Details for: MNX1

Gene ID: 3110

Symbol: MNX1

Ensembl ID: ENSG00000130675

Description: motor neuron and pancreas homeobox 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 21.9472
    Cell Significance Index: 186.5400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 3.4651
    Cell Significance Index: 86.4100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.9234
    Cell Significance Index: 132.5100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.4545
    Cell Significance Index: 70.7200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.2903
    Cell Significance Index: 158.3900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.9874
    Cell Significance Index: 29.7800
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 1.9857
    Cell Significance Index: 21.5200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2733
    Cell Significance Index: 138.5000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9585
    Cell Significance Index: 155.9000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8868
    Cell Significance Index: 800.7500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.8802
    Cell Significance Index: 21.3200
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.7939
    Cell Significance Index: 6.0200
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.7385
    Cell Significance Index: 7.4500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6474
    Cell Significance Index: 14.0300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.6168
    Cell Significance Index: 21.6800
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.4633
    Cell Significance Index: 3.2600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4226
    Cell Significance Index: 9.0000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3553
    Cell Significance Index: 67.6100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.3491
    Cell Significance Index: 40.6800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.2784
    Cell Significance Index: 173.8800
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.2551
    Cell Significance Index: 2.2300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2381
    Cell Significance Index: 23.5500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.1566
    Cell Significance Index: 17.9400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1129
    Cell Significance Index: 22.4000
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.0841
    Cell Significance Index: 0.6400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0688
    Cell Significance Index: 11.7500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0512
    Cell Significance Index: 0.5300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0418
    Cell Significance Index: 4.7700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0197
    Cell Significance Index: 0.6300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0133
    Cell Significance Index: 0.9400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.0085
    Cell Significance Index: 0.0600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0072
    Cell Significance Index: 0.2000
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0066
    Cell Significance Index: 0.0800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0045
    Cell Significance Index: 3.3000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0000
    Cell Significance Index: 0.0100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0007
    Cell Significance Index: -0.2100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0012
    Cell Significance Index: -0.2600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0013
    Cell Significance Index: -2.4900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0015
    Cell Significance Index: -0.8500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0015
    Cell Significance Index: -0.0700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0015
    Cell Significance Index: -2.7900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0015
    Cell Significance Index: -2.2900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0017
    Cell Significance Index: -2.3600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0020
    Cell Significance Index: -1.1100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0048
    Cell Significance Index: -3.6700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0062
    Cell Significance Index: -3.9300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0069
    Cell Significance Index: -2.4900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0086
    Cell Significance Index: -3.9100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0111
    Cell Significance Index: -2.0000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0126
    Cell Significance Index: -2.5300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0156
    Cell Significance Index: -0.8100
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.0213
    Cell Significance Index: -0.2700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0262
    Cell Significance Index: -3.6000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0264
    Cell Significance Index: -3.8400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0265
    Cell Significance Index: -0.3800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0268
    Cell Significance Index: -3.2900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0337
    Cell Significance Index: -3.9800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0354
    Cell Significance Index: -0.6100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0360
    Cell Significance Index: -3.6800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0381
    Cell Significance Index: -3.9700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0390
    Cell Significance Index: -2.3900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0392
    Cell Significance Index: -5.0600
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0413
    Cell Significance Index: -0.3000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0422
    Cell Significance Index: -1.0900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0437
    Cell Significance Index: -2.2100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0488
    Cell Significance Index: -1.2200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0513
    Cell Significance Index: -3.4500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0563
    Cell Significance Index: -3.4600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0568
    Cell Significance Index: -2.3300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0573
    Cell Significance Index: -4.4000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0615
    Cell Significance Index: -4.5800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0618
    Cell Significance Index: -0.8000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0620
    Cell Significance Index: -1.0600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0688
    Cell Significance Index: -1.4400
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0690
    Cell Significance Index: -0.4500
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0704
    Cell Significance Index: -1.1400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0722
    Cell Significance Index: -4.0500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0744
    Cell Significance Index: -2.0300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0745
    Cell Significance Index: -3.2400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0772
    Cell Significance Index: -1.5100
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0782
    Cell Significance Index: -1.1700
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0788
    Cell Significance Index: -1.0800
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0806
    Cell Significance Index: -0.8500
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.0831
    Cell Significance Index: -0.4400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0837
    Cell Significance Index: -1.3800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0840
    Cell Significance Index: -1.2400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0848
    Cell Significance Index: -3.9900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0850
    Cell Significance Index: -3.7600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0868
    Cell Significance Index: -1.2600
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.0943
    Cell Significance Index: -1.1400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0948
    Cell Significance Index: -2.5300
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0966
    Cell Significance Index: -1.2700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0973
    Cell Significance Index: -3.4100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0993
    Cell Significance Index: -2.0600
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0998
    Cell Significance Index: -1.3800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1005
    Cell Significance Index: -2.9600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1014
    Cell Significance Index: -3.8400
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.1026
    Cell Significance Index: -1.4600
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.1061
    Cell Significance Index: -0.9600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1062
    Cell Significance Index: -3.3600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The MNX1 gene is a homeobox gene, which is a family of transcription factors that play essential roles in embryonic development and tissue patterning. The MNX1 protein is a transcriptional repressor that regulates gene expression by binding to specific DNA sequences. Its expression is widespread, with significant levels detected in erythrocytes, megakaryocytes, pancreatic ductal cells, and endocrine cells. This broad expression pattern suggests that MNX1 may have a multifunctional role in development and tissue homeostasis. **Pathways and Functions:** The MNX1 gene is involved in multiple developmental pathways, including: 1. **Central Nervous System Development:** MNX1 regulates the specification of motor neuron cell fate and the morphogenesis of neuron projections. 2. **Endocrine Pancreas Development:** MNX1 is required for the development of pancreatic ductal cells and endocrine cells. 3. **Chromatin Organization:** MNX1 interacts with chromatin remodeling complexes to regulate gene expression. 4. **RNA Polymerase II-Specific Transcription:** MNX1 regulates the activity of RNA polymerase II, a key enzyme in transcriptional elongation. **Functions:** 1. **Transcriptional Regulation:** MNX1 acts as a transcriptional repressor, regulating the expression of target genes involved in motor neuron and pancreatic development. 2. **Cell Fate Specification:** MNX1 is required for the specification of motor neuron cell fate and the maintenance of pancreatic cell identity. 3. **Tissue Homeostasis:** MNX1 may play a role in maintaining tissue homeostasis by regulating the expression of genes involved in cell proliferation and differentiation. **Clinical Significance:** Dysregulation of the MNX1 gene has been implicated in various human diseases, including: 1. **Neurological Disorders:** Mutations in MNX1 have been associated with neurological disorders, such as amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA). 2. **Pancreatic Diseases:** MNX1 expression is reduced in pancreatic cancer, suggesting a potential role in pancreatic tumorigenesis. 3. **Developmental Abnormalities:** MNX1 mutations have been linked to developmental abnormalities, including congenital anomalies and birth defects. In conclusion, the MNX1 gene is a critical regulator of motor neuron and pancreatic development, with implications for our understanding of human disease. Further research is needed to elucidate the mechanisms by which MNX1 regulates gene expression and to identify potential therapeutic targets for the treatment of MNX1-associated diseases.

Genular Protein ID: 1393906430

Symbol: MNX1_HUMAN

Name: Motor neuron and pancreas homeobox protein 1

UniProtKB Accession Codes:

P50219 F5H401 Q9Y648

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7914194

Title: A novel human homeobox gene distantly related to proboscipedia is expressed in lymphoid and pancreatic tissues.

PubMed ID: 7914194

DOI: 10.1016/s0021-9258(17)32115-4

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 10329000

Title: A physical and transcriptional map of the preaxial polydactyly locus on chromosome 7q36.

PubMed ID: 10329000

DOI: 10.1006/geno.1999.5796

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 10631160

Title: Involvement of the HLXB9 homeobox gene in Currarino syndrome.

PubMed ID: 10631160

DOI: 10.1086/302723

PubMed ID: 10749657

Title: Mutation analysis and embryonic expression of the HLXB9 Currarino syndrome gene.

PubMed ID: 10749657

DOI: 10.1086/302899

PubMed ID: 19853743

Title: MNX1 (HLXB9) mutations in Currarino patients.

PubMed ID: 19853743

DOI: 10.1016/j.jpedsurg.2009.03.039

PubMed ID: 22820079

Title: Novel mutations in the MNX1 gene in two families with Currarino syndrome and variable phenotype.

PubMed ID: 22820079

DOI: 10.1016/j.gene.2012.06.096

Sequence Information:

  • Length: 401
  • Mass: 40569
  • Checksum: 67527C8F789DFFDB
  • Sequence:
    • MEKSKNFRID ALLAVDPPRA ASAQSAPLAL VTSLAAAASG TGGGGGGGGA SGGTSGSCSP 
ASSEPPAAPA DRLRAESPSP PRLLAAHCAL LPKPGFLGAG GGGGGTGGGH GGPHHHAHPG 
AAAAAAAAAA AAAAGGLALG LHPGGAQGGA GLPAQAALYG HPVYGYSAAA AAAALAGQHP 
ALSYSYPQVQ GAHPAHPADP IKLGAGTFQL DQWLRASTAG MILPKMPDFN SQAQSNLLGK 
CRRPRTAFTS QQLLELEHQF KLNKYLSRPK RFEVATSLML TETQVKIWFQ NRRMKWKRSK 
KAKEQAAQEA EKQKGGGGGA GKGGAEEPGA EELLGPPAPG DKGSGRRLRD LRDSDPEEDE 
DEDDEDHFPY SNGASVHAAS SDCSSEDDSP PPRPSHQPAP Q

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.