H2BC3 | ENSG00000276410 | NCBI 3018

Details for: H2BC3

Gene ID: 3018

Symbol: H2BC3

Ensembl ID: ENSG00000276410

Description: H2B clustered histone 3

Associated with

Activation of anterior hox genes in hindbrain development during early embryogenesis
(R-HSA-5617472)
Activation of hox genes during differentiation
(R-HSA-5619507)
Amyloid fiber formation
(R-HSA-977225)
Assembly of the orc complex at the origin of replication
(R-HSA-68616)
Assembly of the pre-replicative complex
(R-HSA-68867)
B-wich complex positively regulates rrna expression
(R-HSA-5250924)
Base-excision repair, ap site formation
(R-HSA-73929)
Base excision repair
(R-HSA-73884)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Chromatin modifications during the maternal to zygotic transition (mzt)
(R-HSA-9821002)
Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Chromosome maintenance
(R-HSA-73886)
Defective pyroptosis
(R-HSA-9710421)
Deposition of new cenpa-containing nucleosomes at the centromere
(R-HSA-606279)
Depurination
(R-HSA-73927)
Depyrimidination
(R-HSA-73928)
Deubiquitination
(R-HSA-5688426)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of programmed cell death
(R-HSA-9645723)
Dna damage/telomere stress induced senescence
(R-HSA-2559586)
Dna double-strand break repair
(R-HSA-5693532)
Dna double strand break response
(R-HSA-5693606)
Dna methylation
(R-HSA-5334118)
Dna repair
(R-HSA-73894)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
E3 ubiquitin ligases ubiquitinate target proteins
(R-HSA-8866654)
Epigenetic regulation by wdr5-containing histone modifying complexes
(R-HSA-9917777)
Epigenetic regulation of gene expression
(R-HSA-212165)
Epigenetic regulation of gene expression by mll3 and mll4 complexes
(R-HSA-9818564)
Ercc6 (csb) and ehmt2 (g9a) positively regulate rrna expression
(R-HSA-427389)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Formation of the beta-catenin:tcf transactivating complex
(R-HSA-201722)
G2/m checkpoints
(R-HSA-69481)
G2/m dna damage checkpoint
(R-HSA-69473)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gene silencing by rna
(R-HSA-211000)
Hats acetylate histones
(R-HSA-3214847)
Hcmv infection
(R-HSA-9609646)
Hdacs deacetylate histones
(R-HSA-3214815)
Hdr through homologous recombination (hrr) or single strand annealing (ssa)
(R-HSA-5693567)
Homology directed repair
(R-HSA-5693538)
Infectious disease
(R-HSA-5663205)
Inhibition of dna recombination at telomere
(R-HSA-9670095)
Maternal to zygotic transition (mzt)
(R-HSA-9816359)
Meiosis
(R-HSA-1500620)
Meiotic recombination
(R-HSA-912446)
Meiotic synapsis
(R-HSA-1221632)
Metabolism of proteins
(R-HSA-392499)
Mitotic prophase
(R-HSA-68875)
M phase
(R-HSA-68886)
Negative epigenetic regulation of rrna expression
(R-HSA-5250941)
Nonhomologous end-joining (nhej)
(R-HSA-5693571)
Norc negatively regulates rrna expression
(R-HSA-427413)
Nucleosome assembly
(R-HSA-774815)
Oxidative stress induced senescence
(R-HSA-2559580)
Packaging of telomere ends
(R-HSA-171306)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Post-translational protein modification
(R-HSA-597592)
Prc2 methylates histones and dna
(R-HSA-212300)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Protein ubiquitination
(R-HSA-8852135)
Recruitment and atm-mediated phosphorylation of repair and signaling proteins at dna double strand breaks
(R-HSA-5693565)
Regulation of endogenous retroelements
(R-HSA-9842860)
Regulation of endogenous retroelements by krab-zfp proteins
(R-HSA-9843940)
Regulation of endogenous retroelements by piwi-interacting rnas (pirnas)
(R-HSA-9845323)
Regulation of endogenous retroelements by the human silencing hub (hush) complex
(R-HSA-9843970)
Replacement of protamines by nucleosomes in the male pronucleus
(R-HSA-9821993)
Reproduction
(R-HSA-1474165)
Rho gtpase effectors
(R-HSA-195258)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i promoter escape
(R-HSA-73772)
Rna polymerase i promoter opening
(R-HSA-73728)
Rna polymerase i transcription
(R-HSA-73864)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Signaling by notch
(R-HSA-157118)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Sirt1 negatively regulates rrna expression
(R-HSA-427359)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Telomere maintenance
(R-HSA-157579)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by small rnas
(R-HSA-5578749)
Transcriptional regulation of granulopoiesis
(R-HSA-9616222)
Ub-specific processing proteases
(R-HSA-5689880)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: sebaceous gland cell (CL2000021)
Fold Change: 5.1167
Cell Significance Index: 6.6200
Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 2.2643
Cell Significance Index: 13.9700
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 1.6221
Cell Significance Index: -3.5500
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 1.4383
Cell Significance Index: 36.9700
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.8378
Cell Significance Index: 159.4500
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.8100
Cell Significance Index: 17.2500
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.7424
Cell Significance Index: 21.3900
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.6611
Cell Significance Index: 29.9700
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.6557
Cell Significance Index: 9.3900
Cell Name: sensory neuron (CL0000101)
Fold Change: 0.6281
Cell Significance Index: 3.5700
Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 0.5959
Cell Significance Index: 5.2900
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.5888
Cell Significance Index: 37.9900
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.5546
Cell Significance Index: 54.8700
Cell Name: large intestine goblet cell (CL1000320)
Fold Change: 0.4697
Cell Significance Index: 5.0900
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.4440
Cell Significance Index: 48.2900
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.4355
Cell Significance Index: 6.5300
Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
Fold Change: 0.4186
Cell Significance Index: 3.6600
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.4152
Cell Significance Index: 374.8500
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.3968
Cell Significance Index: 23.8200
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.3805
Cell Significance Index: 61.8900
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.3263
Cell Significance Index: 9.1200
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.3221
Cell Significance Index: 8.6200
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.3213
Cell Significance Index: 6.9600
Cell Name: fast muscle cell (CL0000190)
Fold Change: 0.2611
Cell Significance Index: 3.4200
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 0.2421
Cell Significance Index: 1.7600
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.2281
Cell Significance Index: 15.7800
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.2087
Cell Significance Index: 2.1600
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1890
Cell Significance Index: 6.6400
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 0.1845
Cell Significance Index: 2.5600
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.1538
Cell Significance Index: 18.1400
Cell Name: slow muscle cell (CL0000189)
Fold Change: 0.1464
Cell Significance Index: 2.1900
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.1451
Cell Significance Index: 3.0100
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 0.1396
Cell Significance Index: 1.4000
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.1296
Cell Significance Index: 1.6600
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 0.1004
Cell Significance Index: 0.7800
Cell Name: subcutaneous adipocyte (CL0002521)
Fold Change: 0.0827
Cell Significance Index: 0.3600
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 0.0772
Cell Significance Index: 0.8000
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.0478
Cell Significance Index: 1.5300
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.0365
Cell Significance Index: 0.5500
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.0208
Cell Significance Index: 1.0800
Cell Name: proerythroblast (CL0000547)
Fold Change: 0.0202
Cell Significance Index: 0.2900
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 0.0193
Cell Significance Index: 0.2800
Cell Name: pro-T cell (CL0000827)
Fold Change: 0.0184
Cell Significance Index: 0.4700
Cell Name: Sertoli cell (CL0000216)
Fold Change: 0.0157
Cell Significance Index: 0.2200
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0068
Cell Significance Index: 0.1700
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0058
Cell Significance Index: 2.5500
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.0047
Cell Significance Index: 0.0600
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0043
Cell Significance Index: 0.7700
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.0009
Cell Significance Index: 0.0500
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0006
Cell Significance Index: -0.1100
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0012
Cell Significance Index: -2.3300
Cell Name: odontoblast (CL0000060)
Fold Change: -0.0012
Cell Significance Index: -0.1500
Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0014
Cell Significance Index: -0.7700
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0016
Cell Significance Index: -2.9300
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0022
Cell Significance Index: -3.0000
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0028
Cell Significance Index: -2.0800
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0034
Cell Significance Index: -2.6000
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0036
Cell Significance Index: -2.0400
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0038
Cell Significance Index: -2.7700
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0040
Cell Significance Index: -0.5500
Cell Name: neural progenitor cell (CL0011020)
Fold Change: -0.0040
Cell Significance Index: -0.0400
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0044
Cell Significance Index: -2.7800
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0059
Cell Significance Index: -2.6700
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0082
Cell Significance Index: -0.3600
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0110
Cell Significance Index: -2.3100
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0118
Cell Significance Index: -2.3700
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0119
Cell Significance Index: -0.7300
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0122
Cell Significance Index: -2.0900
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0127
Cell Significance Index: -1.4600
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0177
Cell Significance Index: -2.1800
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0182
Cell Significance Index: -2.6400
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0188
Cell Significance Index: -1.4500
Cell Name: salivary gland cell (CL0009005)
Fold Change: -0.0189
Cell Significance Index: -0.2400
Cell Name: germ cell (CL0000586)
Fold Change: -0.0205
Cell Significance Index: -0.1600
Cell Name: radial glial cell (CL0000681)
Fold Change: -0.0219
Cell Significance Index: -0.1300
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.0240
Cell Significance Index: -0.4100
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0248
Cell Significance Index: -2.5800
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0254
Cell Significance Index: -1.6000
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0257
Cell Significance Index: -1.8200
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0275
Cell Significance Index: -2.8100
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0275
Cell Significance Index: -1.2800
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.0358
Cell Significance Index: -2.8400
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.0374
Cell Significance Index: -0.5100
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0381
Cell Significance Index: -1.7900
Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: -0.0385
Cell Significance Index: -0.5400
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.0392
Cell Significance Index: -1.0300
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0429
Cell Significance Index: -2.2500
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0497
Cell Significance Index: -1.0400
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0572
Cell Significance Index: -2.5300
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.0578
Cell Significance Index: -0.6300
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0599
Cell Significance Index: -1.6000
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0609
Cell Significance Index: -1.9400
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0641
Cell Significance Index: -2.1000
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.0650
Cell Significance Index: -1.6200
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0672
Cell Significance Index: -1.8300
Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.0696
Cell Significance Index: -1.0100
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.0719
Cell Significance Index: -2.5000
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0734
Cell Significance Index: -2.5700
Cell Name: primitive red blood cell (CL0002355)
Fold Change: -0.0760
Cell Significance Index: -0.8600
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.0797
Cell Significance Index: -1.9900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** H2BC3 is a type of histone H2B protein, which is one of the four main histone proteins that make up chromatin. H2BC3 is characterized by its ability to interact with other histones and chromatin-modifying enzymes, such as histone acetyltransferases (HATs) and histone deacetylases (HDACs), to regulate chromatin structure and gene expression. The protein is highly conserved across species, suggesting its essential role in fundamental cellular processes. **Pathways and Functions** H2BC3 is involved in various cellular pathways, including: 1. **DNA Replication and Repair**: H2BC3 is essential for the assembly of the pre-replicative complex and the recruitment of DNA repair proteins to damaged DNA sites. 2. **Chromatin Modifications**: H2BC3 interacts with chromatin-modifying enzymes, such as HATs and HDACs, to regulate chromatin structure and gene expression. 3. **Gene Expression**: H2BC3 influences gene expression by interacting with transcription factors and chromatin-modifying enzymes to regulate chromatin structure and access to transcriptional machinery. 4. **Cell Cycle Regulation**: H2BC3 is involved in the regulation of the cell cycle, particularly in the G2/M phase, where it interacts with cyclin-dependent kinases and other regulatory proteins. 5. **DNA Damage Response**: H2BC3 is involved in the response to DNA damage, where it interacts with DNA repair proteins and chromatin-modifying enzymes to regulate chromatin structure and DNA repair. **Clinical Significance** Dysregulation of H2BC3 has been implicated in various diseases, including: 1. **Cancer**: Alterations in H2BC3 expression have been observed in various types of cancer, including breast, lung, and colon cancer. 2. **Neurological Disorders**: H2BC3 has been implicated in the regulation of neuronal function and has been associated with neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Immunological Disorders**: H2BC3 has been implicated in the regulation of the immune response and has been associated with immunological disorders, such as autoimmune diseases and allergies. In conclusion, H2BC3 is a highly conserved histone protein that plays a crucial role in various cellular processes, including DNA replication, repair, and transcription regulation. Its dysregulation has been implicated in various diseases, highlighting the importance of this gene in human health and disease. Further research is needed to fully understand the mechanisms by which H2BC3 regulates cellular processes and to develop therapeutic strategies to target this gene in disease prevention and treatment.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Histone H2B type 1-B

Genular Protein ID: 4169358240

Symbol: H2B1B_HUMAN

Name: Histone H2B type 1-B

UniProtKB Accession Codes:

P33778 Q4KN36

Database IDs:

Citations:

PubMed ID: 1916825

Title: Isolation and characterization of two human H1 histone genes within clusters of core histone genes.

PubMed ID: 1916825

DOI: 10.1016/0888-7543(91)90183-f

PubMed ID: 12408966

Title: The human and mouse replication-dependent histone genes.

PubMed ID: 12408966

DOI: 10.1016/s0888-7543(02)96850-3

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11709551

Title: Global regulation of post-translational modifications on core histones.

PubMed ID: 11709551

DOI: 10.1074/jbc.m107894200

PubMed ID: 12757711

Title: Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase.

PubMed ID: 12757711

DOI: 10.1016/s0092-8674(03)00355-6

PubMed ID: 16307923

Title: Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation.

PubMed ID: 16307923

DOI: 10.1016/j.molcel.2005.09.025

PubMed ID: 16283522

Title: Inhibition of core histones acetylation by carcinogenic nickel(II).

PubMed ID: 16283522

DOI: 10.1007/s11010-005-8285-1

PubMed ID: 16713563

Title: Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II.

PubMed ID: 16713563

DOI: 10.1016/j.cell.2006.04.029

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21925322

Title: Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification.

PubMed ID: 21925322

DOI: 10.1016/j.cell.2011.08.008

PubMed ID: 21726816

Title: The RING finger protein MSL2 in the MOF complex is an E3 ubiquitin ligase for H2B K34 and is involved in crosstalk with H3 K4 and K79 methylation.

PubMed ID: 21726816

DOI: 10.1016/j.molcel.2011.05.015

PubMed ID: 22389435

Title: Lysine succinylation and lysine malonylation in histones.

PubMed ID: 22389435

DOI: 10.1074/mcp.m111.015875

PubMed ID: 23824326

Title: USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing.

PubMed ID: 23824326

DOI: 10.1101/gad.211037.112

PubMed ID: 24681537

Title: Lysine 2-hydroxyisobutyrylation is a widely distributed active histone mark.

PubMed ID: 24681537

DOI: 10.1038/nchembio.1497

PubMed ID: 27105113

Title: Dynamic competing histone H4 K5K8 acetylation and butyrylation are hallmarks of highly active gene promoters.

PubMed ID: 27105113

DOI: 10.1016/j.molcel.2016.03.014

PubMed ID: 27105115

Title: Metabolic regulation of gene expression by histone lysine beta-hydroxybutyrylation.

PubMed ID: 27105115

DOI: 10.1016/j.molcel.2016.03.036

PubMed ID: 27530147

Title: PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2B(Glu2).

PubMed ID: 27530147

DOI: 10.1038/ncomms12404

PubMed ID: 31542297

Title: Glutarylation of histone H4 lysine 91 regulates chromatin dynamics.

PubMed ID: 31542297

DOI: 10.1016/j.molcel.2019.08.018

PubMed ID: 31645732

Title: Metabolic regulation of gene expression by histone lactylation.

PubMed ID: 31645732

DOI: 10.1038/s41586-019-1678-1

PubMed ID: 34874266

Title: Serine ADP-ribosylation marks nucleosomes for ALC1-dependent chromatin remodeling.

PubMed ID: 34874266

DOI: 10.7554/elife.71502

Sequence Information:

Length: 126
Mass: 13950
Checksum: D2D6B95A9A344EF7
Sequence:

MPEPSKSAPA PKKGSKKAIT KAQKKDGKKR KRSRKESYSI YVYKVLKQVH PDTGISSKAM 
GIMNSFVNDI FERIAGEASR LAHYNKRSTI TSREIQTAVR LLLPGELAKH AVSEGTKAVT 
KYTSSK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: H2BC3

Associated with

Cells (max top 100)

Other Information

Isolation and characterization of two human H1 histone genes within clusters of core histone genes. PubMed ID: 1916825

The human and mouse replication-dependent histone genes. PubMed ID: 12408966

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Global regulation of post-translational modifications on core histones. PubMed ID: 11709551

Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. PubMed ID: 12757711

Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation. PubMed ID: 16307923

Inhibition of core histones acetylation by carcinogenic nickel(II). PubMed ID: 16283522

Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. PubMed ID: 16713563

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification. PubMed ID: 21925322

The RING finger protein MSL2 in the MOF complex is an E3 ubiquitin ligase for H2B K34 and is involved in crosstalk with H3 K4 and K79 methylation. PubMed ID: 21726816

Lysine succinylation and lysine malonylation in histones. PubMed ID: 22389435

USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing. PubMed ID: 23824326

Lysine 2-hydroxyisobutyrylation is a widely distributed active histone mark. PubMed ID: 24681537

Dynamic competing histone H4 K5K8 acetylation and butyrylation are hallmarks of highly active gene promoters. PubMed ID: 27105113

Metabolic regulation of gene expression by histone lysine beta-hydroxybutyrylation. PubMed ID: 27105115

PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2B(Glu2). PubMed ID: 27530147

Glutarylation of histone H4 lysine 91 regulates chromatin dynamics. PubMed ID: 31542297

Metabolic regulation of gene expression by histone lactylation. PubMed ID: 31645732

Serine ADP-ribosylation marks nucleosomes for ALC1-dependent chromatin remodeling. PubMed ID: 34874266