Details for: HLF

Gene ID: 3131

Symbol: HLF

Ensembl ID: ENSG00000108924

Description: HLF transcription factor, PAR bZIP family member

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 2.03
    Marker Score: 1005
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.02
    Marker Score: 30214
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.99
    Marker Score: 18672
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.88
    Marker Score: 597
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.87
    Marker Score: 7833.5
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.87
    Marker Score: 977.5
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.82
    Marker Score: 3693
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.8
    Marker Score: 17090
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.79
    Marker Score: 109994
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.77
    Marker Score: 2141
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.69
    Marker Score: 2036
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.68
    Marker Score: 490
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.65
    Marker Score: 10606
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.61
    Marker Score: 960
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.59
    Marker Score: 1159
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.55
    Marker Score: 2088
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.55
    Marker Score: 1786
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.55
    Marker Score: 1635
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.54
    Marker Score: 11786
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.53
    Marker Score: 1687
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.49
    Marker Score: 1410
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.48
    Marker Score: 6371
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 1.47
    Marker Score: 19615
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168686
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.47
    Marker Score: 7893
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 1.38
    Marker Score: 3888
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 861
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.33
    Marker Score: 11452
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.28
    Marker Score: 3006
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.25
    Marker Score: 19600
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.25
    Marker Score: 4832
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.25
    Marker Score: 846
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.22
    Marker Score: 1387
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.2
    Marker Score: 701
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.19
    Marker Score: 1833
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.16
    Marker Score: 481
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.13
    Marker Score: 42772
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.12
    Marker Score: 2466
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.11
    Marker Score: 256
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 1.07
    Marker Score: 338
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.05
    Marker Score: 20820
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.02
    Marker Score: 2066
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.01
    Marker Score: 4184
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71799
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1
    Marker Score: 2846
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48024
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 502
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.97
    Marker Score: 1027
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 457
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.93
    Marker Score: 539
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 370
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2733
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.91
    Marker Score: 416
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.89
    Marker Score: 5105
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.88
    Marker Score: 600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.86
    Marker Score: 5179
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.83
    Marker Score: 1077
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.82
    Marker Score: 625
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.81
    Marker Score: 257
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.8
    Marker Score: 481
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.8
    Marker Score: 16970
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.79
    Marker Score: 5864
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1255
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.77
    Marker Score: 28411
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 702
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.73
    Marker Score: 1017
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.73
    Marker Score: 484
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.73
    Marker Score: 3059
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.73
    Marker Score: 780
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.71
    Marker Score: 161
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.71
    Marker Score: 341
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.71
    Marker Score: 457
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.7
    Marker Score: 4552
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.7
    Marker Score: 691
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.69
    Marker Score: 291
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.69
    Marker Score: 534
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.69
    Marker Score: 288
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.67
    Marker Score: 2720
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.67
    Marker Score: 943
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.64
    Marker Score: 202
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.63
    Marker Score: 239
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.62
    Marker Score: 730
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.62
    Marker Score: 1189
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.61
    Marker Score: 1641
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.6
    Marker Score: 652
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.59
    Marker Score: 1185
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.59
    Marker Score: 221
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.58
    Marker Score: 940
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.58
    Marker Score: 338
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.57
    Marker Score: 493
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 442
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 172
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.54
    Marker Score: 130
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.54
    Marker Score: 1351

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Other Information

**Key characteristics:** - HLF is a nuclear protein with a molecular weight of approximately 115 kDa. - It is expressed in a variety of cell types, including epithelial cells, neurons, and muscle cells. - HLF is a positive regulator of transcription, meaning that it promotes the expression of genes. - It is involved in the regulation of skeletal muscle cell differentiation. **Pathways and functions:** - HLF is a key regulator of skeletal muscle cell differentiation. - It is required for the expression of genes encoding muscle-specific proteins, such as actin, myosin, and troponin. - HLF also plays a role in the regulation of muscle growth and development. **Clinical significance:** - Mutations in the HLF gene have been linked to a number of human diseases, including liver cancer, heart disease, and cancer. - In one study, mutations in the HLF gene were found to be associated with the development of hepatocellular carcinoma in patients with chronic liver disease. - HLF is a promising target for the treatment of cancer. **Additional notes:** - HLF is a highly conserved protein, with similar genes found in other mammals. - It is a member of the bZIP family of transcription factors, which are characterized by their ability to bind to DNA and regulate gene expression. - HLF is a versatile protein that can interact with a variety of DNA-binding proteins to form different transcriptional complexes.

Genular Protein ID: 3760373074

Symbol: HLF_HUMAN

Name: Hepatic leukemia factor

UniProtKB Accession Codes:

Q16534 A8K1X8 Q6FHS9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 3 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 4 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1516826

Title: Hlf, a novel hepatic bZIP protein, shows altered DNA-binding properties following fusion to E2A in t(17;19) acute lymphoblastic leukemia.

PubMed ID: 1516826

DOI: 10.1101/gad.6.9.1608

PubMed ID: 1386162

Title: Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia.

PubMed ID: 1386162

DOI: 10.1126/science.1386162

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 295
  • Mass: 33199
  • Checksum: 80572A727BBB5635
  • Sequence:
    • MEKMSRPLPL NPTFIPPPYG VLRSLLENPL KLPLHHEDAF SKDKDKEKKL DDESNSPTVP 
QSAFLGPTLW DKTLPYDGDT FQLEYMDLEE FLSENGIPPS PSQHDHSPHP PGLQPASSAA 
PSVMDLSSRA SAPLHPGIPS PNCMQSPIRP GQLLPANRNT PSPIDPDTIQ VPVGYEPDPA 
DLALSSIPGQ EMFDPRKRKF SEEELKPQPM IKKARKVFIP DDLKDDKYWA RRRKNNMAAK 
RSRDARRLKE NQIAIRASFL EKENSALRQE VADLRKELGK CKNILAKYEA RHGPL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.