Gene GYS2 - ENSG00000111713 | NCBI Gene ID: 2998

Details for: GYS2

Gene ID: 2998

Symbol: GYS2

Ensembl ID: ENSG00000111713

Description: glycogen synthase 2

Associated with

Disease
(R-HSA-1643685)
Diseases of carbohydrate metabolism
(R-HSA-5663084)
Diseases of metabolism
(R-HSA-5668914)
Glycogen metabolism
(R-HSA-8982491)
Glycogen storage diseases
(R-HSA-3229121)
Glycogen storage disease type 0 (liver gys2)
(R-HSA-3858516)
Glycogen storage disease type iv (gbe1)
(R-HSA-3878781)
Glycogen synthesis
(R-HSA-3322077)
Metabolism
(R-HSA-1430728)
Metabolism of carbohydrates
(R-HSA-71387)
Cell cortex
(GO:0005938)
Cortical actin cytoskeleton
(GO:0030864)
Cytoplasm
(GO:0005737)
Cytoskeleton
(GO:0005856)
Cytosol
(GO:0005829)
Glycogen (starch) synthase activity
(GO:0004373)
Glycogen biosynthetic process
(GO:0005978)
Glycogen synthase activity, transferring glucose-1-phosphate
(GO:0061547)
Response to glucose
(GO:0009749)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: erythrocyte (CL0000232)
Fold Change: 3.13
Marker Score: 1736.5
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 2.19
Marker Score: 1510
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 1.65
Marker Score: 3409
Cell Name: mural cell (CL0008034)
Fold Change: 1.48
Marker Score: 169876
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.37
Marker Score: 870
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 1.32
Marker Score: 8516
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 1.32
Marker Score: 7108
Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 1.31
Marker Score: 5671
Cell Name: goblet cell (CL0000160)
Fold Change: 1.11
Marker Score: 7398
Cell Name: retinal rod cell (CL0000604)
Fold Change: 1.07
Marker Score: 3056
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71819
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48044
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30408
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2413
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5345
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2740
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.89
Marker Score: 468
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.89
Marker Score: 13893
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.89
Marker Score: 678
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5283
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.86
Marker Score: 271
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1261
Cell Name: brush cell (CL0002204)
Fold Change: 0.78
Marker Score: 708
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.77
Marker Score: 397
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.7
Marker Score: 180
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.69
Marker Score: 1304
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.67
Marker Score: 1081
Cell Name: neutrophil (CL0000775)
Fold Change: 0.64
Marker Score: 388
Cell Name: macrophage (CL0000235)
Fold Change: 0.63
Marker Score: 702
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.63
Marker Score: 414
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.6
Marker Score: 480
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.57
Marker Score: 240
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.56
Marker Score: 149
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.56
Marker Score: 1131
Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 0.55
Marker Score: 207
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.53
Marker Score: 317
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 0.51
Marker Score: 250
Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 0.5
Marker Score: 535
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.49
Marker Score: 476
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.49
Marker Score: 1160
Cell Name: hepatoblast (CL0005026)
Fold Change: 0.46
Marker Score: 1498
Cell Name: mast cell (CL0000097)
Fold Change: 0.41
Marker Score: 239
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.37
Marker Score: 373
Cell Name: cholangiocyte (CL1000488)
Fold Change: 0.37
Marker Score: 137
Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 0.34
Marker Score: 345
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 0.34
Marker Score: 415
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.31
Marker Score: 188
Cell Name: hepatocyte (CL0000182)
Fold Change: 0.3
Marker Score: 202
Cell Name: astrocyte (CL0000127)
Fold Change: 0.29
Marker Score: 254
Cell Name: B cell (CL0000236)
Fold Change: 0.29
Marker Score: 279
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.27
Marker Score: 87
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.27
Marker Score: 127
Cell Name: plasma cell (CL0000786)
Fold Change: 0.26
Marker Score: 289
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 0.25
Marker Score: 1047
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 0.24
Marker Score: 3200
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 0.23
Marker Score: 8592
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 0.23
Marker Score: 357
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.23
Marker Score: 128
Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.22
Marker Score: 97
Cell Name: pericyte (CL0000669)
Fold Change: 0.21
Marker Score: 121
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.2
Marker Score: 179
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 0.2
Marker Score: 107
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.2
Marker Score: 51
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.18
Marker Score: 1054
Cell Name: stromal cell (CL0000499)
Fold Change: 0.17
Marker Score: 200
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 0.17
Marker Score: 69
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.17
Marker Score: 74
Cell Name: fat cell (CL0000136)
Fold Change: 0.17
Marker Score: 93
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.17
Marker Score: 52
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 0.17
Marker Score: 3542
Cell Name: microglial cell (CL0000129)
Fold Change: 0.16
Marker Score: 288
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.16
Marker Score: 9610
Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 0.16
Marker Score: 41
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 0.15
Marker Score: 1290
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 0.15
Marker Score: 1403
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.14
Marker Score: 1484
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.14
Marker Score: 31
Cell Name: interneuron (CL0000099)
Fold Change: 0.14
Marker Score: 63
Cell Name: Kupffer cell (CL0000091)
Fold Change: 0.13
Marker Score: 135
Cell Name: fibroblast (CL0000057)
Fold Change: 0.13
Marker Score: 129
Cell Name: podocyte (CL0000653)
Fold Change: 0.13
Marker Score: 49
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 0.13
Marker Score: 4986
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 0.13
Marker Score: 32
Cell Name: skin fibroblast (CL0002620)
Fold Change: 0.12
Marker Score: 32
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 0.12
Marker Score: 1127
Cell Name: inflammatory macrophage (CL0000863)
Fold Change: 0.12
Marker Score: 37
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 0.12
Marker Score: 1778
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 0.12
Marker Score: 1014
Cell Name: retinal cone cell (CL0000573)
Fold Change: 0.12
Marker Score: 338
Cell Name: T cell (CL0000084)
Fold Change: 0.11
Marker Score: 192
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.11
Marker Score: 426
Cell Name: meningeal macrophage (CL0000879)
Fold Change: 0.11
Marker Score: 30
Cell Name: neuron (CL0000540)
Fold Change: 0.11
Marker Score: 433
Cell Name: retinal pigment epithelial cell (CL0002586)
Fold Change: 0.1
Marker Score: 30
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 0.1
Marker Score: 2024
Cell Name: GABAergic neuron (CL0000617)
Fold Change: 0.1
Marker Score: 419
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: 0.1
Marker Score: 62
Cell Name: mature NK T cell (CL0000814)
Fold Change: 0.1
Marker Score: 46
Cell Name: male germ cell (CL0000015)
Fold Change: 0.1
Marker Score: 28
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 0.1
Marker Score: 48

Hover over a box to see details here...

**Key characteristics:** - GYS2 is a glycosyltransferase that catalyzes the transfer of a glucose molecule from glucose-1-phosphate to a molecule of GTP. - It is a subunit of the GYS2 complex, which also includes GYS1. - It is a highly conserved protein, with a similar sequence in mammals, birds, and fish. **Pathways and functions:** - GYS2 is involved in the regulation of glycogen synthesis in the cytoplasm and cytosol. - It is also involved in the regulation of glycogen synthesis in the liver. - It is a key regulator of hepatic glucose metabolism. - Dysregulation of GYS2 has been linked to a number of diseases, including diabetes, obesity, and metabolic syndrome. **Clinical significance:** - GYS2 is a potential therapeutic target for a number of diseases that are characterized by abnormal glycogen metabolism. - For example, GYS2 inhibitors are being investigated as a treatment for diabetes and obesity. - Understanding the role of GYS2 in glycogen metabolism could lead to the development of new therapies for these diseases. **Additional information:** - The GYS2 gene is located on chromosome 15q21.1. - It is a highly expressed gene in the human body. - It is a well-studied gene, and there are a number of mutations that have been linked to its dysfunction.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

GYS2_HUMAN

Genular Protein ID: 3826584205

Symbol: GYS2_HUMAN

Name: N/A

UniProtKB Accession Codes:

P54840 A0AVD8

Database IDs:

Citations:

PubMed ID: 8203908

Title: Primary structure of human liver glycogen synthase deduced by cDNA cloning.

PubMed ID: 8203908

DOI: 10.1006/abbi.1994.1260

PubMed ID: 9691087

Title: Mutations in the liver glycogen synthase gene in children with hypoglycemia due to glycogen storage disease type 0.

PubMed ID: 9691087

DOI: 10.1172/jci2890

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1731614

Title: Comparative characterization of human and rat liver glycogen synthase.

PubMed ID: 1731614

DOI: 10.1016/0003-9861(92)90019-s

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

Length: 703
Mass: 80989
Checksum: 718F000D6D00CA4A
Sequence:

MLRGRSLSVT SLGGLPQWEV EELPVEELLL FEVAWEVTNK VGGIYTVIQT KAKTTADEWG 
ENYFLIGPYF EHNMKTQVEQ CEPVNDAVRR AVDAMNKHGC QVHFGRWLIE GSPYVVLFDI 
GYSAWNLDRW KGDLWEACSV GIPYHDREAN DMLIFGSLTA WFLKEVTDHA DGKYVVAQFH 
EWQAGIGLIL SRARKLPIAT IFTTHATLLG RYLCAANIDF YNHLDKFNID KEAGERQIYH 
RYCMERASVH CAHVFTTVSE ITAIEAEHML KRKPDVVTPN GLNVKKFSAV HEFQNLHAMY 
KARIQDFVRG HFYGHLDFDL EKTLFLFIAG RYEFSNKGAD IFLESLSRLN FLLRMHKSDI 
TVMVFFIMPA KTNNFNVETL KGQAVRKQLW DVAHSVKEKF GKKLYDALLR GEIPDLNDIL 
DRDDLTIMKR AIFSTQRQSL PPVTTHNMID DSTDPILSTI RRIGLFNNRT DRVKVILHPE 
FLSSTSPLLP MDYEEFVRGC HLGVFPSYYE PWGYTPAECT VMGIPSVTTN LSGFGCFMQE 
HVADPTAYGI YIVDRRFRSP DDSCNQLTKF LYGFCKQSRR QRIIQRNRTE RLSDLLDWRY 
LGRYYQHARH LTLSRAFPDK FHVELTSPPT TEGFKYPRPS SVPPSPSGSQ ASSPQSSDVE 
DEVEDERYDE EEEAERDRLN IKSPFSLSHV PHGKKKLHGE YKN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: GYS2

Associated with

Cells (max top 100)

Other Information

Primary structure of human liver glycogen synthase deduced by cDNA cloning. PubMed ID: 8203908

Mutations in the liver glycogen synthase gene in children with hypoglycemia due to glycogen storage disease type 0. PubMed ID: 9691087

The finished DNA sequence of human chromosome 12. PubMed ID: 16541075

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Comparative characterization of human and rat liver glycogen synthase. PubMed ID: 1731614