Details for: GTF2E1

Gene ID: 2960

Symbol: GTF2E1

Ensembl ID: ENSG00000153767

Description: general transcription factor IIE subunit 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.13
    Marker Score: 1037
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71789
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48013
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30405
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2409
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 487
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 442
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.93
    Marker Score: 14629
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2727
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.89
    Marker Score: 5105
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.87
    Marker Score: 312
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5269
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 310
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1263
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.77
    Marker Score: 464
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.75
    Marker Score: 1531.5
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 378
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.72
    Marker Score: 548
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.72
    Marker Score: 653
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.71
    Marker Score: 284
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2858
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.66
    Marker Score: 213
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 169
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.64
    Marker Score: 1518
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.62
    Marker Score: 772
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.58
    Marker Score: 290
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.57
    Marker Score: 165
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.55
    Marker Score: 534
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 434
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.54
    Marker Score: 168
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.5
    Marker Score: 778
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.49
    Marker Score: 233
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.47
    Marker Score: 672
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.46
    Marker Score: 145
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.45
    Marker Score: 304
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.43
    Marker Score: 904
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.39
    Marker Score: 260
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.37
    Marker Score: 400
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.35
    Marker Score: 356
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.35
    Marker Score: 333
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.34
    Marker Score: 340
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.34
    Marker Score: 149
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.33
    Marker Score: 563
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.33
    Marker Score: 264
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.33
    Marker Score: 3366
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.32
    Marker Score: 673
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.32
    Marker Score: 84
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.31
    Marker Score: 213
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.31
    Marker Score: 98
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3
    Marker Score: 18560
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.3
    Marker Score: 205
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.3
    Marker Score: 702
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3
    Marker Score: 1170
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.3
    Marker Score: 103
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.3
    Marker Score: 473
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.29
    Marker Score: 310
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.29
    Marker Score: 76
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.29
    Marker Score: 119
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.27
    Marker Score: 106
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.27
    Marker Score: 201
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.27
    Marker Score: 1598
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.26
    Marker Score: 651
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.26
    Marker Score: 2222
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.26
    Marker Score: 271
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.25
    Marker Score: 106
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.25
    Marker Score: 689
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.25
    Marker Score: 62
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.25
    Marker Score: 49
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.25
    Marker Score: 280
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.25
    Marker Score: 850
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.25
    Marker Score: 113
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.24
    Marker Score: 8920
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.24
    Marker Score: 154.5
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.24
    Marker Score: 116
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.24
    Marker Score: 160
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 0.24
    Marker Score: 62
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.24
    Marker Score: 452
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.24
    Marker Score: 212
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.24
    Marker Score: 8171
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.24
    Marker Score: 5033
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.24
    Marker Score: 2236
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.23
    Marker Score: 53
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.23
    Marker Score: 220
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.23
    Marker Score: 70
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.23
    Marker Score: 58
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.23
    Marker Score: 47
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 0.23
    Marker Score: 59
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.23
    Marker Score: 113
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.23
    Marker Score: 58
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.23
    Marker Score: 2172
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.23
    Marker Score: 2320
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.23
    Marker Score: 154
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.23
    Marker Score: 420
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.23
    Marker Score: 100
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.23
    Marker Score: 157
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.23
    Marker Score: 5881
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.23
    Marker Score: 112
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.23
    Marker Score: 50
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.23
    Marker Score: 51
  • Cell Name: T follicular regulatory cell (CL0009113)
    Fold Change: 0.23
    Marker Score: 62

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Other Information

**Key characteristics:** * GTF2E1 is a highly conserved protein, with a sequence that is found in humans, mice, and rats. * It is a member of the GTF2 family of transcription factors, which are involved in a variety of cellular processes, including transcription, translation, and cell cycle regulation. * GTF2E1 is a key regulator of HIV-1 transcription and expression. * It is also involved in the regulation of other viral infections, such as hepatitis B virus (HBV) and adenovirus. **Pathways and functions:** * GTF2E1 is involved in a variety of cellular processes, including transcription, translation, and cell cycle regulation. * It is a key regulator of HIV-1 transcription and expression. * It is also involved in the regulation of other viral infections, such as HBV and adenovirus. * GTF2E1 is a critical regulator of the late phase of the HIV life cycle, when the virus establishes a latent infection. * It is also involved in the regulation of the early stages of viral infection, including the entry of the virus into host cells. **Clinical significance:** * Mutations in the GTF2E1 gene have been linked to a number of human diseases, including AIDS and viral infections. * GTF2E1 inhibitors are being investigated as potential treatments for HIV-1 and other viral infections. * Understanding the role of GTF2E1 in viral infection could lead to the development of new treatments for these diseases.

Genular Protein ID: 3864727217

Symbol: T2EA_HUMAN

Name: General transcription factor IIE subunit 1

UniProtKB Accession Codes:

P29083 Q16103

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisProt 1 EMBL 2 EMDB 28 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 42 PDBsum 35 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 9 RefSeq 3 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1956398

Title: Structure and functional properties of human general transcription factor IIE.

PubMed ID: 1956398

DOI: 10.1038/354369a0

PubMed ID: 1956403

Title: Structural motifs and potential sigma homologies in the large subunit of human general transcription factor TFIIE.

PubMed ID: 1956403

DOI: 10.1038/354398a0

PubMed ID: 7651391

Title: The Epstein-Barr virus nuclear protein 2 acidic domain forms a complex with a novel cellular coactivator that can interact with TFIIE.

PubMed ID: 7651391

DOI: 10.1128/mcb.15.9.4735

PubMed ID: 7667268

Title: Evolutionary conservation of human TATA-binding-polypeptide-associated factors TAFII31 and TAFII80 and interactions of TAFII80 with other TAFs and with general transcription factors.

PubMed ID: 7667268

DOI: 10.1073/pnas.92.18.8195

PubMed ID: 15843171

Title: Varicella-zoster virus IE63 protein represses the basal transcription machinery by disorganizing the pre-initiation complex.

PubMed ID: 15843171

DOI: 10.1515/bc.2005.031

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19106100

Title: MCAF1/AM is involved in Sp1-mediated maintenance of cancer-associated telomerase activity.

PubMed ID: 19106100

DOI: 10.1074/jbc.m807098200

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

Sequence Information:

  • Length: 439
  • Mass: 49452
  • Checksum: 9234FFE3F150340B
  • Sequence:
    • MADPDVLTEV PAALKRLAKY VIRGFYGIEH ALALDILIRN SCVKEEDMLE LLKFDRKQLR 
SVLNNLKGDK FIKCRMRVET AADGKTTRHN YYFINYRTLV NVVKYKLDHM RRRIETDERD 
STNRASFKCP VCSSTFTDLE ANQLFDPMTG TFRCTFCHTE VEEDESAMPK KDARTLLARF 
NEQIEPIYAL LRETEDVNLA YEILEPEPTE IPALKQSKDH AATTAGAASL AGGHHREAWA 
TKGPSYEDLY TQNVVINMDD QEDLHRASLE GKSAKERPIW LRESTVQGAY GSEDMKEGGI 
DMDAFQEREE GHAGPDDNEE VMRALLIHEK KTSSAMAGSV GAAAPVTAAN GSDSESETSE 
SDDDSPPRPA AVAVHKREED EEEDDEFEEV ADDPIVMVAG RPFSYSEVSQ RPELVAQMTP 
EEKEAYIAMG QRMFEDLFE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.