Details for: GPR132

Gene ID: 29933

Symbol: GPR132

Ensembl ID: ENSG00000183484

Description: G protein-coupled receptor 132

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 39.8598
    Cell Significance Index: -6.2000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 24.5423
    Cell Significance Index: -6.2300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.0529
    Cell Significance Index: -6.2300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 3.5798
    Cell Significance Index: 114.6600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 1.8102
    Cell Significance Index: -5.5600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.7918
    Cell Significance Index: -4.8000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.5718
    Cell Significance Index: -3.4400
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.0452
    Cell Significance Index: 10.4800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.7300
    Cell Significance Index: 11.0000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.2854
    Cell Significance Index: 5.2800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.2506
    Cell Significance Index: 7.3600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2278
    Cell Significance Index: 22.5400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1986
    Cell Significance Index: 12.8100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1880
    Cell Significance Index: 35.7800
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.1832
    Cell Significance Index: 1.9000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1091
    Cell Significance Index: 6.5500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0639
    Cell Significance Index: 6.9500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0228
    Cell Significance Index: 0.6100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0185
    Cell Significance Index: 3.7100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0109
    Cell Significance Index: 16.8300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0106
    Cell Significance Index: 1.2500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0070
    Cell Significance Index: 2.5100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0063
    Cell Significance Index: 11.6000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0041
    Cell Significance Index: 0.5100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0026
    Cell Significance Index: 2.3700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0019
    Cell Significance Index: 3.5300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0003
    Cell Significance Index: 0.0600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0001
    Cell Significance Index: -0.0700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0010
    Cell Significance Index: -0.0600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0023
    Cell Significance Index: -0.0500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0033
    Cell Significance Index: -0.2300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0038
    Cell Significance Index: -5.1100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0049
    Cell Significance Index: -0.8000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0074
    Cell Significance Index: -0.2600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0075
    Cell Significance Index: -5.7100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0076
    Cell Significance Index: -0.2200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0084
    Cell Significance Index: -6.1400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0085
    Cell Significance Index: -6.3000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0093
    Cell Significance Index: -5.9100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0108
    Cell Significance Index: -3.1100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0111
    Cell Significance Index: -6.2900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0124
    Cell Significance Index: -2.4700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0142
    Cell Significance Index: -6.4300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0152
    Cell Significance Index: -0.3800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0183
    Cell Significance Index: -0.3800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0183
    Cell Significance Index: -0.9500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0203
    Cell Significance Index: -0.4400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0241
    Cell Significance Index: -3.0900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0278
    Cell Significance Index: -2.8400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0299
    Cell Significance Index: -1.3600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0302
    Cell Significance Index: -5.1500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0314
    Cell Significance Index: -6.6100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0346
    Cell Significance Index: -4.7500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0352
    Cell Significance Index: -5.1200
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0438
    Cell Significance Index: -0.6400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0455
    Cell Significance Index: -5.3000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0459
    Cell Significance Index: -5.2600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0514
    Cell Significance Index: -6.6400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0545
    Cell Significance Index: -0.9400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0578
    Cell Significance Index: -6.0200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0591
    Cell Significance Index: -2.5700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0726
    Cell Significance Index: -3.4100
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.0750
    Cell Significance Index: -0.5400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0751
    Cell Significance Index: -5.7600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0785
    Cell Significance Index: -5.2800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0802
    Cell Significance Index: -2.2400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0861
    Cell Significance Index: -4.0200
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0862
    Cell Significance Index: -1.2100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0892
    Cell Significance Index: -6.6500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1004
    Cell Significance Index: -2.5800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1032
    Cell Significance Index: -0.9500
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1077
    Cell Significance Index: -1.8300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1137
    Cell Significance Index: -6.3800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1165
    Cell Significance Index: -5.8900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1170
    Cell Significance Index: -4.1000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1297
    Cell Significance Index: -5.7400
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.1306
    Cell Significance Index: -1.6600
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.1320
    Cell Significance Index: -0.7200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1412
    Cell Significance Index: -2.4200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1421
    Cell Significance Index: -5.3800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1439
    Cell Significance Index: -4.7100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1476
    Cell Significance Index: -4.7000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1505
    Cell Significance Index: -2.1600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1540
    Cell Significance Index: -3.2800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1751
    Cell Significance Index: -4.7700
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1769
    Cell Significance Index: -1.7000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1792
    Cell Significance Index: -6.5800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1839
    Cell Significance Index: -2.6700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1926
    Cell Significance Index: -2.9800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1954
    Cell Significance Index: -3.8200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2046
    Cell Significance Index: -4.4200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2046
    Cell Significance Index: -6.4700
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.2047
    Cell Significance Index: -2.8400
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.2054
    Cell Significance Index: -2.7300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2073
    Cell Significance Index: -5.1700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2134
    Cell Significance Index: -5.1700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2161
    Cell Significance Index: -5.7700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2165
    Cell Significance Index: -5.5300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2187
    Cell Significance Index: -5.8600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2224
    Cell Significance Index: -6.5500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GPR132 exhibits several distinct features that set it apart from other GPCRs: 1. **Tissue specificity**: GPR132 is predominantly expressed in colon goblet cells, enterocytes, cardiac endothelial cells, and specific neural cell types, such as GABAergic interneurons and radial glial cells. 2. **GPCR family**: GPR132 belongs to the Class A/1 rhodopsin-like receptor family, which is characterized by a characteristic seven-transmembrane domain structure. 3. **Signaling pathways**: GPR132 is involved in various signaling pathways, including Gαq signaling events, GPCR downstream signaling, and negative regulation of the G2/M transition of the mitotic cell cycle. **Pathways and Functions:** The GPR132 receptor's signaling pathways are multifaceted, reflecting its role in modulating immune responses and cell cycle regulation: 1. **Gαq signaling**: GPR132 activates the Gαq protein, which in turn triggers various downstream signaling events, including the activation of phospholipase C (PLC) and the production of inositol trisphosphate (IP3) and diacylglycerol (DAG). 2. **GPCR downstream signaling**: GPR132's signaling pathway converges with other GPCR signaling pathways, influencing cell proliferation, differentiation, and survival. 3. **Negative regulation of the G2/M transition**: GPR132's signaling pathway inhibits the G2/M transition of the mitotic cell cycle, which is crucial for cell proliferation and differentiation. **Clinical Significance:** The discovery of GPR132's role in immune regulation and cell cycle control has significant implications for our understanding of various diseases, including: 1. **Immunological disorders**: GPR132's involvement in immune responses suggests its potential role in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Cancer**: The GPR132 receptor's ability to regulate cell proliferation and differentiation makes it a promising target for cancer therapy. 3. **Neurological disorders**: GPR132's expression in neural cells and its involvement in GABAergic signaling suggest its potential role in neurological disorders, such as epilepsy and schizophrenia. In conclusion, GPR132 is a novel GPCR that plays a crucial role in modulating immune responses and cell cycle regulation. Further research is necessary to fully elucidate the mechanisms underlying GPR132's functions and to explore its potential therapeutic applications.

Genular Protein ID: 2339859454

Symbol: GP132_HUMAN

Name: Probable G-protein coupled receptor 132

UniProtKB Accession Codes:

Q9UNW8 A8K7X7 B4E144 Q9BSU2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 EMDB 4 Ensembl 3 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 4 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9770487

Title: A DNA damage and stress inducible G protein-coupled receptor blocks cells in G2/M.

PubMed ID: 9770487

DOI: 10.1073/pnas.95.21.12334

PubMed ID: 19855098

Title: Identification and analysis of two splice variants of human G2A generated by alternative splicing.

PubMed ID: 19855098

DOI: 10.1124/jpet.109.158758

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11474113

Title: Lysophosphatidylcholine as a ligand for the immunoregulatory receptor G2A.

PubMed ID: 11474113

DOI: 10.1126/science.1061781

PubMed ID: 15653487

Title:

PubMed ID: 15653487

DOI: 10.1126/science.307.5707.206b

PubMed ID: 12482833

Title: Expression of G2A, a receptor for lysophosphatidylcholine, by macrophages in murine, rabbit, and human atherosclerotic plaques.

PubMed ID: 12482833

DOI: 10.1161/01.atv.0000040598.18570.54

PubMed ID: 12586833

Title: The lysophospholipid receptor G2A activates a specific combination of G proteins and promotes apoptosis.

PubMed ID: 12586833

DOI: 10.1074/jbc.m209101200

Sequence Information:

  • Length: 380
  • Mass: 42499
  • Checksum: 6DE63D17275ECD74
  • Sequence:
    • MCPMLLKNGY NGNATPVTTT APWASLGLSA KTCNNVSFEE SRIVLVVVYS AVCTLGVPAN 
CLTAWLALLQ VLQGNVLAVY LLCLALCELL YTGTLPLWVI YIRNQHRWTL GLLACKVTAY 
IFFCNIYVSI LFLCCISCDR FVAVVYALES RGRRRRRTAI LISACIFILV GIVHYPVFQT 
EDKETCFDML QMDSRIAGYY YARFTVGFAI PLSIIAFTNH RIFRSIKQSM GLSAAQKAKV 
KHSAIAVVVI FLVCFAPYHL VLLVKAAAFS YYRGDRNAMC GLEERLYTAS VVFLCLSTVN 
GVADPIIYVL ATDHSRQEVS RIHKGWKEWS MKTDVTRLTH SRDTEELQSP VALADHYTFS 
RPVHPPGSPC PAKRLIEESC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.