Details for: GPR171

Gene ID: 29909

Symbol: GPR171

Ensembl ID: ENSG00000174946

Description: G protein-coupled receptor 171

Associated with

  • Adenylate cyclase-modulating g protein-coupled receptor signaling pathway
    (GO:0007188)
  • G protein-coupled peptide receptor activity
    (GO:0008528)
  • G protein-coupled purinergic nucleotide receptor activity
    (GO:0045028)
  • G protein-coupled purinergic nucleotide receptor signaling pathway
    (GO:0035589)
  • G protein-coupled receptor activity
    (GO:0004930)
  • G protein-coupled receptor signaling pathway
    (GO:0007186)
  • Membrane
    (GO:0016020)
  • Negative regulation of myeloid cell differentiation
    (GO:0045638)
  • Neuropeptide binding
    (GO:0042923)
  • Neuropeptide receptor activity
    (GO:0008188)
  • Neuropeptide signaling pathway
    (GO:0007218)
  • Plasma membrane
    (GO:0005886)
  • Regulation of feeding behavior
    (GO:0060259)
  • Regulation of sensory perception of pain
    (GO:0051930)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 77.2123
    Cell Significance Index: -12.0100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 46.9557
    Cell Significance Index: -11.9100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 28.1103
    Cell Significance Index: -11.4200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 23.6062
    Cell Significance Index: -11.1500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 9.7489
    Cell Significance Index: -12.0200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 9.5922
    Cell Significance Index: 337.0600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 4.0371
    Cell Significance Index: 62.4600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.0718
    Cell Significance Index: 60.8500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.4443
    Cell Significance Index: 65.4700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.2702
    Cell Significance Index: -2.7800
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.2514
    Cell Significance Index: 12.9800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0448
    Cell Significance Index: 198.8300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9311
    Cell Significance Index: 92.1100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6966
    Cell Significance Index: 628.9400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4297
    Cell Significance Index: 69.8900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3232
    Cell Significance Index: 35.1600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.2074
    Cell Significance Index: 282.0000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1142
    Cell Significance Index: 7.9000
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.0807
    Cell Significance Index: 0.4400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0725
    Cell Significance Index: 1.5500
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.0639
    Cell Significance Index: 0.4600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0405
    Cell Significance Index: 8.1200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0180
    Cell Significance Index: 27.6900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0108
    Cell Significance Index: 0.3100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0075
    Cell Significance Index: 0.4600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.0052
    Cell Significance Index: 0.0900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0060
    Cell Significance Index: -11.2600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0064
    Cell Significance Index: -3.9800
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.0085
    Cell Significance Index: -0.0900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0101
    Cell Significance Index: -18.5800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0112
    Cell Significance Index: -0.2800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0120
    Cell Significance Index: -7.6400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0121
    Cell Significance Index: -8.9700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0144
    Cell Significance Index: -10.9100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0166
    Cell Significance Index: -9.3400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0170
    Cell Significance Index: -12.4500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0212
    Cell Significance Index: -9.6300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0228
    Cell Significance Index: -8.1900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0240
    Cell Significance Index: -13.0900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0252
    Cell Significance Index: -1.2800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0272
    Cell Significance Index: -0.5900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0284
    Cell Significance Index: -1.1600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0291
    Cell Significance Index: -1.7500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0341
    Cell Significance Index: -9.8200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0350
    Cell Significance Index: -4.4900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0412
    Cell Significance Index: -7.4200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0437
    Cell Significance Index: -9.2100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0476
    Cell Significance Index: -9.4400
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.0477
    Cell Significance Index: -0.8200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0546
    Cell Significance Index: -9.3300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0607
    Cell Significance Index: -1.9500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0714
    Cell Significance Index: -8.7800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0728
    Cell Significance Index: -1.5100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0735
    Cell Significance Index: -10.0900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0783
    Cell Significance Index: -11.3900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0814
    Cell Significance Index: -3.5400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0825
    Cell Significance Index: -9.4600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0987
    Cell Significance Index: -12.7500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1068
    Cell Significance Index: -12.5900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1073
    Cell Significance Index: -3.0000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1082
    Cell Significance Index: -11.0500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1171
    Cell Significance Index: -3.0100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1192
    Cell Significance Index: -8.0200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1192
    Cell Significance Index: -12.4100
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1400
    Cell Significance Index: -1.9900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1547
    Cell Significance Index: -8.6800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1586
    Cell Significance Index: -2.3900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1623
    Cell Significance Index: -7.6300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1697
    Cell Significance Index: -13.0300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1699
    Cell Significance Index: -12.6700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1746
    Cell Significance Index: -11.2700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1760
    Cell Significance Index: -10.8200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2010
    Cell Significance Index: -8.8900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2093
    Cell Significance Index: -10.9900
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2149
    Cell Significance Index: -3.6500
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.2195
    Cell Significance Index: -3.2100
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.2202
    Cell Significance Index: -2.0600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2221
    Cell Significance Index: -11.5700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2222
    Cell Significance Index: -5.9500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2305
    Cell Significance Index: -7.2900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2322
    Cell Significance Index: -4.8600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2369
    Cell Significance Index: -8.9700
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.2587
    Cell Significance Index: -3.5200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2620
    Cell Significance Index: -9.1800
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.2626
    Cell Significance Index: -2.4900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.2744
    Cell Significance Index: -3.2400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2754
    Cell Significance Index: -12.8400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.2877
    Cell Significance Index: -4.6200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3051
    Cell Significance Index: -15.8500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3105
    Cell Significance Index: -9.8900
  • Cell Name: urothelial cell (CL0000731)
    Fold Change: -0.3119
    Cell Significance Index: -2.1800
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.3206
    Cell Significance Index: -4.5600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3265
    Cell Significance Index: -10.6900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3269
    Cell Significance Index: -8.7300
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.3303
    Cell Significance Index: -3.2200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.3495
    Cell Significance Index: -8.4700
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.3567
    Cell Significance Index: -4.8500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3571
    Cell Significance Index: -6.1200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3683
    Cell Significance Index: -12.8000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3767
    Cell Significance Index: -10.1000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GPR171 is a GPCR, a large family of receptors that respond to a variety of extracellular ligands, including peptides, nucleotides, and hormones. Its structure and sequence are characteristic of other GPCRs, with seven transmembrane domains and a conserved extracellular N-terminus. The receptor's ligand-binding domain is located in the extracellular loop between transmembrane domains 3 and 4. GPR171 shares functional similarities with other GPCRs, such as GPR65 and GPR120, which are involved in regulating immune responses and metabolic processes. **Pathways and Functions:** GPR171 is implicated in several signaling pathways, including: 1. **Adenylate cyclase-modulating g protein-coupled receptor signaling pathway**: GPR171 activates adenylate cyclase, a key enzyme in the production of cAMP, a secondary messenger involved in various cellular processes, including immune responses and neuronal communication. 2. **G protein-coupled peptide receptor activity**: GPR171 interacts with G-proteins, which are heterotrimeric complexes that regulate downstream signaling pathways. 3. **Negative regulation of myeloid cell differentiation**: GPR171 inhibits the differentiation of myeloid cells, which are crucial for the development of the immune system. 4. **Regulation of feeding behavior**: GPR171 modulates feeding behavior by influencing the activity of neurons involved in appetite regulation. 5. **Neurotransmitter and neuropeptide signaling**: GPR171 interacts with various neurotransmitters and neuropeptides, such as adenosine, dopamine, and substance P, which play critical roles in neuronal communication. **Clinical Significance:** GPR171's involvement in immune regulation, neuronal communication, and feeding behavior makes it a potential therapeutic target for various diseases, including: 1. **Autoimmune disorders**: GPR171's role in regulating immune responses suggests its potential as a therapeutic target for autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 2. **Neurological disorders**: The receptor's involvement in neuronal communication and neurotransmitter signaling makes it a potential target for treating neurological disorders, such as Parkinson's disease and Alzheimer's disease. 3. **Metabolic disorders**: GPR171's regulation of feeding behavior and metabolism suggests its potential as a therapeutic target for metabolic disorders, such as obesity and diabetes. 4. **Cancer**: The receptor's role in regulating immune responses and inflammation suggests its potential as a therapeutic target for cancer. In conclusion, GPR171 is a multifaceted receptor with a wide range of biological activities, from regulating immune responses to influencing neuronal communication and feeding behavior. Further research is needed to fully elucidate the receptor's functions and to explore its therapeutic potential for various diseases.

Genular Protein ID: 1429734031

Symbol: GP171_HUMAN

Name: G-protein coupled receptor 171

UniProtKB Accession Codes:

O14626 D3DNJ4 Q8IV06

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 4 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9370294

Title: A genetic selection for isolating cDNAs encoding secreted proteins.

PubMed ID: 9370294

DOI: 10.1016/s0378-1119(97)00330-2

PubMed ID: 11524702

Title: Mutations in a novel gene with transmembrane domains underlie Usher syndrome type 3.

PubMed ID: 11524702

DOI: 10.1086/323610

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 34615877

Title: The GPR171 pathway suppresses T cell activation and limits antitumor immunity.

PubMed ID: 34615877

DOI: 10.1038/s41467-021-26135-9

Sequence Information:

  • Length: 319
  • Mass: 36754
  • Checksum: 79B9821C10841114
  • Sequence:
    • MTNSSFFCPV YKDLEPFTYF FYLVFLVGII GSCFATWAFI QKNTNHRCVS IYLINLLTAD 
FLLTLALPVK IVVDLGVAPW KLKIFHCQVT ACLIYINMYL SIIFLAFVSI DRCLQLTHSC 
KIYRIQEPGF AKMISTVVWL MVLLIMVPNM MIPIKDIKEK SNVGCMEFKK EFGRNWHLLT 
NFICVAIFLN FSAIILISNC LVIRQLYRNK DNENYPNVKK ALINILLVTT GYIICFVPYH 
IVRIPYTLSQ TEVITDCSTR ISLFKAKEAT LLLAVSNLCF DPILYYHLSK AFRSKVTETF 
ASPKETKAQK EKLRCENNA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.