Details for: HLF

Gene ID: 3131

Symbol: HLF

Ensembl ID: ENSG00000108924

Description: HLF transcription factor, PAR bZIP family member

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 86.2234
    Cell Significance Index: -21.8700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 47.6359
    Cell Significance Index: -22.4900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 44.4177
    Cell Significance Index: -18.0500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.3745
    Cell Significance Index: -22.6600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 14.3385
    Cell Significance Index: 422.3300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.6997
    Cell Significance Index: -19.0400
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 8.0593
    Cell Significance Index: 62.1200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.7425
    Cell Significance Index: -22.6600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 4.1630
    Cell Significance Index: 70.1300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 3.6640
    Cell Significance Index: 45.4500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 2.4376
    Cell Significance Index: 52.1100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.0303
    Cell Significance Index: 407.2700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.9913
    Cell Significance Index: 104.5500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.8621
    Cell Significance Index: 369.5400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.5962
    Cell Significance Index: 38.6700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.4322
    Cell Significance Index: 63.3500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.3463
    Cell Significance Index: 50.9800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.2757
    Cell Significance Index: 85.7800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.2499
    Cell Significance Index: 34.9300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.2386
    Cell Significance Index: 19.6500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.0495
    Cell Significance Index: 14.9400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7952
    Cell Significance Index: 285.2400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.7615
    Cell Significance Index: 10.3900
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.7062
    Cell Significance Index: 9.4200
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.6814
    Cell Significance Index: 8.2600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.6672
    Cell Significance Index: 19.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.4689
    Cell Significance Index: 882.9300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2773
    Cell Significance Index: 176.0900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2709
    Cell Significance Index: 15.2000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.1944
    Cell Significance Index: 2.8700
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.1930
    Cell Significance Index: 1.7000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1923
    Cell Significance Index: 4.2100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1765
    Cell Significance Index: 8.2300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1643
    Cell Significance Index: 72.6200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1637
    Cell Significance Index: 252.0600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1447
    Cell Significance Index: 100.0600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1217
    Cell Significance Index: 224.3600
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: 0.1142
    Cell Significance Index: 1.2600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1130
    Cell Significance Index: 8.6700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0828
    Cell Significance Index: 15.7500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0563
    Cell Significance Index: 76.5800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0534
    Cell Significance Index: 7.3300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0375
    Cell Significance Index: 17.0200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0089
    Cell Significance Index: 8.0500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0058
    Cell Significance Index: 0.8500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.0001
    Cell Significance Index: 0.0400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0008
    Cell Significance Index: -0.5600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0057
    Cell Significance Index: -4.2900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0071
    Cell Significance Index: -4.4600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0102
    Cell Significance Index: -7.4800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0295
    Cell Significance Index: -5.0400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0377
    Cell Significance Index: -7.9500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0381
    Cell Significance Index: -20.8300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0403
    Cell Significance Index: -0.8700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0453
    Cell Significance Index: -5.8100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0567
    Cell Significance Index: -6.4700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0642
    Cell Significance Index: -18.4800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0827
    Cell Significance Index: -5.2100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0914
    Cell Significance Index: -16.4900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0944
    Cell Significance Index: -15.3500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1189
    Cell Significance Index: -13.6300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1238
    Cell Significance Index: -12.8900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1281
    Cell Significance Index: -9.0600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1395
    Cell Significance Index: -18.0200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1419
    Cell Significance Index: -8.7000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1431
    Cell Significance Index: -17.6000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.1448
    Cell Significance Index: -15.7500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1512
    Cell Significance Index: -15.4400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.1528
    Cell Significance Index: -15.1200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1738
    Cell Significance Index: -10.6800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1817
    Cell Significance Index: -21.4200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.2016
    Cell Significance Index: -13.9500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2033
    Cell Significance Index: -23.7000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2143
    Cell Significance Index: -7.5300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2201
    Cell Significance Index: -17.4300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2376
    Cell Significance Index: -10.3300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2473
    Cell Significance Index: -18.4300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2505
    Cell Significance Index: -4.8900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2581
    Cell Significance Index: -12.1300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2797
    Cell Significance Index: -12.6800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2816
    Cell Significance Index: -8.9700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.3027
    Cell Significance Index: -8.7200
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.3151
    Cell Significance Index: -3.5600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3278
    Cell Significance Index: -21.1500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3479
    Cell Significance Index: -18.1200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3656
    Cell Significance Index: -18.9900
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.3691
    Cell Significance Index: -2.8400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3736
    Cell Significance Index: -9.3200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3759
    Cell Significance Index: -9.0200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3766
    Cell Significance Index: -10.8000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3930
    Cell Significance Index: -9.8300
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.4266
    Cell Significance Index: -5.3200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4273
    Cell Significance Index: -13.9900
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.4284
    Cell Significance Index: -5.7100
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: -0.4288
    Cell Significance Index: -4.6100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.4304
    Cell Significance Index: -8.6400
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.4340
    Cell Significance Index: -5.4400
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.4562
    Cell Significance Index: -6.9400
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.4603
    Cell Significance Index: -4.3800
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.4688
    Cell Significance Index: -6.0800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HLF exhibits characteristics typical of transcription factors, including DNA-binding activity, RNA polymerase II-specific transcriptional activation, and sequence-specific DNA binding. Its ability to regulate transcription by RNA polymerase II is mediated through interactions with other transcriptional regulators, such as the RNA polymerase II cis-regulatory region sequence-specific DNA binding protein. HLF's expression is tissue-specific, with significant levels found in leptomeningeal cells, neurons, and epithelial cells, highlighting its role in various cellular processes. **Pathways and Functions:** HLF is involved in several key pathways, including: 1. **Chromatin regulation**: HLF modulates chromatin structure and accessibility, influencing gene expression. 2. **DNA-binding transcription activator activity**: HLF activates transcription by binding to specific DNA sequences, recruiting RNA polymerase II and other transcriptional co-factors. 3. **RNA polymerase II-specific transcriptional regulation**: HLF regulates transcription by RNA polymerase II, influencing the expression of target genes. 4. **Rhythmic process regulation**: HLF is involved in regulating circadian rhythms, which are essential for maintaining physiological homeostasis. 5. **Skeletal muscle cell differentiation**: HLF plays a crucial role in the differentiation of skeletal muscle cells, highlighting its involvement in muscle development and maintenance. **Clinical Significance:** HLF's involvement in various cellular processes and its expression in multiple tissues suggest its potential role in several diseases and disorders. For example: 1. **Neurological disorders**: HLF's expression in neurons and its involvement in rhythmic process regulation may contribute to the development of neurological disorders, such as Parkinson's disease and Alzheimer's disease. 2. **Cancer**: HLF's role in regulating transcription and chromatin structure may be exploited by cancer cells, leading to the development of novel therapeutic strategies. 3. **Muscular dystrophy**: HLF's involvement in skeletal muscle cell differentiation may provide insights into the pathogenesis of muscular dystrophy and potential therapeutic targets. In conclusion, HLF is a transcription factor with a wide range of functions and implications in various tissues, including neurons, epithelial cells, and skeletal muscle cells. Further research is necessary to elucidate the mechanisms underlying HLF's role in disease and to explore its potential as a therapeutic target.

Genular Protein ID: 3760373074

Symbol: HLF_HUMAN

Name: Hepatic leukemia factor

UniProtKB Accession Codes:

Q16534 A8K1X8 Q6FHS9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 3 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 4 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1516826

Title: Hlf, a novel hepatic bZIP protein, shows altered DNA-binding properties following fusion to E2A in t(17;19) acute lymphoblastic leukemia.

PubMed ID: 1516826

DOI: 10.1101/gad.6.9.1608

PubMed ID: 1386162

Title: Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia.

PubMed ID: 1386162

DOI: 10.1126/science.1386162

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 295
  • Mass: 33199
  • Checksum: 80572A727BBB5635
  • Sequence:
    • MEKMSRPLPL NPTFIPPPYG VLRSLLENPL KLPLHHEDAF SKDKDKEKKL DDESNSPTVP 
QSAFLGPTLW DKTLPYDGDT FQLEYMDLEE FLSENGIPPS PSQHDHSPHP PGLQPASSAA 
PSVMDLSSRA SAPLHPGIPS PNCMQSPIRP GQLLPANRNT PSPIDPDTIQ VPVGYEPDPA 
DLALSSIPGQ EMFDPRKRKF SEEELKPQPM IKKARKVFIP DDLKDDKYWA RRRKNNMAAK 
RSRDARRLKE NQIAIRASFL EKENSALRQE VADLRKELGK CKNILAKYEA RHGPL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.