Details for: LINC00339

Gene ID: 29092

Symbol: LINC00339

Ensembl ID: ENSG00000218510

Description: long intergenic non-protein coding RNA 339

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 20.3761
    Cell Significance Index: -9.6200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 17.1078
    Cell Significance Index: -8.8000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.6037
    Cell Significance Index: -6.9800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.4679
    Cell Significance Index: -7.5800
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.1713
    Cell Significance Index: 13.2600
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.7577
    Cell Significance Index: 6.4400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5173
    Cell Significance Index: 98.4500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5070
    Cell Significance Index: 30.4400
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.4954
    Cell Significance Index: 6.2600
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.3681
    Cell Significance Index: 4.3500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3238
    Cell Significance Index: 8.6800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2834
    Cell Significance Index: 17.8600
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.2368
    Cell Significance Index: 2.4500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2285
    Cell Significance Index: 10.3600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2189
    Cell Significance Index: 23.8100
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.2172
    Cell Significance Index: 1.3600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2152
    Cell Significance Index: 6.2000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1846
    Cell Significance Index: 4.0000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.1821
    Cell Significance Index: 52.4000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1748
    Cell Significance Index: 95.4600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1591
    Cell Significance Index: 4.3300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1273
    Cell Significance Index: 21.7400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1114
    Cell Significance Index: 15.3000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1066
    Cell Significance Index: 5.5400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0938
    Cell Significance Index: 6.4900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0800
    Cell Significance Index: 3.7300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0746
    Cell Significance Index: 2.1900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0689
    Cell Significance Index: 13.8300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0618
    Cell Significance Index: 11.1400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0531
    Cell Significance Index: 47.9200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0427
    Cell Significance Index: 1.5000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0411
    Cell Significance Index: 14.7400
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.0329
    Cell Significance Index: 0.3500
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0299
    Cell Significance Index: 0.6900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0299
    Cell Significance Index: 3.8300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0267
    Cell Significance Index: 4.3500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0246
    Cell Significance Index: 3.0300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0211
    Cell Significance Index: 2.0900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.0110
    Cell Significance Index: 0.2800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0089
    Cell Significance Index: 0.2900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0019
    Cell Significance Index: -1.4500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0039
    Cell Significance Index: -0.2000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0052
    Cell Significance Index: -9.7000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0053
    Cell Significance Index: -0.5400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0116
    Cell Significance Index: -8.6200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0134
    Cell Significance Index: -7.5500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0158
    Cell Significance Index: -9.8700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0180
    Cell Significance Index: -0.4500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0221
    Cell Significance Index: -2.5800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0222
    Cell Significance Index: -10.0700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0305
    Cell Significance Index: -0.5100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0415
    Cell Significance Index: -0.8600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0443
    Cell Significance Index: -9.3400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0474
    Cell Significance Index: -2.4900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0489
    Cell Significance Index: -5.6100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0511
    Cell Significance Index: -3.9200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0686
    Cell Significance Index: -3.2300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0743
    Cell Significance Index: -4.1700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0759
    Cell Significance Index: -0.9100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0846
    Cell Significance Index: -5.2000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0891
    Cell Significance Index: -1.9500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1097
    Cell Significance Index: -3.1500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1119
    Cell Significance Index: -6.8600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1255
    Cell Significance Index: -2.3200
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.1301
    Cell Significance Index: -1.3900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1393
    Cell Significance Index: -4.8400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1420
    Cell Significance Index: -5.8200
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.1529
    Cell Significance Index: -0.9500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1558
    Cell Significance Index: -2.6700
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.1605
    Cell Significance Index: -1.6300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1711
    Cell Significance Index: -2.7200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1734
    Cell Significance Index: -4.6300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1877
    Cell Significance Index: -3.6700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1935
    Cell Significance Index: -2.6400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1967
    Cell Significance Index: -6.8900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2054
    Cell Significance Index: -5.1300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2080
    Cell Significance Index: -3.0700
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.2141
    Cell Significance Index: -2.9700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2151
    Cell Significance Index: -6.8500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2156
    Cell Significance Index: -7.0600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2223
    Cell Significance Index: -8.1600
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.2244
    Cell Significance Index: -2.7300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2329
    Cell Significance Index: -6.8600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2335
    Cell Significance Index: -10.3300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2413
    Cell Significance Index: -5.1400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2689
    Cell Significance Index: -11.6900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2723
    Cell Significance Index: -10.3100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2744
    Cell Significance Index: -6.5800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2798
    Cell Significance Index: -6.9800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2827
    Cell Significance Index: -6.0000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2865
    Cell Significance Index: -6.1900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2871
    Cell Significance Index: -7.5500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.2961
    Cell Significance Index: -4.8800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.3066
    Cell Significance Index: -5.1700
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.3101
    Cell Significance Index: -5.2200
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.3123
    Cell Significance Index: -6.3600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.3177
    Cell Significance Index: -7.7000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.3207
    Cell Significance Index: -8.1700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.3210
    Cell Significance Index: -6.7000
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.3251
    Cell Significance Index: -3.2600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** LINC00339 is a 1,943 nucleotide long lincRNA, primarily expressed in cells of the immune system, including T cells, B cells, and dendritic cells. Its expression is also observed in epithelial cells, such as those found in the respiratory tract, gastrointestinal tract, and pancreas. Notably, LINC00339 is expressed in cells of the neural system, including GABAergic interneurons and radial glial cells, suggesting a potential role in neuroimmunological interactions. **Pathways and Functions:** LINC00339 has been implicated in several signaling pathways, including the NF-κB, MAPK, and PI3K/AKT pathways, which are crucial for immune cell activation, proliferation, and differentiation. Its expression has been linked to the regulation of immune responses, including the production of cytokines, chemokines, and other inflammatory mediators. Furthermore, LINC00339 has been shown to modulate the activity of immune cells, including T cells, B cells, and dendritic cells, influencing their ability to recognize and respond to pathogens. In addition to its immune regulatory functions, LINC00339 has been implicated in tissue homeostasis and development. Its expression has been observed in embryonic stem cells, suggesting a role in early development and patterning. LINC00339 has also been linked to the regulation of epithelial cell function, including the maintenance of epithelial barrier integrity and the regulation of cell proliferation and differentiation. **Clinical Significance:** The dysregulation of LINC00339 has been implicated in various immune-related disorders, including autoimmune diseases, such as rheumatoid arthritis, lupus, and multiple sclerosis. Its expression has also been altered in cancers, including leukemia, lymphoma, and colorectal cancer, suggesting a potential role in tumor progression and metastasis. Furthermore, LINC00339 has been implicated in neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. Its expression has been altered in these conditions, suggesting a potential role in disease pathogenesis. In conclusion, LINC00339 is a complex lincRNA with a multifaceted role in immune regulation, tissue homeostasis, and disease pathogenesis. Further research is needed to fully elucidate the mechanisms by which LINC00339 regulates immune responses and tissue homeostasis, as well as its clinical significance in immune-related disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.