ANAPC4 | ENSG00000053900 | NCBI 29945

Details for: ANAPC4

Gene ID: 29945

Symbol: ANAPC4

Ensembl ID: ENSG00000053900

Description: anaphase promoting complex subunit 4

Associated with

Aberrant regulation of mitotic cell cycle due to rb1 defects
(R-HSA-9687139)
Aberrant regulation of mitotic exit in cancer due to rb1 defects
(R-HSA-9687136)
Activation of apc/c and apc/c:cdc20 mediated degradation of mitotic proteins
(R-HSA-176814)
Adaptive immune system
(R-HSA-1280218)
Antigen processing: ubiquitination & proteasome degradation
(R-HSA-983168)
Apc-cdc20 mediated degradation of nek2a
(R-HSA-179409)
Apc/c-mediated degradation of cell cycle proteins
(R-HSA-174143)
Apc/c:cdc20 mediated degradation of cyclin b
(R-HSA-174048)
Apc/c:cdc20 mediated degradation of mitotic proteins
(R-HSA-176409)
Apc/c:cdc20 mediated degradation of securin
(R-HSA-174154)
Apc/c:cdh1 mediated degradation of cdc20 and other apc/c:cdh1 targeted proteins in late mitosis/early g1
(R-HSA-174178)
Apc:cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
(R-HSA-179419)
Assembly of the pre-replicative complex
(R-HSA-68867)
Autodegradation of cdh1 by cdh1:apc/c
(R-HSA-174084)
Cdc20:phospho-apc/c mediated degradation of cyclin a
(R-HSA-174184)
Cdk-mediated phosphorylation and removal of cdc6
(R-HSA-69017)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Conversion from apc/c:cdc20 to apc/c:cdh1 in late anaphase
(R-HSA-176407)
Disease
(R-HSA-1643685)
Diseases of mitotic cell cycle
(R-HSA-9675126)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Immune system
(R-HSA-168256)
Inactivation of apc/c via direct inhibition of the apc/c complex
(R-HSA-141430)
Inhibition of the proteolytic activity of apc/c required for the onset of anaphase by mitotic spindle checkpoint components
(R-HSA-141405)
Mitotic anaphase
(R-HSA-68882)
Mitotic metaphase and anaphase
(R-HSA-2555396)
Mitotic spindle checkpoint
(R-HSA-69618)
M phase
(R-HSA-68886)
Phosphorylation of the apc/c
(R-HSA-176412)
Regulation of apc/c activators between g1/s and early anaphase
(R-HSA-176408)
Rna polymerase ii transcription
(R-HSA-73857)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Separation of sister chromatids
(R-HSA-2467813)
S phase
(R-HSA-69242)
Switching of origins to a post-replicative state
(R-HSA-69052)
Synthesis of dna
(R-HSA-69239)
Transcriptional regulation by ventx
(R-HSA-8853884)
Anaphase-promoting complex
(GO:0005680)
Anaphase-promoting complex-dependent catabolic process
(GO:0031145)
Cell division
(GO:0051301)
Cytosol
(GO:0005829)
Nuclear periphery
(GO:0034399)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Protein branched polyubiquitination
(GO:0141198)
Protein k11-linked ubiquitination
(GO:0070979)
Protein k48-linked ubiquitination
(GO:0070936)
Protein phosphatase binding
(GO:0019903)
Regulation of meiotic cell cycle
(GO:0051445)
Regulation of mitotic cell cycle
(GO:0007346)
Regulation of mitotic metaphase/anaphase transition
(GO:0030071)
Ubiquitin-protein transferase activity
(GO:0004842)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 160.2749
Cell Significance Index: -24.9300
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 95.6461
Cell Significance Index: -24.2600
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 63.7581
Cell Significance Index: -26.2700
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 56.1930
Cell Significance Index: -26.5300
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 54.2760
Cell Significance Index: -22.0500
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 23.2000
Cell Significance Index: -22.1500
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 21.3471
Cell Significance Index: -26.3200
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 8.8769
Cell Significance Index: -23.7800
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 8.0190
Cell Significance Index: -24.6300
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 6.7371
Cell Significance Index: -26.5900
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 6.4014
Cell Significance Index: -14.0100
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.1628
Cell Significance Index: 233.2500
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.8619
Cell Significance Index: 140.1800
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.8453
Cell Significance Index: 91.9500
Cell Name: decidual cell (CL2000002)
Fold Change: 0.7741
Cell Significance Index: 12.4200
Cell Name: peg cell (CL4033014)
Fold Change: 0.6850
Cell Significance Index: 15.8300
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.6676
Cell Significance Index: 239.4600
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.6401
Cell Significance Index: 38.4300
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.6306
Cell Significance Index: 569.3400
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.6183
Cell Significance Index: 17.2800
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.6056
Cell Significance Index: 120.1800
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.5387
Cell Significance Index: 7.3500
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.4556
Cell Significance Index: 20.6500
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.4320
Cell Significance Index: 235.9300
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.4069
Cell Significance Index: 8.8200
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.4063
Cell Significance Index: 28.1000
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4053
Cell Significance Index: 40.0900
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.3744
Cell Significance Index: 23.0100
Cell Name: preadipocyte (CL0002334)
Fold Change: 0.3633
Cell Significance Index: 7.0900
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.3591
Cell Significance Index: 10.3500
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.3507
Cell Significance Index: 63.2300
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.3275
Cell Significance Index: 38.1700
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.3203
Cell Significance Index: 16.6400
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.2941
Cell Significance Index: 36.1700
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.2835
Cell Significance Index: 15.9100
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.2197
Cell Significance Index: 30.1700
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.1882
Cell Significance Index: 130.1600
Cell Name: cortical interneuron (CL0008031)
Fold Change: 0.1785
Cell Significance Index: 4.2800
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1693
Cell Significance Index: 74.8300
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.1677
Cell Significance Index: 12.8700
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.1545
Cell Significance Index: 8.0500
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.1225
Cell Significance Index: 5.7100
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0929
Cell Significance Index: 17.6800
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.0876
Cell Significance Index: 5.8900
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0822
Cell Significance Index: 154.8500
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.0784
Cell Significance Index: 5.0600
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0764
Cell Significance Index: 1.9100
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0682
Cell Significance Index: 2.4000
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.0551
Cell Significance Index: 6.5000
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.0476
Cell Significance Index: 1.3000
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0315
Cell Significance Index: 20.0000
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0195
Cell Significance Index: 35.9800
Cell Name: odontoblast (CL0000060)
Fold Change: 0.0176
Cell Significance Index: 2.2600
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0159
Cell Significance Index: 24.4800
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0034
Cell Significance Index: 1.5500
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.0015
Cell Significance Index: 0.0400
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0034
Cell Significance Index: -4.6700
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0054
Cell Significance Index: -0.2400
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0201
Cell Significance Index: -14.7400
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0211
Cell Significance Index: -3.0600
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0228
Cell Significance Index: -1.6100
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0230
Cell Significance Index: -0.8700
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0257
Cell Significance Index: -1.6200
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0297
Cell Significance Index: -22.5000
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0315
Cell Significance Index: -23.3700
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0462
Cell Significance Index: -26.0400
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0477
Cell Significance Index: -29.8000
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0539
Cell Significance Index: -2.5400
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0555
Cell Significance Index: -9.4800
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0700
Cell Significance Index: -1.4900
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0760
Cell Significance Index: -7.7600
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0805
Cell Significance Index: -23.1500
Cell Name: lactocyte (CL0002325)
Fold Change: -0.1091
Cell Significance Index: -14.0900
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.1169
Cell Significance Index: -2.4300
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1388
Cell Significance Index: -29.2400
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.1573
Cell Significance Index: -4.2200
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1601
Cell Significance Index: -18.3400
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.1689
Cell Significance Index: -5.4100
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.2032
Cell Significance Index: -15.1500
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2071
Cell Significance Index: -21.5600
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.2383
Cell Significance Index: -6.8000
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.2480
Cell Significance Index: -6.5200
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.2550
Cell Significance Index: -8.8600
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.2602
Cell Significance Index: -13.6600
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.2617
Cell Significance Index: -5.7300
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.2892
Cell Significance Index: -4.8400
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.2897
Cell Significance Index: -4.1600
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2906
Cell Significance Index: -23.0200
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.3180
Cell Significance Index: -6.7500
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.3274
Cell Significance Index: -5.6100
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.3566
Cell Significance Index: -21.8600
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.3735
Cell Significance Index: -9.6000
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.3856
Cell Significance Index: -19.4900
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.3987
Cell Significance Index: -5.7100
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.4015
Cell Significance Index: -8.0600
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.4283
Cell Significance Index: -12.5800
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.4297
Cell Significance Index: -14.0700
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.4499
Cell Significance Index: -14.3300
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.4612
Cell Significance Index: -9.1200
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.4748
Cell Significance Index: -12.1300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** ANAPC4 is a subunit of the APC complex, which is composed of multiple subunits. The APC complex is a large protein complex that plays a central role in regulating the mitotic cell cycle. ANAPC4 is a key component of the APC complex, and its expression is tightly regulated during the cell cycle. ANAPC4 is also involved in the regulation of the adaptive immune response, particularly in the processing and presentation of antigens. **Pathways and Functions:** ANAPC4 is involved in several key pathways, including: 1. **Aberrant regulation of mitotic cell cycle due to rb1 defects:** ANAPC4 plays a crucial role in regulating the mitotic cell cycle, particularly in the progression from metaphase to anaphase. Mutations in the retinoblastoma (rb1) gene can lead to aberrant regulation of the mitotic cell cycle, resulting in cancer. 2. **Activation of apc/c and apc/c:cdc20 mediated degradation of mitotic proteins:** ANAPC4 is involved in the activation of the APC complex, which leads to the degradation of mitotic proteins, ensuring proper cell division. 3. **Adaptive immune system:** ANAPC4 is involved in the processing and presentation of antigens, particularly through the ubiquitin-protein transferase activity of the APC complex. 4. **Antigen processing: ubiquitination & proteasome degradation:** ANAPC4 is involved in the ubiquitination and degradation of antigens, which is essential for the adaptive immune response. **Clinical Significance:** ANAPC4 has significant clinical implications, particularly in the context of cancer and immune-related disorders. Mutations in the ANAPC4 gene have been associated with cancer, including breast, lung, and colon cancer. Additionally, ANAPC4 has been implicated in autoimmune disorders, such as multiple sclerosis and type 1 diabetes. In cancer, ANAPC4 mutations can lead to aberrant regulation of the mitotic cell cycle, resulting in uncontrolled cell division and tumor growth. In autoimmune disorders, ANAPC4 may play a role in the dysregulation of the adaptive immune response, leading to tissue damage and disease. **Conclusion:** In conclusion, ANAPC4 is a critical component of the APC complex, which plays a central role in regulating the mitotic cell cycle and adaptive immune response. Its dysregulation has significant clinical implications, particularly in the context of cancer and autoimmune disorders. Further research is needed to fully understand the role of ANAPC4 in these processes and to explore its potential as a therapeutic target. **Recommendations:** 1. Further research is needed to fully understand the role of ANAPC4 in the mitotic cell cycle and adaptive immune response. 2. The development of therapeutic strategies targeting ANAPC4 may be beneficial in treating cancer and autoimmune disorders. 3. The study of ANAPC4 in the context of disease may provide insights into the underlying mechanisms of these disorders and lead to the development of new treatments.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Anaphase-promoting complex subunit 4
B3KN47_HUMAN

Genular Protein ID: 220585651

Symbol: APC4_HUMAN

Name: Anaphase-promoting complex subunit 4

UniProtKB Accession Codes:

Q9UJX5 A8K8H1 E9PCR4 Q6PCC6 Q9NSH6

Database IDs:

Citations:

PubMed ID: 9469815

Title: Identification of a cullin homology region in a subunit of the anaphase-promoting complex.

PubMed ID: 9469815

DOI: 10.1126/science.279.5354.1219

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 14657031

Title: Mitotic regulation of the human anaphase-promoting complex by phosphorylation.

PubMed ID: 14657031

DOI: 10.1093/emboj/cdg627

PubMed ID: 18485873

Title: Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex.

PubMed ID: 18485873

DOI: 10.1016/j.cell.2008.04.012

PubMed ID: 18445686

Title: EML3 is a nuclear microtubule-binding protein required for the correct alignment of chromosomes in metaphase.

PubMed ID: 18445686

DOI: 10.1242/jcs.019174

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 29033132

Title: Assembly and function of heterotypic ubiquitin chains in cell-cycle and protein quality control.

PubMed ID: 29033132

DOI: 10.1016/j.cell.2017.09.040

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 34595750

Title: A homozygous loss-of-function mutation in FBXO43 causes human non-obstructive azoospermia.

PubMed ID: 34595750

DOI: 10.1111/cge.14069

PubMed ID: 16364912

Title: Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C.

PubMed ID: 16364912

DOI: 10.1016/j.molcel.2005.11.008

PubMed ID: 25043029

Title: Molecular architecture and mechanism of the anaphase-promoting complex.

PubMed ID: 25043029

DOI: 10.1038/nature13543

PubMed ID: 26083744

Title: Atomic structure of the APC/C and its mechanism of protein ubiquitination.

PubMed ID: 26083744

DOI: 10.1038/nature14471

PubMed ID: 27259151

Title: Dual RING E3 architectures regulate multiubiquitination and ubiquitin chain elongation by APC/C.

PubMed ID: 27259151

DOI: 10.1016/j.cell.2016.05.037

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

Length: 808
Mass: 92116
Checksum: 80362CC8D8B2063F
Sequence:

MLRFPTCFPS FRVVGEKQLP QEIIFLVWSP KRDLIALANT AGEVLLHRLA SFHRVWSFPP 
NENTGKEVTC LAWRPDGKLL AFALADTKKI VLCDVEKPES LHSFSVEAPV SCMHWMEVTV 
ESSVLTSFYN AEDESNLLLP KLPTLPKNYS NTSKIFSEEN SDEIIKLLGD VRLNILVLGG 
SSGFIELYAY GMFKIARVTG IAGTCLALCL SSDLKSLSVV TEVSTNGASE VSYFQLETNL 
LYSFLPEVTR MARKFTHISA LLQYINLSLT CMCEAWEEIL MQMDSRLTKF VQEKNTTTSV 
QDEFMHLLLW GKASAELQTL LMNQLTVKGL KKLGQSIESS YSSIQKLVIS HLQSGSESLL 
YHLSELKGMA SWKQKYEPLG LDAAGIEEAI TAVGSFILKA NELLQVIDSS MKNFKAFFRW 
LYVAMLRMTE DHVLPELNKM TQKDITFVAE FLTEHFNEAP DLYNRKGKYF NVERVGQYLK 
DEDDDLVSPP NTEGNQWYDF LQNSSHLKES PLLFPYYPRK SLHFVKRRME NIIDQCLQKP 
ADVIGKSMNQ AICIPLYRDT RSEDSTRRLF KFPFLWNNKT SNLHYLLFTI LEDSLYKMCI 
LRRHTDISQS VSNGLIAIKF GSFTYATTEK VRRSIYSCLD AQFYDDETVT VVLKDTVGRE 
GRDRLLVQLP LSLVYNSEDS AEYQFTGTYS TRLDEQCSAI PTRTMHFEKH WRLLESMKAQ 
YVAGNGFRKV SCVLSSNLRH VRVFEMDIDD EWELDESSDE EEEASNKPVK IKEEVLSESE 
AENQQAGAAA LAPEIVIKVE KLDPELDS

Genular Protein ID: 1515147919

Symbol: B3KN47_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KN47

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

Length: 697
Mass: 79600
Checksum: 892D20D0722AEC1A
Sequence:

MHWMEVTVES SVLTSFYNAE DESNLLLPKL PTLPKNYSNT SKIFSEENSD EIIKLLGDVR 
LNILVLGGSS GFIELYAYGM FKIARVTGIA GTCLALCLSS DLKSLSVVTE VSTNGASEVS 
YFQLETNLLY SFLPEVTRMA RKFTHISALL QYINLSLTCM CEAWEEILMQ MDSRLTKFVQ 
EKNTTTSVQD EFMHLLLWGK ASAELQTLLM NQLTVKGLKK LGQSIESSYS SIQKLVISHL 
QSGSESLLYH LSESKGMASW KQKYEPLGLD AAGIEEAITA VGSFILKANE LLQVIDSSMK 
NFKAFFRWLY VAMLRMTEDH VLPELNKVMT QKDITFVAEF LTEHFNEAPD LYNRKGKYFN 
VERVGQYLKD EDDDLVSPPN TEGNQWYDFL QNSSHLKESP LLFPYYPRKS LHFVKRRMEN 
IIDQCLQKPA DVIGKSMNQA ICIPLYRDTR SEDSTRRLFK FPFLWNNKTS NLHYLLFTIL 
EDSLYKMCIL RRHTDISQSV SNGLIAIKFG SFTYATTEKV RRSIYSCLDA QFYDDETVTV 
VLKDTVGREG RDRLLVQLPL SLVYNSEDSA EYQFTGTYST RLDEQCSAIP TRTMHFEKHW 
RLLESMKAQY VAGNGFRKVS CVLSSNLRHV RVFEMDIDDE WELDESSDEE EEASNKPVKI 
KEEVLSESEA ENQQAGAAAL APEIVIKVEK LDPELDS

Database document:

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Details for: ANAPC4

Associated with

Cells (max top 100)

Other Information

Identification of a cullin homology region in a subunit of the anaphase-promoting complex. PubMed ID: 9469815

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

Mitotic regulation of the human anaphase-promoting complex by phosphorylation. PubMed ID: 14657031

Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex. PubMed ID: 18485873

EML3 is a nuclear microtubule-binding protein required for the correct alignment of chromosomes in metaphase. PubMed ID: 18445686

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Assembly and function of heterotypic ubiquitin chains in cell-cycle and protein quality control. PubMed ID: 29033132

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

A homozygous loss-of-function mutation in FBXO43 causes human non-obstructive azoospermia. PubMed ID: 34595750

Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C. PubMed ID: 16364912

Molecular architecture and mechanism of the anaphase-promoting complex. PubMed ID: 25043029

Atomic structure of the APC/C and its mechanism of protein ubiquitination. PubMed ID: 26083744

Dual RING E3 architectures regulate multiubiquitination and ubiquitin chain elongation by APC/C. PubMed ID: 27259151

The consensus coding sequences of human breast and colorectal cancers. PubMed ID: 16959974

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Database document:

PubMed ID: 9469815

PubMed ID: 14702039

PubMed ID: 15489334

PubMed ID: 17974005

PubMed ID: 14657031

PubMed ID: 18485873

PubMed ID: 18445686

PubMed ID: 18669648

PubMed ID: 19690332

PubMed ID: 20068231

PubMed ID: 23186163

PubMed ID: 29033132

PubMed ID: 28112733

PubMed ID: 34595750

PubMed ID: 16364912

PubMed ID: 25043029

PubMed ID: 26083744

PubMed ID: 27259151

PubMed ID: 16959974

PubMed ID: 14702039