Details for: REPIN1

Gene ID: 29803

Symbol: REPIN1

Ensembl ID: ENSG00000214022

Description: replication initiator 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 143.4310
    Cell Significance Index: -22.3100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 79.9351
    Cell Significance Index: -20.2800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 58.1417
    Cell Significance Index: -27.4500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 55.5559
    Cell Significance Index: -22.5700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 40.9077
    Cell Significance Index: -27.4500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 23.6818
    Cell Significance Index: -22.6100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 19.6439
    Cell Significance Index: -24.2200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.6175
    Cell Significance Index: -23.0900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.8502
    Cell Significance Index: -21.0400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.2911
    Cell Significance Index: -24.8300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.5865
    Cell Significance Index: 155.2800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.6205
    Cell Significance Index: 263.5500
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.6100
    Cell Significance Index: 25.8300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0299
    Cell Significance Index: 53.5000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.0277
    Cell Significance Index: 46.5800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.0213
    Cell Significance Index: 35.4900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.7402
    Cell Significance Index: 46.6500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.6865
    Cell Significance Index: 18.6900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6815
    Cell Significance Index: 372.2100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6541
    Cell Significance Index: 18.8500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6467
    Cell Significance Index: 14.0100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6393
    Cell Significance Index: 115.2500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.6081
    Cell Significance Index: 15.9900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.5536
    Cell Significance Index: 14.8400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5478
    Cell Significance Index: 25.5400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5364
    Cell Significance Index: 34.6100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.5099
    Cell Significance Index: 26.7700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4405
    Cell Significance Index: 6.0100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4382
    Cell Significance Index: 53.8800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4118
    Cell Significance Index: 56.5500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4107
    Cell Significance Index: 284.0400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.3969
    Cell Significance Index: 20.6800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.3828
    Cell Significance Index: 12.2600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3678
    Cell Significance Index: 62.8100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3510
    Cell Significance Index: 66.7900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3470
    Cell Significance Index: 69.6000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3003
    Cell Significance Index: 22.3800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2998
    Cell Significance Index: 14.0900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.2787
    Cell Significance Index: 2.2300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2775
    Cell Significance Index: 32.7200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2730
    Cell Significance Index: 5.8200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2680
    Cell Significance Index: 34.3600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.2632
    Cell Significance Index: 2.9900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2481
    Cell Significance Index: 2.2900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2175
    Cell Significance Index: 28.1100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1859
    Cell Significance Index: 82.1700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1683
    Cell Significance Index: 16.6500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1633
    Cell Significance Index: 58.5800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1534
    Cell Significance Index: 5.3900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1429
    Cell Significance Index: 10.1100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0092
    Cell Significance Index: 6.7200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: -0.0010
    Cell Significance Index: -0.8800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0018
    Cell Significance Index: -1.3900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0071
    Cell Significance Index: -5.2900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0074
    Cell Significance Index: -0.1900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0120
    Cell Significance Index: -7.4800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0132
    Cell Significance Index: -24.7800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0176
    Cell Significance Index: -0.3000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0177
    Cell Significance Index: -32.7300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0213
    Cell Significance Index: -32.8000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0241
    Cell Significance Index: -32.7300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0304
    Cell Significance Index: -17.1600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0365
    Cell Significance Index: -7.6900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0386
    Cell Significance Index: -3.9400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0434
    Cell Significance Index: -3.3300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0495
    Cell Significance Index: -2.5000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0525
    Cell Significance Index: -6.0200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0668
    Cell Significance Index: -19.2100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0710
    Cell Significance Index: -32.2200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1030
    Cell Significance Index: -4.2200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1051
    Cell Significance Index: -5.9000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1239
    Cell Significance Index: -14.4400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1458
    Cell Significance Index: -28.9300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1756
    Cell Significance Index: -4.3900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1951
    Cell Significance Index: -11.9900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2084
    Cell Significance Index: -30.2900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2237
    Cell Significance Index: -17.7200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2294
    Cell Significance Index: -26.1900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2497
    Cell Significance Index: -6.6800
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: -0.2607
    Cell Significance Index: -2.8300
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.2982
    Cell Significance Index: -1.8400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3154
    Cell Significance Index: -3.7600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3155
    Cell Significance Index: -7.2900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3259
    Cell Significance Index: -9.6000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3862
    Cell Significance Index: -23.6800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4357
    Cell Significance Index: -12.4900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4778
    Cell Significance Index: -9.9100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5329
    Cell Significance Index: -18.6700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5438
    Cell Significance Index: -17.3200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5696
    Cell Significance Index: -18.6500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.5700
    Cell Significance Index: -8.5900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5712
    Cell Significance Index: -20.9700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.5783
    Cell Significance Index: -12.5000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.5891
    Cell Significance Index: -12.3300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6039
    Cell Significance Index: -26.7100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.6144
    Cell Significance Index: -6.3600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6252
    Cell Significance Index: -13.2700
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.6401
    Cell Significance Index: -4.9300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.6609
    Cell Significance Index: -12.2200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.6726
    Cell Significance Index: -17.9600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** REP1 is a small, non-coding gene that belongs to the replication initiator 1 family. Its protein product, REPI1, is a DNA-binding protein that interacts with chromatin and other proteins to regulate DNA replication. REP1 exhibits high expression levels in rapidly proliferating cells, such as stem cells and neural crest cells, suggesting its role in cell proliferation and differentiation. The gene's expression profile is also noted in various epithelial cells, including bladder urothelial cells and intestinal crypt stem cells, indicating its involvement in tissue development and homeostasis. **Pathways and Functions:** REP1 is involved in several key cellular pathways, including: 1. **Chromatin Insulator Sequence Binding**: REP1 interacts with chromatin insulators to regulate the recruitment of replication machinery and maintain genome stability. 2. **DNA Replication**: REP1 plays a crucial role in the recognition and binding of nuclear origins of replication, facilitating the unwinding of DNA double helices and the initiation of replication. 3. **Metal Ion Binding**: REP1 binds to metal ions, such as zinc and copper, which are essential for the function of various DNA-binding proteins. 4. **Regulation of Transcription by RNA Polymerase II**: REP1 interacts with RNA polymerase II to regulate transcriptional activity and maintain genome stability. 5. **RNA Binding**: REP1 binds to RNA, influencing the regulation of gene expression and the stability of RNA molecules. **Clinical Significance:** Dysregulation of REP1 expression and function has been implicated in various diseases, including: 1. **Cancer**: REP1 expression is often downregulated in cancer cells, leading to impaired DNA replication and cell proliferation. 2. **Neurodegenerative Disorders**: REP1 mutations have been linked to neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, which are characterized by impaired DNA replication and cell proliferation. 3. **Immune System Disorders**: REP1 plays a role in the regulation of immune cell proliferation and differentiation, and its dysregulation may contribute to immune system disorders, such as autoimmune diseases. In conclusion, REP1 is a crucial gene involved in DNA replication, cell proliferation, and transcriptional regulation. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the function and regulation of this gene.

Genular Protein ID: 341978056

Symbol: REPI1_HUMAN

Name: 60 kDa origin-specific DNA-binding protein

UniProtKB Accession Codes:

Q9BWE0 C9J3L7 D3DWZ1 Q7LE03 Q9BUZ6 Q9NZH2 Q9UMP5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 4 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 13 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10606657

Title: The dhfr oribeta-binding protein RIP60 contains 15 zinc fingers: DNA binding and looping by the central three fingers and an associated proline-rich region.

PubMed ID: 10606657

DOI: 10.1093/nar/28.2.570

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2174103

Title: Purification of RIP60 and RIP100, mammalian proteins with origin-specific DNA-binding and ATP-dependent DNA helicase activities.

PubMed ID: 2174103

DOI: 10.1128/mcb.10.12.6225-6235.1990

PubMed ID: 2247056

Title: RIP60, a mammalian origin-binding protein, enhances DNA bending near the dihydrofolate reductase origin of replication.

PubMed ID: 2247056

DOI: 10.1128/mcb.10.12.6236-6243.1990

PubMed ID: 8355269

Title: RIP60 dimers and multiples of dimers assemble link structures at an origin of bidirectional replication in the dihydrofolate reductase amplicon of Chinese hamster ovary cells.

PubMed ID: 8355269

DOI: 10.1006/jmbi.1993.1430

PubMed ID: 11328883

Title: Condensation by DNA looping facilitates transfer of large DNA molecules into mammalian cells.

PubMed ID: 11328883

DOI: 10.1093/nar/29.9.1982

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20727851

Title: Repin1 maybe involved in the regulation of cell size and glucose transport in adipocytes.

PubMed ID: 20727851

DOI: 10.1016/j.bbrc.2010.08.049

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 37749079

Title: REPIN1 regulates iron metabolism and osteoblast apoptosis in osteoporosis.

PubMed ID: 37749079

DOI: 10.1038/s41419-023-06160-w

PubMed ID: 29915365

Title: Metabolic effects of genetic variation in the human REPIN1 gene.

PubMed ID: 29915365

DOI: 10.1038/s41366-018-0123-0

Sequence Information:

  • Length: 567
  • Mass: 63575
  • Checksum: 00D43EC28E176237
  • Sequence:
    • MLERRCRGPL AMGLAQPRLL SGPSQESPQT LGKESRGLRQ QGTSVAQSGA QAPGRAHRCA 
HCRRHFPGWV ALWLHTRRCQ ARLPLPCPEC GRRFRHAPFL ALHRQVHAAA TPDLGFACHL 
CGQSFRGWVA LVLHLRAHSA AKRPIACPKC ERRFWRRKQL RAHLRRCHPP APEARPFICG 
NCGRSFAQWD QLVAHKRVHV AEALEEAAAK ALGPRPRGRP AVTAPRPGGD AVDRPFQCAC 
CGKRFRHKPN LIAHRRVHTG ERPHQCPECG KRFTNKPYLT SHRRIHTGEK PYPCKECGRR 
FRHKPNLLSH SKIHKRSEGS AQAAPGPGSP QLPAGPQESA AEPTPAVPLK PAQEPPPGAP 
PEHPQDPIEA PPSLYSCDDC GRSFRLERFL RAHQRQHTGE RPFTCAECGK NFGKKTHLVA 
HSRVHSGERP FACEECGRRF SQGSHLAAHR RDHAPDRPFV CPDCGKAFRH KPYLAAHRRI 
HTGEKPYVCP DCGKAFSQKS NLVSHRRIHT GERPYACPDC DRSFSQKSNL ITHRKSHIRD 
GAFCCAICGQ TFDDEERLLA HQKKHDV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.