Details for: HCFC2

Gene ID: 29915

Symbol: HCFC2

Ensembl ID: ENSG00000111727

Description: host cell factor C2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 159.5677
    Cell Significance Index: -24.8200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 99.7266
    Cell Significance Index: -25.3000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 54.8374
    Cell Significance Index: -25.8900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 20.6982
    Cell Significance Index: -25.5200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.2129
    Cell Significance Index: -24.6800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.7590
    Cell Significance Index: -20.7600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.5509
    Cell Significance Index: -25.8500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.1769
    Cell Significance Index: -11.3300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0175
    Cell Significance Index: 100.6600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9520
    Cell Significance Index: 190.9700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8969
    Cell Significance Index: 809.8700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.7446
    Cell Significance Index: 57.1400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.6104
    Cell Significance Index: 15.6900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5544
    Cell Significance Index: 198.8500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5420
    Cell Significance Index: 88.1500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5358
    Cell Significance Index: 58.2800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5250
    Cell Significance Index: 33.0900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4878
    Cell Significance Index: 29.9800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4679
    Cell Significance Index: 28.0900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.4673
    Cell Significance Index: 9.1200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.4161
    Cell Significance Index: 6.2700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4001
    Cell Significance Index: 79.4100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3923
    Cell Significance Index: 8.5000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.3851
    Cell Significance Index: 8.4300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3207
    Cell Significance Index: 221.8300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3030
    Cell Significance Index: 17.0000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2962
    Cell Significance Index: 53.3900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2741
    Cell Significance Index: 18.9600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2690
    Cell Significance Index: 7.7500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.2473
    Cell Significance Index: 5.9300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2292
    Cell Significance Index: 31.4800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2276
    Cell Significance Index: 26.5200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1877
    Cell Significance Index: 8.5100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1829
    Cell Significance Index: 12.3000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1378
    Cell Significance Index: 6.1000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1365
    Cell Significance Index: 60.3700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1263
    Cell Significance Index: 3.5300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1254
    Cell Significance Index: 4.7500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1214
    Cell Significance Index: 15.5600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1160
    Cell Significance Index: 5.4100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1156
    Cell Significance Index: 14.2100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0850
    Cell Significance Index: 1.1600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0575
    Cell Significance Index: 2.0200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0538
    Cell Significance Index: 10.2400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0461
    Cell Significance Index: 7.8800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0418
    Cell Significance Index: 18.9600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0372
    Cell Significance Index: 20.3100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0313
    Cell Significance Index: 58.9100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0213
    Cell Significance Index: 13.5500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0046
    Cell Significance Index: 8.5600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0025
    Cell Significance Index: 3.8300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0016
    Cell Significance Index: 2.1200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0059
    Cell Significance Index: -4.3500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0069
    Cell Significance Index: -4.3100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0184
    Cell Significance Index: -13.5000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0209
    Cell Significance Index: -3.0400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0278
    Cell Significance Index: -15.6900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0317
    Cell Significance Index: -23.9900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0567
    Cell Significance Index: -11.9400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0747
    Cell Significance Index: -21.4800
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.0752
    Cell Significance Index: -0.5800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0771
    Cell Significance Index: -4.0500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0905
    Cell Significance Index: -9.2400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1026
    Cell Significance Index: -2.7400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1032
    Cell Significance Index: -5.3600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1043
    Cell Significance Index: -7.3800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1153
    Cell Significance Index: -1.4300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1181
    Cell Significance Index: -13.5300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1230
    Cell Significance Index: -14.5100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1293
    Cell Significance Index: -16.7100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1479
    Cell Significance Index: -3.1500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1764
    Cell Significance Index: -11.3800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1851
    Cell Significance Index: -3.8400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1886
    Cell Significance Index: -19.6400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1899
    Cell Significance Index: -4.0600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2026
    Cell Significance Index: -6.4900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2079
    Cell Significance Index: -5.6600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2120
    Cell Significance Index: -3.1300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2184
    Cell Significance Index: -24.9300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2223
    Cell Significance Index: -13.6300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2277
    Cell Significance Index: -6.1000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2296
    Cell Significance Index: -10.7900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2300
    Cell Significance Index: -5.7500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2323
    Cell Significance Index: -6.6300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2346
    Cell Significance Index: -5.7300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2376
    Cell Significance Index: -17.7100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2784
    Cell Significance Index: -22.0500
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.2855
    Cell Significance Index: -4.1000
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.2997
    Cell Significance Index: -4.3100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.3410
    Cell Significance Index: -5.6200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3507
    Cell Significance Index: -4.1800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3637
    Cell Significance Index: -7.7200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3720
    Cell Significance Index: -6.2300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3867
    Cell Significance Index: -12.3200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3885
    Cell Significance Index: -7.8000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3907
    Cell Significance Index: -12.7900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3961
    Cell Significance Index: -8.2900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.4655
    Cell Significance Index: -9.2100
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.5084
    Cell Significance Index: -6.3400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.5131
    Cell Significance Index: -4.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HCFC2 is a member of the host cell factor (HCF) family, which is involved in regulating gene expression and transcription. The gene is characterized by its ability to form complexes with histone-modifying enzymes, such as WDR5, and its involvement in chromatin remodeling and epigenetic regulation. HCFC2 is also implicated in the regulation of transcription by RNA polymerase II and the negative regulation of transcription by RNA polymerase II. Additionally, HCFC2 is involved in the formation of the MLL1 complex and the regulation of DNA-templated transcription. **Pathways and Functions:** HCFC2 is involved in several key pathways, including: 1. **Antiviral Innate Immune Response**: HCFC2 is involved in the regulation of antiviral responses, particularly in the context of dsRNA-mediated signaling. 2. **Chromatin Remodeling**: HCFC2 forms complexes with histone-modifying enzymes, such as WDR5, to regulate chromatin structure and gene expression. 3. **Gene Expression (Transcription)**: HCFC2 regulates transcription by RNA polymerase II and is involved in the negative regulation of transcription by RNA polymerase II. 4. **Immune Response Involved in Response to Exogenous dsRNA**: HCFC2 is involved in the regulation of immune responses to exogenous dsRNA. 5. **Regulation of Toll-like Receptor 3 Signaling Pathway**: HCFC2 regulates the signaling pathway of Toll-like receptor 3, which is involved in the recognition of viral dsRNA. **Clinical Significance:** The clinical significance of HCFC2 is still being explored, but its involvement in neural development and function suggests that dysregulation of this gene may contribute to neurological disorders. For example, alterations in HCFC2 expression have been observed in neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. Additionally, HCFC2's role in regulating immune responses suggests that it may be involved in autoimmune disorders. In conclusion, HCFC2 is a multifaceted gene that plays a crucial role in various cellular processes, including the antiviral innate immune response, chromatin remodeling, and regulation of gene expression. Its involvement in neural development and function highlights its importance in understanding neurological disorders and developing new therapeutic strategies. **Potential Therapeutic Applications:** Given its role in regulating gene expression and chromatin remodeling, HCFC2 may be a potential target for the treatment of various diseases, including: 1. **Neurological Disorders**: Dysregulation of HCFC2 expression has been observed in neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. 2. **Autoimmune Disorders**: HCFC2's role in regulating immune responses suggests that it may be involved in autoimmune disorders such as multiple sclerosis. 3. **Cancer**: HCFC2's involvement in chromatin remodeling and gene expression regulation suggests that it may be a potential target for cancer therapy. Further research is needed to fully understand the functions and potential therapeutic applications of HCFC2.

Genular Protein ID: 3195061499

Symbol: HCFC2_HUMAN

Name: Host cell factor 2

UniProtKB Accession Codes:

Q9Y5Z7 B2R8Q5 C0H5X3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 4 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 2 ExpressionAtlas 1 GO 19 Gene3D 3 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10196288

Title: Herpes simplex virus transactivator VP16 discriminates between HCF-1 and a novel family member, HCF-2.

PubMed ID: 10196288

DOI: 10.1128/jvi.73.5.3930-3940.1999

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15199122

Title: Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression.

PubMed ID: 15199122

DOI: 10.1128/mcb.24.13.5639-5649.2004

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 792
  • Mass: 86779
  • Checksum: EADF5FF25F70856C
  • Sequence:
    • MAAPSLLNWR RVSSFTGPVP RARHGHRAVA IRELMIIFGG GNEGIADELH VYNTATNQWF 
LPAVRGDIPP GCAAHGFVCD GTRILVFGGM VEYGRYSNEL YELQASRWLW KKVKPHPPPS 
GLPPCPRLGH SFSLYGNKCY LFGGLANESE DSNNNVPRYL NDFYELELQH GSGVVGWSIP 
VTKGVVPSPR ESHTAVIYCK KDSGSPKMYV FGGMCGARLD DLWQLDLETM SWSKPETKGT 
VPLPRSLHTA SVIGNKMYIF GGWVPHKGEN TETSPHDCEW RCTSSFSYLN LDTTEWTTLV 
SDSQEDKKNS RPRPRAGHCA VAIGTRLYFW SGRDGYKKAL NSQVCCKDLW YLDTEKPPAP 
SQVQLIKATT NSFHVKWDEV STVEGYLLQL STDLPYQAAS SDSSAAPNMQ GVRMDPHRQG 
SNNIVPNSIN DTINSTKTEQ PATKETSMKN KPDFKALTDS NAILYPSLAS NASNHNSHVV 
DMLRKNEGPH TSANVGVLSS CLDVRTVIPE TSVSSTVSST QTMVTQQTIK TESSSTNGAV 
VKDETSLTTF STKSEVDETY ALPATKISRV ETHATATPFS KETPSNPVAT VKAGERQWCD 
VGIFKNNTAL VSQFYLLPKG KQSISKVGNA DVPDYSLLKK QDLVPGTGYR FRVAAINGCG 
IGPFSKISEF KTCIPGFPGA PSAVRISKNV EGIHLSWEPP TSPSGNILEY SAYLAIRTAQ 
IQDNPSQLVF MRIYCGLKTS CIVTAGQLAN AHIDYTSRPA IVFRISAKNE KGYGPATQVR 
WLQGNNKKAP LN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.