Details for: GRM6

Gene ID: 2916

Symbol: GRM6

Ensembl ID: ENSG00000113262

Description: glutamate metabotropic receptor 6

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 2.98
    Marker Score: 1556
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.18
    Marker Score: 2189
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.62
    Marker Score: 1177
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.47
    Marker Score: 1469
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.42
    Marker Score: 1066
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 862
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.18
    Marker Score: 491
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4825
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71838
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48062
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1
    Marker Score: 513
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.99
    Marker Score: 466
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 378
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5355
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.92
    Marker Score: 422
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 329
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 712
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 401
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 467
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.6
    Marker Score: 477
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 175
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.45
    Marker Score: 2980
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.42
    Marker Score: 801
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.42
    Marker Score: 1230
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.29
    Marker Score: 588
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.25
    Marker Score: 3944
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.22
    Marker Score: 132
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.21
    Marker Score: 90
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.21
    Marker Score: 61
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.19
    Marker Score: 1648
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.17
    Marker Score: 79
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.16
    Marker Score: 327
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.15
    Marker Score: 78
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.13
    Marker Score: 79
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.13
    Marker Score: 372
  • Cell Name: bipolar neuron (CL0000103)
    Fold Change: 0.12
    Marker Score: 39
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.11
    Marker Score: 177
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.11
    Marker Score: 48
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.11
    Marker Score: 34
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.1
    Marker Score: 84
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.09
    Marker Score: 855
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.09
    Marker Score: 761
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.09
    Marker Score: 28
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.09
    Marker Score: 98
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.08
    Marker Score: 92
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.08
    Marker Score: 5042
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.08
    Marker Score: 26
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.08
    Marker Score: 317
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.08
    Marker Score: 21
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.08
    Marker Score: 52
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.07
    Marker Score: 65
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.07
    Marker Score: 672
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.07
    Marker Score: 425
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.07
    Marker Score: 41
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.07
    Marker Score: 28
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.07
    Marker Score: 64
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.07
    Marker Score: 30
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.06
    Marker Score: 23
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.06
    Marker Score: 47
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.06
    Marker Score: 43
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.06
    Marker Score: 24
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.06
    Marker Score: 605
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.06
    Marker Score: 172
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.06
    Marker Score: 13
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.06
    Marker Score: 3096
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.06
    Marker Score: 25.5
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.05
    Marker Score: 68
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.05
    Marker Score: 2009
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.05
    Marker Score: 208
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.05
    Marker Score: 93
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.05
    Marker Score: 13
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.05
    Marker Score: 84
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.05
    Marker Score: 13
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.05
    Marker Score: 21
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.05
    Marker Score: 13
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.05
    Marker Score: 60
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.05
    Marker Score: 89
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.05
    Marker Score: 24
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.05
    Marker Score: 12
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.05
    Marker Score: 13
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.05
    Marker Score: 59
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.05
    Marker Score: 10
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.05
    Marker Score: 12
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.04
    Marker Score: 73
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 0.04
    Marker Score: 12
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.04
    Marker Score: 2242
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.04
    Marker Score: 82

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Other Information

**Key characteristics:** * GRM6 is a transmembrane protein with a molecular weight of approximately 140 kDa. * It is a member of the glutamate receptor family, which is the largest family of G protein-coupled receptors. * GRM6 is expressed in a variety of cell types, including rod bipolar cells, blood vessel endothelial cells, colon goblet cells, enterocytes of the epithelium of the large intestine, photoreceptor cells, intestinal crypt stem cells of the small intestine, transit amplifying cells of the small intestine, enterocytes of the epithelium of the small intestine, and cerebral cortex GABAergic interneurons. **Pathways and functions:** * GRM6 is a key component of the adenylate cyclase-inhibiting g protein-coupled glutamate receptor signaling pathway, which is involved in synaptic transmission. * It is also involved in the detection of light stimulus involved in visual perception. * GRM6 is a ligand for G protein-coupled receptor 5 (GPCR5), which is a receptor for the neurotransmitter glutamate. * When GRM6 binds to glutamate, it activates GPCR5, which leads to the inhibition of adenylate cyclase. * This inhibition of adenylate cyclase prevents the production of cyclic GMP, which is a second messenger that is involved in synaptic transmission. * As a result of the inhibition of adenylate cyclase, the glutamate receptor is unable to activate the G protein, which leads to the inhibition of downstream signaling pathways. **Clinical significance:** * Mutations in GRM6 have been linked to several neurological disorders, including autism, schizophrenia, and epilepsy. * These mutations can disrupt the function of GRM6, leading to the overactivity of glutamate receptors and the development of these neurological disorders.

Genular Protein ID: 1818841443

Symbol: GRM6_HUMAN

Name: Metabotropic glutamate receptor 6

UniProtKB Accession Codes:

O15303

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 5 ChEMBL 1 DNASU 1 DisGeNET 1 DrugCentral 1 EMBL 2 Ensembl 3 GO 18 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRINTS 3 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9215706

Title: The whole nucleotide sequence and chromosomal localization of the gene for human metabotropic glutamate receptor subtype 6.

PubMed ID: 9215706

DOI: 10.1111/j.1460-9568.1997.tb01477.x

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 23452348

Title: Metabotropic glutamate receptor 6 signaling enhances TRPM1 calcium channel function and increases melanin content in human melanocytes.

PubMed ID: 23452348

DOI: 10.1111/pcmr.12083

PubMed ID: 15781871

Title: Night blindness and abnormal cone electroretinogram ON responses in patients with mutations in the GRM6 gene encoding mGluR6.

PubMed ID: 15781871

DOI: 10.1073/pnas.0501233102

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 17405131

Title: Night blindness-associated mutations in the ligand-binding, cysteine-rich, and intracellular domains of the metabotropic glutamate receptor 6 abolish protein trafficking.

PubMed ID: 17405131

DOI: 10.1002/humu.20499

PubMed ID: 23714322

Title: Genotype and phenotype of 101 Dutch patients with congenital stationary night blindness.

PubMed ID: 23714322

DOI: 10.1016/j.ophtha.2013.03.002

Sequence Information:

  • Length: 877
  • Mass: 95468
  • Checksum: 2AB27C5627B388C6
  • Sequence:
    • MARPRRAREP LLVALLPLAW LAQAGLARAA GSVRLAGGLT LGGLFPVHAR GAAGRACGQL 
KKEQGVHRLE AMLYALDRVN ADPELLPGVR LGARLLDTCS RDTYALEQAL SFVQALIRGR 
GDGDEVGVRC PGGVPPLRPA PPERVVAVVG ASASSVSIMV ANVLRLFAIP QISYASTAPE 
LSDSTRYDFF SRVVPPDSYQ AQAMVDIVRA LGWNYVSTLA SEGNYGESGV EAFVQISREA 
GGVCIAQSIK IPREPKPGEF SKVIRRLMET PNARGIIIFA NEDDIRRVLE AARQANLTGH 
FLWVGSDSWG AKTSPILSLE DVAVGAITIL PKRASIDGFD QYFMTRSLEN NRRNIWFAEF 
WEENFNCKLT SSGTQSDDST RKCTGEERIG RDSTYEQEGK VQFVIDAVYA IAHALHSMHQ 
ALCPGHTGLC PAMEPTDGRM LLQYIRAVRF NGSAGTPVMF NENGDAPGRY DIFQYQATNG 
SASSGGYQAV GQWAETLRLD VEALQWSGDP HEVPSSLCSL PCGPGERKKM VKGVPCCWHC 
EACDGYRFQV DEFTCEACPG DMRPTPNHTG CRPTPVVRLS WSSPWAAPPL LLAVLGIVAT 
TTVVATFVRY NNTPIVRASG RELSYVLLTG IFLIYAITFL MVAEPGAAVC AARRLFLGLG 
TTLSYSALLT KTNRIYRIFE QGKRSVTPPP FISPTSQLVI TFSLTSLQVV GMIAWLGARP 
PHSVIDYEEQ RTVDPEQARG VLKCDMSDLS LIGCLGYSLL LMVTCTVYAI KARGVPETFN 
EAKPIGFTMY TTCIIWLAFV PIFFGTAQSA EKIYIQTTTL TVSLSLSASV SLGMLYVPKT 
YVILFHPEQN VQKRKRSLKA TSTVAAPPKG EDAEAHK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.