Details for: LRP12

Gene ID: 29967

Symbol: LRP12

Ensembl ID: ENSG00000147650

Description: LDL receptor related protein 12

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 168.6969
    Cell Significance Index: -26.2400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 100.8108
    Cell Significance Index: -25.5700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 60.4689
    Cell Significance Index: -24.9100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 56.2354
    Cell Significance Index: -26.5500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 53.5375
    Cell Significance Index: -21.7500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 22.7915
    Cell Significance Index: -21.7600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 21.3309
    Cell Significance Index: -26.3000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.8213
    Cell Significance Index: -26.3100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.6978
    Cell Significance Index: -26.4300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 3.9442
    Cell Significance Index: 65.0000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.3643
    Cell Significance Index: 104.5800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 2.1194
    Cell Significance Index: 60.4800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.9339
    Cell Significance Index: 73.2300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.8184
    Cell Significance Index: 364.7600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.3885
    Cell Significance Index: 93.3600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.0288
    Cell Significance Index: 369.0100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9623
    Cell Significance Index: 95.1900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.9158
    Cell Significance Index: 51.3900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.8685
    Cell Significance Index: 66.6500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7082
    Cell Significance Index: 639.4900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.6895
    Cell Significance Index: 14.6900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6127
    Cell Significance Index: 423.8000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.6063
    Cell Significance Index: 16.2500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.5984
    Cell Significance Index: 36.7800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.5299
    Cell Significance Index: 15.1900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5027
    Cell Significance Index: 81.7600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.4568
    Cell Significance Index: 10.9600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4559
    Cell Significance Index: 49.5900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.4384
    Cell Significance Index: 5.4400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3621
    Cell Significance Index: 4.9400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3461
    Cell Significance Index: 20.7800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3209
    Cell Significance Index: 8.0200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.2877
    Cell Significance Index: 4.6200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2699
    Cell Significance Index: 119.3200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2071
    Cell Significance Index: 28.4400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1718
    Cell Significance Index: 11.8800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.1513
    Cell Significance Index: 3.8900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1284
    Cell Significance Index: 2.2000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1084
    Cell Significance Index: 19.5400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0870
    Cell Significance Index: 47.4900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0814
    Cell Significance Index: 15.5000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0791
    Cell Significance Index: 3.6900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0717
    Cell Significance Index: 3.2500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0477
    Cell Significance Index: 1.3800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0320
    Cell Significance Index: 2.2600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0159
    Cell Significance Index: 7.2000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0125
    Cell Significance Index: 1.4600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0108
    Cell Significance Index: 2.1500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0054
    Cell Significance Index: 10.2000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0026
    Cell Significance Index: 1.6400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0014
    Cell Significance Index: 2.1600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0042
    Cell Significance Index: -7.7600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0089
    Cell Significance Index: -12.1600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0106
    Cell Significance Index: -1.3000
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: -0.0235
    Cell Significance Index: -0.1800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0240
    Cell Significance Index: -17.6100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0255
    Cell Significance Index: -18.8900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0267
    Cell Significance Index: -1.6800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0299
    Cell Significance Index: -4.3500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0326
    Cell Significance Index: -24.6900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0397
    Cell Significance Index: -1.4000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0426
    Cell Significance Index: -24.0200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0458
    Cell Significance Index: -28.5700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0469
    Cell Significance Index: -1.3100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0649
    Cell Significance Index: -1.4200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0669
    Cell Significance Index: -1.4500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0736
    Cell Significance Index: -12.5700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0754
    Cell Significance Index: -21.7000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0860
    Cell Significance Index: -11.0300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0901
    Cell Significance Index: -4.6800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0902
    Cell Significance Index: -2.2000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1225
    Cell Significance Index: -6.4300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1271
    Cell Significance Index: -7.7900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1300
    Cell Significance Index: -27.3800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1393
    Cell Significance Index: -4.5600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1572
    Cell Significance Index: -16.0600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1701
    Cell Significance Index: -21.9700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1893
    Cell Significance Index: -21.6900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2110
    Cell Significance Index: -6.7200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2244
    Cell Significance Index: -26.4600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2277
    Cell Significance Index: -3.8100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2293
    Cell Significance Index: -23.8800
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.2649
    Cell Significance Index: -2.5200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2818
    Cell Significance Index: -4.1600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2862
    Cell Significance Index: -7.7900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3074
    Cell Significance Index: -24.3500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3092
    Cell Significance Index: -14.5300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3125
    Cell Significance Index: -6.1800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3150
    Cell Significance Index: -23.4800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3439
    Cell Significance Index: -7.3000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3463
    Cell Significance Index: -18.0400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3631
    Cell Significance Index: -7.2900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3797
    Cell Significance Index: -24.5000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3892
    Cell Significance Index: -8.3200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3922
    Cell Significance Index: -13.6300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4053
    Cell Significance Index: -7.9100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.4300
    Cell Significance Index: -9.2900
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.4565
    Cell Significance Index: -6.0900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4567
    Cell Significance Index: -16.0000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4723
    Cell Significance Index: -12.4200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** LRP12 is a type II transmembrane receptor that belongs to the low-density lipoprotein receptor-related protein (LRP) family. Its primary function is to bind and internalize lipids, including lipoproteins, cholesterol, and fatty acids, facilitating their transport and metabolism. LRP12 is also involved in the regulation of various cellular processes, including cell migration, proliferation, and differentiation. Notably, its expression is highly restricted to specific neuronal populations, suggesting a critical role in neural development and function. **Pathways and Functions:** LRP12 is embedded in multiple signaling pathways, including: 1. **Endocytosis and Lipid Metabolism:** LRP12 mediates the uptake of lipids from the plasma membrane, promoting their transport to lysosomes for degradation or recycling. This process is essential for maintaining lipid homeostasis and regulating lipid-soluble vitamin metabolism. 2. **Neuronal Development and Migration:** LRP12 plays a crucial role in the development and migration of neurons during embryogenesis. Its expression is restricted to specific neuronal populations, and its absence or dysfunction can lead to abnormalities in neuronal migration and positioning. 3. **Visual Phototransduction:** LRP12 has been implicated in the regulation of visual phototransduction, a complex process involving the conversion of light into electrical signals in the retina. 4. **Signal Transduction:** LRP12 can modulate various signaling pathways, including those involved in cell growth, differentiation, and survival. **Clinical Significance:** Dysregulation of LRP12 has been implicated in several diseases and disorders, including: 1. **Atherosclerosis:** LRP12 plays a critical role in lipid metabolism, and its dysfunction can contribute to the development of atherosclerosis. 2. **Neurodegenerative Disorders:** Abnormalities in LRP12 expression and function have been linked to neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Visual Impairment:** Mutations in LRP12 have been associated with visual impairment and blindness. 4. **Cancer:** LRP12 has been implicated in the regulation of cell growth and differentiation, and its dysregulation can contribute to cancer development. In conclusion, LRP12 is a complex gene that plays a multifaceted role in lipid metabolism, neuronal development, and signal transduction. Its dysregulation can contribute to various diseases and disorders, highlighting the need for further research into the molecular mechanisms underlying its function and the development of therapeutic strategies to modulate its activity.

Genular Protein ID: 2736649081

Symbol: LRP12_HUMAN

Name: Low-density lipoprotein receptor-related protein 12

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9927190

Title: Cloning and characterization of a novel gene encoding a putative transmembrane protein with altered expression in some human transformed and tumor-derived cell lines.

PubMed ID: 9927190

DOI: 10.1038/sj.onc.1202290

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12809483

Title: ST7 is a novel low-density lipoprotein receptor-related protein (LRP) with a cytoplasmic tail that interacts with proteins related to signal transduction pathways.

PubMed ID: 12809483

DOI: 10.1021/bi034081y

PubMed ID: 31332380

Title: Noncoding CGG repeat expansions in neuronal intranuclear inclusion disease, oculopharyngodistal myopathy and an overlapping disease.

PubMed ID: 31332380

DOI: 10.1038/s41588-019-0458-z

PubMed ID: 37339631

Title: CGG repeat expansion in LRP12 in amyotrophic lateral sclerosis.

PubMed ID: 37339631

DOI: 10.1016/j.ajhg.2023.05.014

Sequence Information:

  • Length: 859
  • Mass: 94984
  • Checksum: 41A8FD8121E32A92
  • Sequence:
  • MACRWSTKES PRWRSALLLL FLAGVYGNGA LAEHSENVHI SGVSTACGET PEQIRAPSGI 
    ITSPGWPSEY PAKINCSWFI RANPGEIITI SFQDFDIQGS RRCNLDWLTI ETYKNIESYR 
    ACGSTIPPPY ISSQDHIWIR FHSDDNISRK GFRLAYFSGK SEEPNCACDQ FRCGNGKCIP 
    EAWKCNNMDE CGDSSDEEIC AKEANPPTAA AFQPCAYNQF QCLSRFTKVY TCLPESLKCD 
    GNIDCLDLGD EIDCDVPTCG QWLKYFYGTF NSPNYPDFYP PGSNCTWLID TGDHRKVILR 
    FTDFKLDGTG YGDYVKIYDG LEENPHKLLR VLTAFDSHAP LTVVSSSGQI RVHFCADKVN 
    AARGFNATYQ VDGFCLPWEI PCGGNWGCYT EQQRCDGYWH CPNGRDETNC TMCQKEEFPC 
    SRNGVCYPRS DRCNYQNHCP NGSDEKNCFF CQPGNFHCKN NRCVFESWVC DSQDDCGDGS 
    DEENCPVIVP TRVITAAVIG SLICGLLLVI ALGCTCKLYS LRMFERRSFE TQLSRVEAEL 
    LRREAPPSYG QLIAQGLIPP VEDFPVCSPN QASVLENLRL AVRSQLGFTS VRLPMAGRSS 
    NIWNRIFNFA RSRHSGSLAL VSADGDEVVP SQSTSREPER NHTHRSLFSV ESDDTDTENE 
    RRDMAGASGG VAAPLPQKVP PTTAVEATVG ACASSSTQST RGGHADNGRD VTSVEPPSVS 
    PARHQLTSAL SRMTQGLRWV RFTLGRSSSL SQNQSPLRQL DNGVSGREDD DDVEMLIPIS 
    DGSSDFDVND CSRPLLDLAS DQGQGLRQPY NATNPGVRPS NRDGPCERCG IVHTAQIPDT 
    CLEVTLKNET SDDEALLLC

Genular Protein ID: 609178045

Symbol: Q59H02_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 793
  • Mass: 87909
  • Checksum: E3B82E6D458917FA
  • Sequence:
  • ACDYPAKINC SWFIRANPGE IITISFQDFD IQGSRRCNLD WLTIETYKNI ESYRACGSTI 
    PPPYISSQDH IWIRFHSDDN ISRKGFRLAY FSGKSEEPNC ACDQFRCGNG KCIPEAWKCN 
    NMDECGDSSD EEICAKEANP PTAAAFQPCA YNQFQCLSRF TKVYTCLPES LKCDGNIDCL 
    DLGDEIDCDV PTCGQWLKYF YGTFNSPNYP DFYPPGSNCT WLIDTGDHRK VILRFTDFKL 
    DGTGYGDYVK IYDGLEENPH KLLRVLTAFD SHAPLTVVSS SGQIRVHFCA DKVNAARGFN 
    ATYQVDGFCL PWEIPCGGNW GCYTEQQRCD GYWHCPNGRD ETNCTMCQKE EFPCSRNGVC 
    YPRSDRCNYQ NHCPNGSDEK NCFFCQPGNF HCKNNRCVFE SWVCDSQDDC GDGSDEENCP 
    VIVPTRVITA AVIGSLICGL LLVIALGCTC KLYSLRMFER RSFETQLSRV EAELLRREAP 
    PSYGQLIAQG LIPPVEDFPV CSPNQASVLE NLRLAVRSQL GFTSVRLPMA GRSSNIWNRI 
    FNFARSRHSG SLALVSADGD EVVPSQSTSR EPERNHTHRS LFSVESDDTD TENERRDMAG 
    ASGGVAAPLP QKVPPTTAVE ATVGACASSS TQSTRGGHAD NGRDVTSVEP PSVSPARHQL 
    TSALSRMTQG LRWVRFTLGR SSSLSQNQSP LRQLDNGVSG REDDDDVEML IPISDGSSDF 
    DVNDCSRPLL DLASDQGQGL RQPYNATNPG VRPSNRDGPC ERCGIVHTAQ IPDTCLEVTL 
    KNETSDDEAL LLC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.