Details for: HGF

Gene ID: 3082

Symbol: HGF

Ensembl ID: ENSG00000019991

Description: hepatocyte growth factor

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 2.4
    Marker Score: 903
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.69
    Marker Score: 57424
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.48
    Marker Score: 3016
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169267
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.28
    Marker Score: 47154
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.17
    Marker Score: 648
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.12
    Marker Score: 2160
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.07
    Marker Score: 681
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.05
    Marker Score: 601
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251791
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.04
    Marker Score: 22095
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71809.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48034
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.98
    Marker Score: 2574
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.97
    Marker Score: 1836.5
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.96
    Marker Score: 400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5345
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2735
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.88
    Marker Score: 531
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5281
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.79
    Marker Score: 197
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.78
    Marker Score: 12279
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.78
    Marker Score: 197
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 595.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1256
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 703
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.77
    Marker Score: 4600
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 391
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.73
    Marker Score: 1007
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.72
    Marker Score: 342.5
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.71
    Marker Score: 972
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.65
    Marker Score: 444
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.64
    Marker Score: 413
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.63
    Marker Score: 414
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.61
    Marker Score: 734
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.59
    Marker Score: 136
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.53
    Marker Score: 141
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.53
    Marker Score: 501
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.52
    Marker Score: 445
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.51
    Marker Score: 496
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.48
    Marker Score: 3183
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.46
    Marker Score: 149
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.46
    Marker Score: 5192
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.46
    Marker Score: 440
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.43
    Marker Score: 97
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.41
    Marker Score: 632
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.4
    Marker Score: 103
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.4
    Marker Score: 236
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.39
    Marker Score: 485
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.38
    Marker Score: 253
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.38
    Marker Score: 95
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.38
    Marker Score: 130
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.37
    Marker Score: 166
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.37
    Marker Score: 249
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.37
    Marker Score: 266
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.37
    Marker Score: 303
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.36
    Marker Score: 195
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.36
    Marker Score: 7071
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.35
    Marker Score: 1359
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.35
    Marker Score: 874
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.34
    Marker Score: 1047
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.33
    Marker Score: 378
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.33
    Marker Score: 81
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.33
    Marker Score: 162
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.32
    Marker Score: 202
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.3
    Marker Score: 585
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.3
    Marker Score: 71
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.29
    Marker Score: 145
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.29
    Marker Score: 4681
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.29
    Marker Score: 82
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.28
    Marker Score: 299
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.28
    Marker Score: 477
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.28
    Marker Score: 328
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.28
    Marker Score: 99
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.27
    Marker Score: 88
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.27
    Marker Score: 86
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.27
    Marker Score: 177
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.27
    Marker Score: 643
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.27
    Marker Score: 238
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.27
    Marker Score: 119
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.26
    Marker Score: 181
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.26
    Marker Score: 410
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.26
    Marker Score: 110.5
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.25
    Marker Score: 283
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.25
    Marker Score: 65
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.25
    Marker Score: 13988
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.25
    Marker Score: 260
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.24
    Marker Score: 279
  • Cell Name: adipose microvascular endothelial cell (CL2000072)
    Fold Change: 0.24
    Marker Score: 70
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.23
    Marker Score: 97
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.23
    Marker Score: 105
  • Cell Name: basophil mast progenitor cell (CL0002028)
    Fold Change: 0.23
    Marker Score: 69
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.23
    Marker Score: 121
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.22
    Marker Score: 192
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.22
    Marker Score: 132
  • Cell Name: eosinophil (CL0000771)
    Fold Change: 0.22
    Marker Score: 71

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Other Information

**Key characteristics:** * HGF is a glycoprotein with a molecular weight of approximately 180 kDa. * It is secreted by various cell types, including hepatocytes, fibroblasts, and immune cells. * HGF is a potent mitogen for hepatocytes, promoting cell proliferation, migration, and survival. * It also inhibits apoptosis in hepatocytes. * HGF plays a role in wound healing, tissue regeneration, and tumor growth. **Pathways and functions:** * HGF binds to its receptor, known as MET, which is expressed on the surface of various cell types. * Binding of HGF to MET induces the activation of the PI3K/Akt pathway. * This pathway is involved in cell growth, proliferation, and survival. * HGF also activates the MAPK1/MAPK3 signaling pathway, which is involved in cell migration and survival. * It also regulates the expression of several genes involved in cell cycle regulation, cell growth, and apoptosis. **Clinical significance:** * HGF is a key growth factor in the liver. * Mutations in the HGF gene have been linked to various liver diseases, including liver cancer and cirrhosis. * Overexpression of HGF has been observed in many human carcinomas. * Blockade of HGF signaling has shown efficacy in treating liver cancer in preclinical models. **Conclusion:** The HGF gene plays a critical role in the liver, regulating hepatocyte growth, differentiation, and survival. Aberrant expression of HGF has been linked to various liver diseases, highlighting its potential as a therapeutic target.

Genular Protein ID: 2927579749

Symbol: HGF_HUMAN

Name: Hepatocyte growth factor

UniProtKB Accession Codes:

P14210 A1L3U6 Q02935 Q13494 Q14519 Q3KRB2 Q8TCE2 Q9BYL9 Q9BYM0 Q9UDU6

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CDD 3 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 6 EMBL 36 EPD 1 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 37 Gene3D 3 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MEROPS 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 48 PDBsum 35 PIR 1 PIRSF 2 PRINTS 2 PRO 1 PROSITE 4 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 6 RNAct 1 Reactome 18 RefSeq 9 SASBDB 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2528952

Title: Molecular cloning and sequence analysis of cDNA for human hepatocyte growth factor.

PubMed ID: 2528952

DOI: 10.1016/0006-291x(89)92316-4

PubMed ID: 2531289

Title: Molecular cloning and expression of human hepatocyte growth factor.

PubMed ID: 2531289

DOI: 10.1038/342440a0

PubMed ID: 2145836

Title: Isolation and expression of cDNA for different forms of hepatocyte growth factor from human leukocyte.

PubMed ID: 2145836

DOI: 10.1016/s0006-291x(05)80212-8

PubMed ID: 1831432

Title: Organization of the human hepatocyte growth factor-encoding gene.

PubMed ID: 1831432

DOI: 10.1016/0378-1119(91)90080-u

PubMed ID: 1826653

Title: An alternatively processed mRNA generated from human hepatocyte growth factor gene.

PubMed ID: 1826653

DOI: 10.1111/j.1432-1033.1991.tb15876.x

PubMed ID: 1824873

Title: A broad-spectrum human lung fibroblast-derived mitogen is a variant of hepatocyte growth factor.

PubMed ID: 1824873

DOI: 10.1073/pnas.88.2.415

PubMed ID: 1831266

Title: Evidence for the identity of human scatter factor and human hepatocyte growth factor.

PubMed ID: 1831266

DOI: 10.1073/pnas.88.16.7001

PubMed ID: 1720571

Title: Identification of a competitive HGF antagonist encoded by an alternative transcript.

PubMed ID: 1720571

DOI: 10.1126/science.1720571

PubMed ID: 1280830

Title: A functional domain in the heavy chain of scatter factor/hepatocyte growth factor binds the c-Met receptor and induces cell dissociation but not mitogenesis.

PubMed ID: 1280830

DOI: 10.1073/pnas.89.23.11574

PubMed ID: 8662798

Title: Hepatocyte growth factor (HGF)/NK1 is a naturally occurring HGF/scatter factor variant with partial agonist/antagonist activity.

PubMed ID: 8662798

DOI: 10.1074/jbc.271.22.13110

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1832556

Title: Structural organization and the transcription initiation site of the human hepatocyte growth factor gene.

PubMed ID: 1832556

DOI: 10.1021/bi00102a007

PubMed ID: 1826837

Title: Identification of the N-terminal residue of the heavy chain of both native and recombinant human hepatocyte growth factor.

PubMed ID: 1826837

DOI: 10.1016/0006-291x(91)91616-k

PubMed ID: 1482348

Title: Hepatocyte growth factor is linked by O-glycosylated oligosaccharide on the alpha chain.

PubMed ID: 1482348

DOI: 10.1016/0006-291x(92)90219-b

PubMed ID: 1321034

Title: Structure-function analysis of hepatocyte growth factor: identification of variants that lack mitogenic activity yet retain high affinity receptor binding.

PubMed ID: 1321034

DOI: 10.1002/j.1460-2075.1992.tb05315.x

PubMed ID: 19576567

Title: Noncoding mutations of HGF are associated with nonsyndromic hearing loss, DFNB39.

PubMed ID: 19576567

DOI: 10.1016/j.ajhg.2009.06.003

PubMed ID: 20977675

Title: TMPRSS13, a type II transmembrane serine protease, is inhibited by hepatocyte growth factor activator inhibitor type 1 and activates pro-hepatocyte growth factor.

PubMed ID: 20977675

DOI: 10.1111/j.1742-4658.2010.07894.x

PubMed ID: 22242148

Title: SRPX2 is a novel chondroitin sulfate proteoglycan that is overexpressed in gastrointestinal cancer.

PubMed ID: 22242148

DOI: 10.1371/journal.pone.0027922

PubMed ID: 9493272

Title: The solution structure of the N-terminal domain of hepatocyte growth factor reveals a potential heparin-binding site.

PubMed ID: 9493272

DOI: 10.1016/s0969-2126(98)00012-4

PubMed ID: 9817840

Title: Crystal structure of the NK1 fragment of human hepatocyte growth factor at 2.0-A resolution.

PubMed ID: 9817840

DOI: 10.1016/s0969-2126(98)00138-5

PubMed ID: 15167892

Title: Crystal structure of the HGF beta-chain in complex with the Sema domain of the Met receptor.

PubMed ID: 15167892

DOI: 10.1038/sj.emboj.7600243

PubMed ID: 20624990

Title: Structural basis for agonism and antagonism of hepatocyte growth factor.

PubMed ID: 20624990

DOI: 10.1073/pnas.1005183107

Sequence Information:

  • Length: 728
  • Mass: 83134
  • Checksum: 2D997938295ADD2F
  • Sequence:
    • MWVTKLLPAL LLQHVLLHLL LLPIAIPYAE GQRKRRNTIH EFKKSAKTTL IKIDPALKIK 
TKKVNTADQC ANRCTRNKGL PFTCKAFVFD KARKQCLWFP FNSMSSGVKK EFGHEFDLYE 
NKDYIRNCII GKGRSYKGTV SITKSGIKCQ PWSSMIPHEH SFLPSSYRGK DLQENYCRNP 
RGEEGGPWCF TSNPEVRYEV CDIPQCSEVE CMTCNGESYR GLMDHTESGK ICQRWDHQTP 
HRHKFLPERY PDKGFDDNYC RNPDGQPRPW CYTLDPHTRW EYCAIKTCAD NTMNDTDVPL 
ETTECIQGQG EGYRGTVNTI WNGIPCQRWD SQYPHEHDMT PENFKCKDLR ENYCRNPDGS 
ESPWCFTTDP NIRVGYCSQI PNCDMSHGQD CYRGNGKNYM GNLSQTRSGL TCSMWDKNME 
DLHRHIFWEP DASKLNENYC RNPDDDAHGP WCYTGNPLIP WDYCPISRCE GDTTPTIVNL 
DHPVISCAKT KQLRVVNGIP TRTNIGWMVS LRYRNKHICG GSLIKESWVL TARQCFPSRD 
LKDYEAWLGI HDVHGRGDEK CKQVLNVSQL VYGPEGSDLV LMKLARPAVL DDFVSTIDLP 
NYGCTIPEKT SCSVYGWGYT GLINYDGLLR VAHLYIMGNE KCSQHHRGKV TLNESEICAG 
AEKIGSGPCE GDYGGPLVCE QHKMRMVLGV IVPGRGCAIP NRPGIFVRVA YYAKWIHKII 
LTYKVPQS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.