Details for: MNX1

Gene ID: 3110

Symbol: MNX1

Ensembl ID: ENSG00000130675

Description: motor neuron and pancreas homeobox 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 3.71
    Marker Score: 2058
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 2.8
    Marker Score: 1588
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.08
    Marker Score: 2093.5
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.86
    Marker Score: 977.5
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.3
    Marker Score: 1354
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.18
    Marker Score: 609.5
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.03
    Marker Score: 429
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71826
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48050
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 509
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 462
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5333
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 327
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.81
    Marker Score: 794.5
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.79
    Marker Score: 315
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 692
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 462
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.67
    Marker Score: 2791
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.59
    Marker Score: 187
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 442
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.51
    Marker Score: 508
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.51
    Marker Score: 114
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.5
    Marker Score: 264
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.49
    Marker Score: 190
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.48
    Marker Score: 602
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.47
    Marker Score: 886
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 278
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.46
    Marker Score: 7185.5
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.42
    Marker Score: 184
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.41
    Marker Score: 843.5
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.4
    Marker Score: 393
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.37
    Marker Score: 779
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.36
    Marker Score: 135
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.35
    Marker Score: 234
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.34
    Marker Score: 240
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.34
    Marker Score: 243
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.34
    Marker Score: 690
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.33
    Marker Score: 787
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.32
    Marker Score: 2150
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.31
    Marker Score: 180
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.3
    Marker Score: 287
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.29
    Marker Score: 76
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.27
    Marker Score: 113
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.27
    Marker Score: 113
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.25
    Marker Score: 152
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.25
    Marker Score: 61
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.25
    Marker Score: 145
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.25
    Marker Score: 68
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.24
    Marker Score: 921
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.23
    Marker Score: 121
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.22
    Marker Score: 456
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.22
    Marker Score: 62
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.21
    Marker Score: 61
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.2
    Marker Score: 82
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.2
    Marker Score: 971
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2
    Marker Score: 68
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.2
    Marker Score: 449
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.19
    Marker Score: 69
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.17
    Marker Score: 239
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.17
    Marker Score: 76
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.16
    Marker Score: 42
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 0.16
    Marker Score: 503
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.15
    Marker Score: 361
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.15
    Marker Score: 46
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.15
    Marker Score: 38
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.14
    Marker Score: 68
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.14
    Marker Score: 49
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.14
    Marker Score: 894
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.14
    Marker Score: 99
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.13
    Marker Score: 29
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.13
    Marker Score: 417
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.13
    Marker Score: 139
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.13
    Marker Score: 58
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.12
    Marker Score: 39
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.12
    Marker Score: 31
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.12
    Marker Score: 191
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.11
    Marker Score: 25
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.11
    Marker Score: 106
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.11
    Marker Score: 50
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.11
    Marker Score: 49
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.11
    Marker Score: 192
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.11
    Marker Score: 40
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1
    Marker Score: 71
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.1
    Marker Score: 127
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.1
    Marker Score: 62
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.1
    Marker Score: 24
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.1
    Marker Score: 25
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.09
    Marker Score: 35
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.09
    Marker Score: 1262
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.09
    Marker Score: 143
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.09
    Marker Score: 29
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.09
    Marker Score: 79

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Other Information

**Key characteristics:** - MNX1 is a homeobox gene, which are a class of transcription factors that are responsible for the development of the CNS. - It is expressed in a variety of cell types, including motor neurons, pancreatic cells, and hematopoietic stem cells. - It is a key regulator of neuronal differentiation and survival. - It is involved in the regulation of the development of the spinal cord and the formation of the central nervous system. **Pathways and functions:** - MNX1 is a key regulator of the development of the spinal cord. - It is expressed in motor neurons and is required for the survival and differentiation of motor neurons. - It is also expressed in pancreatic cells, where it plays a role in the development of the pancreas and the regulation of pancreatic function. - It is involved in the development of the endocrine pancreas, where it regulates the production of digestive enzymes. **Clinical significance:** - Mutations in the MNX1 gene have been linked to a number of human diseases, including autism, schizophrenia, and diabetes. - In some cases, mutations in MNX1 can also be caused by chromosomal rearrangements, which can lead to the formation of tumors. - Understanding the role of MNX1 in development and disease can lead to the development of new treatments for these disorders.

Genular Protein ID: 1393906430

Symbol: MNX1_HUMAN

Name: Motor neuron and pancreas homeobox protein 1

UniProtKB Accession Codes:

P50219 F5H401 Q9Y648

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7914194

Title: A novel human homeobox gene distantly related to proboscipedia is expressed in lymphoid and pancreatic tissues.

PubMed ID: 7914194

DOI: 10.1016/s0021-9258(17)32115-4

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 10329000

Title: A physical and transcriptional map of the preaxial polydactyly locus on chromosome 7q36.

PubMed ID: 10329000

DOI: 10.1006/geno.1999.5796

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 10631160

Title: Involvement of the HLXB9 homeobox gene in Currarino syndrome.

PubMed ID: 10631160

DOI: 10.1086/302723

PubMed ID: 10749657

Title: Mutation analysis and embryonic expression of the HLXB9 Currarino syndrome gene.

PubMed ID: 10749657

DOI: 10.1086/302899

PubMed ID: 19853743

Title: MNX1 (HLXB9) mutations in Currarino patients.

PubMed ID: 19853743

DOI: 10.1016/j.jpedsurg.2009.03.039

PubMed ID: 22820079

Title: Novel mutations in the MNX1 gene in two families with Currarino syndrome and variable phenotype.

PubMed ID: 22820079

DOI: 10.1016/j.gene.2012.06.096

Sequence Information:

  • Length: 401
  • Mass: 40569
  • Checksum: 67527C8F789DFFDB
  • Sequence:
    • MEKSKNFRID ALLAVDPPRA ASAQSAPLAL VTSLAAAASG TGGGGGGGGA SGGTSGSCSP 
ASSEPPAAPA DRLRAESPSP PRLLAAHCAL LPKPGFLGAG GGGGGTGGGH GGPHHHAHPG 
AAAAAAAAAA AAAAGGLALG LHPGGAQGGA GLPAQAALYG HPVYGYSAAA AAAALAGQHP 
ALSYSYPQVQ GAHPAHPADP IKLGAGTFQL DQWLRASTAG MILPKMPDFN SQAQSNLLGK 
CRRPRTAFTS QQLLELEHQF KLNKYLSRPK RFEVATSLML TETQVKIWFQ NRRMKWKRSK 
KAKEQAAQEA EKQKGGGGGA GKGGAEEPGA EELLGPPAPG DKGSGRRLRD LRDSDPEEDE 
DEDDEDHFPY SNGASVHAAS SDCSSEDDSP PPRPSHQPAP Q

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.