Details for: SNX8

Gene ID: 29886

Symbol: SNX8

Ensembl ID: ENSG00000106266

Description: sorting nexin 8

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 86.1486
    Cell Significance Index: -13.4000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 74.5141
    Cell Significance Index: -18.9000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 48.2950
    Cell Significance Index: -19.9000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 42.4608
    Cell Significance Index: -17.2500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 28.5236
    Cell Significance Index: -19.1400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 18.1620
    Cell Significance Index: -17.3400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 15.2804
    Cell Significance Index: -18.8400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.9694
    Cell Significance Index: -18.6700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.0493
    Cell Significance Index: -18.5800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.9923
    Cell Significance Index: -19.7000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.5891
    Cell Significance Index: -7.8600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 2.6145
    Cell Significance Index: 21.3200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.4248
    Cell Significance Index: 19.4400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.0863
    Cell Significance Index: 17.9000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0276
    Cell Significance Index: 61.6900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8376
    Cell Significance Index: 166.2200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.8370
    Cell Significance Index: 22.3500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7383
    Cell Significance Index: 120.0700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.7165
    Cell Significance Index: 10.2000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6990
    Cell Significance Index: 76.0300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.6658
    Cell Significance Index: 78.5200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6554
    Cell Significance Index: 591.8200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5439
    Cell Significance Index: 195.1100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4831
    Cell Significance Index: 96.9100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4655
    Cell Significance Index: 13.0100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3421
    Cell Significance Index: 23.6600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.3391
    Cell Significance Index: 9.7200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3356
    Cell Significance Index: 15.7800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3270
    Cell Significance Index: 20.6100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3124
    Cell Significance Index: 9.0000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.3081
    Cell Significance Index: 7.9200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3028
    Cell Significance Index: 6.5600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2876
    Cell Significance Index: 541.6100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2604
    Cell Significance Index: 11.5200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2529
    Cell Significance Index: 16.3200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2370
    Cell Significance Index: 8.9800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2060
    Cell Significance Index: 24.0100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1975
    Cell Significance Index: 11.0800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1815
    Cell Significance Index: 34.5400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1760
    Cell Significance Index: 24.1700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1636
    Cell Significance Index: 21.1400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1527
    Cell Significance Index: 15.1100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1523
    Cell Significance Index: 7.1000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1455
    Cell Significance Index: 11.1700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0988
    Cell Significance Index: 2.4700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0986
    Cell Significance Index: 181.9200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0791
    Cell Significance Index: 34.9700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0569
    Cell Significance Index: 31.0700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0568
    Cell Significance Index: 87.5100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0493
    Cell Significance Index: 8.9000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0375
    Cell Significance Index: 6.4000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0329
    Cell Significance Index: 1.4900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0298
    Cell Significance Index: 0.8500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0206
    Cell Significance Index: 13.0600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0170
    Cell Significance Index: 2.0900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0122
    Cell Significance Index: 0.2600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0107
    Cell Significance Index: 14.5900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0023
    Cell Significance Index: 0.0400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0009
    Cell Significance Index: 0.1100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0124
    Cell Significance Index: -9.3500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0159
    Cell Significance Index: -7.2000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0183
    Cell Significance Index: -1.8700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0186
    Cell Significance Index: -2.7100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0202
    Cell Significance Index: -0.5400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0216
    Cell Significance Index: -15.8100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0227
    Cell Significance Index: -16.8500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0280
    Cell Significance Index: -2.0900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0280
    Cell Significance Index: -15.8000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0293
    Cell Significance Index: -1.5200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0337
    Cell Significance Index: -21.0600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0444
    Cell Significance Index: -1.1900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0512
    Cell Significance Index: -1.0000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0542
    Cell Significance Index: -15.6000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0627
    Cell Significance Index: -1.0500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0631
    Cell Significance Index: -3.8800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0748
    Cell Significance Index: -2.6300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0755
    Cell Significance Index: -5.0800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0966
    Cell Significance Index: -20.3600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1007
    Cell Significance Index: -11.5400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1165
    Cell Significance Index: -6.0700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1203
    Cell Significance Index: -2.5000
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.1248
    Cell Significance Index: -0.9900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1288
    Cell Significance Index: -13.4100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1320
    Cell Significance Index: -1.8900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1529
    Cell Significance Index: -4.4900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1530
    Cell Significance Index: -9.3800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1700
    Cell Significance Index: -1.7600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1823
    Cell Significance Index: -12.8900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2146
    Cell Significance Index: -4.7000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2196
    Cell Significance Index: -17.3900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2601
    Cell Significance Index: -3.1000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2666
    Cell Significance Index: -8.5400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2786
    Cell Significance Index: -14.6300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3073
    Cell Significance Index: -5.6800
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -0.3308
    Cell Significance Index: -1.4400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3384
    Cell Significance Index: -5.1000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3535
    Cell Significance Index: -7.4000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3549
    Cell Significance Index: -9.3300
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.3734
    Cell Significance Index: -3.5500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3869
    Cell Significance Index: -8.3600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Protein Binding:** SNX8 exhibits a high degree of protein binding, interacting with a wide range of proteins, including those involved in membrane trafficking, protein degradation, and signal transduction. 2. **Phosphatidylinositol Binding:** SNX8 possesses a phosphatidylinositol-binding domain, which enables it to interact with phosphatidylinositol-containing lipids, such as phosphatidylinositol 4,5-bisphosphate (PIP2). 3. **Intracellular Membrane-Bounded Organelle Association:** SNX8 is associated with various intracellular membrane-bound organelles, including the early endosome, Golgi apparatus, and retromer complex. 4. **Cell Type-Specific Expression:** SNX8 is expressed in a variety of cell types, including pigmented epithelial cells, endothelial cells, corneal epithelial cells, and immune cells. **Pathways and Functions:** 1. **Intracellular Membrane Trafficking:** SNX8 plays a crucial role in regulating the trafficking of proteins and lipids within the cell, facilitating the sorting and transport of proteins to their destination membranes. 2. **Protein Degradation:** SNX8 interacts with the retromer complex to regulate the degradation of proteins, including those involved in signal transduction and cell growth. 3. **Signal Transduction:** SNX8 is involved in the regulation of signal transduction pathways, including those involved in cell growth, differentiation, and survival. 4. **Cell Adhesion:** SNX8 interacts with integrins and other cell adhesion molecules to regulate cell adhesion and migration. **Clinical Significance:** 1. **Eye Diseases:** SNX8 has been implicated in the pathogenesis of various eye diseases, including age-related macular degeneration and retinitis pigmentosa. 2. **Immune System Disorders:** SNX8 is involved in the regulation of immune responses, and dysregulation of SNX8 has been implicated in autoimmune disorders, such as lupus and rheumatoid arthritis. 3. **Cardiovascular Disease:** SNX8 is expressed in cardiac tissue and has been implicated in the regulation of cardiac function and disease. 4. **Cancer:** SNX8 has been shown to be overexpressed in several types of cancer, including breast cancer and colon cancer, and has been implicated in the regulation of cell growth and metastasis. In conclusion, SNX8 is a multifunctional protein that plays a crucial role in regulating intracellular membrane trafficking, protein transport, and signal transduction. Its dysregulation has been implicated in various diseases, including eye diseases, immune system disorders, cardiovascular disease, and cancer. Further research is needed to fully elucidate the mechanisms by which SNX8 regulates cellular processes and its role in human disease.

Genular Protein ID: 1925774758

Symbol: SNX8_HUMAN

Name: Sorting nexin-8

UniProtKB Accession Codes:

Q9Y5X2 A4D207 Q96I67

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 3 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 7 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11485546

Title: A large family of endosome-localized proteins related to sorting nexin 1.

PubMed ID: 11485546

DOI: 10.1042/0264-6021:3580007

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19782049

Title: Sorting nexin 8 regulates endosome-to-Golgi transport.

PubMed ID: 19782049

DOI: 10.1016/j.bbrc.2009.09.076

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 465
  • Mass: 52569
  • Checksum: 90C5EDB761C31E88
  • Sequence:
    • MTGRAMDPLP AAAVGAAAEA EADEEADPPA SDLPTPQAIE PQAIVQQVPA PSRMQMPQGN 
PLLLSHTLQE LLARDTVQVE LIPEKKGLFL KHVEYEVSSQ RFKSSVYRRY NDFVVFQEML 
LHKFPYRMVP ALPPKRMLGA DREFIEARRR ALKRFVNLVA RHPLFSEDVV LKLFLSFSGS 
DVQNKLKESA QCVGDEFLNC KLATRAKDFL PADIQAQFAI SRELIRNIYN SFHKLRDRAE 
RIASRAIDNA ADLLIFGKEL SAIGSDTTPL PSWAALNSST WGSLKQALKG LSVEFALLAD 
KAAQQGKQEE NDVVEKLNLF LDLLQSYKDL CERHEKGVLH KHQRALHKYS LMKRQMMSAT 
AQNREPESVE QLESRIVEQE NAIQTMELRN YFSLYCLHQE TQLIHVYLPL TSHILRAFVN 
SQIQGHKEMS KVWNDLRPKL SCLFAGPHST LTPPCSPPED GLCPH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.