Details for: NPC1L1

Gene ID: 29881

Symbol: NPC1L1

Ensembl ID: ENSG00000015520

Description: NPC1 like intracellular cholesterol transporter 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 3.9194
    Cell Significance Index: 112.9300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.7173
    Cell Significance Index: 87.0300
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 2.5768
    Cell Significance Index: 19.5400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 2.4726
    Cell Significance Index: 61.6600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.5624
    Cell Significance Index: 297.3300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 1.2243
    Cell Significance Index: 15.4700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 1.2002
    Cell Significance Index: 42.1800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.1724
    Cell Significance Index: 25.4000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.9123
    Cell Significance Index: 18.9300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7609
    Cell Significance Index: 45.6800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7170
    Cell Significance Index: 142.2900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.6129
    Cell Significance Index: 10.1000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.6098
    Cell Significance Index: 9.1900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5747
    Cell Significance Index: 56.8500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5409
    Cell Significance Index: 58.8300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4558
    Cell Significance Index: 411.5700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4503
    Cell Significance Index: 9.5900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3672
    Cell Significance Index: 25.4000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3545
    Cell Significance Index: 57.6600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3152
    Cell Significance Index: 7.8800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.3063
    Cell Significance Index: 5.1600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.2788
    Cell Significance Index: 4.6900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0435
    Cell Significance Index: 0.4500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0377
    Cell Significance Index: 1.7100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0195
    Cell Significance Index: 2.2700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0169
    Cell Significance Index: 0.2500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0133
    Cell Significance Index: 1.7000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0107
    Cell Significance Index: 2.1500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0105
    Cell Significance Index: 7.2800
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0099
    Cell Significance Index: 0.1400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0016
    Cell Significance Index: 1.2000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0012
    Cell Significance Index: 0.4400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0012
    Cell Significance Index: -2.2400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0028
    Cell Significance Index: -5.1900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0034
    Cell Significance Index: -5.2000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0036
    Cell Significance Index: -4.9200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0039
    Cell Significance Index: -0.2400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0045
    Cell Significance Index: -2.5700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0051
    Cell Significance Index: -3.8300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0052
    Cell Significance Index: -3.3300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0055
    Cell Significance Index: -4.0500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0059
    Cell Significance Index: -3.2300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0061
    Cell Significance Index: -3.8200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0079
    Cell Significance Index: -2.2700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0091
    Cell Significance Index: -4.1500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0092
    Cell Significance Index: -1.6500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0126
    Cell Significance Index: -0.8500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0153
    Cell Significance Index: -1.7500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0155
    Cell Significance Index: -3.2800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0160
    Cell Significance Index: -1.9700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0166
    Cell Significance Index: -2.4200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0225
    Cell Significance Index: -3.8500
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0287
    Cell Significance Index: -0.3600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0295
    Cell Significance Index: -1.4900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0299
    Cell Significance Index: -4.1000
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -0.0307
    Cell Significance Index: -0.3100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0308
    Cell Significance Index: -3.9900
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -0.0327
    Cell Significance Index: -0.3500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0338
    Cell Significance Index: -3.4500
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0339
    Cell Significance Index: -0.2300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0342
    Cell Significance Index: -0.4900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0357
    Cell Significance Index: -1.0000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0363
    Cell Significance Index: -0.8800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0370
    Cell Significance Index: -3.8500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0400
    Cell Significance Index: -1.6400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0412
    Cell Significance Index: -1.9200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0473
    Cell Significance Index: -3.6300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0533
    Cell Significance Index: -3.9700
  • Cell Name: colonocyte (CL1000347)
    Fold Change: -0.0534
    Cell Significance Index: -0.3300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0541
    Cell Significance Index: -1.3900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0645
    Cell Significance Index: -0.8800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0648
    Cell Significance Index: -4.1800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0665
    Cell Significance Index: -2.9400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0671
    Cell Significance Index: -3.1600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0682
    Cell Significance Index: -4.1900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0685
    Cell Significance Index: -1.7100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0739
    Cell Significance Index: -2.1100
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0757
    Cell Significance Index: -0.5500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0808
    Cell Significance Index: -3.0600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0829
    Cell Significance Index: -4.6500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0847
    Cell Significance Index: -2.3100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0856
    Cell Significance Index: -3.0000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0870
    Cell Significance Index: -4.5200
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: -0.0876
    Cell Significance Index: -0.3300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0877
    Cell Significance Index: -2.3500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0879
    Cell Significance Index: -1.8400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0895
    Cell Significance Index: -2.8500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0913
    Cell Significance Index: -2.9900
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0991
    Cell Significance Index: -1.3700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1085
    Cell Significance Index: -1.8700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1094
    Cell Significance Index: -2.7300
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.1099
    Cell Significance Index: -1.4200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1135
    Cell Significance Index: -2.2200
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.1142
    Cell Significance Index: -1.3800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1144
    Cell Significance Index: -3.2800
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: -0.1173
    Cell Significance Index: -0.9500
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1201
    Cell Significance Index: -1.6700
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.1201
    Cell Significance Index: -1.2100
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: -0.1224
    Cell Significance Index: -0.7100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1244
    Cell Significance Index: -4.5700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** NPC1L1 is a transmembrane protein expressed in enterocytes of the colon, goblet cells, and other cells involved in cholesterol absorption. Its unique structure, consisting of 12 transmembrane domains, enables it to bind and transport cholesterol with high affinity. The protein's ability to form homodimers and interact with other proteins, such as myosin V, further enhances its cholesterol-binding capacity. Notably, NPC1L1 is highly expressed in cells involved in cholesterol absorption, highlighting its critical role in regulating cholesterol homeostasis. **Pathways and Functions:** NPC1L1 is embedded in the apical plasma membrane of enterocytes, where it plays a crucial role in facilitating the uptake of dietary cholesterol. The protein binds to cholesterol with high affinity, enabling its internalization and subsequent transport to the cytoplasmic vesicle membrane. This process is mediated by the interaction between NPC1L1 and other proteins, such as myosin V, which enhances the protein's cholesterol-binding capacity. In addition to its role in cholesterol absorption, NPC1L1 is also involved in other cellular processes, including: 1. Cholesterol biosynthetic process: NPC1L1 regulates the expression of genes involved in cholesterol biosynthesis, ensuring that cholesterol levels remain within a narrow range. 2. Cholesterol homeostasis: By regulating cholesterol uptake and biosynthesis, NPC1L1 maintains cholesterol homeostasis, preventing excessive levels that can lead to atherosclerosis and other cardiovascular diseases. 3. Lipid metabolism: NPC1L1 interacts with other proteins involved in lipid metabolism, influencing the transport and storage of lipids within the body. **Clinical Significance:** Dysregulation of NPC1L1 has been implicated in various diseases, including: 1. Sitosterolemia: A rare genetic disorder characterized by excessive cholesterol absorption, leading to hypercholesterolemia and cardiovascular disease. 2. Familial hypercholesterolemia: A genetic disorder caused by mutations in the LDLR gene, leading to impaired cholesterol uptake and increased risk of atherosclerosis. 3. Cancer: NPC1L1 has been shown to play a role in the development and progression of certain cancers, including colorectal cancer, where it contributes to cholesterol metabolism and tumor growth. In conclusion, NPC1L1 is a critical component of the intestinal absorption process, playing a pivotal role in maintaining cholesterol homeostasis within the body. Its dysregulation has been implicated in various diseases, highlighting the importance of NPC1L1 in regulating cholesterol metabolism and preventing disease. Further research is necessary to fully understand the complex interactions between NPC1L1 and other proteins involved in cholesterol homeostasis, as well as its clinical significance in various diseases.

Genular Protein ID: 2277716042

Symbol: NPCL1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9UHC9 A4D2J7 B7ZLE6 D3DVK9 Q17RV5 Q6R3Q4 Q9UHC8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 ChEBI 2 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EMBL 12 EMDB 6 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MIM 2 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 Rhea 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10783261

Title: Evidence for a Niemann-Pick C (NPC) gene family: identification and characterization of NPC1L1.

PubMed ID: 10783261

DOI: 10.1006/geno.2000.6151

PubMed ID: 14976318

Title: Niemann-Pick C1 like 1 protein is critical for intestinal cholesterol absorption.

PubMed ID: 14976318

DOI: 10.1126/science.1093131

PubMed ID: 19325169

Title: Membrane topology of human NPC1L1, a key protein in enterohepatic cholesterol absorption.

PubMed ID: 19325169

DOI: 10.1194/jlr.m800669-jlr200

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15671032

Title: Inactivation of NPC1L1 causes multiple lipid transport defects and protects against diet-induced hypercholesterolemia.

PubMed ID: 15671032

DOI: 10.1074/jbc.m409110200

PubMed ID: 15604518

Title: Reduced cholesterol absorption upon PPARdelta activation coincides with decreased intestinal expression of NPC1L1.

PubMed ID: 15604518

DOI: 10.1194/jlr.m400400-jlr200

PubMed ID: 15928087

Title: The target of ezetimibe is Niemann-Pick C1-like 1 (NPC1L1).

PubMed ID: 15928087

DOI: 10.1073/pnas.0500269102

PubMed ID: 19542231

Title: Requirement of myosin Vb.Rab11a.Rab11-FIP2 complex in cholesterol-regulated translocation of NPC1L1 to the cell surface.

PubMed ID: 19542231

DOI: 10.1074/jbc.m109.034355

PubMed ID: 22095670

Title: Novel function of Niemann-Pick C1-like 1 as a negative regulator of Niemann-Pick C2 protein.

PubMed ID: 22095670

DOI: 10.1002/hep.24772

PubMed ID: 21525977

Title: The structure of the NPC1L1 N-terminal domain in a closed conformation.

PubMed ID: 21525977

DOI: 10.1371/journal.pone.0018722

PubMed ID: 15679830

Title: Compound heterozygosity for two non-synonymous polymorphisms in NPC1L1 in a non-responder to ezetimibe.

PubMed ID: 15679830

DOI: 10.1111/j.1399-0004.2004.00388.x

PubMed ID: 25390462

Title: Inactivating mutations in NPC1L1 and protection from coronary heart disease.

PubMed ID: 25390462

DOI: 10.1056/nejmoa1405386

PubMed ID: 29880681

Title: A LIMA1 variant promotes low plasma LDL cholesterol and decreases intestinal cholesterol absorption.

PubMed ID: 29880681

DOI: 10.1126/science.aao6575

Sequence Information:

  • Length: 1359
  • Mass: 148728
  • Checksum: 594F698B48D66DE7
  • Sequence:
    • MAEAGLRGWL LWALLLRLAQ SEPYTTIHQP GYCAFYDECG KNPELSGSLM TLSNVSCLSN 
TPARKITGDH LILLQKICPR LYTGPNTQAC CSAKQLVSLE ASLSITKALL TRCPACSDNF 
VNLHCHNTCS PNQSLFINVT RVAQLGAGQL PAVVAYEAFY QHSFAEQSYD SCSRVRVPAA 
ATLAVGTMCG VYGSALCNAQ RWLNFQGDTG NGLAPLDITF HLLEPGQAVG SGIQPLNEGV 
ARCNESQGDD VATCSCQDCA ASCPAIARPQ ALDSTFYLGQ MPGSLVLIII LCSVFAVVTI 
LLVGFRVAPA RDKSKMVDPK KGTSLSDKLS FSTHTLLGQF FQGWGTWVAS WPLTILVLSV 
IPVVALAAGL VFTELTTDPV ELWSAPNSQA RSEKAFHDQH FGPFFRTNQV ILTAPNRSSY 
RYDSLLLGPK NFSGILDLDL LLELLELQER LRHLQVWSPE AQRNISLQDI CYAPLNPDNT 
SLYDCCINSL LQYFQNNRTL LLLTANQTLM GQTSQVDWKD HFLYCANAPL TFKDGTALAL 
SCMADYGAPV FPFLAIGGYK GKDYSEAEAL IMTFSLNNYP AGDPRLAQAK LWEEAFLEEM 
RAFQRRMAGM FQVTFMAERS LEDEINRTTA EDLPIFATSY IVIFLYISLA LGSYSSWSRV 
MVDSKATLGL GGVAVVLGAV MAAMGFFSYL GIRSSLVILQ VVPFLVLSVG ADNIFIFVLE 
YQRLPRRPGE PREVHIGRAL GRVAPSMLLC SLSEAICFFL GALTPMPAVR TFALTSGLAV 
ILDFLLQMSA FVALLSLDSK RQEASRLDVC CCVKPQELPP PGQGEGLLLG FFQKAYAPFL 
LHWITRGVVL LLFLALFGVS LYSMCHISVG LDQELALPKD SYLLDYFLFL NRYFEVGAPV 
YFVTTLGYNF SSEAGMNAIC SSAGCNNFSF TQKIQYATEF PEQSYLAIPA SSWVDDFIDW 
LTPSSCCRLY ISGPNKDKFC PSTVNSLNCL KNCMSITMGS VRPSVEQFHK YLPWFLNDRP 
NIKCPKGGLA AYSTSVNLTS DGQVLDTVAI LSPRLEYSGT ISAHCNLYLL DSTSRFMAYH 
KPLKNSQDYT EALRAARELA ANITADLRKV PGTDPAFEVF PYTITNVFYE QYLTILPEGL 
FMLSLCLVPT FAVSCLLLGL DLRSGLLNLL SIVMILVDTV GFMALWGISY NAVSLINLVS 
AVGMSVEFVS HITRSFAIST KPTWLERAKE ATISMGSAVF AGVAMTNLPG ILVLGLAKAQ 
LIQIFFFRLN LLITLLGLLH GLVFLPVILS YVGPDVNPAL ALEQKRAEEA VAAVMVASCP 
NHPSRVSTAD NIYVNHSFEG SIKGAGAISN FLPNNGRQF

Genular Protein ID: 1707510107

Symbol: A0A0C4DFX6_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0C4DFX6

Database IDs:

ARBA 10 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChEBI 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 8 Gene3D 1 GeneTree 1 HGNC 1 InterPro 6 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 2 Pfam 4 Proteomes 2 ProteomicsDB 1 RefSeq 1 Rhea 1 SAM 2 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 1332
  • Mass: 145764
  • Checksum: EFE94F80309C3BF2
  • Sequence:
    • MAEAGLRGWL LWALLLRLAQ SEPYTTIHQP GYCAFYDECG KNPELSGSLM TLSNVSCLSN 
TPARKITGDH LILLQKICPR LYTGPNTQAC CSAKQLVSLE ASLSITKALL TRCPACSDNF 
VNLHCHNTCS PNQSLFINVT RVAQLGAGQL PAVVAYEAFY QHSFAEQSYD SCSRVRVPAA 
ATLAVGTMCG VYGSALCNAQ RWLNFQGDTG NGLAPLDITF HLLEPGQAVG SGIQPLNEGV 
ARCNESQGDD VATCSCQDCA ASCPAIARPQ ALDSTFYLGQ MPGSLVLIII LCSVFAVVTI 
LLVGFRVAPA RDKSKMVDPK KGTSLSDKLS FSTHTLLGQF FQGWGTWVAS WPLTILVLSV 
IPVVALAAGL VFTELTTDPV ELWSAPNSQA RSEKAFHDQH FGPFFRTNQV ILTAPNRSSY 
RYDSLLLGPK NFSGILDLDL LLELLELQER LRHLQVWSPE AQRNISLQDI CYAPLNPDNT 
SLYDCCINSL LQYFQNNRTL LLLTANQTLM GQTSQVDWKD HFLYCANAPL TFKDGTALAL 
SCMADYGAPV FPFLAIGGYK GKDYSEAEAL IMTFSLNNYP AGDPRLAQAK LWEEAFLEEM 
RAFQRRMAGM FQVTFMAERS LEDEINRTTA EDLPIFATSY IVIFLYISLA LGSYSSWSRV 
MVDSKATLGL GGVAVVLGAV MAAMGFFSYL GIRSSLVILQ VVPFLVLSVG ADNIFIFVLE 
YQRLPRRPGE PREVHIGRAL GRVAPSMLLC SLSEAICFFL GALTPMPAVR TFALTSGLAV 
ILDFLLQMSA FVALLSLDSK RQEASRLDVC CCVKPQELPP PGQGEGLLLG FFQKAYAPFL 
LHWITRGVVL LLFLALFGVS LYSMCHISVG LDQELALPKD SYLLDYFLFL NRYFEVGAPV 
YFVTTLGYNF SSEAGMNAIC SSAGCNNFSF TQKIQYATEF PEQSYLAIPA SSWVDDFIDW 
LTPSSCCRLY ISGPNKDKFC PSTVNSLNCL KNCMSITMGS VRPSVEQFHK YLPWFLNDRP 
NIKCPKGGLA AYSTSVNLTS DGQVLASRFM AYHKPLKNSQ DYTEALRAAR ELAANITADL 
RKVPGTDPAF EVFPYTITNV FYEQYLTILP EGLFMLSLCL VPTFAVSCLL LGLDLRSGLL 
NLLSIVMILV DTVGFMALWG ISYNAVSLIN LVSAVGMSVE FVSHITRSFA ISTKPTWLER 
AKEATISMGS AVFAGVAMTN LPGILVLGLA KAQLIQIFFF RLNLLITLLG LLHGLVFLPV 
ILSYVGPDVN PALALEQKRA EEAVAAVMVA SCPNHPSRVS TADNIYVNHS FEGSIKGAGA 
ISNFLPNNGR QF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.