Details for: HGF

Gene ID: 3082

Symbol: HGF

Ensembl ID: ENSG00000019991

Description: hepatocyte growth factor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 98.2351
    Cell Significance Index: -15.2800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 57.4823
    Cell Significance Index: -14.5800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 30.2764
    Cell Significance Index: -12.3000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 27.7419
    Cell Significance Index: -14.2700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 12.4011
    Cell Significance Index: -15.2900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.9166
    Cell Significance Index: -15.4600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 3.2466
    Cell Significance Index: 50.2300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.0714
    Cell Significance Index: 88.0500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.8858
    Cell Significance Index: 15.8400
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: 1.0964
    Cell Significance Index: 5.2500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.0591
    Cell Significance Index: 28.3300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2110
    Cell Significance Index: 27.0500
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 0.1061
    Cell Significance Index: 0.4900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0871
    Cell Significance Index: 0.7100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0406
    Cell Significance Index: 62.4900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0151
    Cell Significance Index: 1.0200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0090
    Cell Significance Index: 0.4700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0055
    Cell Significance Index: 3.7800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0002
    Cell Significance Index: -0.0300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0015
    Cell Significance Index: -0.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0040
    Cell Significance Index: -7.5000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0053
    Cell Significance Index: -9.8600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0061
    Cell Significance Index: -3.8800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0165
    Cell Significance Index: -22.4000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0169
    Cell Significance Index: -7.4800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0203
    Cell Significance Index: -15.4000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0211
    Cell Significance Index: -7.5600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0232
    Cell Significance Index: -4.6600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0234
    Cell Significance Index: -17.3500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0265
    Cell Significance Index: -0.1600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0273
    Cell Significance Index: -12.3800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0332
    Cell Significance Index: -18.7300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0347
    Cell Significance Index: -6.8800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0429
    Cell Significance Index: -2.7700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0451
    Cell Significance Index: -2.2800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0457
    Cell Significance Index: -4.6700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0488
    Cell Significance Index: -14.0300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0539
    Cell Significance Index: -9.7100
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0676
    Cell Significance Index: -0.5200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0707
    Cell Significance Index: -1.5000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0802
    Cell Significance Index: -11.6600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0893
    Cell Significance Index: -18.8200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0895
    Cell Significance Index: -11.0000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1031
    Cell Significance Index: -17.6000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1115
    Cell Significance Index: -14.4000
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1156
    Cell Significance Index: -1.4300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1157
    Cell Significance Index: -7.1100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1204
    Cell Significance Index: -14.0300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1225
    Cell Significance Index: -1.7600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1281
    Cell Significance Index: -9.0600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1446
    Cell Significance Index: -15.0600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1645
    Cell Significance Index: -18.8500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1657
    Cell Significance Index: -12.7200
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1760
    Cell Significance Index: -2.4700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1939
    Cell Significance Index: -14.4500
  • Cell Name: brush cell (CL0002204)
    Fold Change: -0.1974
    Cell Significance Index: -1.8100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2104
    Cell Significance Index: -5.8800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2151
    Cell Significance Index: -10.1100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2202
    Cell Significance Index: -6.2900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2203
    Cell Significance Index: -3.5000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2294
    Cell Significance Index: -14.4600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2390
    Cell Significance Index: -4.0000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2439
    Cell Significance Index: -6.2300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2681
    Cell Significance Index: -6.4300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2760
    Cell Significance Index: -14.4900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2862
    Cell Significance Index: -16.0600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2897
    Cell Significance Index: -12.6000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2929
    Cell Significance Index: -7.5300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2967
    Cell Significance Index: -5.7900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3024
    Cell Significance Index: -15.7100
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.3117
    Cell Significance Index: -3.0100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3239
    Cell Significance Index: -6.7800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.3316
    Cell Significance Index: -5.3200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3398
    Cell Significance Index: -6.2800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3459
    Cell Significance Index: -15.3000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3472
    Cell Significance Index: -16.1900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4013
    Cell Significance Index: -11.8200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4050
    Cell Significance Index: -15.3400
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.4108
    Cell Significance Index: -4.7700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.4198
    Cell Significance Index: -8.3000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.4291
    Cell Significance Index: -7.4200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4349
    Cell Significance Index: -15.2400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.4456
    Cell Significance Index: -18.2600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4539
    Cell Significance Index: -14.8600
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.4556
    Cell Significance Index: -4.7000
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.4611
    Cell Significance Index: -6.7200
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.4647
    Cell Significance Index: -2.8800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.4741
    Cell Significance Index: -16.6600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4751
    Cell Significance Index: -17.4400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4847
    Cell Significance Index: -10.3600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4876
    Cell Significance Index: -15.5300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.5014
    Cell Significance Index: -8.8600
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.5251
    Cell Significance Index: -7.5400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.5273
    Cell Significance Index: -13.1500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.5300
    Cell Significance Index: -14.2000
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.5323
    Cell Significance Index: -6.4800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5488
    Cell Significance Index: -14.4300
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.5652
    Cell Significance Index: -8.0400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.5656
    Cell Significance Index: -14.4100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.5725
    Cell Significance Index: -14.2800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** HGF is a 26-kDa protein that belongs to the FGF family, which is characterized by the presence of a conserved tyrosine kinase domain. HGF is produced by various cell types, including hepatic stellate cells, fibroblasts, and immune cells, and its expression is regulated by a complex network of transcription factors and signaling pathways. HGF is highly glycosylated, which is essential for its stability and functionality. Its receptor, c-Met, is a tyrosine kinase receptor that is activated by HGF binding, leading to the activation of downstream signaling pathways. **Pathways and Functions** HGF is involved in various cellular processes, including: 1. **Cell migration and invasion**: HGF promotes cell migration and invasion by activating the c-Met receptor and downstream signaling pathways, such as the PI3K/AKT and MAPK cascades. 2. **Cell proliferation and differentiation**: HGF regulates cell proliferation and differentiation by modulating the expression of growth-related genes and signaling pathways. 3. **Survival and apoptosis**: HGF protects cells against apoptosis by activating anti-apoptotic signaling pathways, such as the PI3K/AKT and NF-κB pathways. 4. **Angiogenesis**: HGF promotes angiogenesis by stimulating the proliferation and migration of endothelial cells. 5. **Tissue repair and remodeling**: HGF plays a role in tissue repair and remodeling by regulating the expression of growth-related genes and signaling pathways. HGF is also involved in various pathological processes, including: 1. **Cancer**: HGF is overexpressed in various types of cancer, including hepatocellular carcinoma, breast cancer, and lung cancer, and its dysregulation contributes to tumor growth, invasion, and metastasis. 2. **Fibrosis**: HGF is involved in the development of fibrosis by promoting the proliferation and activation of hepatic stellate cells and other fibroblasts. 3. **Cardiovascular disorders**: HGF is implicated in the pathogenesis of cardiovascular disorders, including atherosclerosis and cardiac fibrosis. **Clinical Significance** HGF has been implicated in various diseases, including: 1. **Hepatocellular carcinoma**: HGF is overexpressed in hepatocellular carcinoma and is associated with poor prognosis. 2. **Breast cancer**: HGF is overexpressed in breast cancer and is associated with metastasis and poor prognosis. 3. **Lung cancer**: HGF is overexpressed in lung cancer and is associated with metastasis and poor prognosis. 4. **Cardiovascular disorders**: HGF is implicated in the pathogenesis of cardiovascular disorders, including atherosclerosis and cardiac fibrosis. Therapeutic strategies targeting HGF and its receptor, c-Met, have shown promise in preclinical studies and clinical trials. Inhibitors of HGF and c-Met have been tested in various cancers, including hepatocellular carcinoma, breast cancer, and lung cancer, and have shown promising results. In conclusion, HGF is a pleiotropic growth factor that plays a crucial role in various physiological and pathological processes. Its dysregulation has been implicated in various diseases, including cancer, fibrosis, and cardiovascular disorders. Further research is needed to fully understand the mechanisms of HGF and its therapeutic potential.

Genular Protein ID: 2927579749

Symbol: HGF_HUMAN

Name: Hepatocyte growth factor

UniProtKB Accession Codes:

P14210 A1L3U6 Q02935 Q13494 Q14519 Q3KRB2 Q8TCE2 Q9BYL9 Q9BYM0 Q9UDU6

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CDD 3 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 6 EMBL 36 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 36 Gene3D 3 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 12 KEGG 1 MANE-Select 1 MEROPS 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 35 PDBsum 35 PIR 1 PIRSF 2 PRINTS 2 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 6 RNAct 1 Reactome 18 RefSeq 9 SASBDB 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2528952

Title: Molecular cloning and sequence analysis of cDNA for human hepatocyte growth factor.

PubMed ID: 2528952

DOI: 10.1016/0006-291x(89)92316-4

PubMed ID: 2531289

Title: Molecular cloning and expression of human hepatocyte growth factor.

PubMed ID: 2531289

DOI: 10.1038/342440a0

PubMed ID: 2145836

Title: Isolation and expression of cDNA for different forms of hepatocyte growth factor from human leukocyte.

PubMed ID: 2145836

DOI: 10.1016/s0006-291x(05)80212-8

PubMed ID: 1831432

Title: Organization of the human hepatocyte growth factor-encoding gene.

PubMed ID: 1831432

DOI: 10.1016/0378-1119(91)90080-u

PubMed ID: 1826653

Title: An alternatively processed mRNA generated from human hepatocyte growth factor gene.

PubMed ID: 1826653

DOI: 10.1111/j.1432-1033.1991.tb15876.x

PubMed ID: 1824873

Title: A broad-spectrum human lung fibroblast-derived mitogen is a variant of hepatocyte growth factor.

PubMed ID: 1824873

DOI: 10.1073/pnas.88.2.415

PubMed ID: 1831266

Title: Evidence for the identity of human scatter factor and human hepatocyte growth factor.

PubMed ID: 1831266

DOI: 10.1073/pnas.88.16.7001

PubMed ID: 1720571

Title: Identification of a competitive HGF antagonist encoded by an alternative transcript.

PubMed ID: 1720571

DOI: 10.1126/science.1720571

PubMed ID: 1280830

Title: A functional domain in the heavy chain of scatter factor/hepatocyte growth factor binds the c-Met receptor and induces cell dissociation but not mitogenesis.

PubMed ID: 1280830

DOI: 10.1073/pnas.89.23.11574

PubMed ID: 8662798

Title: Hepatocyte growth factor (HGF)/NK1 is a naturally occurring HGF/scatter factor variant with partial agonist/antagonist activity.

PubMed ID: 8662798

DOI: 10.1074/jbc.271.22.13110

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1832556

Title: Structural organization and the transcription initiation site of the human hepatocyte growth factor gene.

PubMed ID: 1832556

DOI: 10.1021/bi00102a007

PubMed ID: 1826837

Title: Identification of the N-terminal residue of the heavy chain of both native and recombinant human hepatocyte growth factor.

PubMed ID: 1826837

DOI: 10.1016/0006-291x(91)91616-k

PubMed ID: 1482348

Title: Hepatocyte growth factor is linked by O-glycosylated oligosaccharide on the alpha chain.

PubMed ID: 1482348

DOI: 10.1016/0006-291x(92)90219-b

PubMed ID: 1321034

Title: Structure-function analysis of hepatocyte growth factor: identification of variants that lack mitogenic activity yet retain high affinity receptor binding.

PubMed ID: 1321034

DOI: 10.1002/j.1460-2075.1992.tb05315.x

PubMed ID: 19576567

Title: Noncoding mutations of HGF are associated with nonsyndromic hearing loss, DFNB39.

PubMed ID: 19576567

DOI: 10.1016/j.ajhg.2009.06.003

PubMed ID: 20977675

Title: TMPRSS13, a type II transmembrane serine protease, is inhibited by hepatocyte growth factor activator inhibitor type 1 and activates pro-hepatocyte growth factor.

PubMed ID: 20977675

DOI: 10.1111/j.1742-4658.2010.07894.x

PubMed ID: 22242148

Title: SRPX2 is a novel chondroitin sulfate proteoglycan that is overexpressed in gastrointestinal cancer.

PubMed ID: 22242148

DOI: 10.1371/journal.pone.0027922

PubMed ID: 9493272

Title: The solution structure of the N-terminal domain of hepatocyte growth factor reveals a potential heparin-binding site.

PubMed ID: 9493272

DOI: 10.1016/s0969-2126(98)00012-4

PubMed ID: 9817840

Title: Crystal structure of the NK1 fragment of human hepatocyte growth factor at 2.0-A resolution.

PubMed ID: 9817840

DOI: 10.1016/s0969-2126(98)00138-5

PubMed ID: 15167892

Title: Crystal structure of the HGF beta-chain in complex with the Sema domain of the Met receptor.

PubMed ID: 15167892

DOI: 10.1038/sj.emboj.7600243

PubMed ID: 20624990

Title: Structural basis for agonism and antagonism of hepatocyte growth factor.

PubMed ID: 20624990

DOI: 10.1073/pnas.1005183107

Sequence Information:

  • Length: 728
  • Mass: 83134
  • Checksum: 2D997938295ADD2F
  • Sequence:
    • MWVTKLLPAL LLQHVLLHLL LLPIAIPYAE GQRKRRNTIH EFKKSAKTTL IKIDPALKIK 
TKKVNTADQC ANRCTRNKGL PFTCKAFVFD KARKQCLWFP FNSMSSGVKK EFGHEFDLYE 
NKDYIRNCII GKGRSYKGTV SITKSGIKCQ PWSSMIPHEH SFLPSSYRGK DLQENYCRNP 
RGEEGGPWCF TSNPEVRYEV CDIPQCSEVE CMTCNGESYR GLMDHTESGK ICQRWDHQTP 
HRHKFLPERY PDKGFDDNYC RNPDGQPRPW CYTLDPHTRW EYCAIKTCAD NTMNDTDVPL 
ETTECIQGQG EGYRGTVNTI WNGIPCQRWD SQYPHEHDMT PENFKCKDLR ENYCRNPDGS 
ESPWCFTTDP NIRVGYCSQI PNCDMSHGQD CYRGNGKNYM GNLSQTRSGL TCSMWDKNME 
DLHRHIFWEP DASKLNENYC RNPDDDAHGP WCYTGNPLIP WDYCPISRCE GDTTPTIVNL 
DHPVISCAKT KQLRVVNGIP TRTNIGWMVS LRYRNKHICG GSLIKESWVL TARQCFPSRD 
LKDYEAWLGI HDVHGRGDEK CKQVLNVSQL VYGPEGSDLV LMKLARPAVL DDFVSTIDLP 
NYGCTIPEKT SCSVYGWGYT GLINYDGLLR VAHLYIMGNE KCSQHHRGKV TLNESEICAG 
AEKIGSGPCE GDYGGPLVCE QHKMRMVLGV IVPGRGCAIP NRPGIFVRVA YYAKWIHKII 
LTYKVPQS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.