Details for: DDX25

Gene ID: 29118

Symbol: DDX25

Ensembl ID: ENSG00000109832

Description: DEAD-box helicase 25

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 2.14
    Marker Score: 4,419
  • Cell Name: germ cell (CL0000586)
    Fold Change: 2.05
    Marker Score: 3,585
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.81
    Marker Score: 1,246
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1,171
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 856
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.22
    Marker Score: 1,758
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.18
    Marker Score: 4,800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4,815
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.15
    Marker Score: 1,768
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.14
    Marker Score: 7,569
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.14
    Marker Score: 10,786
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.12
    Marker Score: 41,195
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.11
    Marker Score: 68,085
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.1
    Marker Score: 10,309
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.08
    Marker Score: 685
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.05
    Marker Score: 9,007
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 797
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,825
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,049
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 508
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.98
    Marker Score: 283
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 461
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.96
    Marker Score: 19,023
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,344
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.93
    Marker Score: 35,442
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 373
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,742
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 325
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9
    Marker Score: 3,488
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.9
    Marker Score: 374
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,289
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.83
    Marker Score: 382
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.83
    Marker Score: 12,394
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.82
    Marker Score: 3,415
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.8
    Marker Score: 8,234
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,265
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.76
    Marker Score: 952
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.74
    Marker Score: 11,540
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 461
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.67
    Marker Score: 1,268
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.65
    Marker Score: 4,996
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.6
    Marker Score: 1,222
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.59
    Marker Score: 145
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.52
    Marker Score: 1,061
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.47
    Marker Score: 571
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.47
    Marker Score: 1,097
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.46
    Marker Score: 438
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.46
    Marker Score: 193
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.43
    Marker Score: 137
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.42
    Marker Score: 8,890
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.4
    Marker Score: 209
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.38
    Marker Score: 103
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.36
    Marker Score: 523
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.36
    Marker Score: 313
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.36
    Marker Score: 171
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.35
    Marker Score: 211
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.33
    Marker Score: 99
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.33
    Marker Score: 86
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.33
    Marker Score: 111
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.32
    Marker Score: 363
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.32
    Marker Score: 85
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.32
    Marker Score: 396
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.32
    Marker Score: 908
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.32
    Marker Score: 137
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.31
    Marker Score: 1,448
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.31
    Marker Score: 308
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.3
    Marker Score: 509
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.29
    Marker Score: 92
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.28
    Marker Score: 130
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.28
    Marker Score: 9,301
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.27
    Marker Score: 2,714
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.25
    Marker Score: 683
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.25
    Marker Score: 100
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.24
    Marker Score: 160
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.23
    Marker Score: 243
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.22
    Marker Score: 98
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.22
    Marker Score: 69
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.22
    Marker Score: 90
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.21
    Marker Score: 124
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.21
    Marker Score: 223
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.21
    Marker Score: 136
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.19
    Marker Score: 556
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.19
    Marker Score: 43
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.18
    Marker Score: 87
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.18
    Marker Score: 65
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.18
    Marker Score: 739
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.17
    Marker Score: 60
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.17
    Marker Score: 1,739
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.16
    Marker Score: 63
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.16
    Marker Score: 670

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DDX25 is a member of the DEAD-box family of RNA helicases, characterized by its ability to unwind RNA molecules and facilitate their movement. This gene is specifically expressed in various cell types, including kidney proximal convoluted tubule epithelial cells, germ cells, dendritic cells, goblet cells, and neurons. The expression patterns of DDX25 suggest its involvement in diverse cellular processes. **Pathways and Functions:** DDX25 is implicated in several critical cellular pathways, including: 1. **RNA metabolism:** DDX25 regulates RNA export from the nucleus, mRNA binding, and poly(A)+ mRNA export from the nucleus, highlighting its role in RNA processing and transport. 2. **Translation regulation:** This helicase is involved in the regulation of translation, where it unwinds RNA secondary structures to facilitate translation initiation and elongation. 3. **Stress response:** DDX25 is activated in response to cytoplasmic stress granule formation, indicating its role in stress response and adaptation. 4. **Spermatogenesis:** As a germ cell-specific gene, DDX25 is essential for spermatid development, underscoring its importance in male reproductive biology. **Clinical Significance:** DDX25's involvement in various cellular processes makes it a potential target for therapeutic interventions in diseases characterized by dysregulated RNA metabolism, such as: 1. **Cancer:** Alterations in DDX25 expression have been linked to cancer progression and metastasis, suggesting its potential as a prognostic marker or therapeutic target. 2. **Neurological disorders:** DDX25's role in neuronal function and stress response may contribute to the pathogenesis of neurodegenerative diseases, such as Alzheimer's and Parkinson's. 3. **Immune system dysfunction:** Dysregulation of DDX25 expression may contribute to immune system disorders, including autoimmune diseases and immunodeficiency. In conclusion, DDX25 is a multifaceted gene with far-reaching implications in RNA metabolism, translation regulation, stress response, and spermatogenesis. Its clinical significance underscores the need for further research to elucidate its role in human diseases and to explore its potential as a therapeutic target. **Recommendations:** 1. Further studies are needed to elucidate the mechanisms underlying DDX25's involvement in human diseases. 2. The expression patterns of DDX25 should be investigated in more detail to identify potential biomarkers for disease diagnosis and monitoring. 3. The therapeutic potential of DDX25 should be explored in preclinical models to determine its efficacy and safety as a potential target for cancer, neurological, and immune system disorders. By continuing to unravel the complexities of DDX25, we may uncover new avenues for therapeutic intervention and improve our understanding of the intricate relationships between RNA metabolism, translation regulation, and cellular stress response.

Genular Protein ID: 2893523249

Symbol: DDX25_HUMAN

Name: ATP-dependent RNA helicase DDX25

UniProtKB Accession Codes:

Q9UHL0 B2R6Z0 Q5XVN2 Q86W81 Q8IYP1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChEBI 6 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 17 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 2 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 Rhea 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10608860

Title: A novel gonadotropin-regulated testicular RNA helicase: a new member of the DEAD-box family.

PubMed ID: 10608860

DOI: 10.1074/jbc.274.53.37932

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20941364

Title: Comparative structural analysis of human DEAD-box RNA helicases.

PubMed ID: 20941364

DOI: 10.1371/journal.pone.0012791

Sequence Information:

  • Length: 483
  • Mass: 54692
  • Checksum: 32247CDDCA177F48
  • Sequence:
    • MASLLWGGDA GAAESERLNS HFSNLSQPRK NLWGIKSTAV RNIDGSINNI NEDDEEDVVD 
LAANSLLNKL IHQSLVESSH RVEVLQKDPS SPLYSVKTFE ELRLKEELLK GIYAMGFNRP 
SKIQEMALPM MLAHPPQNLI AQSQSGTGKT AAFVLAMLSR VNALELFPQC LCLAPTYELA 
LQTGRVVEQM GKFCVDVQVM YAIRGNRIPR GTDITKQIII GTPGTVLDWC FKLKLIDLTK 
IRVFVLDEAD VMIDTQGFSD HSIRIQRALP SECQMLLFSA TFEDSVWHFA ERIIPDPNVI 
KLRKEELTLN NIRQYYVLCE HRKDKYQALC NIYGSITIGQ AIIFCQTRRN AKWLTVEMIQ 
DGHQVSLLSG ELTVEQRASI IQRFRDGKEK VLITTNVCAR GIDVKQVTIV VNFDLPVKQG 
EEPDYETYLH RIGRTGRFGK KGLAFNMIEV DELPSLMKIQ DHFNSSIKQL NAEDMDEIEK 
IDY

Genular Protein ID: 882947696

Symbol: A0A384NYS3_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A384NYS3

Database IDs:

ARBA 3 AlphaFoldDB 1 Antibodypedia 1 CDD 1 CTD 1 DNASU 1 EMBL 2 ExpressionAtlas 1 GO 2 Gene3D 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 Pfam 2 RefSeq 1 SMART 2 SMR 1 SUPFAM 1 VEuPathDB 1

Sequence Information:

  • Length: 369
  • Mass: 42034
  • Checksum: B1CB13391FA4B54E
  • Sequence:
    • MGFNRPSKIQ EMALPMMLAH PPQNLIAQSQ SGTGKTAAFV LAMLSRVNAL ELFPQCLCLA 
PTYELALQTG RVVEQMGKFC VDVQVMYAIR GNRIPRGTDI TKQIIIGTPG TVLDWCFKLK 
LIDLTKIRVF VLDEADVMID TQGFSDHSIR IQRALPSECQ MLLFSATFED SVWHFAERII 
PDPNVIKLRK EELTLNNIRQ YYVLCEHRKD KYQALCNIYG SITIGQAIIF CQTRRNAKWL 
TVEMIQDGHQ VSLLSGELTV EQRASIIQRF RDGKEKVLIT TNVCARGIDV KQVTIVVNFD 
LPVKQGEEPD YETYLHRIGR TGRFGKKGLA FNMIEVDELP SLMKIQDHFN SSIKQLNAED 
MDEIEKIDY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.