Details for: SSU72

Gene ID: 29101

Symbol: SSU72

Ensembl ID: ENSG00000160075

Description: SSU72 homolog, RNA polymerase II CTD phosphatase

Associated with

  • Gene expression (transcription)
    (R-HSA-74160)
  • Rna polymerase ii transcribes snrna genes
    (R-HSA-6807505)
  • Rna polymerase ii transcription
    (R-HSA-73857)
  • Co-transcriptional mrna 3'-end processing, cleavage and polyadenylation pathway
    (GO:0180010)
  • Cytosol
    (GO:0005829)
  • Mrna cleavage and polyadenylation specificity factor complex
    (GO:0005847)
  • Myosin phosphatase activity
    (GO:0017018)
  • Nucleoplasm
    (GO:0005654)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii ctd heptapeptide repeat phosphatase activity
    (GO:0008420)
  • Termination of rna polymerase ii transcription
    (GO:0006369)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 373.1391
    Cell Significance Index: -58.0400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 209.7433
    Cell Significance Index: -53.2000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 159.7776
    Cell Significance Index: -65.8200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 147.1016
    Cell Significance Index: -69.4500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 131.8078
    Cell Significance Index: -67.8000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 103.8863
    Cell Significance Index: -69.7100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 51.5023
    Cell Significance Index: -63.5000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 17.0576
    Cell Significance Index: -67.3100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 16.8505
    Cell Significance Index: -45.1400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 15.6636
    Cell Significance Index: -48.1100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.3028
    Cell Significance Index: -20.3600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 5.6162
    Cell Significance Index: 388.3900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.9834
    Cell Significance Index: 139.1000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.2947
    Cell Significance Index: 107.8500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.9269
    Cell Significance Index: 52.4500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.7691
    Cell Significance Index: 242.9500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.5627
    Cell Significance Index: 281.7100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.5429
    Cell Significance Index: 114.9900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.5025
    Cell Significance Index: 820.5700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.4936
    Cell Significance Index: 183.6500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.4624
    Cell Significance Index: 188.9300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.3660
    Cell Significance Index: 31.5600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.3265
    Cell Significance Index: 586.4600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.2591
    Cell Significance Index: 66.1100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.1973
    Cell Significance Index: 84.6800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.1680
    Cell Significance Index: 75.3600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1442
    Cell Significance Index: 59.4400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.0680
    Cell Significance Index: 9.8400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.0281
    Cell Significance Index: 131.7900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.9698
    Cell Significance Index: 25.5000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8752
    Cell Significance Index: 175.5600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.8007
    Cell Significance Index: 21.3800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.7482
    Cell Significance Index: 88.2400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.6292
    Cell Significance Index: 11.6300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4770
    Cell Significance Index: 94.6700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.4739
    Cell Significance Index: 9.9200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.4273
    Cell Significance Index: 12.2500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3775
    Cell Significance Index: 135.4100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3263
    Cell Significance Index: 7.0700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3219
    Cell Significance Index: 61.2500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2186
    Cell Significance Index: 6.1100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2069
    Cell Significance Index: 9.3800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.1893
    Cell Significance Index: 5.5600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1575
    Cell Significance Index: 108.9300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1431
    Cell Significance Index: 9.0200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1262
    Cell Significance Index: 95.4900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0686
    Cell Significance Index: 61.9300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0522
    Cell Significance Index: 1.8200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0435
    Cell Significance Index: 31.8800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0360
    Cell Significance Index: 3.5600
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.0114
    Cell Significance Index: 0.0700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0078
    Cell Significance Index: 14.6400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0001
    Cell Significance Index: 0.0200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0212
    Cell Significance Index: -39.1400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0316
    Cell Significance Index: -48.6300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0484
    Cell Significance Index: -65.7600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0539
    Cell Significance Index: -34.2100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0596
    Cell Significance Index: -17.1600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0601
    Cell Significance Index: -44.5200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0681
    Cell Significance Index: -1.1400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0795
    Cell Significance Index: -8.1300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0944
    Cell Significance Index: -42.8400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1108
    Cell Significance Index: -62.4700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1289
    Cell Significance Index: -80.5200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1805
    Cell Significance Index: -21.0300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2160
    Cell Significance Index: -4.6000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2740
    Cell Significance Index: -8.7800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2777
    Cell Significance Index: -3.3100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2903
    Cell Significance Index: -4.3500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2914
    Cell Significance Index: -3.3100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3177
    Cell Significance Index: -46.1800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3458
    Cell Significance Index: -8.8400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3590
    Cell Significance Index: -75.6100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3975
    Cell Significance Index: -45.5400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4753
    Cell Significance Index: -37.6400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4850
    Cell Significance Index: -29.8100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4977
    Cell Significance Index: -6.7900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.4981
    Cell Significance Index: -14.3500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4981
    Cell Significance Index: -38.2300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5146
    Cell Significance Index: -34.6000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.5158
    Cell Significance Index: -9.1200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6189
    Cell Significance Index: -64.4400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.6880
    Cell Significance Index: -7.4800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.7935
    Cell Significance Index: -44.5300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.8047
    Cell Significance Index: -13.7900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.9978
    Cell Significance Index: -26.6900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.0823
    Cell Significance Index: -66.3600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.1233
    Cell Significance Index: -49.6900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.1283
    Cell Significance Index: -19.4500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.1679
    Cell Significance Index: -30.0200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.2250
    Cell Significance Index: -32.8300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.3529
    Cell Significance Index: -51.2300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.3708
    Cell Significance Index: -14.1900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.4025
    Cell Significance Index: -41.3100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.5255
    Cell Significance Index: -56.0000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.5366
    Cell Significance Index: -38.4100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.5373
    Cell Significance Index: -53.8600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.5900
    Cell Significance Index: -50.6400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.6035
    Cell Significance Index: -52.5000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.6137
    Cell Significance Index: -46.0500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SSU72 is a homolog of the human RNA polymerase II subunit A, sharing a high degree of sequence similarity with its mammalian counterpart. It is primarily expressed in cells involved in transcriptional regulation, including pancreatic acinar cells, stratified epithelial cells, and mature T cells. The SSU72 protein exhibits phosphatase activity, specifically targeting the CTD of RNAPII subunit A for dephosphorylation. This modification is essential for the regulation of RNAPII activity, as it affects the recruitment of transcriptional co-factors and the stability of transcripts. **Pathways and Functions:** SSU72 is integral to several key transcriptional pathways, including: 1. **Co-transcriptional mRNA 3'-end processing, cleavage, and polyadenylation**: SSU72's phosphatase activity regulates the processing of RNAPII-transcribed mRNAs, ensuring proper cleavage and polyadenylation. 2. **RNA polymerase II transcription**: SSU72 fine-tunes RNAPII activity, influencing the recruitment of transcriptional co-factors and the stability of transcripts. 3. **Regulation of transcription by RNAPII**: SSU72's phosphatase activity modulates RNAPII's ability to transcribe specific genes, influencing the overall transcriptional landscape. 4. **RNA polyadenylation**: SSU72's role in regulating the 3'-end processing of RNAPII-transcribed mRNAs is critical for proper polyadenylation and mRNA stability. **Clinical Significance:** SSU72's involvement in transcriptional regulation has significant implications for various diseases, including: 1. **Cancer**: Dysregulation of SSU72's phosphatase activity has been implicated in the development and progression of various cancers, including pancreatic and lung cancer. 2. **Neurological disorders**: SSU72's role in regulating transcriptional activity may contribute to the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Immunological disorders**: SSU72's involvement in T-cell development and function makes it an attractive target for the treatment of immunological disorders, such as autoimmune diseases. In conclusion, SSU72 is a critical component of the RNAPII transcription complex, playing a pivotal role in regulating gene expression and transcriptional activity. Its dysregulation has significant implications for various diseases, highlighting the importance of further research into the mechanisms underlying SSU72's function and its role in disease pathogenesis.

Genular Protein ID: 2420137072

Symbol: SSU72_HUMAN

Name: RNA polymerase II subunit A C-terminal domain phosphatase SSU72

UniProtKB Accession Codes:

Q9NP77 Q9BZS6 Q9H933

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 DEPOD 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 3 EMBL 10 Ensembl 2 EvolutionaryTrace 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 6 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15659578

Title: Conserved and specific functions of mammalian ssu72.

PubMed ID: 15659578

DOI: 10.1093/nar/gki171

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 29158257

Title: Structural dissection of an interaction between transcription initiation and termination factors implicated in promoter-terminator cross-talk.

PubMed ID: 29158257

DOI: 10.1074/jbc.m117.811521

PubMed ID: 20861839

Title: Crystal structure of the human symplekin-Ssu72-CTD phosphopeptide complex.

PubMed ID: 20861839

DOI: 10.1038/nature09391

PubMed ID: 23070812

Title: An unexpected binding mode for a Pol II CTD peptide phosphorylated at Ser7 in the active site of the CTD phosphatase Ssu72.

PubMed ID: 23070812

DOI: 10.1101/gad.198853.112

Sequence Information:

  • Length: 194
  • Mass: 22574
  • Checksum: CA3A3157A2388A77
  • Sequence:
    • MPSSPLRVAV VCSSNQNRSM EAHNILSKRG FSVRSFGTGT HVKLPGPAPD KPNVYDFKTT 
YDQMYNDLLR KDKELYTQNG ILHMLDRNKR IKPRPERFQN CKDLFDLILT CEERVYDQVV 
EDLNSREQET CQPVHVVNVD IQDNHEEATL GAFLICELCQ CIQHTEDMEN EIDELLQEFE 
EKSGRTFLHT VCFY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.