Details for: HCFC2

Gene ID: 29915

Symbol: HCFC2

Ensembl ID: ENSG00000111727

Description: host cell factor C2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neuron (CL0000540)
    Fold Change: 1.34
    Marker Score: 5,442
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.23
    Marker Score: 10,562
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.22
    Marker Score: 11,627
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.18
    Marker Score: 72,280
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.14
    Marker Score: 1,762
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.09
    Marker Score: 4,232
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.06
    Marker Score: 9,944
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.05
    Marker Score: 39,752
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.03
    Marker Score: 38,095
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1
    Marker Score: 7,684
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,750
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,974
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.98
    Marker Score: 2,152
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.98
    Marker Score: 19,419
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.96
    Marker Score: 9,931
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.96
    Marker Score: 21,442
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.96
    Marker Score: 766
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,403
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.94
    Marker Score: 14,055
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 481
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 437
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,717
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.89
    Marker Score: 3,702
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,293
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.87
    Marker Score: 13,628
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4,948
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 308
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.77
    Marker Score: 353
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 574
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.75
    Marker Score: 1,217
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.75
    Marker Score: 299
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.74
    Marker Score: 2,646
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.73
    Marker Score: 305
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.73
    Marker Score: 380
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 376
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.73
    Marker Score: 3,046
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.71
    Marker Score: 822
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.71
    Marker Score: 862
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.71
    Marker Score: 705
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.7
    Marker Score: 773
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.69
    Marker Score: 2,675
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.69
    Marker Score: 400
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.69
    Marker Score: 256
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.68
    Marker Score: 22,845
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.67
    Marker Score: 1,173
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.67
    Marker Score: 612
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 170
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.66
    Marker Score: 1,582
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.65
    Marker Score: 13,887
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.65
    Marker Score: 2,997
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.63
    Marker Score: 4,075
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.62
    Marker Score: 361
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.62
    Marker Score: 772
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.61
    Marker Score: 367
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.61
    Marker Score: 2,611
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.6
    Marker Score: 337
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.6
    Marker Score: 188
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.59
    Marker Score: 1,134
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.59
    Marker Score: 561
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.58
    Marker Score: 134
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.58
    Marker Score: 384
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.58
    Marker Score: 339
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.58
    Marker Score: 183
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.57
    Marker Score: 498
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.57
    Marker Score: 200
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.57
    Marker Score: 2,378
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.57
    Marker Score: 229
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.56
    Marker Score: 271
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.55
    Marker Score: 2,321
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.55
    Marker Score: 161
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.54
    Marker Score: 162
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.54
    Marker Score: 664
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 427
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.53
    Marker Score: 205
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.53
    Marker Score: 222
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.51
    Marker Score: 187
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.5
    Marker Score: 3,032
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.5
    Marker Score: 128
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.5
    Marker Score: 540
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.5
    Marker Score: 486
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.49
    Marker Score: 135
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.49
    Marker Score: 272
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.48
    Marker Score: 164
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.48
    Marker Score: 741
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.48
    Marker Score: 1,092
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.47
    Marker Score: 435
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.47
    Marker Score: 1,337
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.47
    Marker Score: 2,515
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.47
    Marker Score: 150
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.46
    Marker Score: 447
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.46
    Marker Score: 596
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.46
    Marker Score: 172
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.45
    Marker Score: 109
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.45
    Marker Score: 112
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.45
    Marker Score: 224
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.45
    Marker Score: 143
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.45
    Marker Score: 271
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.44
    Marker Score: 900
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.44
    Marker Score: 1,519

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HCFC2 is a member of the host cell factor (HCF) family, which is involved in regulating gene expression and transcription. The gene is characterized by its ability to form complexes with histone-modifying enzymes, such as WDR5, and its involvement in chromatin remodeling and epigenetic regulation. HCFC2 is also implicated in the regulation of transcription by RNA polymerase II and the negative regulation of transcription by RNA polymerase II. Additionally, HCFC2 is involved in the formation of the MLL1 complex and the regulation of DNA-templated transcription. **Pathways and Functions:** HCFC2 is involved in several key pathways, including: 1. **Antiviral Innate Immune Response**: HCFC2 is involved in the regulation of antiviral responses, particularly in the context of dsRNA-mediated signaling. 2. **Chromatin Remodeling**: HCFC2 forms complexes with histone-modifying enzymes, such as WDR5, to regulate chromatin structure and gene expression. 3. **Gene Expression (Transcription)**: HCFC2 regulates transcription by RNA polymerase II and is involved in the negative regulation of transcription by RNA polymerase II. 4. **Immune Response Involved in Response to Exogenous dsRNA**: HCFC2 is involved in the regulation of immune responses to exogenous dsRNA. 5. **Regulation of Toll-like Receptor 3 Signaling Pathway**: HCFC2 regulates the signaling pathway of Toll-like receptor 3, which is involved in the recognition of viral dsRNA. **Clinical Significance:** The clinical significance of HCFC2 is still being explored, but its involvement in neural development and function suggests that dysregulation of this gene may contribute to neurological disorders. For example, alterations in HCFC2 expression have been observed in neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. Additionally, HCFC2's role in regulating immune responses suggests that it may be involved in autoimmune disorders. In conclusion, HCFC2 is a multifaceted gene that plays a crucial role in various cellular processes, including the antiviral innate immune response, chromatin remodeling, and regulation of gene expression. Its involvement in neural development and function highlights its importance in understanding neurological disorders and developing new therapeutic strategies. **Potential Therapeutic Applications:** Given its role in regulating gene expression and chromatin remodeling, HCFC2 may be a potential target for the treatment of various diseases, including: 1. **Neurological Disorders**: Dysregulation of HCFC2 expression has been observed in neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. 2. **Autoimmune Disorders**: HCFC2's role in regulating immune responses suggests that it may be involved in autoimmune disorders such as multiple sclerosis. 3. **Cancer**: HCFC2's involvement in chromatin remodeling and gene expression regulation suggests that it may be a potential target for cancer therapy. Further research is needed to fully understand the functions and potential therapeutic applications of HCFC2.

Genular Protein ID: 3195061499

Symbol: HCFC2_HUMAN

Name: Host cell factor 2

UniProtKB Accession Codes:

Q9Y5Z7 B2R8Q5 C0H5X3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 4 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 19 Gene3D 3 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10196288

Title: Herpes simplex virus transactivator VP16 discriminates between HCF-1 and a novel family member, HCF-2.

PubMed ID: 10196288

DOI: 10.1128/jvi.73.5.3930-3940.1999

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15199122

Title: Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression.

PubMed ID: 15199122

DOI: 10.1128/mcb.24.13.5639-5649.2004

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 792
  • Mass: 86779
  • Checksum: EADF5FF25F70856C
  • Sequence:
    • MAAPSLLNWR RVSSFTGPVP RARHGHRAVA IRELMIIFGG GNEGIADELH VYNTATNQWF 
LPAVRGDIPP GCAAHGFVCD GTRILVFGGM VEYGRYSNEL YELQASRWLW KKVKPHPPPS 
GLPPCPRLGH SFSLYGNKCY LFGGLANESE DSNNNVPRYL NDFYELELQH GSGVVGWSIP 
VTKGVVPSPR ESHTAVIYCK KDSGSPKMYV FGGMCGARLD DLWQLDLETM SWSKPETKGT 
VPLPRSLHTA SVIGNKMYIF GGWVPHKGEN TETSPHDCEW RCTSSFSYLN LDTTEWTTLV 
SDSQEDKKNS RPRPRAGHCA VAIGTRLYFW SGRDGYKKAL NSQVCCKDLW YLDTEKPPAP 
SQVQLIKATT NSFHVKWDEV STVEGYLLQL STDLPYQAAS SDSSAAPNMQ GVRMDPHRQG 
SNNIVPNSIN DTINSTKTEQ PATKETSMKN KPDFKALTDS NAILYPSLAS NASNHNSHVV 
DMLRKNEGPH TSANVGVLSS CLDVRTVIPE TSVSSTVSST QTMVTQQTIK TESSSTNGAV 
VKDETSLTTF STKSEVDETY ALPATKISRV ETHATATPFS KETPSNPVAT VKAGERQWCD 
VGIFKNNTAL VSQFYLLPKG KQSISKVGNA DVPDYSLLKK QDLVPGTGYR FRVAAINGCG 
IGPFSKISEF KTCIPGFPGA PSAVRISKNV EGIHLSWEPP TSPSGNILEY SAYLAIRTAQ 
IQDNPSQLVF MRIYCGLKTS CIVTAGQLAN AHIDYTSRPA IVFRISAKNE KGYGPATQVR 
WLQGNNKKAP LN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.