Details for: UBN1

Gene ID: 29855

Symbol: UBN1

Ensembl ID: ENSG00000118900

Description: ubinuclein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 209.0067
    Cell Significance Index: -32.5100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 134.6871
    Cell Significance Index: -34.1600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 82.5951
    Cell Significance Index: -39.0000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 79.4078
    Cell Significance Index: -32.2600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 70.5502
    Cell Significance Index: -36.2900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 58.0383
    Cell Significance Index: -38.9500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 34.1034
    Cell Significance Index: -32.5600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 29.3766
    Cell Significance Index: -36.2200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.9607
    Cell Significance Index: -34.7200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.4398
    Cell Significance Index: -37.2500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.6860
    Cell Significance Index: -19.0100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.6050
    Cell Significance Index: -26.4300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.4711
    Cell Significance Index: 170.8900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.3881
    Cell Significance Index: 106.5200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1976
    Cell Significance Index: 130.2700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9952
    Cell Significance Index: 197.5000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.9222
    Cell Significance Index: 59.5000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.9127
    Cell Significance Index: 10.8800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8211
    Cell Significance Index: 164.7100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8155
    Cell Significance Index: 132.6400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7039
    Cell Significance Index: 126.8900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6961
    Cell Significance Index: 85.5900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5496
    Cell Significance Index: 34.6400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4694
    Cell Significance Index: 10.1700
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.4642
    Cell Significance Index: 3.5100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4634
    Cell Significance Index: 63.6400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4596
    Cell Significance Index: 6.2700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4573
    Cell Significance Index: 25.6600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3965
    Cell Significance Index: 11.4300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3891
    Cell Significance Index: 212.5100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3531
    Cell Significance Index: 126.6500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2815
    Cell Significance Index: 124.4600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2657
    Cell Significance Index: 12.3900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2386
    Cell Significance Index: 12.4300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1920
    Cell Significance Index: 132.7900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1888
    Cell Significance Index: 18.6700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1589
    Cell Significance Index: 18.7400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1553
    Cell Significance Index: 7.0400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1352
    Cell Significance Index: 6.3500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1333
    Cell Significance Index: 3.5600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1225
    Cell Significance Index: 3.3400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0840
    Cell Significance Index: 5.9400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0781
    Cell Significance Index: 146.9700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0688
    Cell Significance Index: 11.7400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0572
    Cell Significance Index: 2.0100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0554
    Cell Significance Index: 10.5500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0444
    Cell Significance Index: 1.2400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0390
    Cell Significance Index: 5.0000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0386
    Cell Significance Index: 71.1200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0364
    Cell Significance Index: 0.7100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0323
    Cell Significance Index: 1.6800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0310
    Cell Significance Index: 47.6800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0220
    Cell Significance Index: 29.9400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0201
    Cell Significance Index: 12.7500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0185
    Cell Significance Index: 16.7100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0153
    Cell Significance Index: 0.4100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0036
    Cell Significance Index: 1.6500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0076
    Cell Significance Index: -5.6300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0109
    Cell Significance Index: -0.5700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0116
    Cell Significance Index: -8.4700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0116
    Cell Significance Index: -7.2700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0193
    Cell Significance Index: -0.6700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0319
    Cell Significance Index: -24.1200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0396
    Cell Significance Index: -5.1100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0415
    Cell Significance Index: -23.4000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0695
    Cell Significance Index: -4.2700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0891
    Cell Significance Index: -9.1000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0974
    Cell Significance Index: -20.5100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1045
    Cell Significance Index: -30.0600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1162
    Cell Significance Index: -2.4100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1235
    Cell Significance Index: -14.1000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1284
    Cell Significance Index: -18.6600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1387
    Cell Significance Index: -2.2300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1515
    Cell Significance Index: -10.1900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1592
    Cell Significance Index: -2.3500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1823
    Cell Significance Index: -21.2500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1938
    Cell Significance Index: -22.2000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2064
    Cell Significance Index: -15.3800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2148
    Cell Significance Index: -3.9700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2353
    Cell Significance Index: -3.5300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2373
    Cell Significance Index: -6.2400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2732
    Cell Significance Index: -28.4500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2817
    Cell Significance Index: -12.4600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3072
    Cell Significance Index: -9.8400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3437
    Cell Significance Index: -9.2000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3440
    Cell Significance Index: -8.6000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3551
    Cell Significance Index: -13.4500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3645
    Cell Significance Index: -9.3700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3765
    Cell Significance Index: -7.8800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3767
    Cell Significance Index: -6.3100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3833
    Cell Significance Index: -3.5300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3894
    Cell Significance Index: -30.8400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3924
    Cell Significance Index: -19.8300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3939
    Cell Significance Index: -11.2900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4394
    Cell Significance Index: -26.9400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4603
    Cell Significance Index: -4.7600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4777
    Cell Significance Index: -14.0300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5468
    Cell Significance Index: -13.9700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.5603
    Cell Significance Index: -8.5100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5724
    Cell Significance Index: -9.8100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** UBN1 is a gene that belongs to the family of nucleic acid-binding proteins. The protein product of UBN1, Ubinuclein-1, is a multifunctional protein that interacts with various DNA-binding proteins and nuclear bodies. UBN1 is characterized by its ability to bind to specific DNA sequences and regulate telomere length, as well as its involvement in the formation of SAHF, which is a hallmark of cellular senescence. The gene is also expressed in several cell types, including oogonial cells, primordial germ cells, and cardiac myocytes, suggesting a role in the regulation of cellular differentiation and survival. **Pathways and Functions** UBN1 is involved in several cellular pathways, including: 1. **DNA damage response**: UBN1 has been shown to interact with proteins involved in the repair of DNA damage, such as DNA-dependent protein kinase (DNA-PK) and ATM kinase. 2. **Cellular stress response**: UBN1 is involved in the regulation of cellular stress response pathways, including the mitogen-activated protein kinase (MAPK) pathway. 3. **Nuclear organization**: UBN1 is a component of nuclear bodies, which are structures involved in the regulation of gene expression and DNA repair. 4. **Telomere regulation**: UBN1 has been shown to regulate telomere length and maintain telomere stability. **Functions** The functions of UBN1 can be summarized as follows: 1. **Regulation of cellular senescence**: UBN1 is involved in the formation of SAHF, which is a hallmark of cellular senescence. 2. **Maintenance of telomere length**: UBN1 regulates telomere length and maintains telomere stability. 3. **Regulation of DNA damage response**: UBN1 interacts with proteins involved in the repair of DNA damage. 4. **Regulation of cellular stress response**: UBN1 is involved in the regulation of cellular stress response pathways. **Clinical Significance** The clinical significance of UBN1 is an area of ongoing research. However, alterations in UBN1 expression have been implicated in various diseases, including: 1. **Aging-related diseases**: UBN1 has been shown to be involved in the regulation of cellular aging and senescence. 2. **Cancer**: UBN1 has been implicated in the regulation of telomere length and DNA damage response in cancer cells. 3. **Cardiovascular disease**: UBN1 has been shown to be expressed in cardiac myocytes and may play a role in the regulation of cardiac function and disease. In conclusion, UBN1 is a multifunctional protein that plays a critical role in various cellular processes, including DNA damage response, cellular stress response, and nuclear organization. Further research is needed to fully understand the functions and clinical significance of UBN1.

Genular Protein ID: 376410084

Symbol: UBN1_HUMAN

Name: Ubinuclein-1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10725330

Title: Ubinuclein, a novel nuclear protein interacting with cellular and viral transcription factors.

PubMed ID: 10725330

DOI: 10.1083/jcb.148.6.1165

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 14718166

Title: Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis.

PubMed ID: 14718166

DOI: 10.1016/s0092-8674(03)01064-x

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18823282

Title: Characterization of the ubinuclein protein as a new member of the nuclear and adhesion complex components (NACos).

PubMed ID: 18823282

DOI: 10.1042/bc20080072

PubMed ID: 19029251

Title: Human UBN1 is an ortholog of yeast Hpc2p and has an essential role in the HIRA/ASF1a chromatin-remodeling pathway in senescent cells.

PubMed ID: 19029251

DOI: 10.1128/mcb.01047-08

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 1134
  • Mass: 121520
  • Checksum: 8DE68C63D4E8E01B
  • Sequence:
  • MSEPHRVQFT SLPGSLNPAF LKKSRKEEAG AGEQHQDCEP AAAAVRITLT LFEPDHKRCP 
    EFFYPELVKN IRGKVKGLQP GDKKKDLSDP FNDEEKERHK VEALARKFEE KYGGKKRRKD 
    RIQDLIDMGY GYDESDSFID NSEAYDELVP ASLTTKYGGF YINSGTLQFR QASESEDDFI 
    KEKKKKSPKK RKLKEGGEKI KKKKKDDTYD KEKKSKKSKF SKAGFTALNA SKEKKKKKYS 
    GALSVKEMLK KFQKEKEAQK KREEEHKPVA VPSAEAQGLR ELEGASDPLL SLFGSTSDND 
    LLQAATAMDS LTDLDLEHLL SESPEGSPFR DMDDGSDSLG VGLDQEFRQP SSLPEGLPAP 
    LEKRVKELAQ AARAAEGESR QKFFTQDING ILLDIEAQTR ELSSQVRSGV YAYLASFLPC 
    SKDALLKRAR KLHLYEQGGR LKEPLQKLKE AIGRAMPEQM AKYQDECQAH TQAKVAKMLE 
    EEKDKEQRDR ICSDEEEDEE KGGRRIMGPR KKFQWNDEIR ELLCQVVKIK LESQDLERNN 
    KAQAWEDCVK GFLDAEVKPL WPKGWMQART LFKESRRGHG HLTSILAKKK VMAPSKIKVK 
    ESSTKPDKKV SVPSGQIGGP IALPSDHQTG GLSIGASSRE LPSQASGGLA NPPPVNLEDS 
    LDEDLIRNPA SSVEAVSKEL AALNSRAAGN SEFTLPAPSK APAEKVGGVL CTEEKRNFAK 
    PSPSAPPPAS SLQSPLNFLA EQALALGQSS QEKKPESSGY KELSCQAPLN KGLPEVHQSK 
    AKHHSLPRTS HGPQVAVPVP GPQVKVFHAG TQQQKNFTPP SPFANKLQGP KASPTQCHRS 
    LLQLVKTAAK GQGFHPSAPA TSGGLSASSS SSHKTPASSS SALSHPAKPH SVSSAGSSYK 
    NNPFASSISK HGVSSGSSSS GGTPVQSSVS GSLVPGIQPP SVGQATSRPV PSSAGKKMPV 
    SQKLTLVAPP GGPNGDSSGG TQGVAKLLTS PSLKPSAVSS VTSSTSLSKG ASGTVLLAGS 
    SLMASPYKSS SPKLSGAMSS NSLGIITPVP IPVHVLSFSA DSSAKAGVSK DAIVTGPAPG 
    SFHHGLGHSL LAGLHSSPPH AAPLPHAAVP THIPQSLPGA SQLHGKGPAV PRKL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.