Details for: TBX21

Gene ID: 30009

Symbol: TBX21

Ensembl ID: ENSG00000073861

Description: T-box transcription factor 21

Associated with

  • Cell fate specification
    (GO:0001708)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Lymphocyte migration
    (GO:0072676)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of interleukin-2 production
    (GO:0032703)
  • Negative regulation of t-helper 2 cell cytokine production
    (GO:2000552)
  • Negative regulation of t-helper 17 cell differentiation
    (GO:2000320)
  • Negative regulation of t-helper 17 cell lineage commitment
    (GO:2000329)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Neuronal cell body
    (GO:0043025)
  • Nucleus
    (GO:0005634)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of isotype switching to igg isotypes
    (GO:0048304)
  • Positive regulation of t-helper 1 cell cytokine production
    (GO:2000556)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Proteasome-mediated ubiquitin-dependent protein catabolic process
    (GO:0043161)
  • Protein binding
    (GO:0005515)
  • Regulation of t cell differentiation
    (GO:0045580)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Response to virus
    (GO:0009615)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific dna binding
    (GO:0043565)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • T-helper 1 cell lineage commitment
    (GO:0002296)
  • Transcription cis-regulatory region binding
    (GO:0000976)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 22.4372
    Cell Significance Index: -3.4900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 13.9960
    Cell Significance Index: -3.5500
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 3.1515
    Cell Significance Index: 8.4400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 2.8225
    Cell Significance Index: -3.4800
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.9324
    Cell Significance Index: 20.5600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 1.0028
    Cell Significance Index: -3.0800
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.6713
    Cell Significance Index: 6.9600
  • Cell Name: activated type II NK T cell (CL0000931)
    Fold Change: 0.5586
    Cell Significance Index: 1.4300
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.3693
    Cell Significance Index: 3.6000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.2993
    Cell Significance Index: 8.0100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.2949
    Cell Significance Index: 8.6600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 0.2781
    Cell Significance Index: -0.7500
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.1092
    Cell Significance Index: 1.3800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0350
    Cell Significance Index: 2.2600
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.0067
    Cell Significance Index: 0.0600
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.0039
    Cell Significance Index: 0.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0016
    Cell Significance Index: -3.0000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0024
    Cell Significance Index: -4.3400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0027
    Cell Significance Index: -4.2000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0031
    Cell Significance Index: -2.3700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0034
    Cell Significance Index: -4.6300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0049
    Cell Significance Index: -3.6100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0062
    Cell Significance Index: -4.5500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0064
    Cell Significance Index: -3.6200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0070
    Cell Significance Index: -4.4700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0072
    Cell Significance Index: -3.9500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0079
    Cell Significance Index: -2.8400
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0081
    Cell Significance Index: -0.1100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0095
    Cell Significance Index: -4.3100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0112
    Cell Significance Index: -3.2100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0135
    Cell Significance Index: -2.7000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0138
    Cell Significance Index: -2.7400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0177
    Cell Significance Index: -3.7300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0183
    Cell Significance Index: -3.1300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0186
    Cell Significance Index: -2.1900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0189
    Cell Significance Index: -3.4000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0228
    Cell Significance Index: -0.9900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0231
    Cell Significance Index: -2.9600
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0250
    Cell Significance Index: -0.4300
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0267
    Cell Significance Index: -0.3900
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.0275
    Cell Significance Index: -0.2200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0283
    Cell Significance Index: -4.1200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0290
    Cell Significance Index: -3.9800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0294
    Cell Significance Index: -3.3700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0309
    Cell Significance Index: -1.4500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0324
    Cell Significance Index: -3.3100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0324
    Cell Significance Index: -4.1800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0326
    Cell Significance Index: -4.0100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0340
    Cell Significance Index: -3.5400
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0348
    Cell Significance Index: -0.1900
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0391
    Cell Significance Index: -0.3300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0419
    Cell Significance Index: -0.6000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0420
    Cell Significance Index: -2.1200
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0458
    Cell Significance Index: -0.3900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0476
    Cell Significance Index: -0.8200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0513
    Cell Significance Index: -2.1000
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0517
    Cell Significance Index: -0.4900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0560
    Cell Significance Index: -4.1700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0564
    Cell Significance Index: -1.4500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0566
    Cell Significance Index: -4.3400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0570
    Cell Significance Index: -3.8300
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.0602
    Cell Significance Index: -0.7700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0641
    Cell Significance Index: -2.9900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0673
    Cell Significance Index: -0.8000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0680
    Cell Significance Index: -4.1800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0701
    Cell Significance Index: -4.3000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0708
    Cell Significance Index: -1.9800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0738
    Cell Significance Index: -4.1400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0797
    Cell Significance Index: -4.1400
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0800
    Cell Significance Index: -0.8300
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.0813
    Cell Significance Index: -0.5900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0856
    Cell Significance Index: -3.0000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0916
    Cell Significance Index: -2.2200
  • Cell Name: brush cell (CL0002204)
    Fold Change: -0.0965
    Cell Significance Index: -0.8900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0993
    Cell Significance Index: -2.6600
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.1000
    Cell Significance Index: -0.8100
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1011
    Cell Significance Index: -1.1200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1024
    Cell Significance Index: -4.5300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1051
    Cell Significance Index: -3.4400
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1064
    Cell Significance Index: -1.0800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1077
    Cell Significance Index: -3.4300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1143
    Cell Significance Index: -3.6600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1196
    Cell Significance Index: -4.5300
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1198
    Cell Significance Index: -1.3500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1218
    Cell Significance Index: -4.4700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1243
    Cell Significance Index: -4.3200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1329
    Cell Significance Index: -4.6700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1343
    Cell Significance Index: -3.8500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1349
    Cell Significance Index: -3.8500
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.1355
    Cell Significance Index: -1.4900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1369
    Cell Significance Index: -3.6600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1378
    Cell Significance Index: -3.5100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1379
    Cell Significance Index: -3.4400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1394
    Cell Significance Index: -3.5600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1416
    Cell Significance Index: -2.1900
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1416
    Cell Significance Index: -4.4800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1425
    Cell Significance Index: -3.5600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1491
    Cell Significance Index: -3.9200
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.1520
    Cell Significance Index: -1.5800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1521
    Cell Significance Index: -3.3300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TBX21 is a member of the T-box family of transcription factors, which are characterized by the presence of a T-box domain. This domain is essential for the recognition and binding to specific DNA sequences, thereby regulating gene expression. TBX21 is specifically expressed in various immune cells, including T helper cells, natural killer cells, and innate lymphoid cells. Its expression is tightly regulated during the development and differentiation of these cells, and its dysregulation has been implicated in several immune-related disorders. **Pathways and Functions** TBX21 plays a critical role in the regulation of immune responses through several key pathways: 1. **T-cell differentiation**: TBX21 is essential for the differentiation of T helper cells, particularly the Th1 subtype, which plays a crucial role in cell-mediated immunity. 2. **Cytokine production**: TBX21 regulates the production of cytokines, such as interferon-gamma (IFN-γ), which is essential for the activation of immune responses against viral and bacterial infections. 3. **Immune cell development**: TBX21 is involved in the development and maturation of various immune cells, including natural killer cells and innate lymphoid cells. 4. **Transcriptional regulation**: TBX21 regulates the expression of target genes involved in immune responses, including those involved in the production of cytokines and the activation of immune cells. **Clinical Significance** Dysregulation of TBX21 has been implicated in several immune-related disorders, including: 1. **Autoimmune diseases**: TBX21 has been implicated in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and lupus, where Th1 cell dysfunction contributes to disease progression. 2. **Viral infections**: TBX21 is essential for the control of viral infections, such as HIV and tuberculosis, where Th1 cell responses are critical for clearance of the virus. 3. **Cancer**: TBX21 has been implicated in the regulation of immune responses in cancer, where Th1 cell responses can contribute to tumor control and progression. 4. **Immunodeficiency disorders**: TBX21 is essential for the development and function of T helper cells, and its dysregulation can contribute to immunodeficiency disorders, such as HIV-associated immunodeficiency. In conclusion, TBX21 is a critical gene involved in the regulation of immune responses, particularly in the differentiation and function of T helper cells. Its dysregulation has been implicated in several immune-related disorders, highlighting the importance of TBX21 in maintaining immune homeostasis. Further research is necessary to fully understand the mechanisms by which TBX21 regulates immune responses and to develop therapeutic strategies to modulate its activity in disease.

Genular Protein ID: 3676625549

Symbol: TBX21_HUMAN

Name: T-box transcription factor TBX21

UniProtKB Accession Codes:

Q9UL17

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 GO 27 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 5 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10761931

Title: A novel transcription factor, T-bet, directs Th1 lineage commitment.

PubMed ID: 10761931

DOI: 10.1016/s0092-8674(00)80702-3

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15806396

Title: Functional promoter polymorphism in the TBX21 gene associated with aspirin-induced asthma.

PubMed ID: 15806396

DOI: 10.1007/s00439-005-1285-0

PubMed ID: 15662016

Title: T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3.

PubMed ID: 15662016

DOI: 10.1126/science.1103336

PubMed ID: 24845384

Title: Deubiquitination and stabilization of T-bet by USP10.

PubMed ID: 24845384

DOI: 10.1016/j.bbrc.2014.05.037

PubMed ID: 27292648

Title: T-bet activates Th1 genes through mediator and the super elongation complex.

PubMed ID: 27292648

DOI: 10.1016/j.celrep.2016.05.054

PubMed ID: 33296702

Title: Human T-bet Governs Innate and Innate-like Adaptive IFN-gamma Immunity against Mycobacteria.

PubMed ID: 33296702

DOI: 10.1016/j.cell.2020.10.046

Sequence Information:

  • Length: 535
  • Mass: 58328
  • Checksum: 51F351335598CEF2
  • Sequence:
    • MGIVEPGCGD MLTGTEPMPG SDEGRAPGAD PQHRYFYPEP GAQDADERRG GGSLGSPYPG 
GALVPAPPSR FLGAYAYPPR PQAAGFPGAG ESFPPPADAE GYQPGEGYAA PDPRAGLYPG 
PREDYALPAG LEVSGKLRVA LNNHLLWSKF NQHQTEMIIT KQGRRMFPFL SFTVAGLEPT 
SHYRMFVDVV LVDQHHWRYQ SGKWVQCGKA EGSMPGNRLY VHPDSPNTGA HWMRQEVSFG 
KLKLTNNKGA SNNVTQMIVL QSLHKYQPRL HIVEVNDGEP EAACNASNTH IFTFQETQFI 
AVTAYQNAEI TQLKIDNNPF AKGFRENFES MYTSVDTSIP SPPGPNCQFL GGDHYSPLLP 
NQYPVPSRFY PDLPGQAKDV VPQAYWLGAP RDHSYEAEFR AVSMKPAFLP SAPGPTMSYY 
RGQEVLAPGA GWPVAPQYPP KMGPASWFRP MRTLPMEPGP GGSEGRGPED QGPPLVWTEI 
APIRPESSDS GLGEGDSKRR RVSPYPSSGD SSSPAGAPSP FDKEAEGQFY NYFPN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.