Details for: GTF2E1

Gene ID: 2960

Symbol: GTF2E1

Ensembl ID: ENSG00000153767

Description: general transcription factor IIE subunit 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 53.6018
    Cell Significance Index: -8.3400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 33.3539
    Cell Significance Index: -8.4600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 20.3761
    Cell Significance Index: -9.6200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 20.0612
    Cell Significance Index: -8.1500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 8.5573
    Cell Significance Index: -8.1700
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 8.0703
    Cell Significance Index: 48.3600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 7.2590
    Cell Significance Index: -8.9500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.9490
    Cell Significance Index: -7.9000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.3086
    Cell Significance Index: -9.1100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.2588
    Cell Significance Index: 239.5700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.8546
    Cell Significance Index: 22.9000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7120
    Cell Significance Index: 70.4300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5971
    Cell Significance Index: 539.1700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5667
    Cell Significance Index: 34.0200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5017
    Cell Significance Index: 54.5700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4038
    Cell Significance Index: 65.6700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4002
    Cell Significance Index: 5.4600
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.2814
    Cell Significance Index: 3.9500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2643
    Cell Significance Index: 18.2800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2504
    Cell Significance Index: 29.1800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2262
    Cell Significance Index: 44.8800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2050
    Cell Significance Index: 12.9200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1660
    Cell Significance Index: 33.3100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1472
    Cell Significance Index: 3.1900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1141
    Cell Significance Index: 62.3300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1127
    Cell Significance Index: 77.9300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1105
    Cell Significance Index: 5.7400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1052
    Cell Significance Index: 18.9600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0972
    Cell Significance Index: 2.8000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0928
    Cell Significance Index: 2.3200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0889
    Cell Significance Index: 3.0900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0877
    Cell Significance Index: 38.7600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0723
    Cell Significance Index: 8.8900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0711
    Cell Significance Index: 9.7700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0414
    Cell Significance Index: 1.9300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0411
    Cell Significance Index: 5.9800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0408
    Cell Significance Index: 14.6300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0320
    Cell Significance Index: 1.4500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0236
    Cell Significance Index: 1.6700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0225
    Cell Significance Index: 0.7900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0133
    Cell Significance Index: 1.7000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0047
    Cell Significance Index: 0.8000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0034
    Cell Significance Index: 0.0900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0004
    Cell Significance Index: -0.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0023
    Cell Significance Index: -4.2500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0039
    Cell Significance Index: -2.4800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0052
    Cell Significance Index: -9.5600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0061
    Cell Significance Index: -9.4200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0064
    Cell Significance Index: -8.7000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0066
    Cell Significance Index: -0.5100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0078
    Cell Significance Index: -5.7500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0090
    Cell Significance Index: -6.8500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0102
    Cell Significance Index: -7.5500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0140
    Cell Significance Index: -7.8900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0143
    Cell Significance Index: -6.5100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0147
    Cell Significance Index: -0.4000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0154
    Cell Significance Index: -0.6800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0164
    Cell Significance Index: -10.2200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0211
    Cell Significance Index: -0.5900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0217
    Cell Significance Index: -0.8200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0233
    Cell Significance Index: -0.1900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0234
    Cell Significance Index: -1.5100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0236
    Cell Significance Index: -6.7900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0239
    Cell Significance Index: -0.5100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0249
    Cell Significance Index: -1.4000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0285
    Cell Significance Index: -2.9100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0412
    Cell Significance Index: -5.3200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0415
    Cell Significance Index: -0.7000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0470
    Cell Significance Index: -2.2100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0502
    Cell Significance Index: -10.5800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0511
    Cell Significance Index: -3.8100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0513
    Cell Significance Index: -1.3500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0566
    Cell Significance Index: -2.9500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0574
    Cell Significance Index: -6.5800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0656
    Cell Significance Index: -4.4100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0766
    Cell Significance Index: -1.9700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0796
    Cell Significance Index: -4.1800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0853
    Cell Significance Index: -8.8800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0903
    Cell Significance Index: -5.5500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0939
    Cell Significance Index: -7.4400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0949
    Cell Significance Index: -3.0400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1100
    Cell Significance Index: -2.8100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1117
    Cell Significance Index: -6.8500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1187
    Cell Significance Index: -1.7000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1197
    Cell Significance Index: -3.5200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1299
    Cell Significance Index: -6.5600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1333
    Cell Significance Index: -2.7900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1338
    Cell Significance Index: -3.5800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1418
    Cell Significance Index: -1.6900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1471
    Cell Significance Index: -3.2200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1840
    Cell Significance Index: -5.2500
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1883
    Cell Significance Index: -2.8600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2018
    Cell Significance Index: -7.0700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2118
    Cell Significance Index: -3.6300
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.2141
    Cell Significance Index: -2.9700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2189
    Cell Significance Index: -4.6800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2198
    Cell Significance Index: -7.0000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2245
    Cell Significance Index: -7.3500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2294
    Cell Significance Index: -8.4200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2317
    Cell Significance Index: -1.4000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** GTF2E1 is widely expressed in human tissues, with notable expression in the choroid plexus epithelial cell, cerebral cortex GABAergic interneuron, forebrain radial glial cell, absorptive cell, intestinal crypt stem cell of colon, tuft cell of colon, BEST4+ intestinal epithelial cell, cardiac muscle myoblast, and human cells in general. 2. **Protein Structure:** The GTF2E1 protein is a subunit of the TFIIIE complex, consisting of three subunits (TFIID, TFIIE, and TFIIF). The GTF2E1 subunit is essential for the recognition and binding of RNA polymerase II to the promoter region. 3. **Function:** GTF2E1 plays a critical role in the initiation and elongation phases of transcription, facilitating the recruitment of RNA polymerase II to the promoter region and the assembly of the transcription pre-initiation complex. **Pathways and Functions:** 1. **Transcriptional Regulation:** GTF2E1 is involved in the regulation of gene expression through the recruitment of RNA polymerase II to the promoter region and the assembly of the transcription pre-initiation complex. 2. **HIV Transcription and Replication:** GTF2E1 is essential for the initiation and elongation phases of HIV transcription, facilitating the recruitment of RNA polymerase II to the HIV promoter region and the assembly of the HIV transcription pre-initiation complex. 3. **Gene Expression in Immune Cells:** GTF2E1 is expressed in immune cells, such as GABAergic interneurons and cardiac muscle myoblasts, and plays a role in the regulation of gene expression in these cells. 4. **Metal Ion Binding:** GTF2E1 has been shown to bind metal ions, such as zinc and magnesium, which are essential for the proper functioning of RNA polymerase II. **Clinical Significance:** 1. **HIV Infection:** GTF2E1 is essential for the replication of HIV, and alterations in its expression or function may contribute to the pathogenesis of HIV infection. 2. **Neurological Disorders:** GTF2E1 is expressed in the brain and plays a role in the regulation of gene expression in neural cells. Alterations in its expression or function may contribute to the development of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Cancer:** GTF2E1 is expressed in various types of cancer, including colorectal cancer and breast cancer. Alterations in its expression or function may contribute to the development and progression of cancer. 4. **Immunological Disorders:** GTF2E1 is expressed in immune cells and plays a role in the regulation of gene expression in these cells. Alterations in its expression or function may contribute to the development of immunological disorders, such as autoimmune diseases and immunodeficiency disorders. In conclusion, GTF2E1 is a crucial component of the transcription factor TFIIIE complex, playing a pivotal role in the regulation of gene expression in various cell types, including those of the immune system, nervous system, and epithelial tissues. Its clinical significance extends to the pathogenesis of HIV infection, neurological disorders, cancer, and immunological disorders. Further research is necessary to fully elucidate the functional significance of GTF2E1 and its role in human disease.

Genular Protein ID: 3864727217

Symbol: T2EA_HUMAN

Name: General transcription factor IIE subunit 1

UniProtKB Accession Codes:

P29083 Q16103

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEBI 4 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 2 EMDB 41 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 10 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 48 PDBsum 48 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 9 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1956398

Title: Structure and functional properties of human general transcription factor IIE.

PubMed ID: 1956398

DOI: 10.1038/354369a0

PubMed ID: 1956403

Title: Structural motifs and potential sigma homologies in the large subunit of human general transcription factor TFIIE.

PubMed ID: 1956403

DOI: 10.1038/354398a0

PubMed ID: 7651391

Title: The Epstein-Barr virus nuclear protein 2 acidic domain forms a complex with a novel cellular coactivator that can interact with TFIIE.

PubMed ID: 7651391

DOI: 10.1128/mcb.15.9.4735

PubMed ID: 7667268

Title: Evolutionary conservation of human TATA-binding-polypeptide-associated factors TAFII31 and TAFII80 and interactions of TAFII80 with other TAFs and with general transcription factors.

PubMed ID: 7667268

DOI: 10.1073/pnas.92.18.8195

PubMed ID: 15843171

Title: Varicella-zoster virus IE63 protein represses the basal transcription machinery by disorganizing the pre-initiation complex.

PubMed ID: 15843171

DOI: 10.1515/bc.2005.031

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19106100

Title: MCAF1/AM is involved in Sp1-mediated maintenance of cancer-associated telomerase activity.

PubMed ID: 19106100

DOI: 10.1074/jbc.m807098200

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 27193682

Title: Near-atomic resolution visualization of human transcription promoter opening.

PubMed ID: 27193682

DOI: 10.1038/nature17970

Sequence Information:

  • Length: 439
  • Mass: 49452
  • Checksum: 9234FFE3F150340B
  • Sequence:
    • MADPDVLTEV PAALKRLAKY VIRGFYGIEH ALALDILIRN SCVKEEDMLE LLKFDRKQLR 
SVLNNLKGDK FIKCRMRVET AADGKTTRHN YYFINYRTLV NVVKYKLDHM RRRIETDERD 
STNRASFKCP VCSSTFTDLE ANQLFDPMTG TFRCTFCHTE VEEDESAMPK KDARTLLARF 
NEQIEPIYAL LRETEDVNLA YEILEPEPTE IPALKQSKDH AATTAGAASL AGGHHREAWA 
TKGPSYEDLY TQNVVINMDD QEDLHRASLE GKSAKERPIW LRESTVQGAY GSEDMKEGGI 
DMDAFQEREE GHAGPDDNEE VMRALLIHEK KTSSAMAGSV GAAAPVTAAN GSDSESETSE 
SDDDSPPRPA AVAVHKREED EEEDDEFEEV ADDPIVMVAG RPFSYSEVSQ RPELVAQMTP 
EEKEAYIAMG QRMFEDLFE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.