Details for: KCNIP3

Gene ID: 30818

Symbol: KCNIP3

Ensembl ID: ENSG00000115041

Description: potassium voltage-gated channel interacting protein 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 48.6904
    Cell Significance Index: -12.3500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.1373
    Cell Significance Index: -12.3800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.0104
    Cell Significance Index: -4.4000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.7724
    Cell Significance Index: 108.6700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.2681
    Cell Significance Index: 254.3800
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.2285
    Cell Significance Index: 10.1600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.9638
    Cell Significance Index: 30.8700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.7010
    Cell Significance Index: 16.9800
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.5791
    Cell Significance Index: 7.7300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5173
    Cell Significance Index: 98.4500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4242
    Cell Significance Index: 152.1400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.3564
    Cell Significance Index: 10.1700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.3529
    Cell Significance Index: 15.6100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3188
    Cell Significance Index: 4.3500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2820
    Cell Significance Index: 10.6800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2629
    Cell Significance Index: 237.3600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2511
    Cell Significance Index: 24.8400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2305
    Cell Significance Index: 15.5000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1680
    Cell Significance Index: 4.8400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1356
    Cell Significance Index: 22.0600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1246
    Cell Significance Index: 4.3800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1163
    Cell Significance Index: 80.4500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0937
    Cell Significance Index: 10.1900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0792
    Cell Significance Index: 1.9800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0570
    Cell Significance Index: 107.2900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0252
    Cell Significance Index: 1.7400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0160
    Cell Significance Index: 0.9600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0051
    Cell Significance Index: 0.2300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0015
    Cell Significance Index: 0.2100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0046
    Cell Significance Index: -0.8300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0046
    Cell Significance Index: -8.4900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0050
    Cell Significance Index: -7.7000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0055
    Cell Significance Index: -3.5000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0058
    Cell Significance Index: -0.1000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0060
    Cell Significance Index: -4.3700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0078
    Cell Significance Index: -1.5400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0092
    Cell Significance Index: -12.5200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0144
    Cell Significance Index: -6.5300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0150
    Cell Significance Index: -9.3400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0164
    Cell Significance Index: -12.1800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0169
    Cell Significance Index: -7.4500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0178
    Cell Significance Index: -13.4900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0192
    Cell Significance Index: -10.4900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0213
    Cell Significance Index: -11.9900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0258
    Cell Significance Index: -0.5600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0265
    Cell Significance Index: -0.7400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0270
    Cell Significance Index: -3.3200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0285
    Cell Significance Index: -4.8700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0367
    Cell Significance Index: -10.5600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0417
    Cell Significance Index: -6.0600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0459
    Cell Significance Index: -3.5200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0582
    Cell Significance Index: -2.7200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0592
    Cell Significance Index: -7.5900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0629
    Cell Significance Index: -13.2500
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.0644
    Cell Significance Index: -0.7100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0675
    Cell Significance Index: -4.1500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0810
    Cell Significance Index: -8.2700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0928
    Cell Significance Index: -10.6300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0944
    Cell Significance Index: -1.3500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0947
    Cell Significance Index: -3.1000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0953
    Cell Significance Index: -12.3100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1008
    Cell Significance Index: -3.2100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1046
    Cell Significance Index: -12.1900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1061
    Cell Significance Index: -11.0500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1075
    Cell Significance Index: -1.6200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1410
    Cell Significance Index: -7.9100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1419
    Cell Significance Index: -6.1700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1476
    Cell Significance Index: -11.6900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1503
    Cell Significance Index: -11.2000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2005
    Cell Significance Index: -4.1600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2012
    Cell Significance Index: -7.0500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2121
    Cell Significance Index: -5.2900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2219
    Cell Significance Index: -11.6500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2336
    Cell Significance Index: -10.9800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2342
    Cell Significance Index: -8.1400
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.2374
    Cell Significance Index: -3.3300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2393
    Cell Significance Index: -12.4300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2504
    Cell Significance Index: -5.4100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2531
    Cell Significance Index: -5.3900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2567
    Cell Significance Index: -6.9900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2572
    Cell Significance Index: -6.6100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2854
    Cell Significance Index: -6.2500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.3064
    Cell Significance Index: -7.6400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.3093
    Cell Significance Index: -3.3700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.3227
    Cell Significance Index: -5.5800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3411
    Cell Significance Index: -8.1800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3430
    Cell Significance Index: -7.2800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3551
    Cell Significance Index: -6.9300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3569
    Cell Significance Index: -13.1000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3755
    Cell Significance Index: -10.7700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3800
    Cell Significance Index: -7.6300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3814
    Cell Significance Index: -10.0300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.4038
    Cell Significance Index: -7.9900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4070
    Cell Significance Index: -8.5200
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.4133
    Cell Significance Index: -4.7600
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.4180
    Cell Significance Index: -4.6400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.4185
    Cell Significance Index: -6.0100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.4229
    Cell Significance Index: -6.7100
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.4234
    Cell Significance Index: -4.4200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.4245
    Cell Significance Index: -8.8600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** KCNIP3 is a 65-kDa protein that interacts with voltage-gated potassium channels, regulating their activity and localization at the plasma membrane. It also possesses transcriptional regulatory properties, influencing the expression of genes involved in cellular differentiation, proliferation, and survival. KCNIP3's unique structure, comprising an N-terminal domain with a proline-rich region and a C-terminal domain containing a CSEN (Calsenilin) motif, enables it to interact with various proteins and modulate their activity. **Pathways and Functions:** KCNIP3 is involved in several critical signaling pathways, including: 1. **Potassium Channel Regulation:** KCNIP3 interacts with voltage-gated potassium channels, modulating their activity and localization at the plasma membrane. This regulation is essential for maintaining proper ion balance and cellular excitability. 2. **Transcriptional Regulation:** KCNIP3 acts as a transcriptional regulator, influencing the expression of genes involved in cellular differentiation, proliferation, and survival. It interacts with RNA polymerase II and other transcription factors to modulate gene expression. 3. **Signaling Pathways:** KCNIP3 is involved in various signaling pathways, including those mediated by calcium ions, nitric oxide, and prostaglandins. These pathways regulate cellular responses to stress, injury, and inflammation. **Clinical Significance:** KCNIP3's dysregulation has been implicated in various human diseases, including: 1. **Neurological Disorders:** KCNIP3 mutations have been associated with epilepsy, migraines, and other neurological conditions. Its dysregulation may contribute to altered ion channel function and excitability in the nervous system. 2. **Cardiac Arrhythmias:** KCNIP3's role in regulating potassium channels may contribute to the development of cardiac arrhythmias, such as long QT syndrome. 3. **Cancer:** KCNIP3's transcriptional regulatory properties may influence cancer cell proliferation, survival, and differentiation, highlighting its potential as a therapeutic target. **Significantly Expressed Cells:** KCNIP3 is expressed in various cell types, including: 1. **Retinal Cone Cells:** KCNIP3 is essential for maintaining proper ion balance and visual function in retinal cone cells. 2. **Erythrocytes:** KCNIP3 regulates potassium channels in erythrocytes, influencing their deformability and survival. 3. **Colon Goblet Cells:** KCNIP3's transcriptional regulatory properties may influence the expression of genes involved in intestinal epithelial cell differentiation and homeostasis. In conclusion, KCNIP3 is a multifunctional protein that plays a critical role in regulating ion channels, transcriptional control, and cellular signaling pathways. Its dysregulation has been implicated in various human diseases, highlighting the need for further research into the mechanisms underlying KCNIP3's functions and its potential therapeutic applications.

Genular Protein ID: 571389093

Symbol: CSEN_HUMAN

Name: Calsenilin

UniProtKB Accession Codes:

Q9Y2W7 H7BY46 Q3YAC3 Q3YAC4 Q53TJ5 Q96T40 Q9UJ84 Q9UJ85

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 9 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9771752

Title: Calsenilin: a calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment.

PubMed ID: 9771752

DOI: 10.1038/2673

PubMed ID: 10078534

Title: DREAM is a Ca2+-regulated transcriptional repressor.

PubMed ID: 10078534

DOI: 10.1038/18044

PubMed ID: 10676964

Title: Modulation of A-type potassium channels by a family of calcium sensors.

PubMed ID: 10676964

DOI: 10.1038/35000592

PubMed ID: 16112838

Title: Structure, alternative splicing, and expression of the human and mouse KCNIP gene family.

PubMed ID: 16112838

DOI: 10.1016/j.ygeno.2005.07.001

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11278424

Title: Calsenilin is a substrate for caspase-3 that preferentially interacts with the familial Alzheimer's disease-associated C-terminal fragment of presenilin 2.

PubMed ID: 11278424

DOI: 10.1074/jbc.m008597200

PubMed ID: 11259376

Title: Pro-apoptotic function of calsenilin/DREAM/KChIP3.

PubMed ID: 11259376

DOI: 10.1096/fj.00-0541fje

PubMed ID: 11988022

Title: Calsenilin enhances apoptosis by altering endoplasmic reticulum calcium signaling.

PubMed ID: 11988022

DOI: 10.1006/mcne.2001.1096

PubMed ID: 12829703

Title: A fundamental role for KChIPs in determining the molecular properties and trafficking of Kv4.2 potassium channels.

PubMed ID: 12829703

DOI: 10.1074/jbc.m306142200

PubMed ID: 12837631

Title: Phosphorylation of calsenilin at Ser63 regulates its cleavage by caspase-3.

PubMed ID: 12837631

DOI: 10.1016/s1044-7431(03)00072-1

PubMed ID: 15485870

Title: KChIP3 rescues the functional expression of Shal channel tetramerization mutants.

PubMed ID: 15485870

DOI: 10.1074/jbc.m409721200

PubMed ID: 14720210

Title: Induction of pro-apoptotic calsenilin/DREAM/KChIP3 in Alzheimer's disease and cultured neurons after amyloid-beta exposure.

PubMed ID: 14720210

DOI: 10.1111/j.1471-4159.2004.02159.x

PubMed ID: 16123112

Title: Multiprotein assembly of Kv4.2, KChIP3 and DPP10 produces ternary channel complexes with ISA-like properties.

PubMed ID: 16123112

DOI: 10.1113/jphysiol.2005.087858

PubMed ID: 18957440

Title: Multiple Kv channel-interacting proteins contain an N-terminal transmembrane domain that regulates Kv4 channel trafficking and gating.

PubMed ID: 18957440

DOI: 10.1074/jbc.m806852200

PubMed ID: 21070824

Title: Sumoylation regulates nuclear localization of repressor DREAM.

PubMed ID: 21070824

DOI: 10.1016/j.bbamcr.2010.11.001

PubMed ID: 17962406

Title: Solution structure and calcium-binding properties of EF-hands 3 and 4 of calsenilin.

PubMed ID: 17962406

DOI: 10.1110/ps.072928007

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 256
  • Mass: 29231
  • Checksum: 635C3EDF8B91E1C5
  • Sequence:
    • MQPAKEVTKA SDGSLLGDLG HTPLSKKEGI KWQRPRLSRQ ALMRCCLVKW ILSSTAPQGS 
DSSDSELELS TVRHQPEGLD QLQAQTKFTK KELQSLYRGF KNECPTGLVD EDTFKLIYAQ 
FFPQGDATTY AHFLFNAFDA DGNGAIHFED FVVGLSILLR GTVHEKLKWA FNLYDINKDG 
YITKEEMLAI MKSIYDMMGR HTYPILREDA PAEHVERFFE KMDRNQDGVV TIEEFLEACQ 
KDENIMSSMQ LFENVI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.