Details for: ERO1A

Gene ID: 30001

Symbol: ERO1A

Ensembl ID: ENSG00000197930

Description: endoplasmic reticulum oxidoreductase 1 alpha

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 93.9163
    Cell Significance Index: -44.3400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 90.4846
    Cell Significance Index: -36.7600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 82.8367
    Cell Significance Index: -42.6100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 38.7225
    Cell Significance Index: -36.9700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.9205
    Cell Significance Index: -39.9700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.9118
    Cell Significance Index: -33.5200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.9177
    Cell Significance Index: -15.1400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.3998
    Cell Significance Index: 124.6600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.2340
    Cell Significance Index: 30.4800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.7006
    Cell Significance Index: 1535.5200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.3968
    Cell Significance Index: 762.8500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3402
    Cell Significance Index: 268.8500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2778
    Cell Significance Index: 138.9900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.0411
    Cell Significance Index: 373.4300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.0305
    Cell Significance Index: 9.4900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9895
    Cell Significance Index: 196.3700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.9820
    Cell Significance Index: 26.7300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.8723
    Cell Significance Index: 40.6700
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.8122
    Cell Significance Index: 13.0300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7964
    Cell Significance Index: 143.5600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5917
    Cell Significance Index: 12.8200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5272
    Cell Significance Index: 64.8300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.5138
    Cell Significance Index: 58.8600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5000
    Cell Significance Index: 23.5000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.4932
    Cell Significance Index: 10.8000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.4094
    Cell Significance Index: 6.8900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.3834
    Cell Significance Index: 19.9700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3825
    Cell Significance Index: 11.0200
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.3637
    Cell Significance Index: 2.2600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3578
    Cell Significance Index: 26.6700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3575
    Cell Significance Index: 247.2600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.3463
    Cell Significance Index: 10.1700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3096
    Cell Significance Index: 7.7400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.3058
    Cell Significance Index: 575.8700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.2695
    Cell Significance Index: 4.1700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.2088
    Cell Significance Index: 283.9200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2087
    Cell Significance Index: 92.2800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1973
    Cell Significance Index: 9.9700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1885
    Cell Significance Index: 290.2100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1770
    Cell Significance Index: 80.3300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.1557
    Cell Significance Index: 2.2400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1442
    Cell Significance Index: 4.1400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1393
    Cell Significance Index: 13.7800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1355
    Cell Significance Index: 6.1400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1158
    Cell Significance Index: 15.9000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1059
    Cell Significance Index: 5.9400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0758
    Cell Significance Index: 12.9500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0738
    Cell Significance Index: 136.1200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0427
    Cell Significance Index: 27.1200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0281
    Cell Significance Index: 5.3500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0166
    Cell Significance Index: 0.5900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0166
    Cell Significance Index: 1.2800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0130
    Cell Significance Index: 0.8800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0105
    Cell Significance Index: 1.3600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0045
    Cell Significance Index: 0.1200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0196
    Cell Significance Index: -2.5100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0276
    Cell Significance Index: -20.8800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0289
    Cell Significance Index: -21.4200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0471
    Cell Significance Index: -34.5700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0669
    Cell Significance Index: -37.7200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0749
    Cell Significance Index: -7.6500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0814
    Cell Significance Index: -50.8600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1028
    Cell Significance Index: -10.7000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1095
    Cell Significance Index: -15.9200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1171
    Cell Significance Index: -5.1800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1212
    Cell Significance Index: -14.1300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1281
    Cell Significance Index: -36.8700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1293
    Cell Significance Index: -8.1500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1324
    Cell Significance Index: -0.8000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1952
    Cell Significance Index: -4.5100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2002
    Cell Significance Index: -7.5800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2048
    Cell Significance Index: -3.5100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2082
    Cell Significance Index: -43.8600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.2103
    Cell Significance Index: -34.2000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2196
    Cell Significance Index: -25.9000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2256
    Cell Significance Index: -14.5600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2333
    Cell Significance Index: -16.5000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2337
    Cell Significance Index: -6.5300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2581
    Cell Significance Index: -13.5500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4605
    Cell Significance Index: -28.2300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4723
    Cell Significance Index: -5.6300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4997
    Cell Significance Index: -39.5800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5091
    Cell Significance Index: -9.4100
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.5291
    Cell Significance Index: -8.0500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.5616
    Cell Significance Index: -23.0100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.6395
    Cell Significance Index: -39.3100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6566
    Cell Significance Index: -21.0300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.7158
    Cell Significance Index: -18.4000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7707
    Cell Significance Index: -24.5500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.8068
    Cell Significance Index: -23.0200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.8219
    Cell Significance Index: -26.9100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.8348
    Cell Significance Index: -22.3300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.8442
    Cell Significance Index: -14.2200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.8459
    Cell Significance Index: -9.6100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.9199
    Cell Significance Index: -11.4100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.9216
    Cell Significance Index: -33.8300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.9279
    Cell Significance Index: -32.5100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.9348
    Cell Significance Index: -15.6500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.9615
    Cell Significance Index: -28.3200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.9738
    Cell Significance Index: -21.0400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ERO1A is a member of the ERO1 family of proteins, which are oxidoreductases that catalyze the reduction of disulfide bonds in proteins. ERO1A is specifically localized to the endoplasmic reticulum, where it plays a crucial role in protein folding and maturation. Its expression is highly regulated, with significant expression in cells undergoing rapid growth and differentiation, such as extravillous trophoblasts and pancreatic acinar cells. **Pathways and Functions:** ERO1A is involved in several key pathways, including: 1. **Protein Folding and Maturation:** ERO1A is essential for the proper folding of proteins in the endoplasmic reticulum, particularly those containing disulfide bonds. Its activity is critical for maintaining protein homeostasis and preventing protein misfolding and aggregation. 2. **Redox Homeostasis:** ERO1A helps to regulate the redox state of the endoplasmic reticulum by reducing disulfide bonds and maintaining the balance between oxidants and antioxidants. 3. **Endoplasmic Reticulum Stress Response:** ERO1A is activated in response to ER stress, triggering a signaling cascade that leads to the activation of chaperones and other proteins involved in protein folding and quality control. 4. **Cellular Responses to Stimuli:** ERO1A is also involved in cellular responses to various stimuli, including hypoxia, oxidative stress, and temperature changes. **Clinical Significance:** Dysregulation of ERO1A has been implicated in various diseases, including: 1. **Cancer:** ERO1A overexpression has been observed in several types of cancer, including breast, lung, and pancreatic cancer. 2. **Metabolic Disorders:** ERO1A dysfunction has been linked to metabolic disorders, such as diabetes and obesity. 3. **Neurodegenerative Diseases:** ERO1A has been implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. 4. **Endoplasmic Reticulum Stress:** ERO1A is a key player in the ER stress response, and its dysregulation can lead to ER stress-related diseases. In conclusion, ERO1A is a critical gene that plays a vital role in maintaining cellular homeostasis. Its dysregulation has significant implications for various diseases, highlighting the need for further research into the mechanisms of ERO1A and its role in human disease.

Genular Protein ID: 835404646

Symbol: ERO1A_HUMAN

Name: ERO1-like protein alpha

UniProtKB Accession Codes:

Q96HE7 A8K9X4 A8MYW1 Q7LD45 Q9P1Q9 Q9UKV6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 27 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIRSF 1 PRIDE 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10671517

Title: ERO1-L, a human protein that favors disulfide bond formation in the endoplasmic reticulum.

PubMed ID: 10671517

DOI: 10.1074/jbc.275.7.4827

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11707280

Title: The C-terminal domain of yeast Ero1p mediates membrane localization and is essential for function.

PubMed ID: 11707280

DOI: 10.1016/s0014-5793(01)03034-4

PubMed ID: 11847130

Title: ERp44, a novel endoplasmic reticulum folding assistant of the thioredoxin family.

PubMed ID: 11847130

DOI: 10.1093/emboj/21.4.835

PubMed ID: 10970843

Title: The CXXCXXC motif determines the folding, structure and stability of human Ero1-Lalpha.

PubMed ID: 10970843

DOI: 10.1093/emboj/19.17.4493

PubMed ID: 10818100

Title: Endoplasmic reticulum oxidoreductin 1-lbeta (ERO1-Lbeta), a human gene induced in the course of the unfolded protein response.

PubMed ID: 10818100

DOI: 10.1074/jbc.m003061200

PubMed ID: 11707400

Title: Manipulation of oxidative protein folding and PDI redox state in mammalian cells.

PubMed ID: 11707400

DOI: 10.1093/emboj/20.22.6288

PubMed ID: 12403808

Title: Unfolded cholera toxin is transferred to the ER membrane and released from protein disulfide isomerase upon oxidation by Ero1.

PubMed ID: 12403808

DOI: 10.1083/jcb.200207120

PubMed ID: 12752442

Title: The cellular oxygen tension regulates expression of the endoplasmic oxidoreductase ERO1-Lalpha.

PubMed ID: 12752442

DOI: 10.1046/j.1432-1033.2003.03590.x

PubMed ID: 14517240

Title: Thiol-mediated protein retention in the endoplasmic reticulum: the role of ERp44.

PubMed ID: 14517240

DOI: 10.1093/emboj/cdg491

PubMed ID: 15136577

Title: Two conserved cysteine triads in human Ero1alpha cooperate forefficient disulfide bond formation in the ER.

PubMed ID: 15136577

DOI: 10.1074/jbc.m403192200

PubMed ID: 15161913

Title: Glutathione limits Ero1-dependent oxidation in the endoplasmic reticulum.

PubMed ID: 15161913

DOI: 10.1074/jbc.m404992200

PubMed ID: 15475357

Title: PDILT, a divergent testis-specific protein disulfide isomerase with a non-classical SXXC motif that engages in disulfide-dependent interactions in the endoplasmic reticulum.

PubMed ID: 15475357

DOI: 10.1074/jbc.m408651200

PubMed ID: 18833192

Title: A novel disulphide switch mechanism in Ero1alpha balances ER oxidation in human cells.

PubMed ID: 18833192

DOI: 10.1038/emboj.2008.202

PubMed ID: 18971943

Title: Low reduction potential of Ero1alpha regulatory disulphides ensures tight control of substrate oxidation.

PubMed ID: 18971943

DOI: 10.1038/emboj.2008.230

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21091435

Title: The endoplasmic reticulum sulfhydryl oxidase Ero1beta drives efficient oxidative protein folding with loose regulation.

PubMed ID: 21091435

DOI: 10.1042/bj20101357

PubMed ID: 23027870

Title: Hyperactivity of the Ero1alpha oxidase elicits endoplasmic reticulum stress but no broad antioxidant response.

PubMed ID: 23027870

DOI: 10.1074/jbc.m112.405050

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29858230

Title: Secretory kinase Fam20C tunes endoplasmic reticulum redox state via phosphorylation of Ero1alpha.

PubMed ID: 29858230

DOI: 10.15252/embj.201798699

PubMed ID: 20834232

Title: Crystal structures of human Ero1alpha reveal the mechanisms of regulated and targeted oxidation of PDI.

PubMed ID: 20834232

DOI: 10.1038/emboj.2010.222

Sequence Information:

  • Length: 468
  • Mass: 54393
  • Checksum: 92ECE6531C9CCA33
  • Sequence:
    • MGRGWGFLFG LLGAVWLLSS GHGEEQPPET AAQRCFCQVS GYLDDCTCDV ETIDRFNNYR 
LFPRLQKLLE SDYFRYYKVN LKRPCPFWND ISQCGRRDCA VKPCQSDEVP DGIKSASYKY 
SEEANNLIEE CEQAERLGAV DESLSEETQK AVLQWTKHDD SSDNFCEADD IQSPEAEYVD 
LLLNPERYTG YKGPDAWKIW NVIYEENCFK PQTIKRPLNP LASGQGTSEE NTFYSWLEGL 
CVEKRAFYRL ISGLHASINV HLSARYLLQE TWLEKKWGHN ITEFQQRFDG ILTEGEGPRR 
LKNLYFLYLI ELRALSKVLP FFERPDFQLF TGNKIQDEEN KMLLLEILHE IKSFPLHFDE 
NSFFAGDKKE AHKLKEDFRL HFRNISRIMD CVGCFKCRLW GKLQTQGLGT ALKILFSEKL 
IANMPESGPS YEFHLTRQEI VSLFNAFGRI STSVKELENF RNLLQNIH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.