Details for: GPR171

Gene ID: 29909

Symbol: GPR171

Ensembl ID: ENSG00000174946

Description: G protein-coupled receptor 171

Associated with

  • Adenylate cyclase-modulating g protein-coupled receptor signaling pathway
    (GO:0007188)
  • G protein-coupled peptide receptor activity
    (GO:0008528)
  • G protein-coupled purinergic nucleotide receptor activity
    (GO:0045028)
  • G protein-coupled purinergic nucleotide receptor signaling pathway
    (GO:0035589)
  • G protein-coupled receptor activity
    (GO:0004930)
  • G protein-coupled receptor signaling pathway
    (GO:0007186)
  • Membrane
    (GO:0016020)
  • Negative regulation of myeloid cell differentiation
    (GO:0045638)
  • Neuropeptide binding
    (GO:0042923)
  • Neuropeptide receptor activity
    (GO:0008188)
  • Neuropeptide signaling pathway
    (GO:0007218)
  • Plasma membrane
    (GO:0005886)
  • Regulation of feeding behavior
    (GO:0060259)
  • Regulation of sensory perception of pain
    (GO:0051930)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.27
    Marker Score: 1,327
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.99
    Marker Score: 1,984
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 1.87
    Marker Score: 1,094
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.82
    Marker Score: 563
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1,162
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 1.56
    Marker Score: 1,131
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 1.44
    Marker Score: 457
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.43
    Marker Score: 14,199
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.37
    Marker Score: 8,746
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 1.3
    Marker Score: 666
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 1.26
    Marker Score: 1,395
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.25
    Marker Score: 848
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.22
    Marker Score: 3,420
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.2
    Marker Score: 942
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 1.18
    Marker Score: 2,663
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.16
    Marker Score: 482
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4,801
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 1.13
    Marker Score: 819
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.13
    Marker Score: 947
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.07
    Marker Score: 7,146
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,792
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 1.03
    Marker Score: 443
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,811
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,035
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 504
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.98
    Marker Score: 539
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 0.98
    Marker Score: 317
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 457
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.96
    Marker Score: 550
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,411
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,335
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 370
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,735
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.91
    Marker Score: 418
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,281
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.86
    Marker Score: 1,478
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.84
    Marker Score: 784
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.81
    Marker Score: 621
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.79
    Marker Score: 173
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,254
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 703
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.77
    Marker Score: 1,245
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 392
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.75
    Marker Score: 483
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.71
    Marker Score: 457
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.68
    Marker Score: 339
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.64
    Marker Score: 429
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.62
    Marker Score: 674
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.6
    Marker Score: 508
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.57
    Marker Score: 508
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.57
    Marker Score: 2,431
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.54
    Marker Score: 395
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.53
    Marker Score: 267
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.5
    Marker Score: 900
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.5
    Marker Score: 443
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 0.48
    Marker Score: 149
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.48
    Marker Score: 25,409
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.48
    Marker Score: 287
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.47
    Marker Score: 1,229
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.47
    Marker Score: 1,488
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 275
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.44
    Marker Score: 243
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.43
    Marker Score: 1,195
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.42
    Marker Score: 543
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.42
    Marker Score: 818
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.41
    Marker Score: 301
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.4
    Marker Score: 139
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.4
    Marker Score: 125
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.39
    Marker Score: 299
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.39
    Marker Score: 942
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.38
    Marker Score: 252
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.38
    Marker Score: 457
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.37
    Marker Score: 244
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.36
    Marker Score: 514
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.34
    Marker Score: 328
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.34
    Marker Score: 702
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 0.34
    Marker Score: 988
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.34
    Marker Score: 76
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 0.33
    Marker Score: 114
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.32
    Marker Score: 320
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.32
    Marker Score: 656
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.32
    Marker Score: 3,726
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.31
    Marker Score: 143
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.28
    Marker Score: 175
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.28
    Marker Score: 309
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.28
    Marker Score: 312
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.28
    Marker Score: 74
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.28
    Marker Score: 481
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.27
    Marker Score: 156
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.27
    Marker Score: 226
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.26
    Marker Score: 265
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.26
    Marker Score: 92
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 0.25
    Marker Score: 113
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 0.24
    Marker Score: 64
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.24
    Marker Score: 136
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.23
    Marker Score: 160

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GPR171 is a GPCR, a large family of receptors that respond to a variety of extracellular ligands, including peptides, nucleotides, and hormones. Its structure and sequence are characteristic of other GPCRs, with seven transmembrane domains and a conserved extracellular N-terminus. The receptor's ligand-binding domain is located in the extracellular loop between transmembrane domains 3 and 4. GPR171 shares functional similarities with other GPCRs, such as GPR65 and GPR120, which are involved in regulating immune responses and metabolic processes. **Pathways and Functions:** GPR171 is implicated in several signaling pathways, including: 1. **Adenylate cyclase-modulating g protein-coupled receptor signaling pathway**: GPR171 activates adenylate cyclase, a key enzyme in the production of cAMP, a secondary messenger involved in various cellular processes, including immune responses and neuronal communication. 2. **G protein-coupled peptide receptor activity**: GPR171 interacts with G-proteins, which are heterotrimeric complexes that regulate downstream signaling pathways. 3. **Negative regulation of myeloid cell differentiation**: GPR171 inhibits the differentiation of myeloid cells, which are crucial for the development of the immune system. 4. **Regulation of feeding behavior**: GPR171 modulates feeding behavior by influencing the activity of neurons involved in appetite regulation. 5. **Neurotransmitter and neuropeptide signaling**: GPR171 interacts with various neurotransmitters and neuropeptides, such as adenosine, dopamine, and substance P, which play critical roles in neuronal communication. **Clinical Significance:** GPR171's involvement in immune regulation, neuronal communication, and feeding behavior makes it a potential therapeutic target for various diseases, including: 1. **Autoimmune disorders**: GPR171's role in regulating immune responses suggests its potential as a therapeutic target for autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 2. **Neurological disorders**: The receptor's involvement in neuronal communication and neurotransmitter signaling makes it a potential target for treating neurological disorders, such as Parkinson's disease and Alzheimer's disease. 3. **Metabolic disorders**: GPR171's regulation of feeding behavior and metabolism suggests its potential as a therapeutic target for metabolic disorders, such as obesity and diabetes. 4. **Cancer**: The receptor's role in regulating immune responses and inflammation suggests its potential as a therapeutic target for cancer. In conclusion, GPR171 is a multifaceted receptor with a wide range of biological activities, from regulating immune responses to influencing neuronal communication and feeding behavior. Further research is needed to fully elucidate the receptor's functions and to explore its therapeutic potential for various diseases.

Genular Protein ID: 1429734031

Symbol: GP171_HUMAN

Name: G-protein coupled receptor 171

UniProtKB Accession Codes:

O14626 D3DNJ4 Q8IV06

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 4 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9370294

Title: A genetic selection for isolating cDNAs encoding secreted proteins.

PubMed ID: 9370294

DOI: 10.1016/s0378-1119(97)00330-2

PubMed ID: 11524702

Title: Mutations in a novel gene with transmembrane domains underlie Usher syndrome type 3.

PubMed ID: 11524702

DOI: 10.1086/323610

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 34615877

Title: The GPR171 pathway suppresses T cell activation and limits antitumor immunity.

PubMed ID: 34615877

DOI: 10.1038/s41467-021-26135-9

Sequence Information:

  • Length: 319
  • Mass: 36754
  • Checksum: 79B9821C10841114
  • Sequence:
    • MTNSSFFCPV YKDLEPFTYF FYLVFLVGII GSCFATWAFI QKNTNHRCVS IYLINLLTAD 
FLLTLALPVK IVVDLGVAPW KLKIFHCQVT ACLIYINMYL SIIFLAFVSI DRCLQLTHSC 
KIYRIQEPGF AKMISTVVWL MVLLIMVPNM MIPIKDIKEK SNVGCMEFKK EFGRNWHLLT 
NFICVAIFLN FSAIILISNC LVIRQLYRNK DNENYPNVKK ALINILLVTT GYIICFVPYH 
IVRIPYTLSQ TEVITDCSTR ISLFKAKEAT LLLAVSNLCF DPILYYHLSK AFRSKVTETF 
ASPKETKAQK EKLRCENNA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.