Details for: H2BC3

Gene ID: 3018

Symbol: H2BC3

Ensembl ID: ENSG00000276410

Description: H2B clustered histone 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 2.35
    Marker Score: 4872
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.98
    Marker Score: 2101
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1168.5
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.36
    Marker Score: 608
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7689
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 507
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 461
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.97
    Marker Score: 511.5
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.96
    Marker Score: 304.5
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5341
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 324
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.88
    Marker Score: 597
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5287
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.83
    Marker Score: 496.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 707
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.72
    Marker Score: 553.5
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.72
    Marker Score: 499
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.7
    Marker Score: 282
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.7
    Marker Score: 1638
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.69
    Marker Score: 703
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2841
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.64
    Marker Score: 206
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.6
    Marker Score: 1043
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.57
    Marker Score: 208.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.55
    Marker Score: 351.5
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.53
    Marker Score: 5347
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.51
    Marker Score: 672
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.5
    Marker Score: 1253
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.49
    Marker Score: 371
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.49
    Marker Score: 147
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.45
    Marker Score: 142
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.43
    Marker Score: 1180
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 375
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.36
    Marker Score: 557.5
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.35
    Marker Score: 90
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.32
    Marker Score: 106
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.3
    Marker Score: 266
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.29
    Marker Score: 362
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.28
    Marker Score: 270
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.28
    Marker Score: 396
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.28
    Marker Score: 87
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.27
    Marker Score: 309
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.25
    Marker Score: 168
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.24
    Marker Score: 84
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.24
    Marker Score: 158
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.23
    Marker Score: 62
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.23
    Marker Score: 2307
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.23
    Marker Score: 256
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.23
    Marker Score: 130
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.22
    Marker Score: 323
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.22
    Marker Score: 162
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.22
    Marker Score: 92
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.22
    Marker Score: 310
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.22
    Marker Score: 643
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.21
    Marker Score: 153
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.21
    Marker Score: 121.5
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.2
    Marker Score: 135.5
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.2
    Marker Score: 73
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.2
    Marker Score: 144.5
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.2
    Marker Score: 278
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.2
    Marker Score: 175
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 0.19
    Marker Score: 225.5
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.18
    Marker Score: 94
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.17
    Marker Score: 115
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.17
    Marker Score: 181
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.17
    Marker Score: 100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.17
    Marker Score: 169
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.17
    Marker Score: 266
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.16
    Marker Score: 194.5
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.16
    Marker Score: 503
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.15
    Marker Score: 1001
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.15
    Marker Score: 43
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.15
    Marker Score: 140
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.14
    Marker Score: 53
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.14
    Marker Score: 65
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.14
    Marker Score: 49
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.14
    Marker Score: 36
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.14
    Marker Score: 77
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.14
    Marker Score: 309
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.13
    Marker Score: 48
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.13
    Marker Score: 59
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.13
    Marker Score: 219
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.13
    Marker Score: 102
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 0.13
    Marker Score: 39
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.13
    Marker Score: 79
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.13
    Marker Score: 70
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 0.13
    Marker Score: 32
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 0.12
    Marker Score: 41
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.12
    Marker Score: 30
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.12
    Marker Score: 106
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.12
    Marker Score: 80
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.12
    Marker Score: 87

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Other Information

**Key characteristics:** * H2B3 is a highly conserved protein, with a similar sequence found in organisms from yeast to humans. * It is a globular protein with a molecular weight of approximately 150 kDa. * H2B3 is a tetramer, meaning it is composed of four subunits that are held together by hydrogen bonds. * It is a nucleosome assembly factor, which means that it helps to assemble chromatin into higher-order structures. **Pathways and functions:** * H2B3 is involved in a variety of cellular processes, including differentiation, cell cycle, and development. * It is essential for the proper formation of the primary cilium in the kidney, which is responsible for absorbing fluid and nutrients from the blood. * H2B3 is also involved in the regulation of gene expression. It is a key regulator of the expression of genes involved in cell cycle regulation, apoptosis, and differentiation. * Mutations in H2B3 have been linked to a number of human diseases, including cancer and developmental disorders. **Clinical significance:** * H2B3 is a promising target for cancer therapy. * Inhibitors of H2B3 have been shown to be effective in inhibiting cancer cell growth and proliferation. * H2B3 is a potential therapeutic target for a variety of human diseases, including cancer and developmental disorders.

Genular Protein ID: 4169358240

Symbol: H2B1B_HUMAN

Name: Histone H2B type 1-B

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1916825

Title: Isolation and characterization of two human H1 histone genes within clusters of core histone genes.

PubMed ID: 1916825

DOI: 10.1016/0888-7543(91)90183-f

PubMed ID: 12408966

Title: The human and mouse replication-dependent histone genes.

PubMed ID: 12408966

DOI: 10.1016/s0888-7543(02)96850-3

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11709551

Title: Global regulation of post-translational modifications on core histones.

PubMed ID: 11709551

DOI: 10.1074/jbc.m107894200

PubMed ID: 12757711

Title: Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase.

PubMed ID: 12757711

DOI: 10.1016/s0092-8674(03)00355-6

PubMed ID: 16307923

Title: Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation.

PubMed ID: 16307923

DOI: 10.1016/j.molcel.2005.09.025

PubMed ID: 16283522

Title: Inhibition of core histones acetylation by carcinogenic nickel(II).

PubMed ID: 16283522

DOI: 10.1007/s11010-005-8285-1

PubMed ID: 16713563

Title: Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II.

PubMed ID: 16713563

DOI: 10.1016/j.cell.2006.04.029

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21925322

Title: Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification.

PubMed ID: 21925322

DOI: 10.1016/j.cell.2011.08.008

PubMed ID: 21726816

Title: The RING finger protein MSL2 in the MOF complex is an E3 ubiquitin ligase for H2B K34 and is involved in crosstalk with H3 K4 and K79 methylation.

PubMed ID: 21726816

DOI: 10.1016/j.molcel.2011.05.015

PubMed ID: 22389435

Title: Lysine succinylation and lysine malonylation in histones.

PubMed ID: 22389435

DOI: 10.1074/mcp.m111.015875

PubMed ID: 23824326

Title: USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing.

PubMed ID: 23824326

DOI: 10.1101/gad.211037.112

PubMed ID: 24681537

Title: Lysine 2-hydroxyisobutyrylation is a widely distributed active histone mark.

PubMed ID: 24681537

DOI: 10.1038/nchembio.1497

PubMed ID: 27105113

Title: Dynamic competing histone H4 K5K8 acetylation and butyrylation are hallmarks of highly active gene promoters.

PubMed ID: 27105113

DOI: 10.1016/j.molcel.2016.03.014

PubMed ID: 27105115

Title: Metabolic regulation of gene expression by histone lysine beta-hydroxybutyrylation.

PubMed ID: 27105115

DOI: 10.1016/j.molcel.2016.03.036

PubMed ID: 27530147

Title: PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2B(Glu2).

PubMed ID: 27530147

DOI: 10.1038/ncomms12404

PubMed ID: 31542297

Title: Glutarylation of histone H4 lysine 91 regulates chromatin dynamics.

PubMed ID: 31542297

DOI: 10.1016/j.molcel.2019.08.018

PubMed ID: 31645732

Title: Metabolic regulation of gene expression by histone lactylation.

PubMed ID: 31645732

DOI: 10.1038/s41586-019-1678-1

PubMed ID: 34874266

Title: Serine ADP-ribosylation marks nucleosomes for ALC1-dependent chromatin remodeling.

PubMed ID: 34874266

DOI: 10.7554/elife.71502

Sequence Information:

  • Length: 126
  • Mass: 13950
  • Checksum: D2D6B95A9A344EF7
  • Sequence:
  • MPEPSKSAPA PKKGSKKAIT KAQKKDGKKR KRSRKESYSI YVYKVLKQVH PDTGISSKAM 
    GIMNSFVNDI FERIAGEASR LAHYNKRSTI TSREIQTAVR LLLPGELAKH AVSEGTKAVT 
    KYTSSK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.