Details for: ASTE1

Gene ID: 28990

Symbol: ASTE1

Ensembl ID: ENSG00000034533

Description: asteroid homolog 1

Associated with

  • 3' overhang single-stranded dna endodeoxyribonuclease activity
    (GO:1990599)
  • Double-strand break repair via homologous recombination
    (GO:0000724)
  • Double-strand break repair via nonhomologous end joining
    (GO:0006303)
  • Protein binding
    (GO:0005515)
  • Single-stranded dna endodeoxyribonuclease activity
    (GO:0000014)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 67.5045
    Cell Significance Index: -10.5000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 40.1548
    Cell Significance Index: -10.1900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 25.5011
    Cell Significance Index: -10.3600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 24.6334
    Cell Significance Index: -11.6300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 10.8511
    Cell Significance Index: -10.3600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 9.0514
    Cell Significance Index: -11.1600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.0166
    Cell Significance Index: -10.7600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.8674
    Cell Significance Index: -11.3200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.8242
    Cell Significance Index: 30.0600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8872
    Cell Significance Index: 87.7600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8493
    Cell Significance Index: 50.9900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7456
    Cell Significance Index: 673.1900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6689
    Cell Significance Index: 72.7600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4976
    Cell Significance Index: 80.9400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3583
    Cell Significance Index: 24.7800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3346
    Cell Significance Index: 7.2500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2976
    Cell Significance Index: 13.4900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2754
    Cell Significance Index: 52.4100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2435
    Cell Significance Index: 48.8400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2230
    Cell Significance Index: 6.4300
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.2124
    Cell Significance Index: 2.1300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2009
    Cell Significance Index: 4.4000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1436
    Cell Significance Index: 8.0600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1319
    Cell Significance Index: 26.1800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1191
    Cell Significance Index: 21.4700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.1188
    Cell Significance Index: 1.7900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1056
    Cell Significance Index: 2.6400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1033
    Cell Significance Index: 37.0600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1006
    Cell Significance Index: 13.8200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0713
    Cell Significance Index: 31.5200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0710
    Cell Significance Index: 3.6900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0704
    Cell Significance Index: 8.6600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0685
    Cell Significance Index: 4.3200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0547
    Cell Significance Index: 37.8000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0542
    Cell Significance Index: 29.5900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0379
    Cell Significance Index: 2.9100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0356
    Cell Significance Index: 1.2500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0352
    Cell Significance Index: 2.2700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0340
    Cell Significance Index: 4.0100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0337
    Cell Significance Index: 2.3800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0326
    Cell Significance Index: 4.7400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0305
    Cell Significance Index: 3.9100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0228
    Cell Significance Index: 2.6600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0075
    Cell Significance Index: 0.2000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0061
    Cell Significance Index: 8.3000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0005
    Cell Significance Index: 0.3400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0002
    Cell Significance Index: 0.3700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0015
    Cell Significance Index: -2.3800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0016
    Cell Significance Index: -2.9500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0034
    Cell Significance Index: -0.1600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0094
    Cell Significance Index: -6.9000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0122
    Cell Significance Index: -9.2300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0124
    Cell Significance Index: -9.1700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0139
    Cell Significance Index: -6.3200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0161
    Cell Significance Index: -0.5200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0173
    Cell Significance Index: -9.7500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0194
    Cell Significance Index: -1.1900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0216
    Cell Significance Index: -3.6900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0216
    Cell Significance Index: -13.4600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0259
    Cell Significance Index: -7.4600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0277
    Cell Significance Index: -2.8300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0313
    Cell Significance Index: -0.8000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0397
    Cell Significance Index: -4.5500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0450
    Cell Significance Index: -1.9900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0463
    Cell Significance Index: -0.9700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0478
    Cell Significance Index: -0.8000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0549
    Cell Significance Index: -7.0900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0560
    Cell Significance Index: -0.5800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0571
    Cell Significance Index: -2.6900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0585
    Cell Significance Index: -12.3300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0632
    Cell Significance Index: -4.7100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0641
    Cell Significance Index: -1.7900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0663
    Cell Significance Index: -3.4800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0712
    Cell Significance Index: -2.7000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0753
    Cell Significance Index: -5.0600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0823
    Cell Significance Index: -2.2400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0849
    Cell Significance Index: -2.2800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0856
    Cell Significance Index: -1.0200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1064
    Cell Significance Index: -11.0800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1065
    Cell Significance Index: -2.8000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1105
    Cell Significance Index: -2.9500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1148
    Cell Significance Index: -7.0400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1148
    Cell Significance Index: -2.2400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1342
    Cell Significance Index: -10.6300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1434
    Cell Significance Index: -7.4700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1456
    Cell Significance Index: -5.0600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1529
    Cell Significance Index: -2.6200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1606
    Cell Significance Index: -3.4200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1758
    Cell Significance Index: -4.5200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1825
    Cell Significance Index: -5.3600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2078
    Cell Significance Index: -4.8000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2095
    Cell Significance Index: -6.8600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2181
    Cell Significance Index: -11.0200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2215
    Cell Significance Index: -7.0600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2315
    Cell Significance Index: -8.1100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2423
    Cell Significance Index: -5.8100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2425
    Cell Significance Index: -7.6700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2523
    Cell Significance Index: -3.7300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2690
    Cell Significance Index: -3.6700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2709
    Cell Significance Index: -5.7500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ASTE1 is a member of the asteroid protein family, which is characterized by its unique structure and ability to interact with various cellular components. The protein contains a DNA-binding domain and a nuclear localization signal, indicating its involvement in transcriptional regulation and nuclear processes. ASTE1 is also associated with several cellular pathways, including nuclease activity and protein binding, suggesting its role in DNA repair, transcriptional regulation, and cell signaling. **Pathways and Functions** ASTE1 is involved in several cellular pathways, including: 1. **Nuclease activity**: ASTE1 has been shown to interact with nucleases, suggesting its role in DNA repair and maintenance of genomic stability. 2. **Protein binding**: ASTE1 interacts with various proteins, including transcription factors and signaling molecules, indicating its involvement in transcriptional regulation, cell signaling, and protein-protein interactions. 3. **Transcription regulation**: ASTE1 has been shown to regulate transcriptional activity in specific cell types, including GABAergic interneurons and intestinal epithelial cells. 4. **Cell signaling**: ASTE1 is involved in cell signaling pathways, including the Wnt/β-catenin pathway, which is critical for development and tissue homeostasis. **Clinical Significance** While ASTE1 is not a well-studied gene, its involvement in various cellular pathways suggests potential implications for human disease. Alterations in ASTE1 expression or function may contribute to: 1. **Neurological disorders**: ASTE1 is highly expressed in GABAergic interneurons, which are involved in regulating neuronal activity and synaptic plasticity. Alterations in ASTE1 expression may contribute to neurological disorders, such as epilepsy and schizophrenia. 2. **Intestinal disorders**: ASTE1 is expressed in intestinal epithelial cells, which are involved in maintaining intestinal homeostasis. Alterations in ASTE1 expression may contribute to intestinal disorders, such as inflammatory bowel disease (IBD) and colorectal cancer. 3. **Cancer**: ASTE1 has been shown to interact with various proteins involved in cell signaling and transcriptional regulation, suggesting its potential role in cancer development and progression. In conclusion, ASTE1 is a multifunctional protein involved in various cellular processes, including DNA repair, transcription regulation, and cell signaling. Its involvement in multiple cellular pathways suggests a crucial role in maintaining cellular homeostasis and tissue integrity. Further studies are needed to fully understand the function and clinical significance of ASTE1.

Genular Protein ID: 3048814182

Symbol: ASTE1_HUMAN

Name: Single-strand DNA endonuclease ASTE1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10931946

Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.

PubMed ID: 10931946

DOI: 10.1073/pnas.160270997

PubMed ID: 34354233

Title: ASTE1 promotes shieldin-complex-mediated DNA repair by attenuating end resection.

PubMed ID: 34354233

DOI: 10.1038/s41556-021-00723-9

Sequence Information:

  • Length: 679
  • Mass: 77093
  • Checksum: 488DE83A8CD8E82B
  • Sequence:
  • MGIRGLMSFV EDHSNEFFTD LKLRDTKIVI DGYALFHRLC FSSNLDLRYG GDYDSFADVV 
    QKFFESLFAC NICPYVVLDG GCDISDKKLT TLKDRAREKI QMAHSLSVGG SGYVCPLLIR 
    EVFIQVLIKL RVCFVQCFSE ADRDIMTLAN HWNCPVLSSD SDFCIFDLKT GFCPLNSFQW 
    RNMNTIKGTQ NYIPAKCFSL DAFCHHFSNM NKALLPLFAV LCGNDHVNLP IMETFLSKAR 
    LPLGATSSKG RRHHRILGLL NWLSHFANPT EALDNVLKYL PKKDRENVKE LLCCSMEEYQ 
    QSQVKLQDFF QCGTYVCPDA LNLGLPEWVL VALAKGQLSP FISDALVLRR TILPTQVENM 
    QQPNAHRISQ PIRQIIYGLL LNASPHLDKT SWNALPPQPL AFSEVERINK NIRTSIIDAV 
    ELAKDHSDLS RLTELSLRRR QMLLLETLKV KQTILEPIPT SLKLPIAVSC YWLQHTETKA 
    KLHHLQSLLL TMLVGPLIAI INSPGKEELQ EDGAKMLYAE FQRVKAQTRL GTRLDLDTAH 
    IFCQWQSCLQ MGMYLNQLLS TPLPEPDLTR LYSGSLVHGL CQQLLASTSV ESLLSICPEA 
    KQLYEYLFNA TRSYAPAEIF LPKGRSNSKK KRQKKQNTSC SKNRGRTTAH TKCWYEGNNR 
    FGLLMVENLE EHSEASNIE

Genular Protein ID: 2428194485

Symbol: D6RG30_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

Sequence Information:

  • Length: 704
  • Mass: 79920
  • Checksum: C70FC41C88F37304
  • Sequence:
  • MGIRGLMSFV EDHSNEFFTD LKLRDTKIVI DGYALFHRLC FSSNLDLRYG GDYDSFADVV 
    QKFFESLFAC NICPYVVLDG GCDISDKKLT TLKDRAREKI QMAHSLSVGG SGYVCPLLIR 
    EVFIQVLIKL RVCFVQCFSE ADRDIMTLAN HWNCPVLSSD SDFCIFDLKT GFCPLNSFQW 
    RNMNTIKGTQ NYIPAKCFSL DAFCHHFSNM NKALLPLFAV LCGNDHVNLP IMETFLSKAR 
    LPLGATSSKG RRHHRILGLL NWLSHFANPT EALDNVLKYL PKKDRENVKE LLCCSMEEYQ 
    QSQVKLQDFF QCGTYVCPDA LNLGLPEWVL VALAKGQLSP FISDALVLRR TILPTQVENM 
    QQPNAHRISQ PIRQIIYGLL LNASPHLDKT SWNALPPQPL AFSEVERINK NIRTSIIDAV 
    ELAKDHSDLS RLTELSLRRR QMLLLETLKV KQTILEPIPT SLKLPIAVSC YWLQHTETKA 
    KLHHLQSLLL TMLVGPLIAI INSPGKEELQ EDGAKMLYAE FQRVKAQTRL GTRLDLDTAH 
    IFCQWQSCLQ MGMYLNQLLS TPLPEPDLTR PSAFNTLNED IWTHTKYGGT LHVSRLYSGS 
    LVHGLCQQLL ASTSVESLLS ICPEAKQLYE YLFNATRSYA PAEIFLPKGR SNSKKKRQKK 
    QNTSCSKNRG RTTAHTKCWY EGNNRFGLLM VENLEEHSEA SNIE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.