequence:
    • SPLRMSRKGP RAEVCADCSA PDPGWASISR GVLVCDECCS VHRSLGRHIS IVKHLRHSAW 
PPTLLQMVHT LASNGANSIW EHSLLDPAQV QSGRRKANPQ DKVHPIKSEF IRAKYQMLAF 
VHKLPCRDDD GVTAKDLSKQ LHSSVRTGNL ETCLRLLSLG AQANFFHPEK GTTPLHVAAK 
AGQTLQAELL VVYGADPGSP DVNGRTPIDY ARQAGHHELA ERLVECQYEL TDRLAFYLCG 
RKPDHKNGHY IIPQMADRSR QKCMSQSLDL SELAKAAKKK LQALSNRLFE ELAMDVYDEV 
DRRENDAVWL ATQNHSTLVT ERSAVPFLPV NPEYSATRNQ GRQKLARFNA REFATLIIDI 
LSEAKRRQQG KSLSSPTDNL ELSLRSQSDL DDQHDYDSVA SDEDTDQEPL RSTGATRSNR 
ARSMDSSDLS DGAVTLQEYL ELKKALATSE AKVQQLMKVN SSLSDELRRL QREIHKLQAE 
NLQLRQPPGP VPTPPLPSER AEHTPMAPGG STHRRDRQAF SMYEPGSALK PFGGPPGDEL 
TTRLQPFHST ELEDDAIYSV HVPAGLYRIR KGVSASAVPF TPSSPLLSCS QEGSRHTSKL 
SRHGSGADSD YENTQSGDPL LGLEGKRFLE LGKEEDFHPE LESLDGDLDP GLPSTEDVIL 
KTEQVTKNIQ ELLRAAQEFK HDSFVPCSEK IHLAVTEMAS LFPKRPALEP VRSSLRLLNA 
SAYRLQSECR KTVPPEPGAP VDFQLLTQQV IQCAYDIAKA AKQLVTITTR EKKQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.