Details for: ICOS

Gene ID: 29851

Symbol: ICOS

Ensembl ID: ENSG00000163600

Description: inducible T cell costimulator

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 23.6057
    Cell Significance Index: -9.5900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.3522
    Cell Significance Index: -8.9800
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.5900
    Cell Significance Index: 25.9700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 2.5359
    Cell Significance Index: 39.2400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.0321
    Cell Significance Index: 59.6800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 1.6930
    Cell Significance Index: -5.2000
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.5469
    Cell Significance Index: 5.6700
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.0477
    Cell Significance Index: 0.2600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0092
    Cell Significance Index: 0.2500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0040
    Cell Significance Index: -7.6200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0057
    Cell Significance Index: -10.4900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0067
    Cell Significance Index: -10.3400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0077
    Cell Significance Index: -10.4900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0086
    Cell Significance Index: -6.5300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0129
    Cell Significance Index: -9.4800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0131
    Cell Significance Index: -7.3600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0140
    Cell Significance Index: -7.6600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0148
    Cell Significance Index: -9.3700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0179
    Cell Significance Index: -0.9100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0198
    Cell Significance Index: -7.1100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0203
    Cell Significance Index: -9.2100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0233
    Cell Significance Index: -1.0200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0341
    Cell Significance Index: -4.3700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0379
    Cell Significance Index: -7.6000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0404
    Cell Significance Index: -4.7600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0405
    Cell Significance Index: -1.6600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0429
    Cell Significance Index: -7.3200
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0438
    Cell Significance Index: -0.4100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0499
    Cell Significance Index: -9.0000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0554
    Cell Significance Index: -1.4200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0569
    Cell Significance Index: -7.8200
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0574
    Cell Significance Index: -0.8400
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0589
    Cell Significance Index: -1.0000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0636
    Cell Significance Index: -9.2500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0640
    Cell Significance Index: -7.3300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0722
    Cell Significance Index: -8.8800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0739
    Cell Significance Index: -7.6900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0778
    Cell Significance Index: -10.0500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0792
    Cell Significance Index: -3.7200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0870
    Cell Significance Index: -8.8900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1008
    Cell Significance Index: -1.7400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1143
    Cell Significance Index: -7.6900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1224
    Cell Significance Index: -3.4200
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.1257
    Cell Significance Index: -1.7100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1290
    Cell Significance Index: -9.9000
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1309
    Cell Significance Index: -1.5500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1340
    Cell Significance Index: -9.9900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1401
    Cell Significance Index: -3.6000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1497
    Cell Significance Index: -9.1800
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.1561
    Cell Significance Index: -1.3300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1592
    Cell Significance Index: -10.2700
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1633
    Cell Significance Index: -1.5700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1638
    Cell Significance Index: -10.0700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1839
    Cell Significance Index: -9.5800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1848
    Cell Significance Index: -10.3700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1890
    Cell Significance Index: -9.8200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2147
    Cell Significance Index: -5.2000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2162
    Cell Significance Index: -10.0800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2207
    Cell Significance Index: -7.7300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2331
    Cell Significance Index: -10.3100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2367
    Cell Significance Index: -7.7500
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.2427
    Cell Significance Index: -4.1700
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.2432
    Cell Significance Index: -1.7500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2437
    Cell Significance Index: -7.7600
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.2470
    Cell Significance Index: -2.1600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2523
    Cell Significance Index: -9.2600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2608
    Cell Significance Index: -5.4600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2705
    Cell Significance Index: -7.7200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2707
    Cell Significance Index: -10.2500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2779
    Cell Significance Index: -3.9800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2799
    Cell Significance Index: -7.5000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2895
    Cell Significance Index: -7.7300
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.3088
    Cell Significance Index: -3.1200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3089
    Cell Significance Index: -7.7100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.3228
    Cell Significance Index: -8.0500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.3281
    Cell Significance Index: -8.3600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.3285
    Cell Significance Index: -4.7700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.3325
    Cell Significance Index: -10.5200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3337
    Cell Significance Index: -9.8300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3391
    Cell Significance Index: -9.2300
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.3460
    Cell Significance Index: -6.9000
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.3469
    Cell Significance Index: -4.1000
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.3492
    Cell Significance Index: -4.0500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3501
    Cell Significance Index: -10.0400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3589
    Cell Significance Index: -7.7600
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.3601
    Cell Significance Index: -3.5100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.3691
    Cell Significance Index: -9.2200
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.3701
    Cell Significance Index: -4.7400
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.3744
    Cell Significance Index: -3.9700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.3771
    Cell Significance Index: -7.8700
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.3836
    Cell Significance Index: -7.5500
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.3846
    Cell Significance Index: -4.8600
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.3853
    Cell Significance Index: -7.8400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3875
    Cell Significance Index: -7.7800
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.3887
    Cell Significance Index: -3.6900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.3935
    Cell Significance Index: -9.6000
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.3940
    Cell Significance Index: -3.4000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3977
    Cell Significance Index: -8.4400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4004
    Cell Significance Index: -9.2500
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.4128
    Cell Significance Index: -3.7500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Inducible expression:** ICOS is expressed on the surface of activated T cells, indicating its role in T cell activation and regulation. 2. **Cell surface protein:** ICOS is a transmembrane protein that interacts with other molecules to regulate T cell signaling. 3. **Costimulatory function:** ICOS provides a second signal necessary for T cell activation, in addition to the primary signal provided by the T cell receptor (TCR). 4. **Cross-talk with other signaling pathways:** ICOS interacts with various signaling pathways, including the PI3K/AKT and MAPK/ERK pathways, to regulate T cell activation and proliferation. **Pathways and Functions:** 1. **Adaptive immune system:** ICOS is essential for the proper functioning of the adaptive immune system, which involves the coordinated activation of T cells and B cells. 2. **Cell-cell adhesion:** ICOS interacts with CD28, a co-stimulatory molecule, to regulate T cell adhesion and migration. 3. **Constitutive signaling by aberrant PI3K in cancer:** ICOS has been implicated in the regulation of PI3K/AKT signaling in cancer cells, contributing to tumorigenesis and metastasis. 4. **Negative regulation of the PI3K/AKT network:** ICOS acts as a negative regulator of the PI3K/AKT pathway, preventing excessive T cell activation and proliferation. 5. **Immune response regulation:** ICOS plays a crucial role in regulating the intensity and duration of immune responses, preventing autoimmune damage and tissue damage. **Clinical Significance:** 1. **Autoimmune diseases:** Dysregulation of ICOS has been implicated in various autoimmune diseases, including rheumatoid arthritis, lupus, and multiple sclerosis. 2. **Inflammatory diseases:** ICOS has been linked to inflammatory diseases, such as atherosclerosis and inflammatory bowel disease. 3. **Cancer:** ICOS has been shown to contribute to tumorigenesis and metastasis in various cancers, including lung, breast, and colon cancer. 4. **Immunotherapy:** Targeting ICOS may provide a novel therapeutic strategy for the treatment of autoimmune and inflammatory diseases. In conclusion, ICOS is a critical regulator of T cell activation and immune response, playing a key role in maintaining immune homeostasis. Dysregulation of ICOS has been implicated in various autoimmune and inflammatory diseases, highlighting its importance in understanding the pathogenesis of these conditions. Further research is needed to fully elucidate the mechanisms of ICOS and its role in human disease.

Genular Protein ID: 1270874966

Symbol: ICOS_HUMAN

Name: Inducible T-cell costimulator

UniProtKB Accession Codes:

Q9Y6W8 Q8N6W8

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 2 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 5 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9930702

Title: ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28.

PubMed ID: 9930702

DOI: 10.1038/16717

PubMed ID: 11006126

Title: Identification and characterization of rat AILIM/ICOS, a novel T-cell costimulatory molecule, related to the CD28/CTLA4 family.

PubMed ID: 11006126

DOI: 10.1006/bbrc.2000.3466

PubMed ID: 10779774

Title: Characterization of human inducible costimulator ligand expression and function.

PubMed ID: 10779774

DOI: 10.4049/jimmunol.164.9.4689

PubMed ID: 11735222

Title: Assembly and annotation of human chromosome 2q33 sequence containing the CD28, CTLA4, and ICOS gene cluster: analysis by computational, comparative, and microarray approaches.

PubMed ID: 11735222

DOI: 10.1006/geno.2001.6655

PubMed ID: 12753665

Title: Allelic variation of the inducible costimulator (ICOS) gene: detection of polymorphisms, analysis of the promoter region, and extended haplotype estimation.

PubMed ID: 12753665

DOI: 10.1034/j.1399-0039.2003.00019.x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11169414

Title: Induction, binding specificity and function of human ICOS.

PubMed ID: 11169414

DOI: 10.1002/1521-4141(200012)30:12<3707::aid-immu3707>3.0.co;2-q

PubMed ID: 12577056

Title: Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency.

PubMed ID: 12577056

DOI: 10.1038/ni902

Sequence Information:

  • Length: 199
  • Mass: 22625
  • Checksum: 214EC741C9BDC9FC
  • Sequence:
    • MKSGLWYFFL FCLRIKVLTG EINGSANYEM FIFHNGGVQI LCKYPDIVQQ FKMQLLKGGQ 
ILCDLTKTKG SGNTVSIKSL KFCHSQLSNN SVSFFLYNLD HSHANYYFCN LSIFDPPPFK 
VTLTGGYLHI YESQLCCQLK FWLPIGCAAF VVVCILGCIL ICWLTKKKYS SSVHDPNGEY 
MFMRAVNTAK KSRLTDVTL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.