Details for: DDX25

Gene ID: 29118

Symbol: DDX25

Ensembl ID: ENSG00000109832

Description: DEAD-box helicase 25

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 66.4758
    Cell Significance Index: -10.3400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 41.0419
    Cell Significance Index: -10.4100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.1390
    Cell Significance Index: 71.7900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8452
    Cell Significance Index: 169.5400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.8412
    Cell Significance Index: 18.4200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.7744
    Cell Significance Index: 9.6100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4495
    Cell Significance Index: 161.2400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.4352
    Cell Significance Index: 16.4800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.4312
    Cell Significance Index: 22.6400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.4223
    Cell Significance Index: 18.6800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.2721
    Cell Significance Index: 6.5900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2378
    Cell Significance Index: 5.0700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.2085
    Cell Significance Index: 5.9500
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.1972
    Cell Significance Index: 1.5200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1715
    Cell Significance Index: 10.5400
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.1569
    Cell Significance Index: 1.1900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1367
    Cell Significance Index: 9.1900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1032
    Cell Significance Index: 1.2300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0594
    Cell Significance Index: 41.0900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0327
    Cell Significance Index: 0.5600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0229
    Cell Significance Index: 0.5500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0190
    Cell Significance Index: 8.3900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.0099
    Cell Significance Index: 0.2100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0037
    Cell Significance Index: 6.8800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0019
    Cell Significance Index: 3.4500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0008
    Cell Significance Index: 1.1700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0053
    Cell Significance Index: -7.2500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0075
    Cell Significance Index: -5.5100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0080
    Cell Significance Index: -5.9200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0081
    Cell Significance Index: -5.1300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0081
    Cell Significance Index: -4.5700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0152
    Cell Significance Index: -9.4800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0153
    Cell Significance Index: -11.5800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0168
    Cell Significance Index: -9.1500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0195
    Cell Significance Index: -8.8600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0224
    Cell Significance Index: -3.2600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0237
    Cell Significance Index: -0.3400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0277
    Cell Significance Index: -4.5100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0293
    Cell Significance Index: -8.4400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0310
    Cell Significance Index: -3.9800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0346
    Cell Significance Index: -0.8900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0349
    Cell Significance Index: -0.7000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0391
    Cell Significance Index: -7.7600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0425
    Cell Significance Index: -0.8400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0446
    Cell Significance Index: -7.6100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0455
    Cell Significance Index: -8.2100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0466
    Cell Significance Index: -9.8200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0576
    Cell Significance Index: -1.6100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0628
    Cell Significance Index: -8.6300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0684
    Cell Significance Index: -8.4100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0703
    Cell Significance Index: -2.3000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0720
    Cell Significance Index: -8.2500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0763
    Cell Significance Index: -2.4300
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0771
    Cell Significance Index: -0.9000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0794
    Cell Significance Index: -10.2600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0820
    Cell Significance Index: -4.6000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0824
    Cell Significance Index: -9.7200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0917
    Cell Significance Index: -9.3700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0936
    Cell Significance Index: -10.9100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0946
    Cell Significance Index: -5.6800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0973
    Cell Significance Index: -10.1300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1065
    Cell Significance Index: -7.3700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1091
    Cell Significance Index: -1.3600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1139
    Cell Significance Index: -2.4600
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.1188
    Cell Significance Index: -1.4400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1199
    Cell Significance Index: -9.5000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1252
    Cell Significance Index: -9.6100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1313
    Cell Significance Index: -6.1200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1370
    Cell Significance Index: -10.2100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1471
    Cell Significance Index: -3.6700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1473
    Cell Significance Index: -2.0100
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.1539
    Cell Significance Index: -1.2700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1572
    Cell Significance Index: -1.4900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1606
    Cell Significance Index: -5.6300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1616
    Cell Significance Index: -4.2500
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1735
    Cell Significance Index: -2.1900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1752
    Cell Significance Index: -7.6200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1776
    Cell Significance Index: -9.2500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1827
    Cell Significance Index: -1.9900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1858
    Cell Significance Index: -8.4200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2095
    Cell Significance Index: -7.2800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2097
    Cell Significance Index: -4.3900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2109
    Cell Significance Index: -5.7400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2120
    Cell Significance Index: -9.9700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2173
    Cell Significance Index: -11.2900
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.2190
    Cell Significance Index: -2.8400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2194
    Cell Significance Index: -4.5800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2215
    Cell Significance Index: -3.8300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2381
    Cell Significance Index: -8.7400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2398
    Cell Significance Index: -6.9100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2452
    Cell Significance Index: -8.6200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2523
    Cell Significance Index: -7.4300
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.2540
    Cell Significance Index: -2.8700
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.2585
    Cell Significance Index: -2.4600
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.2659
    Cell Significance Index: -2.7700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2696
    Cell Significance Index: -5.8400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2770
    Cell Significance Index: -8.7600
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.2943
    Cell Significance Index: -3.5200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3001
    Cell Significance Index: -8.0400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3038
    Cell Significance Index: -9.7300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DDX25 is a member of the DEAD-box family of RNA helicases, characterized by its ability to unwind RNA molecules and facilitate their movement. This gene is specifically expressed in various cell types, including kidney proximal convoluted tubule epithelial cells, germ cells, dendritic cells, goblet cells, and neurons. The expression patterns of DDX25 suggest its involvement in diverse cellular processes. **Pathways and Functions:** DDX25 is implicated in several critical cellular pathways, including: 1. **RNA metabolism:** DDX25 regulates RNA export from the nucleus, mRNA binding, and poly(A)+ mRNA export from the nucleus, highlighting its role in RNA processing and transport. 2. **Translation regulation:** This helicase is involved in the regulation of translation, where it unwinds RNA secondary structures to facilitate translation initiation and elongation. 3. **Stress response:** DDX25 is activated in response to cytoplasmic stress granule formation, indicating its role in stress response and adaptation. 4. **Spermatogenesis:** As a germ cell-specific gene, DDX25 is essential for spermatid development, underscoring its importance in male reproductive biology. **Clinical Significance:** DDX25's involvement in various cellular processes makes it a potential target for therapeutic interventions in diseases characterized by dysregulated RNA metabolism, such as: 1. **Cancer:** Alterations in DDX25 expression have been linked to cancer progression and metastasis, suggesting its potential as a prognostic marker or therapeutic target. 2. **Neurological disorders:** DDX25's role in neuronal function and stress response may contribute to the pathogenesis of neurodegenerative diseases, such as Alzheimer's and Parkinson's. 3. **Immune system dysfunction:** Dysregulation of DDX25 expression may contribute to immune system disorders, including autoimmune diseases and immunodeficiency. In conclusion, DDX25 is a multifaceted gene with far-reaching implications in RNA metabolism, translation regulation, stress response, and spermatogenesis. Its clinical significance underscores the need for further research to elucidate its role in human diseases and to explore its potential as a therapeutic target. **Recommendations:** 1. Further studies are needed to elucidate the mechanisms underlying DDX25's involvement in human diseases. 2. The expression patterns of DDX25 should be investigated in more detail to identify potential biomarkers for disease diagnosis and monitoring. 3. The therapeutic potential of DDX25 should be explored in preclinical models to determine its efficacy and safety as a potential target for cancer, neurological, and immune system disorders. By continuing to unravel the complexities of DDX25, we may uncover new avenues for therapeutic intervention and improve our understanding of the intricate relationships between RNA metabolism, translation regulation, and cellular stress response.

Genular Protein ID: 2893523249

Symbol: DDX25_HUMAN

Name: ATP-dependent RNA helicase DDX25

UniProtKB Accession Codes:

Q9UHL0 B2R6Z0 Q5XVN2 Q86W81 Q8IYP1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChEBI 6 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 17 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 Rhea 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10608860

Title: A novel gonadotropin-regulated testicular RNA helicase: a new member of the DEAD-box family.

PubMed ID: 10608860

DOI: 10.1074/jbc.274.53.37932

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20941364

Title: Comparative structural analysis of human DEAD-box RNA helicases.

PubMed ID: 20941364

DOI: 10.1371/journal.pone.0012791

Sequence Information:

  • Length: 483
  • Mass: 54692
  • Checksum: 32247CDDCA177F48
  • Sequence:
    • MASLLWGGDA GAAESERLNS HFSNLSQPRK NLWGIKSTAV RNIDGSINNI NEDDEEDVVD 
LAANSLLNKL IHQSLVESSH RVEVLQKDPS SPLYSVKTFE ELRLKEELLK GIYAMGFNRP 
SKIQEMALPM MLAHPPQNLI AQSQSGTGKT AAFVLAMLSR VNALELFPQC LCLAPTYELA 
LQTGRVVEQM GKFCVDVQVM YAIRGNRIPR GTDITKQIII GTPGTVLDWC FKLKLIDLTK 
IRVFVLDEAD VMIDTQGFSD HSIRIQRALP SECQMLLFSA TFEDSVWHFA ERIIPDPNVI 
KLRKEELTLN NIRQYYVLCE HRKDKYQALC NIYGSITIGQ AIIFCQTRRN AKWLTVEMIQ 
DGHQVSLLSG ELTVEQRASI IQRFRDGKEK VLITTNVCAR GIDVKQVTIV VNFDLPVKQG 
EEPDYETYLH RIGRTGRFGK KGLAFNMIEV DELPSLMKIQ DHFNSSIKQL NAEDMDEIEK 
IDY

Genular Protein ID: 882947696

Symbol: A0A384NYS3_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A384NYS3

Database IDs:

ARBA 3 AlphaFoldDB 1 Antibodypedia 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 ExpressionAtlas 1 GO 7 Gene3D 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 Pfam 2 RefSeq 1 SMART 2 SMR 1 SUPFAM 1 VEuPathDB 1

Sequence Information:

  • Length: 369
  • Mass: 42034
  • Checksum: B1CB13391FA4B54E
  • Sequence:
    • MGFNRPSKIQ EMALPMMLAH PPQNLIAQSQ SGTGKTAAFV LAMLSRVNAL ELFPQCLCLA 
PTYELALQTG RVVEQMGKFC VDVQVMYAIR GNRIPRGTDI TKQIIIGTPG TVLDWCFKLK 
LIDLTKIRVF VLDEADVMID TQGFSDHSIR IQRALPSECQ MLLFSATFED SVWHFAERII 
PDPNVIKLRK EELTLNNIRQ YYVLCEHRKD KYQALCNIYG SITIGQAIIF CQTRRNAKWL 
TVEMIQDGHQ VSLLSGELTV EQRASIIQRF RDGKEKVLIT TNVCARGIDV KQVTIVVNFD 
LPVKQGEEPD YETYLHRIGR TGRFGKKGLA FNMIEVDELP SLMKIQDHFN SSIKQLNAED 
MDEIEKIDY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.