Details for: C6orf15

Gene ID: 29113

Symbol: C6orf15

Ensembl ID: ENSG00000204542

Description: chromosome 6 open reading frame 15

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 1.8813
    Cell Significance Index: 8.0900
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.4807
    Cell Significance Index: 6.6700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2851
    Cell Significance Index: 13.4000
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.2630
    Cell Significance Index: 3.0100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.1317
    Cell Significance Index: 3.2900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1083
    Cell Significance Index: 5.6300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0716
    Cell Significance Index: 9.2500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.0629
    Cell Significance Index: 0.6900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0403
    Cell Significance Index: 0.5500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0144
    Cell Significance Index: 7.8400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0094
    Cell Significance Index: 0.4100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0071
    Cell Significance Index: -4.0200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0074
    Cell Significance Index: -1.4700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0075
    Cell Significance Index: -1.0300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0090
    Cell Significance Index: -1.6200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0092
    Cell Significance Index: -6.8400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0095
    Cell Significance Index: -0.1400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0112
    Cell Significance Index: -2.2400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0136
    Cell Significance Index: -1.3900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0148
    Cell Significance Index: -1.8200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0184
    Cell Significance Index: -1.3700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0194
    Cell Significance Index: -2.2200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0227
    Cell Significance Index: -1.0600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0256
    Cell Significance Index: -0.9400
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0264
    Cell Significance Index: -0.2800
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0361
    Cell Significance Index: -0.7200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0393
    Cell Significance Index: -1.7800
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0404
    Cell Significance Index: -0.5600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0427
    Cell Significance Index: -1.2300
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: -0.0432
    Cell Significance Index: -0.3500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0437
    Cell Significance Index: -1.0100
  • Cell Name: serous cell of epithelium of trachea (CL1000330)
    Fold Change: -0.0467
    Cell Significance Index: -0.3600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0480
    Cell Significance Index: -1.6900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0540
    Cell Significance Index: -1.1200
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0550
    Cell Significance Index: -0.7100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0630
    Cell Significance Index: -0.6700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0632
    Cell Significance Index: -1.5800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0636
    Cell Significance Index: -1.6200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0740
    Cell Significance Index: -2.1200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0794
    Cell Significance Index: -2.1200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0816
    Cell Significance Index: -2.2200
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0839
    Cell Significance Index: -1.0800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0842
    Cell Significance Index: -14.3800
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -0.0850
    Cell Significance Index: -0.9100
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0892
    Cell Significance Index: -1.1200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0989
    Cell Significance Index: -1.5300
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.1037
    Cell Significance Index: -1.0700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.1047
    Cell Significance Index: -1.8500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1115
    Cell Significance Index: -1.6800
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.1169
    Cell Significance Index: -0.9300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1199
    Cell Significance Index: -1.9800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1201
    Cell Significance Index: -2.0100
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.1289
    Cell Significance Index: -1.3200
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1337
    Cell Significance Index: -1.7600
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.1348
    Cell Significance Index: -1.3900
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: -0.1390
    Cell Significance Index: -0.6400
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.1391
    Cell Significance Index: -1.4800
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.1393
    Cell Significance Index: -2.2400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1416
    Cell Significance Index: -2.1500
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.1417
    Cell Significance Index: -1.0300
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1429
    Cell Significance Index: -1.7000
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.1488
    Cell Significance Index: -1.8100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1508
    Cell Significance Index: -2.1600
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1523
    Cell Significance Index: -2.2200
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1527
    Cell Significance Index: -2.1700
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1528
    Cell Significance Index: -2.6000
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.1533
    Cell Significance Index: -1.6700
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1535
    Cell Significance Index: -2.0400
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.1540
    Cell Significance Index: -2.1300
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.1545
    Cell Significance Index: -1.5300
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: -0.1549
    Cell Significance Index: -1.0900
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: -0.1559
    Cell Significance Index: -1.5600
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.1584
    Cell Significance Index: -2.2200
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.1590
    Cell Significance Index: -2.1200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1596
    Cell Significance Index: -3.1200
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.1604
    Cell Significance Index: -1.8200
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1609
    Cell Significance Index: -2.1000
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.1611
    Cell Significance Index: -1.9600
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.1617
    Cell Significance Index: -2.1100
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.1628
    Cell Significance Index: -2.0500
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.1643
    Cell Significance Index: -1.7300
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.1650
    Cell Significance Index: -2.2000
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.1662
    Cell Significance Index: -1.6400
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1668
    Cell Significance Index: -2.2900
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1669
    Cell Significance Index: -2.1900
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.1690
    Cell Significance Index: -1.8300
  • Cell Name: airway submucosal gland duct basal cell (CL4033024)
    Fold Change: -0.1699
    Cell Significance Index: -1.4900
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.1721
    Cell Significance Index: -2.1800
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1741
    Cell Significance Index: -2.1400
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: -0.1749
    Cell Significance Index: -1.1000
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1770
    Cell Significance Index: -2.0000
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1776
    Cell Significance Index: -2.1300
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.1779
    Cell Significance Index: -1.7400
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1786
    Cell Significance Index: -2.1100
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.1795
    Cell Significance Index: -1.9500
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: -0.1797
    Cell Significance Index: -1.6900
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.1799
    Cell Significance Index: -1.9100
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.1803
    Cell Significance Index: -1.9000
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.1807
    Cell Significance Index: -1.7300
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1838
    Cell Significance Index: -2.1700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The C6orf15 gene is a small, uncharacterized protein-coding gene located on chromosome 6. Its expression is widespread, with significant levels detected in T cells, plasma cells, B cells, goblet cells, absorptive cells, intestinal crypt stem cells, transit amplifying cells, abnormal cells, intestinal epithelial cells, and neoplastic cells. This broad expression pattern suggests that C6orf15 may play a crucial role in maintaining tissue homeostasis, immune function, and cellular proliferation. **Pathways and Functions:** The C6orf15 gene is involved in various biological processes, including the extracellular matrix organization, extracellular region, and protein binding. Specifically, its protein product, CF015_HUMAN, is predicted to interact with other proteins, influencing cellular signaling pathways and modulating immune responses. The gene's involvement in the extracellular matrix organization suggests that it may contribute to tissue architecture and cell migration. Moreover, its expression in stem cells and epithelial cells implies that C6orf15 may be involved in cell differentiation, proliferation, and survival. **Clinical Significance:** The clinical significance of the C6orf15 gene is still unknown, but its expression in various cell types and tissues raises several possibilities. For instance, alterations in C6orf15 expression may contribute to the development of immune-related disorders, such as autoimmune diseases or cancer. Furthermore, the gene's involvement in cellular proliferation and differentiation suggests that it may play a role in the pathogenesis of certain cancers. Additionally, C6orf15's expression in epithelial cells and stem cells implies that it may be involved in maintaining tissue homeostasis and preventing tissue damage. **Potential Implications:** The discovery of the C6orf15 gene has significant implications for our understanding of immune function, tissue homeostasis, and disease pathogenesis. Further research is needed to elucidate the gene's exact functions and its role in various diseases. Potential avenues for investigation include: 1. Investigating the gene's expression in different disease states, such as autoimmune diseases or cancer. 2. Analyzing the protein-protein interactions mediated by CF015_HUMAN. 3. Exploring the gene's role in cellular proliferation, differentiation, and survival. 4. Developing novel therapeutic strategies targeting C6orf15 or its interacting proteins. In conclusion, the C6orf15 gene is a mysterious but intriguing gene that warrants further investigation. Its widespread expression in various cell types and tissues suggests that it may play a crucial role in maintaining tissue homeostasis, immune function, and cellular proliferation. As we continue to unravel the secrets of this enigmatic gene, we may uncover new insights into the pathogenesis of various diseases and develop novel therapeutic strategies.

Genular Protein ID: 1771305660

Symbol: CF015_HUMAN

Name: Uncharacterized protein C6orf15

UniProtKB Accession Codes:

Q6UXA7 B0S7V8 Q0EFA6 Q2L6G7 Q5SQ81 Q86Z05 Q9UIG3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 Ensembl 6 ExpressionAtlas 1 GO 3 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10545595

Title: Association analysis using refined microsatellite markers localizes a susceptibility locus for psoriasis vulgaris within a 111kb segment telomeric to the HLA-C gene.

PubMed ID: 10545595

DOI: 10.1093/hmg/8.12.2165

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 16702430

Title: Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity.

PubMed ID: 16702430

DOI: 10.1534/genetics.106.057034

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15217361

Title: STG does not associate with psoriasis in the Swedish population.

PubMed ID: 15217361

DOI: 10.1111/j.0906-6705.2004.00170.x

Sequence Information:

  • Length: 325
  • Mass: 34195
  • Checksum: 8ED611FD4F9364E3
  • Sequence:
    • MQGRVAGSCA PLGLLLVCLH LPGLFARSIG VVEEKVSQNL GTNLPQLGQP SSTGPSNSEH 
PQPALDPRSN DLARVPLKLS VPASDGFPPA GGSAVQRWPP SWGLPAMDSW PPEDPWQMMA 
AAAEDRLGEA LPEELSYLSS AAALAPGSGP LPGESSPDAT GLSPKASLLH QDSESRRLPR 
SNSLGAGGKI LSQRPPWSLI HRVLPDHPWG TLNPSVSWGG GGPGTGWGTR PMPHPEGIWG 
INNQPPGTSW GNINRYPGGS WGNINRYPGG SWGNINRYPG GSWGNIHLYP GINNPFPPGV 
LRPPGSSWNI PAGFPNPPSP RLQWG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.