Details for: MACROD1

Gene ID: 28992

Symbol: MACROD1

Ensembl ID: ENSG00000133315

Description: mono-ADP ribosylhydrolase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 157.4462
    Cell Significance Index: -24.4900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 97.8933
    Cell Significance Index: -24.8300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 57.5168
    Cell Significance Index: -27.1600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 40.3861
    Cell Significance Index: -27.1000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 21.3795
    Cell Significance Index: -26.3600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.0267
    Cell Significance Index: -26.8600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.8372
    Cell Significance Index: -26.9800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.7660
    Cell Significance Index: -17.7100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.4641
    Cell Significance Index: -9.7700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 2.1345
    Cell Significance Index: 52.0800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.7900
    Cell Significance Index: 107.4600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.7679
    Cell Significance Index: 24.1200
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 1.5627
    Cell Significance Index: 25.2200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.3743
    Cell Significance Index: 105.4700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.3674
    Cell Significance Index: 61.9800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2226
    Cell Significance Index: 1103.9600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1937
    Cell Significance Index: 62.0100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.1893
    Cell Significance Index: 30.5700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.1236
    Cell Significance Index: 130.9400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.0818
    Cell Significance Index: 50.4400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0597
    Cell Significance Index: 210.3100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.0385
    Cell Significance Index: 11.2900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9774
    Cell Significance Index: 350.5600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.9201
    Cell Significance Index: 57.9900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.8555
    Cell Significance Index: 59.1600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.7965
    Cell Significance Index: 22.2600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.7173
    Cell Significance Index: 53.4600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.6726
    Cell Significance Index: 86.9000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6090
    Cell Significance Index: 60.2400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5952
    Cell Significance Index: 119.4000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5751
    Cell Significance Index: 12.4600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4740
    Cell Significance Index: 327.8100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4510
    Cell Significance Index: 12.2800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3998
    Cell Significance Index: 176.7600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3966
    Cell Significance Index: 28.0500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3638
    Cell Significance Index: 49.9600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.3405
    Cell Significance Index: 10.9100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.3201
    Cell Significance Index: 6.7000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3132
    Cell Significance Index: 56.4600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2925
    Cell Significance Index: 13.7500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2733
    Cell Significance Index: 16.8000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2517
    Cell Significance Index: 30.9500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2497
    Cell Significance Index: 6.5700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2388
    Cell Significance Index: 130.4400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2228
    Cell Significance Index: 38.0400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1662
    Cell Significance Index: 3.5400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1460
    Cell Significance Index: 18.7200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1164
    Cell Significance Index: 22.1600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1092
    Cell Significance Index: 5.7400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0755
    Cell Significance Index: 142.2400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0296
    Cell Significance Index: 18.8000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0286
    Cell Significance Index: 20.9400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0192
    Cell Significance Index: 35.4900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0156
    Cell Significance Index: 24.0800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0088
    Cell Significance Index: 0.1300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0017
    Cell Significance Index: -0.0600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0106
    Cell Significance Index: -8.0200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0147
    Cell Significance Index: -19.9500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0206
    Cell Significance Index: -9.3600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0361
    Cell Significance Index: -26.7400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0472
    Cell Significance Index: -26.6400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0495
    Cell Significance Index: -30.9400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0496
    Cell Significance Index: -1.3300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0522
    Cell Significance Index: -5.3300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0597
    Cell Significance Index: -0.5500
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0719
    Cell Significance Index: -0.5500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0767
    Cell Significance Index: -22.0700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0808
    Cell Significance Index: -5.2100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0863
    Cell Significance Index: -12.5400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1103
    Cell Significance Index: -1.5800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1386
    Cell Significance Index: -10.9800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1454
    Cell Significance Index: -30.6300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1647
    Cell Significance Index: -18.8700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2113
    Cell Significance Index: -22.0000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2116
    Cell Significance Index: -24.9500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2146
    Cell Significance Index: -12.0400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2309
    Cell Significance Index: -3.4600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2371
    Cell Significance Index: -15.9400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2387
    Cell Significance Index: -4.0900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2579
    Cell Significance Index: -7.4300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2589
    Cell Significance Index: -6.2100
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.2605
    Cell Significance Index: -2.7200
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.2786
    Cell Significance Index: -5.8100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2796
    Cell Significance Index: -4.6800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3034
    Cell Significance Index: -6.4900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3034
    Cell Significance Index: -13.4200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3480
    Cell Significance Index: -21.3400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3756
    Cell Significance Index: -5.6600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3766
    Cell Significance Index: -14.2600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.3964
    Cell Significance Index: -5.6400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.3966
    Cell Significance Index: -6.6800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3989
    Cell Significance Index: -4.7600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.4167
    Cell Significance Index: -6.1500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4424
    Cell Significance Index: -10.2200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4573
    Cell Significance Index: -11.4300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4603
    Cell Significance Index: -11.7600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4608
    Cell Significance Index: -4.7700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4749
    Cell Significance Index: -10.0800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5047
    Cell Significance Index: -13.5000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5351
    Cell Significance Index: -15.3400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MACROD1 is a unique enzyme that exhibits a range of enzymatic activities, including: 1. **ADP-ribosylhydrolase activity**: MACROD1 can hydrolyze ADP-ribose from ADP-ribose labeled proteins, thereby de-ADP-ribosylating them. 2. **Deacetylase activity**: MACROD1 can also remove acetyl groups from proteins, thereby regulating protein activity and stability. 3. **Hydrolase activity**: MACROD1 can catalyze the hydrolysis of glycosyl bonds, which is essential for the degradation of glycosylated proteins. These enzymatic activities suggest that MACROD1 plays a crucial role in regulating protein function, stability, and degradation. **Pathways and Functions:** MACROD1 is involved in various cellular pathways, including: 1. **DNA damage response**: MACROD1 is required for the repair of DNA damage by hydrolyzing ADP-ribose from DNA repair proteins, such as PARP1. 2. **Protein de-ADP-ribosylation**: MACROD1 can de-ADP-ribosylate proteins, which is essential for regulating their activity and stability. 3. **Purine nucleoside metabolism**: MACROD1 is involved in the degradation of purine nucleosides, which is essential for maintaining nucleotide homeostasis. These pathways suggest that MACROD1 plays a crucial role in maintaining cellular homeostasis and regulating protein function. **Clinical Significance:** MACROD1 has been implicated in various diseases, including: 1. **Neurodegenerative disorders**: Mutations in MACROD1 have been associated with neurodegenerative disorders, such as Huntington's disease and frontotemporal dementia. 2. **Cancer**: MACROD1 has been shown to be overexpressed in various types of cancer, including breast cancer and lung cancer. 3. **Inflammatory disorders**: MACROD1 has been implicated in the regulation of inflammation, and its dysregulation has been associated with inflammatory disorders, such as rheumatoid arthritis. In conclusion, MACROD1 is a multifunctional enzyme that plays a crucial role in maintaining cellular homeostasis and regulating protein function. Its dysregulation has been implicated in various diseases, highlighting the need for further research into its role in human health and disease. **Future Directions:** Further research is needed to fully understand the role of MACROD1 in human health and disease. Some potential avenues for future research include: 1. **Investigating the mechanisms of MACROD1-mediated protein de-ADP-ribosylation**: Understanding how MACROD1 regulates protein function and stability will provide insights into its role in disease. 2. **Exploring the clinical significance of MACROD1 in neurodegenerative disorders**: Further research is needed to understand the role of MACROD1 in neurodegenerative disorders and to develop potential therapeutic strategies. 3. **Investigating the relationship between MACROD1 and inflammation**: Understanding the role of MACROD1 in regulating inflammation will provide insights into its role in inflammatory disorders.

Genular Protein ID: 1417058601

Symbol: MACD1_HUMAN

Name: O-acetyl-ADP-ribose deacetylase MACROD1

UniProtKB Accession Codes:

Q9BQ69 Q9UH96

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 25 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 5 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 Rhea 13 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12578638

Title: The application of RACE technique to clone the full-length cDNA of a novel leukemia associated gene LRP16.

PubMed ID: 12578638

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12790785

Title: Up-regulation of LRP16 mRNA by 17beta-estradiol through activation of estrogen receptor alpha (ERalpha), but not ERbeta, and promotion of human breast cancer MCF-7 cell proliferation: a preliminary report.

PubMed ID: 12790785

DOI: 10.1677/erc.0.0100217

PubMed ID: 17893710

Title: Induction of the LRP16 gene by estrogen promotes the invasive growth of Ishikawa human endometrial cancer cells through the downregulation of E-cadherin.

PubMed ID: 17893710

DOI: 10.1038/cr.2007.79

PubMed ID: 17914104

Title: Estrogenically regulated LRP16 interacts with estrogen receptor alpha and enhances the receptor's transcriptional activity.

PubMed ID: 17914104

DOI: 10.1677/erc-06-0082

PubMed ID: 17532767

Title: LRP16 is fused to RUNX1 in monocytic leukemia cell line with t(11;21)(q13;q22).

PubMed ID: 17532767

DOI: 10.1111/j.1600-0609.2007.00858.x

PubMed ID: 19022849

Title: The single-macro domain protein LRP16 is an essential cofactor of androgen receptor.

PubMed ID: 19022849

DOI: 10.1677/erc-08-0150

PubMed ID: 19403568

Title: Differential induction of LRP16 by liganded and unliganded estrogen receptor alpha in SKOV3 ovarian carcinoma cells.

PubMed ID: 19403568

DOI: 10.1677/joe-09-0054

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23474714

Title: Macrodomain-containing proteins are new mono-ADP-ribosylhydrolases.

PubMed ID: 23474714

DOI: 10.1038/nsmb.2521

PubMed ID: 23474712

Title: A family of macrodomain proteins reverses cellular mono-ADP-ribosylation.

PubMed ID: 23474712

DOI: 10.1038/nsmb.2523

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 31599159

Title: The ARH and Macrodomain Families of alpha-ADP-ribose-acceptor Hydrolases Catalyze alpha-NAD+ Hydrolysis.

PubMed ID: 31599159

DOI: 10.1021/acschembio.9b00429

PubMed ID: 21257746

Title: Identification of macrodomain proteins as novel O-acetyl-ADP-ribose deacetylases.

PubMed ID: 21257746

DOI: 10.1074/jbc.m110.206771

Sequence Information:

  • Length: 325
  • Mass: 35505
  • Checksum: 82294BFC904FA4D0
  • Sequence:
    • MSLQSRLSGR LAQLRAAGQL LVPPRPRPGH LAGATRTRSS TCGPPAFLGV FGRRARTSAG 
VGAWGAAAVG RTAGVRTWAP LAMAAKVDLS TSTDWKEAKS FLKGLSDKQR EEHYFCKDFV 
RLKKIPTWKE MAKGVAVKVE EPRYKKDKQL NEKISLLRSD ITKLEVDAIV NAANSSLLGG 
GGVDGCIHRA AGPLLTDECR TLQSCKTGKA KITGGYRLPA KYVIHTVGPI AYGEPSASQA 
AELRSCYLSS LDLLLEHRLR SVAFPCISTG VFGYPCEAAA EIVLATLREW LEQHKDKVDR 
LIICVFLEKD EDIYRSRLPH YFPVA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.