Details for: C6orf15

Gene ID: 29113

Symbol: C6orf15

Ensembl ID: ENSG00000204542

Description: chromosome 6 open reading frame 15

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: T cell (CL0000084)
    Fold Change: 2.33
    Marker Score: 4,016
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.98
    Marker Score: 2,212
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.27
    Marker Score: 1,209
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7,693
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,406
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,348
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,742
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.89
    Marker Score: 1,445
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,292
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.86
    Marker Score: 501
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 713
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.75
    Marker Score: 1,200
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.73
    Marker Score: 701
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.69
    Marker Score: 4,422
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.68
    Marker Score: 540
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.56
    Marker Score: 893
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.43
    Marker Score: 387
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.32
    Marker Score: 73
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.25
    Marker Score: 73
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.24
    Marker Score: 78
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.22
    Marker Score: 69
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.21
    Marker Score: 67
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.2
    Marker Score: 73
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.19
    Marker Score: 74
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.17
    Marker Score: 191
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.17
    Marker Score: 60
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.16
    Marker Score: 58
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.15
    Marker Score: 316
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.15
    Marker Score: 101
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.15
    Marker Score: 74
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.15
    Marker Score: 131
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 0.15
    Marker Score: 53
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.14
    Marker Score: 66
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.14
    Marker Score: 83
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.14
    Marker Score: 73
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.13
    Marker Score: 210
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 0.13
    Marker Score: 51
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.13
    Marker Score: 40
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.12
    Marker Score: 302
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.12
    Marker Score: 63
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.12
    Marker Score: 64
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.12
    Marker Score: 74
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.11
    Marker Score: 79
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.11
    Marker Score: 74
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.11
    Marker Score: 73
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.11
    Marker Score: 112
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.09
    Marker Score: 71
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.08
    Marker Score: 73
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.08
    Marker Score: 59
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.07
    Marker Score: 127
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.07
    Marker Score: 74
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.07
    Marker Score: 125
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.06
    Marker Score: 65
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.06
    Marker Score: 72
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.06
    Marker Score: 69
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.06
    Marker Score: 73
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.05
    Marker Score: 70
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.05
    Marker Score: 96
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.05
    Marker Score: 125
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.05
    Marker Score: 52
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.05
    Marker Score: 70
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.05
    Marker Score: 116
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.05
    Marker Score: 49
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.05
    Marker Score: 74
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.05
    Marker Score: 239
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.04
    Marker Score: 652
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.04
    Marker Score: 67
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.04
    Marker Score: 72
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.04
    Marker Score: 55
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.04
    Marker Score: 73
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.04
    Marker Score: 499
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.04
    Marker Score: 114
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.03
    Marker Score: 94
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.03
    Marker Score: 74
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.03
    Marker Score: 46
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.03
    Marker Score: 63
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.03
    Marker Score: 107
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.03
    Marker Score: 970
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.03
    Marker Score: 89
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.02
    Marker Score: 55
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.02
    Marker Score: 72
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.01
    Marker Score: 64
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.01
    Marker Score: 50
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.01
    Marker Score: 3,014
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.01
    Marker Score: 81
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.01
    Marker Score: 68
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.01
    Marker Score: 82
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.01
    Marker Score: 64
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.01
    Marker Score: 65
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0
    Marker Score: 74
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0
    Marker Score: 53
  • Cell Name: mural cell (CL0008034)
    Fold Change: 0
    Marker Score: 73

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The C6orf15 gene is a small, uncharacterized protein-coding gene located on chromosome 6. Its expression is widespread, with significant levels detected in T cells, plasma cells, B cells, goblet cells, absorptive cells, intestinal crypt stem cells, transit amplifying cells, abnormal cells, intestinal epithelial cells, and neoplastic cells. This broad expression pattern suggests that C6orf15 may play a crucial role in maintaining tissue homeostasis, immune function, and cellular proliferation. **Pathways and Functions:** The C6orf15 gene is involved in various biological processes, including the extracellular matrix organization, extracellular region, and protein binding. Specifically, its protein product, CF015_HUMAN, is predicted to interact with other proteins, influencing cellular signaling pathways and modulating immune responses. The gene's involvement in the extracellular matrix organization suggests that it may contribute to tissue architecture and cell migration. Moreover, its expression in stem cells and epithelial cells implies that C6orf15 may be involved in cell differentiation, proliferation, and survival. **Clinical Significance:** The clinical significance of the C6orf15 gene is still unknown, but its expression in various cell types and tissues raises several possibilities. For instance, alterations in C6orf15 expression may contribute to the development of immune-related disorders, such as autoimmune diseases or cancer. Furthermore, the gene's involvement in cellular proliferation and differentiation suggests that it may play a role in the pathogenesis of certain cancers. Additionally, C6orf15's expression in epithelial cells and stem cells implies that it may be involved in maintaining tissue homeostasis and preventing tissue damage. **Potential Implications:** The discovery of the C6orf15 gene has significant implications for our understanding of immune function, tissue homeostasis, and disease pathogenesis. Further research is needed to elucidate the gene's exact functions and its role in various diseases. Potential avenues for investigation include: 1. Investigating the gene's expression in different disease states, such as autoimmune diseases or cancer. 2. Analyzing the protein-protein interactions mediated by CF015_HUMAN. 3. Exploring the gene's role in cellular proliferation, differentiation, and survival. 4. Developing novel therapeutic strategies targeting C6orf15 or its interacting proteins. In conclusion, the C6orf15 gene is a mysterious but intriguing gene that warrants further investigation. Its widespread expression in various cell types and tissues suggests that it may play a crucial role in maintaining tissue homeostasis, immune function, and cellular proliferation. As we continue to unravel the secrets of this enigmatic gene, we may uncover new insights into the pathogenesis of various diseases and develop novel therapeutic strategies.

Genular Protein ID: 1771305660

Symbol: CF015_HUMAN

Name: Uncharacterized protein C6orf15

UniProtKB Accession Codes:

Q6UXA7 B0S7V8 Q0EFA6 Q2L6G7 Q5SQ81 Q86Z05 Q9UIG3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 Ensembl 6 ExpressionAtlas 1 GO 3 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SAM 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 10545595

Title: Association analysis using refined microsatellite markers localizes a susceptibility locus for psoriasis vulgaris within a 111kb segment telomeric to the HLA-C gene.

PubMed ID: 10545595

DOI: 10.1093/hmg/8.12.2165

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 16702430

Title: Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity.

PubMed ID: 16702430

DOI: 10.1534/genetics.106.057034

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15217361

Title: STG does not associate with psoriasis in the Swedish population.

PubMed ID: 15217361

DOI: 10.1111/j.0906-6705.2004.00170.x

Sequence Information:

  • Length: 325
  • Mass: 34195
  • Checksum: 8ED611FD4F9364E3
  • Sequence:
    • MQGRVAGSCA PLGLLLVCLH LPGLFARSIG VVEEKVSQNL GTNLPQLGQP SSTGPSNSEH 
PQPALDPRSN DLARVPLKLS VPASDGFPPA GGSAVQRWPP SWGLPAMDSW PPEDPWQMMA 
AAAEDRLGEA LPEELSYLSS AAALAPGSGP LPGESSPDAT GLSPKASLLH QDSESRRLPR 
SNSLGAGGKI LSQRPPWSLI HRVLPDHPWG TLNPSVSWGG GGPGTGWGTR PMPHPEGIWG 
INNQPPGTSW GNINRYPGGS WGNINRYPGG SWGNINRYPG GSWGNIHLYP GINNPFPPGV 
LRPPGSSWNI PAGFPNPPSP RLQWG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.