Details for: GPR132

Gene ID: 29933

Symbol: GPR132

Ensembl ID: ENSG00000183484

Description: G protein-coupled receptor 132

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.58
    Marker Score: 1,147
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.33
    Marker Score: 1,323
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.31
    Marker Score: 2,479
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.23
    Marker Score: 835
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4,782
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.06
    Marker Score: 488
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.04
    Marker Score: 2,114
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.01
    Marker Score: 606
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,788
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,013
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,405
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 494
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 448
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,410
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,320
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,731
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.9
    Marker Score: 362
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 316
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.88
    Marker Score: 364
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,283
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.82
    Marker Score: 12,753
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,244
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 695
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 580
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 385
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.73
    Marker Score: 236
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7
    Marker Score: 448
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.68
    Marker Score: 781
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.67
    Marker Score: 336
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.59
    Marker Score: 179
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.59
    Marker Score: 5,829
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.58
    Marker Score: 547
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.56
    Marker Score: 791
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.55
    Marker Score: 169
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.54
    Marker Score: 1,393
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.52
    Marker Score: 564
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.49
    Marker Score: 1,231
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.49
    Marker Score: 25,871
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.49
    Marker Score: 203
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.46
    Marker Score: 271
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.46
    Marker Score: 25,768
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.45
    Marker Score: 1,413
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.45
    Marker Score: 440
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.44
    Marker Score: 304
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.44
    Marker Score: 157
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.43
    Marker Score: 419
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.43
    Marker Score: 115
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.42
    Marker Score: 1,024
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.42
    Marker Score: 134
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.42
    Marker Score: 306
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.42
    Marker Score: 356
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.41
    Marker Score: 800
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.41
    Marker Score: 650
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.4
    Marker Score: 2,441
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.4
    Marker Score: 163
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.39
    Marker Score: 1,108
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.39
    Marker Score: 426
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 0.39
    Marker Score: 460
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.39
    Marker Score: 186
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.39
    Marker Score: 419
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.39
    Marker Score: 234
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.39
    Marker Score: 418
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.37
    Marker Score: 211
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.36
    Marker Score: 360
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.36
    Marker Score: 395
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.35
    Marker Score: 734
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.35
    Marker Score: 2,266
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.34
    Marker Score: 228
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.34
    Marker Score: 197
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.34
    Marker Score: 90
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.33
    Marker Score: 253
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.33
    Marker Score: 211
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.33
    Marker Score: 214
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.32
    Marker Score: 286
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.31
    Marker Score: 568
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.31
    Marker Score: 243
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.31
    Marker Score: 550
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.31
    Marker Score: 1,275
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.31
    Marker Score: 292
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.31
    Marker Score: 152
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.29
    Marker Score: 406
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.29
    Marker Score: 91
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.29
    Marker Score: 122
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.29
    Marker Score: 124
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.29
    Marker Score: 103
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.28
    Marker Score: 98
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.28
    Marker Score: 169
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.28
    Marker Score: 366
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.28
    Marker Score: 62
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.28
    Marker Score: 161
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.28
    Marker Score: 260
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.28
    Marker Score: 2,797
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.28
    Marker Score: 168
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.28
    Marker Score: 202
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.27
    Marker Score: 199
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.27
    Marker Score: 478
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.27
    Marker Score: 60
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.27
    Marker Score: 611

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GPR132 exhibits several distinct features that set it apart from other GPCRs: 1. **Tissue specificity**: GPR132 is predominantly expressed in colon goblet cells, enterocytes, cardiac endothelial cells, and specific neural cell types, such as GABAergic interneurons and radial glial cells. 2. **GPCR family**: GPR132 belongs to the Class A/1 rhodopsin-like receptor family, which is characterized by a characteristic seven-transmembrane domain structure. 3. **Signaling pathways**: GPR132 is involved in various signaling pathways, including Gαq signaling events, GPCR downstream signaling, and negative regulation of the G2/M transition of the mitotic cell cycle. **Pathways and Functions:** The GPR132 receptor's signaling pathways are multifaceted, reflecting its role in modulating immune responses and cell cycle regulation: 1. **Gαq signaling**: GPR132 activates the Gαq protein, which in turn triggers various downstream signaling events, including the activation of phospholipase C (PLC) and the production of inositol trisphosphate (IP3) and diacylglycerol (DAG). 2. **GPCR downstream signaling**: GPR132's signaling pathway converges with other GPCR signaling pathways, influencing cell proliferation, differentiation, and survival. 3. **Negative regulation of the G2/M transition**: GPR132's signaling pathway inhibits the G2/M transition of the mitotic cell cycle, which is crucial for cell proliferation and differentiation. **Clinical Significance:** The discovery of GPR132's role in immune regulation and cell cycle control has significant implications for our understanding of various diseases, including: 1. **Immunological disorders**: GPR132's involvement in immune responses suggests its potential role in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Cancer**: The GPR132 receptor's ability to regulate cell proliferation and differentiation makes it a promising target for cancer therapy. 3. **Neurological disorders**: GPR132's expression in neural cells and its involvement in GABAergic signaling suggest its potential role in neurological disorders, such as epilepsy and schizophrenia. In conclusion, GPR132 is a novel GPCR that plays a crucial role in modulating immune responses and cell cycle regulation. Further research is necessary to fully elucidate the mechanisms underlying GPR132's functions and to explore its potential therapeutic applications.

Genular Protein ID: 2339859454

Symbol: GP132_HUMAN

Name: Probable G-protein coupled receptor 132

UniProtKB Accession Codes:

Q9UNW8 A8K7X7 B4E144 Q9BSU2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 Ensembl 3 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PRINTS 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 4 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9770487

Title: A DNA damage and stress inducible G protein-coupled receptor blocks cells in G2/M.

PubMed ID: 9770487

DOI: 10.1073/pnas.95.21.12334

PubMed ID: 19855098

Title: Identification and analysis of two splice variants of human G2A generated by alternative splicing.

PubMed ID: 19855098

DOI: 10.1124/jpet.109.158758

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11474113

Title: Lysophosphatidylcholine as a ligand for the immunoregulatory receptor G2A.

PubMed ID: 11474113

DOI: 10.1126/science.1061781

PubMed ID: 15653487

Title:

PubMed ID: 15653487

DOI: 10.1126/science.307.5707.206b

PubMed ID: 12482833

Title: Expression of G2A, a receptor for lysophosphatidylcholine, by macrophages in murine, rabbit, and human atherosclerotic plaques.

PubMed ID: 12482833

DOI: 10.1161/01.atv.0000040598.18570.54

PubMed ID: 12586833

Title: The lysophospholipid receptor G2A activates a specific combination of G proteins and promotes apoptosis.

PubMed ID: 12586833

DOI: 10.1074/jbc.m209101200

Sequence Information:

  • Length: 380
  • Mass: 42499
  • Checksum: 6DE63D17275ECD74
  • Sequence:
    • MCPMLLKNGY NGNATPVTTT APWASLGLSA KTCNNVSFEE SRIVLVVVYS AVCTLGVPAN 
CLTAWLALLQ VLQGNVLAVY LLCLALCELL YTGTLPLWVI YIRNQHRWTL GLLACKVTAY 
IFFCNIYVSI LFLCCISCDR FVAVVYALES RGRRRRRTAI LISACIFILV GIVHYPVFQT 
EDKETCFDML QMDSRIAGYY YARFTVGFAI PLSIIAFTNH RIFRSIKQSM GLSAAQKAKV 
KHSAIAVVVI FLVCFAPYHL VLLVKAAAFS YYRGDRNAMC GLEERLYTAS VVFLCLSTVN 
GVADPIIYVL ATDHSRQEVS RIHKGWKEWS MKTDVTRLTH SRDTEELQSP VALADHYTFS 
RPVHPPGSPC PAKRLIEESC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.