Details for: EEF2K
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 2.11
Marker Score: 45,114 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 1.84
Marker Score: 68,000 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 1.82
Marker Score: 1,067 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 1.72
Marker Score: 7,211 - Cell Name: basal cell of epidermis (CL0002187)
Fold Change: 1.71
Marker Score: 747 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 1.61
Marker Score: 15,187 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.6
Marker Score: 1,818 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 1.55
Marker Score: 30,808 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 1.55
Marker Score: 3,875 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 1.53
Marker Score: 1,007 - Cell Name: mural cell (CL0008034)
Fold Change: 1.47
Marker Score: 168,525 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 1.45
Marker Score: 1,604 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.41
Marker Score: 14,574 - Cell Name: photoreceptor cell (CL0000210)
Fold Change: 1.41
Marker Score: 1,059 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 1.38
Marker Score: 10,599 - Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 1.36
Marker Score: 51,663 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.35
Marker Score: 12,846 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.33
Marker Score: 11,423 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.31
Marker Score: 2,017 - Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 1.26
Marker Score: 877 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.24
Marker Score: 76,353 - Cell Name: neuron (CL0000540)
Fold Change: 1.23
Marker Score: 5,006 - Cell Name: ciliated cell (CL0000064)
Fold Change: 1.14
Marker Score: 3,936 - Cell Name: alveolar type 2 fibroblast cell (CL4028006)
Fold Change: 1.12
Marker Score: 622 - Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 1.07
Marker Score: 274 - Cell Name: mature astrocyte (CL0002627)
Fold Change: 1.05
Marker Score: 691 - Cell Name: lens fiber cell (CL0011004)
Fold Change: 1.04
Marker Score: 330 - Cell Name: fat cell (CL0000136)
Fold Change: 1.01
Marker Score: 564 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 1
Marker Score: 885 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,738 - Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1
Marker Score: 2,347 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47,963 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,400 - Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 0.98
Marker Score: 409 - Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 0.97
Marker Score: 889 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 0.95
Marker Score: 3,936 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,403 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.94
Marker Score: 485 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.93
Marker Score: 440 - Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 0.91
Marker Score: 732 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2,716 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.91
Marker Score: 1,470 - Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 0.9
Marker Score: 1,740 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.9
Marker Score: 1,087 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 0.89
Marker Score: 13,338 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.88
Marker Score: 256 - Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 0.87
Marker Score: 3,109 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,295 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.87
Marker Score: 4,948 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.86
Marker Score: 310 - Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 0.85
Marker Score: 569 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 0.83
Marker Score: 484 - Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 0.83
Marker Score: 7,195 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.81
Marker Score: 1,093 - Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 0.8
Marker Score: 389 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.8
Marker Score: 1,816 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.79
Marker Score: 26,624 - Cell Name: lung goblet cell (CL1000143)
Fold Change: 0.79
Marker Score: 227 - Cell Name: astrocyte (CL0000127)
Fold Change: 0.78
Marker Score: 680 - Cell Name: keratocyte (CL0002363)
Fold Change: 0.78
Marker Score: 180 - Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 0.78
Marker Score: 204 - Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 0.77
Marker Score: 738 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.77
Marker Score: 591 - Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 0.76
Marker Score: 209 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.76
Marker Score: 303 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 0.75
Marker Score: 16,799 - Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 0.74
Marker Score: 215 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.74
Marker Score: 3,084 - Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.73
Marker Score: 377 - Cell Name: basal cell (CL0000646)
Fold Change: 0.72
Marker Score: 935 - Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 0.72
Marker Score: 589 - Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 0.71
Marker Score: 416 - Cell Name: subcutaneous fat cell (CL0002521)
Fold Change: 0.71
Marker Score: 260 - Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 0.7
Marker Score: 347 - Cell Name: contractile cell (CL0000183)
Fold Change: 0.7
Marker Score: 380 - Cell Name: taste receptor cell (CL0000209)
Fold Change: 0.7
Marker Score: 605 - Cell Name: duct epithelial cell (CL0000068)
Fold Change: 0.7
Marker Score: 326 - Cell Name: proerythroblast (CL0000547)
Fold Change: 0.7
Marker Score: 473 - Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.69
Marker Score: 223 - Cell Name: A2 amacrine cell (CL0004219)
Fold Change: 0.69
Marker Score: 219 - Cell Name: skin fibroblast (CL0002620)
Fold Change: 0.69
Marker Score: 179 - Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 0.69
Marker Score: 5,100 - Cell Name: adventitial cell (CL0002503)
Fold Change: 0.68
Marker Score: 169 - Cell Name: brush cell (CL0002204)
Fold Change: 0.67
Marker Score: 616 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.67
Marker Score: 430 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.67
Marker Score: 172 - Cell Name: oocyte (CL0000023)
Fold Change: 0.67
Marker Score: 165 - Cell Name: fast muscle cell (CL0000190)
Fold Change: 0.67
Marker Score: 201 - Cell Name: germ cell (CL0000586)
Fold Change: 0.67
Marker Score: 1,164 - Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 0.66
Marker Score: 1,253 - Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 0.66
Marker Score: 813 - Cell Name: cell of skeletal muscle (CL0000188)
Fold Change: 0.65
Marker Score: 498 - Cell Name: lung ciliated cell (CL1000271)
Fold Change: 0.64
Marker Score: 305 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.63
Marker Score: 197 - Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 0.63
Marker Score: 1,252 - Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 0.61
Marker Score: 886 - Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.61
Marker Score: 1,494 - Cell Name: podocyte (CL0000653)
Fold Change: 0.6
Marker Score: 220 - Cell Name: osteoclast (CL0000092)
Fold Change: 0.59
Marker Score: 296 - Cell Name: cardiac neuron (CL0010022)
Fold Change: 0.59
Marker Score: 736
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2522327892
Symbol: EF2K_HUMAN
Name: Eukaryotic elongation factor 2 kinase
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9144159
Title: Identification of a new class of protein kinases represented by eukaryotic elongation factor-2 kinase.
PubMed ID: 9144159
PubMed ID: 15616553
Title: The sequence and analysis of duplication-rich human chromosome 16.
PubMed ID: 15616553
DOI: 10.1038/nature03187
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11015200
Title: Mapping the functional domains of elongation factor-2 kinase.
PubMed ID: 11015200
DOI: 10.1021/bi0007270
PubMed ID: 11500363
Title: A novel method to identify protein kinase substrates: eEF2 kinase is phosphorylated and inhibited by SAPK4/p38delta.
PubMed ID: 11500363
PubMed ID: 11500364
Title: Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase.
PubMed ID: 11500364
PubMed ID: 15144186
Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.
PubMed ID: 15144186
DOI: 10.1021/ac035352d
PubMed ID: 14709557
Title: Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398.
PubMed ID: 14709557
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 16964243
Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
PubMed ID: 16964243
DOI: 10.1038/nbt1240
PubMed ID: 18337751
Title: cdc2-cyclin B regulates eEF2 kinase activity in a cell cycle- and amino acid-dependent manner.
PubMed ID: 18337751
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21112387
Title: The channel-kinase TRPM7 regulates phosphorylation of the translational factor eEF2 via eEF2-k.
PubMed ID: 21112387
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22216903
Title: Identification of autophosphorylation sites in eukaryotic elongation factor-2 kinase.
PubMed ID: 22216903
DOI: 10.1042/bj20111530
PubMed ID: 22223895
Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
PubMed ID: 22223895
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 17344846
Title: Patterns of somatic mutation in human cancer genomes.
PubMed ID: 17344846
DOI: 10.1038/nature05610
Sequence Information:
- Length: 725
- Mass: 82144
- Checksum: 9D2900E50EFF12DA
- Sequence:
MADEDLIFRL EGVDGGQSPR AGHDGDSDGD SDDEEGYFIC PITDDPSSNQ NVNSKVNKYY SNLTKSERYS SSGSPANSFH FKEAWKHAIQ KAKHMPDPWA EFHLEDIATE RATRHRYNAV TGEWLDDEVL IKMASQPFGR GAMRECFRTK KLSNFLHAQQ WKGASNYVAK RYIEPVDRDV YFEDVRLQME AKLWGEEYNR HKPPKQVDIM QMCIIELKDR PGKPLFHLEH YIEGKYIKYN SNSGFVRDDN IRLTPQAFSH FTFERSGHQL IVVDIQGVGD LYTDPQIHTE TGTDFGDGNL GVRGMALFFY SHACNRICES MGLAPFDLSP RERDAVNQNT KLLQSAKTIL RGTEEKCGSP QVRTLSGSRP PLLRPLSENS GDENMSDVTF DSLPSSPSSA TPHSQKLDHL HWPVFSDLDN MASRDHDHLD NHRESENSGD SGYPSEKRGE LDDPEPREHG HSYSNRKYES DEDSLGSSGR VCVEKWNLLN SSRLHLPRAS AVALEVQRLN ALDLEKKIGK SILGKVHLAM VRYHEGGRFC EKGEEWDQES AVFHLEHAAN LGELEAIVGL GLMYSQLPHH ILADVSLKET EENKTKGFDY LLKAAEAGDR QSMILVARAF DSGQNLSPDR CQDWLEALHW YNTALEMTDC DEGGEYDGMQ DEPRYMMLAR EAEMLFTGGY GLEKDPQRSG DLYTQAAEAA MEAMKGRLAN QYYQKAEEAW AQMEE
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.