ANAPC2 | ENSG00000176248 | NCBI 29882

Details for: ANAPC2

Gene ID: 29882

Symbol: ANAPC2

Ensembl ID: ENSG00000176248

Description: anaphase promoting complex subunit 2

Associated with

Aberrant regulation of mitotic cell cycle due to rb1 defects
(R-HSA-9687139)
Aberrant regulation of mitotic exit in cancer due to rb1 defects
(R-HSA-9687136)
Activation of apc/c and apc/c:cdc20 mediated degradation of mitotic proteins
(R-HSA-176814)
Adaptive immune system
(R-HSA-1280218)
Antigen processing: ubiquitination & proteasome degradation
(R-HSA-983168)
Apc-cdc20 mediated degradation of nek2a
(R-HSA-179409)
Apc/c-mediated degradation of cell cycle proteins
(R-HSA-174143)
Apc/c:cdc20 mediated degradation of cyclin b
(R-HSA-174048)
Apc/c:cdc20 mediated degradation of mitotic proteins
(R-HSA-176409)
Apc/c:cdc20 mediated degradation of securin
(R-HSA-174154)
Apc/c:cdh1 mediated degradation of cdc20 and other apc/c:cdh1 targeted proteins in late mitosis/early g1
(R-HSA-174178)
Apc:cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
(R-HSA-179419)
Assembly of the pre-replicative complex
(R-HSA-68867)
Autodegradation of cdh1 by cdh1:apc/c
(R-HSA-174084)
Cdc20:phospho-apc/c mediated degradation of cyclin a
(R-HSA-174184)
Cdk-mediated phosphorylation and removal of cdc6
(R-HSA-69017)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Conversion from apc/c:cdc20 to apc/c:cdh1 in late anaphase
(R-HSA-176407)
Disease
(R-HSA-1643685)
Diseases of mitotic cell cycle
(R-HSA-9675126)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Immune system
(R-HSA-168256)
Inactivation of apc/c via direct inhibition of the apc/c complex
(R-HSA-141430)
Inhibition of the proteolytic activity of apc/c required for the onset of anaphase by mitotic spindle checkpoint components
(R-HSA-141405)
Mitotic anaphase
(R-HSA-68882)
Mitotic metaphase and anaphase
(R-HSA-2555396)
Mitotic spindle checkpoint
(R-HSA-69618)
M phase
(R-HSA-68886)
Phosphorylation of the apc/c
(R-HSA-176412)
Regulation of apc/c activators between g1/s and early anaphase
(R-HSA-176408)
Rna polymerase ii transcription
(R-HSA-73857)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Separation of sister chromatids
(R-HSA-2467813)
S phase
(R-HSA-69242)
Switching of origins to a post-replicative state
(R-HSA-69052)
Synthesis of dna
(R-HSA-69239)
Transcriptional regulation by ventx
(R-HSA-8853884)
Anaphase-promoting complex
(GO:0005680)
Anaphase-promoting complex-dependent catabolic process
(GO:0031145)
Cell differentiation
(GO:0030154)
Cell division
(GO:0051301)
Cytosol
(GO:0005829)
Metaphase/anaphase transition of mitotic cell cycle
(GO:0007091)
Negative regulation of gene expression
(GO:0010629)
Nervous system development
(GO:0007399)
Nucleoplasm
(GO:0005654)
Positive regulation of axon extension
(GO:0045773)
Positive regulation of dendrite morphogenesis
(GO:0050775)
Positive regulation of synapse maturation
(GO:0090129)
Positive regulation of synaptic plasticity
(GO:0031915)
Protein binding
(GO:0005515)
Protein branched polyubiquitination
(GO:0141198)
Protein k11-linked ubiquitination
(GO:0070979)
Protein k48-linked ubiquitination
(GO:0070936)
Regulation of meiotic cell cycle
(GO:0051445)
Regulation of mitotic cell cycle
(GO:0007346)
Ubiquitin protein ligase binding
(GO:0031625)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 64.9007
Cell Significance Index: -10.1000
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 40.9236
Cell Significance Index: -10.3800
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 26.7318
Cell Significance Index: -10.8600
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 26.0949
Cell Significance Index: -12.3200
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 11.5162
Cell Significance Index: -11.0000
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 9.5462
Cell Significance Index: -11.7700
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 4.1846
Cell Significance Index: -11.2100
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 3.0664
Cell Significance Index: -12.1000
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 2.2343
Cell Significance Index: -4.8900
Cell Name: decidual cell (CL2000002)
Fold Change: 1.6885
Cell Significance Index: 27.0900
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.9541
Cell Significance Index: 94.3800
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.7594
Cell Significance Index: 685.6500
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.6176
Cell Significance Index: 17.8000
Cell Name: pro-T cell (CL0000827)
Fold Change: 0.5132
Cell Significance Index: 13.1100
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.5101
Cell Significance Index: 82.9600
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.5079
Cell Significance Index: 6.9300
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.4721
Cell Significance Index: 51.3500
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.4693
Cell Significance Index: 21.2700
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.4433
Cell Significance Index: 12.3900
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.3960
Cell Significance Index: 20.6300
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.3561
Cell Significance Index: 18.5000
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.3393
Cell Significance Index: 7.3500
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.3185
Cell Significance Index: 19.1200
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.2995
Cell Significance Index: 8.0300
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.2782
Cell Significance Index: 12.9700
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.2648
Cell Significance Index: 31.2300
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.2468
Cell Significance Index: 17.0700
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2433
Cell Significance Index: 46.3000
Cell Name: odontoblast (CL0000060)
Fold Change: 0.2125
Cell Significance Index: 27.2400
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.2090
Cell Significance Index: 13.1700
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1784
Cell Significance Index: 6.2700
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.1752
Cell Significance Index: 9.2000
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.1620
Cell Significance Index: 3.3900
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.1408
Cell Significance Index: 2.1100
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.1389
Cell Significance Index: 10.3500
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.1318
Cell Significance Index: 26.4400
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.1285
Cell Significance Index: 88.8500
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1101
Cell Significance Index: 48.6700
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.1099
Cell Significance Index: 19.8200
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.0961
Cell Significance Index: 13.2000
Cell Name: lactocyte (CL0002325)
Fold Change: 0.0925
Cell Significance Index: 11.9500
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0822
Cell Significance Index: 1.7500
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.0745
Cell Significance Index: 1.9600
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0722
Cell Significance Index: 25.9000
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0716
Cell Significance Index: 1.7900
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0714
Cell Significance Index: 14.1600
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.0711
Cell Significance Index: 4.5900
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0662
Cell Significance Index: 36.1600
Cell Name: germ cell (CL0000586)
Fold Change: 0.0569
Cell Significance Index: 0.4300
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.0540
Cell Significance Index: 2.5400
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.0320
Cell Significance Index: 0.8700
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 0.0276
Cell Significance Index: 0.3000
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0205
Cell Significance Index: 3.5000
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.0181
Cell Significance Index: 2.2300
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.0180
Cell Significance Index: 1.2700
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0016
Cell Significance Index: 3.0000
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0042
Cell Significance Index: -7.6600
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0057
Cell Significance Index: -8.8100
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0082
Cell Significance Index: -6.1800
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0088
Cell Significance Index: -11.9800
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0095
Cell Significance Index: -6.9400
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0100
Cell Significance Index: -6.3800
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0126
Cell Significance Index: -1.2900
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0165
Cell Significance Index: -12.2300
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0169
Cell Significance Index: -7.6700
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0185
Cell Significance Index: -0.3100
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0212
Cell Significance Index: -11.9700
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0224
Cell Significance Index: -14.0100
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0225
Cell Significance Index: -0.7200
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0362
Cell Significance Index: -10.4100
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.0375
Cell Significance Index: -1.1000
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0532
Cell Significance Index: -1.4200
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.0536
Cell Significance Index: -0.5600
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0572
Cell Significance Index: -8.3200
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0620
Cell Significance Index: -7.1000
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0627
Cell Significance Index: -7.3100
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0658
Cell Significance Index: -5.0500
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0676
Cell Significance Index: -14.2400
Cell Name: proerythroblast (CL0000547)
Fold Change: -0.1103
Cell Significance Index: -1.5800
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1106
Cell Significance Index: -11.5200
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.1139
Cell Significance Index: -2.4400
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1222
Cell Significance Index: -8.2200
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.1225
Cell Significance Index: -2.1000
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1240
Cell Significance Index: -7.6200
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.1264
Cell Significance Index: -7.7500
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1312
Cell Significance Index: -10.4000
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.1545
Cell Significance Index: -2.7300
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.1692
Cell Significance Index: -4.8500
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1916
Cell Significance Index: -10.7500
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.1937
Cell Significance Index: -8.5700
Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.2114
Cell Significance Index: -2.5200
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.2120
Cell Significance Index: -5.4500
Cell Name: kidney cell (CL1000497)
Fold Change: -0.2254
Cell Significance Index: -1.8000
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.2278
Cell Significance Index: -7.9200
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.2363
Cell Significance Index: -6.3200
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.2370
Cell Significance Index: -4.3800
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.2437
Cell Significance Index: -9.2300
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.2455
Cell Significance Index: -8.6000
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.2483
Cell Significance Index: -3.1800
Cell Name: epithelial cell of sweat gland (CL1000448)
Fold Change: -0.2519
Cell Significance Index: -0.1800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** ANAPC2 is a highly conserved gene, with its expression observed in various cell types, including germ cells, pulmonary interstitial fibroblasts, and intestinal crypt stem cells. The gene is characterized by its ability to regulate multiple cellular processes, including cell cycle progression, antigen processing, and immune system function. ANAPC2 is also known to interact with various proteins, including cyclin B, securin, and Nek2A, to regulate mitotic protein degradation. **Pathways and Functions:** ANAPC2 is embedded in the Anaphase Promoting Complex (APC), a key regulator of the cell cycle. The APC is responsible for the degradation of mitotic proteins, including cyclin B and securin, ensuring proper anaphase progression. ANAPC2 is also involved in the regulation of antigen processing and presentation, working in conjunction with the major histocompatibility complex (MHC) to present antigens to the immune system. Additionally, ANAPC2 plays a role in adaptive immune system function, influencing the activation and proliferation of immune cells. **Functions:** 1. **Cell Cycle Regulation:** ANAPC2 is essential for the degradation of mitotic proteins, ensuring proper anaphase progression and preventing aberrant cell cycle progression. 2. **Antigen Processing and Presentation:** ANAPC2 interacts with MHC to present antigens to the immune system, facilitating immune recognition and response. 3. **Adaptive Immune System Function:** ANAPC2 influences the activation and proliferation of immune cells, contributing to effective immune responses. 4. **Mitotic Spindle Checkpoint:** ANAPC2 is involved in the regulation of the mitotic spindle checkpoint, ensuring proper chromosome segregation and preventing aneuploidy. **Clinical Significance:** Dysregulation of ANAPC2 has been implicated in various human diseases, including cancer, autoimmune disorders, and immune-related conditions. For example, alterations in ANAPC2 expression have been observed in certain types of cancer, such as breast and colon cancer, where it may contribute to tumor progression and metastasis. Additionally, ANAPC2 has been linked to autoimmune diseases, such as rheumatoid arthritis, where it may play a role in the regulation of immune responses. In conclusion, ANAPC2 is a multifunctional gene that plays critical roles in cell cycle regulation, antigen processing and presentation, and adaptive immune system function. Its dysregulation has been implicated in various human diseases, highlighting the importance of further research into the mechanisms and functions of this gene.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Anaphase-promoting complex subunit 2

Genular Protein ID: 3859598537

Symbol: ANC2_HUMAN

Name: Anaphase-promoting complex subunit 2

UniProtKB Accession Codes:

Q9UJX6 Q5VSG1 Q96DG5 Q96GG4 Q9P2E1

Database IDs:

Citations:

PubMed ID: 9469815

Title: Identification of a cullin homology region in a subunit of the anaphase-promoting complex.

PubMed ID: 9469815

DOI: 10.1126/science.279.5354.1219

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10718198

Title: Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10718198

DOI: 10.1093/dnares/7.1.65

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 11739784

Title: APC2 cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex.

PubMed ID: 11739784

DOI: 10.1091/mbc.12.12.3839

PubMed ID: 14657031

Title: Mitotic regulation of the human anaphase-promoting complex by phosphorylation.

PubMed ID: 14657031

DOI: 10.1093/emboj/cdg627

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18485873

Title: Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex.

PubMed ID: 18485873

DOI: 10.1016/j.cell.2008.04.012

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 29033132

Title: Assembly and function of heterotypic ubiquitin chains in cell-cycle and protein quality control.

PubMed ID: 29033132

DOI: 10.1016/j.cell.2017.09.040

PubMed ID: 16364912

Title: Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C.

PubMed ID: 16364912

DOI: 10.1016/j.molcel.2005.11.008

PubMed ID: 25043029

Title: Molecular architecture and mechanism of the anaphase-promoting complex.

PubMed ID: 25043029

DOI: 10.1038/nature13543

PubMed ID: 26083744

Title: Atomic structure of the APC/C and its mechanism of protein ubiquitination.

PubMed ID: 26083744

DOI: 10.1038/nature14471

PubMed ID: 27259151

Title: Dual RING E3 architectures regulate multiubiquitination and ubiquitin chain elongation by APC/C.

PubMed ID: 27259151

DOI: 10.1016/j.cell.2016.05.037

PubMed ID: 34595750

Title: A homozygous loss-of-function mutation in FBXO43 causes human non-obstructive azoospermia.

PubMed ID: 34595750

DOI: 10.1111/cge.14069

Sequence Information:

Length: 822
Mass: 93828
Checksum: 94A2B1D015805573
Sequence:

MAAAVVVAEG DSDSRPGQEL LVAWNTVSTG LVPPAALGLV SSRTSGAVPP KEEELRAAVE 
VLRGHGLHSV LEEWFVEVLQ NDLQANISPE FWNAISQCEN SADEPQCLLL LLDAFGLLES 
RLDPYLRSLE LLEKWTRLGL LMGTGAQGLR EEVHTMLRGV LFFSTPRTFQ EMIQRLYGCF 
LRVYMQSKRK GEGGTDPELE GELDSRYARR RYYRLLQSPL CAGCSSDKQQ CWCRQALEQF 
HQLSQVLHRL SLLERVSAEA VTTTLHQVTR ERMEDRCRGE YERSFLREFH KWIERVVGWL 
GKVFLQDGPA RPASPEAGNT LRRWRCHVQR FFYRIYASLR IEELFSIVRD FPDSRPAIED 
LKYCLERTDQ RQQLLVSLKA ALETRLLHPG VNTCDIITLY ISAIKALRVL DPSMVILEVA 
CEPIRRYLRT REDTVRQIVA GLTGDSDGTG DLAVELSKTD PASLETGQDS EDDSGEPEDW 
VPDPVDADPG KSSSKRRSSD IISLLVSIYG SKDLFINEYR SLLADRLLHQ FSFSPEREIR 
NVELLKLRFG EAPMHFCEVM LKDMADSRRI NANIREEDEK RPAEEQPPFG VYAVILSSEF 
WPPFKDEKLE VPEDIRAALE AYCKKYEQLK AMRTLSWKHT LGLVTMDVEL ADRTLSVAVT 
PVQAVILLYF QDQASWTLEE LSKAVKMPVA LLRRRMSVWL QQGVLREEPP GTFSVIEEER 
PQDRDNMVLI DSDDESDSGM ASQADQKEEE LLLFWTYIQA MLTNLESLSL DRIYNMLRMF 
VVTGPALAEI DLQELQGYLQ KKVRDQQLVY SAGVYRLPKN CS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ANAPC2

Associated with

Cells (max top 100)

Other Information

Identification of a cullin homology region in a subunit of the anaphase-promoting complex. PubMed ID: 9469815

DNA sequence and analysis of human chromosome 9. PubMed ID: 15164053

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. PubMed ID: 10718198

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. PubMed ID: 12168954

APC2 cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex. PubMed ID: 11739784

Mitotic regulation of the human anaphase-promoting complex by phosphorylation. PubMed ID: 14657031

A probability-based approach for high-throughput protein phosphorylation analysis and site localization. PubMed ID: 16964243

Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex. PubMed ID: 18485873

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Initial characterization of the human central proteome. PubMed ID: 21269460

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Assembly and function of heterotypic ubiquitin chains in cell-cycle and protein quality control. PubMed ID: 29033132

Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C. PubMed ID: 16364912

Molecular architecture and mechanism of the anaphase-promoting complex. PubMed ID: 25043029

Atomic structure of the APC/C and its mechanism of protein ubiquitination. PubMed ID: 26083744

Dual RING E3 architectures regulate multiubiquitination and ubiquitin chain elongation by APC/C. PubMed ID: 27259151

A homozygous loss-of-function mutation in FBXO43 causes human non-obstructive azoospermia. PubMed ID: 34595750