Details for: DMGDH
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 69.1760
Cell Significance Index: -10.7600 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 42.6189
Cell Significance Index: -10.8100 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 9.9503
Cell Significance Index: -9.5000 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 8.7635
Cell Significance Index: -10.8100 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 3.9317
Cell Significance Index: 66.2300 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 3.8107
Cell Significance Index: -8.3400 - Cell Name: hepatoblast (CL0005026)
Fold Change: 3.1077
Cell Significance Index: 52.2700 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 2.7597
Cell Significance Index: -10.8900 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.7175
Cell Significance Index: 340.8500 - Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: 1.2758
Cell Significance Index: 12.8700 - Cell Name: adipocyte of breast (CL0002617)
Fold Change: 1.2055
Cell Significance Index: 15.1800 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 1.1752
Cell Significance Index: 31.4900 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.1515
Cell Significance Index: 219.1500 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.9935
Cell Significance Index: 37.6200 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.9884
Cell Significance Index: 43.7200 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.9030
Cell Significance Index: 11.2000 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.8066
Cell Significance Index: 61.9000 - Cell Name: preadipocyte (CL0002334)
Fold Change: 0.7885
Cell Significance Index: 15.3900 - Cell Name: hippocampal astrocyte (CL0002604)
Fold Change: 0.7659
Cell Significance Index: 10.7100 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.7104
Cell Significance Index: 70.2800 - Cell Name: photoreceptor cell (CL0000210)
Fold Change: 0.6967
Cell Significance Index: 9.7900 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.6414
Cell Significance Index: 579.1700 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 0.5344
Cell Significance Index: 15.2500 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.5056
Cell Significance Index: 8.6700 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.5039
Cell Significance Index: 4.6400 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.4644
Cell Significance Index: 26.0600 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.4629
Cell Significance Index: 9.9000 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.3761
Cell Significance Index: 61.1700 - Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 0.3715
Cell Significance Index: 2.8400 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.3654
Cell Significance Index: 39.7500 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.2905
Cell Significance Index: 8.3700 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.2848
Cell Significance Index: 12.9100 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.2761
Cell Significance Index: 99.0200 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.2428
Cell Significance Index: 6.0700 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.2404
Cell Significance Index: 14.4300 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.2209
Cell Significance Index: 13.9200 - Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 0.1745
Cell Significance Index: 1.0100 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.1693
Cell Significance Index: 11.7100 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.1544
Cell Significance Index: 30.9800 - Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 0.1439
Cell Significance Index: 1.9400 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.1394
Cell Significance Index: 262.4000 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.1202
Cell Significance Index: 8.0800 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0938
Cell Significance Index: 42.5600 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0922
Cell Significance Index: 58.5700 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.0757
Cell Significance Index: 1.6400 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0727
Cell Significance Index: 2.5600 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0655
Cell Significance Index: 11.8100 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0568
Cell Significance Index: 104.7600 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.0555
Cell Significance Index: 6.4700 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0487
Cell Significance Index: 74.9400 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0434
Cell Significance Index: 58.9700 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 0.0352
Cell Significance Index: 0.5200 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.0340
Cell Significance Index: 0.9500 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.0174
Cell Significance Index: 0.2500 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0145
Cell Significance Index: 7.9100 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0141
Cell Significance Index: 10.3700 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.0071
Cell Significance Index: 0.9800 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0069
Cell Significance Index: 1.1800 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0051
Cell Significance Index: 3.5500 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0047
Cell Significance Index: 2.0900 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.0031
Cell Significance Index: 0.4500 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0002
Cell Significance Index: -0.0200 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0094
Cell Significance Index: -6.9500 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0112
Cell Significance Index: -0.6900 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0138
Cell Significance Index: -10.4100 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0163
Cell Significance Index: -9.1800 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0181
Cell Significance Index: -0.4700 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0183
Cell Significance Index: -11.4200 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0248
Cell Significance Index: -7.1400 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0260
Cell Significance Index: -3.3300 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0332
Cell Significance Index: -3.4000 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0522
Cell Significance Index: -11.0100 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0557
Cell Significance Index: -5.8000 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0621
Cell Significance Index: -0.8900 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.0627
Cell Significance Index: -0.9400 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.0687
Cell Significance Index: -5.4400 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.0721
Cell Significance Index: -0.8600 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0742
Cell Significance Index: -9.5800 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0766
Cell Significance Index: -3.5700 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0772
Cell Significance Index: -4.0100 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0784
Cell Significance Index: -8.9800 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.0836
Cell Significance Index: -1.1400 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0838
Cell Significance Index: -9.8800 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0838
Cell Significance Index: -3.9400 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0840
Cell Significance Index: -4.4100 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0906
Cell Significance Index: -1.9300 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.1076
Cell Significance Index: -1.8600 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.1192
Cell Significance Index: -1.7600 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1316
Cell Significance Index: -9.8100 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.1378
Cell Significance Index: -6.9600 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.1403
Cell Significance Index: -8.6000 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.1414
Cell Significance Index: -4.5300 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.1446
Cell Significance Index: -3.0000 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: -0.1459
Cell Significance Index: -2.2200 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.1489
Cell Significance Index: -3.5700 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.1521
Cell Significance Index: -4.8500 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.1593
Cell Significance Index: -2.4000 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.1621
Cell Significance Index: -3.5500 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: -0.1653
Cell Significance Index: -2.1200 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.1685
Cell Significance Index: -11.9200
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3231566122
Symbol: M2GD_HUMAN
Name: Dimethylglycine dehydrogenase, mitochondrial
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10767172
Title: Structure and analysis of the human dimethylglycine dehydrogenase gene.
PubMed ID: 10767172
PubMed ID: 11231903
Title: Cloning of dimethylglycine dehydrogenase and a new human inborn error of metabolism, dimethylglycine dehydrogenase deficiency.
PubMed ID: 11231903
DOI: 10.1086/319520
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15372022
Title: The DNA sequence and comparative analysis of human chromosome 5.
PubMed ID: 15372022
DOI: 10.1038/nature02919
PubMed ID: 10102904
Title: Defect in dimethylglycine dehydrogenase, a new inborn error of metabolism: NMR spectroscopy study.
PubMed ID: 10102904
PubMed ID: 27486859
Title: Structure and biochemical properties of recombinant human dimethylglycine dehydrogenase and comparison to the disease-related H109R variant.
PubMed ID: 27486859
DOI: 10.1111/febs.13828
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
Sequence Information:
- Length: 866
- Mass: 96811
- Checksum: 2EC1FA7DCB6C1F8C
- Sequence:
MLRPGAQLLR GLLLRSCPLQ GSPGRPRSVC GREGEEKPPL SAETQWKDRA ETVIIGGGCV GVSLAYHLAK AGMKDVVLLE KSELTAGSTW HAAGLTTYFH PGINLKKIHY DSIKLYEKLE EETGQVVGFH QPGSIRLATT PVRVDEFKYQ MTRTGWHATE QYLIEPEKIQ EMFPLLNMNK VLAGLYNPGD GHIDPYSLTM ALAAGARKCG ALLKYPAPVT SLKARSDGTW DVETPQGSMR ANRIVNAAGF WAREVGKMIG LEHPLIPVQH QYVVTSTISE VKALKRELPV LRDLEGSYYL RQERDGLLFG PYESQEKMKV QDSWVTNGVP PGFGKELFES DLDRIMEHIK AAMEMVPVLK KADIINVVNG PITYSPDILP MVGPHQGVRN YWVAIGFGYG IIHAGGVGKY LSDWILHGEP PFDLIELDPN RYGKWTTTQY TEAKARESYG FNNIVGYPKE ERFAGRPTQR VSGLYQRLES KCSMGFHAGW EQPHWFYKPG QDTQYRPSFR RTNWFEPVGS EYKQVMQRVA VTDLSPFGKF NIKGQDSIRL LDHLFANVIP KVGFTNISHM LTPKGRVYAE LTVSHQSPGE FLLITGSGSE LHDLRWIEEE AVKGGYDVEI KNITDELGVL GVAGPQARKV LQKLTSEDLS DDVFKFLQTK SLKVSNIPVT AIRISYTGEL GWELYHRRED SVALYDAIMN AGQEEGIDNF GTYAMNALRL EKAFRAWGLE MNCDTNPLEA GLEYFVKLNK PADFIGKQAL KQIKAKGLKR RLVCLTLATD DVDPEGNESI WYNGKVVGNT TSGSYSYSIQ KSLAFAYVPV QLSEVGQQVE VELLGKNYPA VIIQEPLVLT EPTRNRLQKK GGKDKT
Genular Protein ID: 3444250781
Symbol: B3KQ84_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
Sequence Information:
- Length: 866
- Mass: 96812
- Checksum: 1031B8E9AFDF60C9
- Sequence:
MLRPGAQLLR GLLLRSCPLQ GSPGRPRSVC GREGEEKPPL SAETQWKDRA ETVIIGGGCV GVSLAYHLAK AGMKDVVLLE KSELTAGSTW HAAGLTTYFH PGINLKKIHY DSIKLYEKLE EETGQVVGFH QPGSIRLATT PVRVDEFKYQ MTRTGWHATE QYLIEPEKIQ EMFPLLNMNK VLAGLYNPGD GHIDPYSLTM ALAAGARKCG ALLKYPAPVT SLKARSDGTW DVETPQGSMR ANRIVNAAGF WAREVGKMIG LEHPLIPVQH QYVVTSTIPE VKALKRELPV LRDLEGSYYL RQERDGLLFG PYESQEKMKV QDSWVTNGVP PGFGKELFES DLDRIMEHIK AAMEMVPVLK KADIINVVNG PITYSPDILP MVGPHQGVRN YWVAIGFGYG IIHAGGVGKY LSDWILHGEP PFDLIELDPN RYGKWTTTQY TEAKARESYG FNNIVGYPKE ERFAGRPTQR VSGLYQRLES KCSMGFRAGW EQPHWFYKPG QDTQYRPSFR RTNWFEPVGS EYKQVMQRVA VTDLSPFGKF NIKGQDSIRL LDHLFANVIP KVGFTNISHM LTPKGRVYAE LTVSHQSPGE FLLITGSGSE LHDLRWIEEE AVKGGYDVEI KNITDELGVL GVAGPQARKV LQKLTSEDLS DDVFKFLQTK SLKVSNIPVT AIRISYTGEL GWELYHRRED SVALYDAIMN AGQEEGIDNF GTYAMNALRL EKAFRAWGLE MNCDTNPLEA GLEYFVKLNK PADFIGKQAL KQIKAKGLKR RLVCLTLATD DVDPEGNESI WYNGKVVGNT TSGSYSYSIQ KSLAFAYVPV QLSEVGQQVE VELLGKNYPA AIIQEPLVLT EPTRNRLQKK GGKDKT
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.