Details for: HIVEP1

Gene ID: 3096

Symbol: HIVEP1

Ensembl ID: ENSG00000095951

Description: HIVEP zinc finger 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.1
    Marker Score: 16134.5
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.1
    Marker Score: 8136
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.05
    Marker Score: 43790.5
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.02
    Marker Score: 18965
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.91
    Marker Score: 28622
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.87
    Marker Score: 115115
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.8
    Marker Score: 17139
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.8
    Marker Score: 1054
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.78
    Marker Score: 15294
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.76
    Marker Score: 1050
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.71
    Marker Score: 500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.65
    Marker Score: 3622
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.64
    Marker Score: 62250
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.53
    Marker Score: 2357
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167904
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.46
    Marker Score: 5949.5
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.41
    Marker Score: 1710
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.39
    Marker Score: 5774
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.36
    Marker Score: 2381
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.36
    Marker Score: 8759
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.33
    Marker Score: 7161
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.32
    Marker Score: 5712
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.31
    Marker Score: 26127
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.3
    Marker Score: 3057
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.29
    Marker Score: 1356
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.28
    Marker Score: 43295
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.27
    Marker Score: 477
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.26
    Marker Score: 46396
  • Cell Name: interneuron (CL0000099)
    Fold Change: 1.24
    Marker Score: 568
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.23
    Marker Score: 396
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.23
    Marker Score: 2360.5
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.21
    Marker Score: 18926
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.2
    Marker Score: 1356
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.18
    Marker Score: 1301
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.16
    Marker Score: 611
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.16
    Marker Score: 1235
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.14
    Marker Score: 358
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.12
    Marker Score: 1294.5
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.12
    Marker Score: 673
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.1
    Marker Score: 4619
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.09
    Marker Score: 1580
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.08
    Marker Score: 2189
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.06
    Marker Score: 616
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.06
    Marker Score: 1423
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.04
    Marker Score: 4814.5
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.04
    Marker Score: 1117
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.02
    Marker Score: 5009
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.02
    Marker Score: 566
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.02
    Marker Score: 2496
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.01
    Marker Score: 10455
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.01
    Marker Score: 16143
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.01
    Marker Score: 4190.5
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1
    Marker Score: 3715.5
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1
    Marker Score: 341
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1
    Marker Score: 1204
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71705.5
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1
    Marker Score: 287
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47930.5
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.98
    Marker Score: 411
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30392
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.97
    Marker Score: 360
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.96
    Marker Score: 350
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.96
    Marker Score: 833
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.96
    Marker Score: 535.5
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.95
    Marker Score: 627.5
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.95
    Marker Score: 354
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2399
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.94
    Marker Score: 1176
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.94
    Marker Score: 5665
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.94
    Marker Score: 4942
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.94
    Marker Score: 3347
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.94
    Marker Score: 812
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.93
    Marker Score: 1376
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 481
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.93
    Marker Score: 648
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 435
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.92
    Marker Score: 986
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.92
    Marker Score: 512
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.92
    Marker Score: 31161
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.9
    Marker Score: 1468
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2705
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.89
    Marker Score: 244
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.89
    Marker Score: 1104
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.89
    Marker Score: 19946
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.89
    Marker Score: 281
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.88
    Marker Score: 680
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.88
    Marker Score: 3119
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.88
    Marker Score: 777
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5294
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 307
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.85
    Marker Score: 4584.5
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.85
    Marker Score: 4855
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.84
    Marker Score: 265
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.84
    Marker Score: 1184
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.82
    Marker Score: 545
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.81
    Marker Score: 313
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.81
    Marker Score: 6134
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 603
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.77
    Marker Score: 449
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.77
    Marker Score: 366

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Other Information

**Key characteristics:** - It is a protein of the Zinc finger family, which are a group of proteins that are involved in DNA binding and transcriptional regulation. - HIVEP1 is a zinc finger protein that is expressed in a variety of brain cell types, including GABAergic interneurons, astrocytes, and neurons. - It is a key regulator of the Bmp signaling pathway, which is involved in the development and survival of neurons. - HIVEP1 also regulates the transcription of a number of other genes, including those involved in learning and memory. **Pathways and functions:** - HIVEP1 is involved in the regulation of the Bmp signaling pathway, which is a key pathway for the development and survival of neurons. - It is also involved in the regulation of transcription, and it has been shown to regulate the expression of a number of genes involved in learning and memory. - HIVEP1 is also involved in the regulation of the cytosol, DNA-binding transcription factor activity, and rna polymerase ii-specific transcription. **Clinical significance:** - Mutations in HIVEP1 have been linked to a number of neurological disorders, including autism, schizophrenia, and epilepsy. - These mutations can disrupt the function of HIVEP1, leading to the development of these neurological disorders. - As a result, HIVEP1 is a promising target for the treatment of these disorders.

Genular Protein ID: 3978406538

Symbol: ZEP1_HUMAN

Name: Zinc finger protein 40

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2106471

Title: A DNA-binding protein containing two widely separated zinc finger motifs that recognize the same DNA sequence.

PubMed ID: 2106471

DOI: 10.1101/gad.4.1.29

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2108316

Title: A large protein containing zinc finger domains binds to related sequence elements in the enhancers of the class I major histocompatibility complex and kappa immunoglobulin genes.

PubMed ID: 2108316

DOI: 10.1128/mcb.10.4.1406-1414.1990

PubMed ID: 1727488

Title: Regulation of human immunodeficiency virus enhancer function by PRDII-BF1 and c-rel gene products.

PubMed ID: 1727488

DOI: 10.1128/jvi.66.1.244-250.1992

PubMed ID: 8289330

Title: Transcription factor PRDII-BF1 activates human immunodeficiency virus type 1 gene expression.

PubMed ID: 8289330

DOI: 10.1128/jvi.68.2.1002-1009.1994

PubMed ID: 11818340

Title: GAAP-1: a transcriptional activator of p53 and IRF-1 possesses pro-apoptotic activity.

PubMed ID: 11818340

DOI: 10.1093/embo-reports/kvf032

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19732766

Title: Cirhin up-regulates a canonical NF-kappaB element through strong interaction with Cirip/HIVEP1.

PubMed ID: 19732766

DOI: 10.1016/j.yexcr.2009.08.017

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 2248949

Title: High-resolution three-dimensional structure of a single zinc finger from a human enhancer binding protein in solution.

PubMed ID: 2248949

DOI: 10.1021/bi00492a004

PubMed ID: 1567844

Title: High-resolution solution structure of the double Cys2His2 zinc finger from the human enhancer binding protein MBP-1.

PubMed ID: 1567844

DOI: 10.1021/bi00131a004

Sequence Information:

  • Length: 2718
  • Mass: 296835
  • Checksum: 27AD2BB4E9484033
  • Sequence:
  • MPRTKQIHPR NLRDKIEEAQ KELNGAEVSK KEILQAGVKG TSESLKGVKR KKIVAENHLK 
    KIPKSPLRNP LQAKHKQNTE ESSFAVLHSA SESHKKQNYI PVKNGKQFTK QNGETPGIIA 
    EASKSEESVS PKKPLFLQQP SELRRWRSEG ADPAKFSDLD EQCDSSSLSS KTRTDNSECI 
    SSHCGTTSPS YTNTAFDVLL KAMEPELSTL SQKGSPCAIK TEKLRPNKTA RSPPKLKNSS 
    MDAPNQTSQE LVAESQSSCT SYTVHMSAAQ KNEQGAMQSA SHLYHQHEHF VPKSNQHNQQ 
    LPGCSGFTGS LTNLQNQENA KLEQVYNIAV TSSVGLTSPS SRSQVTPQNQ QMDSASPLSI 
    SPANSTQSPP MPIYNSTHVA SVVNQSVEQM CNLLLKDQKP KKQGKYICEY CNRACAKPSV 
    LLKHIRSHTG ERPYPCVTCG FSFKTKSNLY KHKKSHAHTI KLGLVLQPDA GGLFLSHESP 
    KALSIHSDVE DSGESEEEGA TDERQHDLGA MELQPVHIIK RMSNAETLLK SSFTPSSPEN 
    VIGDFLLQDR SAESQAVTEL PKVVVHHVTV SPLRTDSPKA MDPKPELSSA QKQKDLQVTN 
    VQPLSANMSQ GGVSRLETNE NSHQKGDMNP LEGKQDSHVG TVHAQLQRQQ ATDYSQEQQG 
    KLLSPRSLGS TDSGYFSRSE SADQTVSPPT PFARRLPSTE QDSGRSNGPS AALVTTSTPS 
    ALPTGEKALL LPGQMRPPLA TKTLEERISK LISDNEALVD DKQLDSVKPR RTSLSRRGSI 
    DSPKSYIFKD SFQFDLKPVG RRTSSSSDIP KSPFTPTEKS KQVFLLSVPS LDCLPITRSN 
    SMPTTGYSAV PANIIPPPHP LRGSQSFDDK IGAFYDDVFV SGPNAPVPQS GHPRTLVRQA 
    AIEDSSANES HVLGTGQSLD ESHQGCHAAG EAMSVRSKAL AQGPHIEKKK SHQGRGTMFE 
    CETCRNRYRK LENFENHKKF YCSELHGPKT KVAMREPEHS PVPGGLQPQI LHYRVAGSSG 
    IWEQTPQIRK RRKMKSVGDD EELQQNESGT SPKSSEGLQF QNALGCNPSL PKHNVTIRSD 
    QQHKNIQLQN SHIHLVARGP EQTMDPKLST IMEQQISSAA QDKIELQRHG TGISVIQHTN 
    SLSRPNSFDK PEPFERASPV SFQELNRTGK SGSLKVIGIS QEESHPSRDG SHPHQLALSD 
    ALRGELQESS RKSPSERHVL GQPSRLVRQH NIQVPEILVT EEPDRDLEAQ CHDQEKSEKF 
    SWPQRSETLS KLPTEKLPPK KKRLRLAEIE HSSTESSFDS TLSRSLSRES SLSHTSSFSA 
    SLDIEDVSKT EASPKIDFLN KAEFLMIPAG LNTLNVPGCH REMRRTASEQ INCTQTSMEV 
    SDLRSKSFDC GSITPPQTTP LTELQPPSSP SRVGVTGHVP LLERRRGPLV RQISLNIAPD 
    SHLSPVHPTS FQNTALPSVN AVPYQGPQLT STSLAEFSAN TLHSQTQVKD LQAETSNSSS 
    TNVFPVQQLC DINLLNQIHA PPSHQSTQLS LQVSTQGSKP DKNSVLSGSS KSEDCFAPKY 
    QLHCQVFTSG PSCSSNPVHS LPNQVISDPV GTDHCVTSAT LPTKLIDSMS NSHPLLPPEL 
    RPLGSQVQKV PSSFMLPIRL QSSVPAYCFA TLTSLPQILV TQDLPNQPIC QTNHSVVPIS 
    EEQNSVPTLQ KGHQNALPNP EKEFLCENVF SEMSQNSSLS ESLPITQKIS VGRLSPQQES 
    SASSKRMLSP ANSLDIAMEK HQKRAKDENG AVCATDVRPL EALSSRVNEA SKQKKPILVR 
    QVCTTEPLDG VMLEKDVFSQ PEISNEAVNL TNVLPADNSS TGCSKFVVIE PISELQEFEN 
    IKSSTSLTLT VRSSPAPSEN THISPLKCTD NNQERKSPGV KNQGDKVNIQ EQSQQPVTSL 
    SLFNIKDTQQ LAFPSLKTTT NFTWCYLLRQ KSLHLPQKDQ KTSAYTDWTV SASNPNPLGL 
    PTKVALALLN SKQNTGKSLY CQAITTHSKS DLLVYSSKWK SSLSKRALGN QKSTVVEFSN 
    KDASEINSEQ DKENSLIKSE PRRIKIFDGG YKSNEEYVYV RGRGRGKYIC EECGIRCKKP 
    SMLKKHIRTH TDVRPYHCTY CNFSFKTKGN LTKHMKSKAH SKKCVDLGVS VGLIDEQDTE 
    ESDEKQRFSY ERSGYDLEES DGPDEDDNEN EDDDEDSQAE SVLSATPSVT ASPQHLPSRS 
    SLQDPVSTDE DVRITDCFSG VHTDPMDVLP RALLTRMTVL STAQSDYNRK TLSPGKARQR 
    AARDENDTIP SVDTSRSPCH QMSVDYPESE EILRSSMAGK AVAITQSPSS VRLPPAAAEH 
    SPQTAAGMPS VASPHPDPQE QKQQITLQPT PGLPSPHTHL FSHLPLHSQQ QSRTPYNMVP 
    VGGIHVVPAG LTYSTFVPLQ AGPVQLTIPA VSVVHRTLGT HRNTVTEVSG TTNPAGVAEL 
    SSVVPCIPIG QIRVPGLQNL STPGLQSLPS LSMETVNIVG LANTNMAPQV HPPGLALNAV 
    GLQVLTANPS SQSSPAPQAH IPGLQILNIA LPTLIPSVSQ VAVDAQGAPE MPASQSKACE 
    TQPKQTSVAS ANQVSRTESP QGLPTVQREN AKKVLNPPAP AGDHARLDGL SKMDTEKAAS 
    ANHVKPKPEL TSIQGQPAST SQPLLKAHSE VFTKPSGQQT LSPDRQVPRP TALPRRQPTV 
    HFSDVSSDDD EDRLVIAT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.