Details for: HMMR

Gene ID: 3161

Symbol: HMMR

Ensembl ID: ENSG00000072571

Description: hyaluronan mediated motility receptor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 32.4866
    Cell Significance Index: -8.2400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 18.6335
    Cell Significance Index: -7.5700
  • Cell Name: basophilic erythroblast (CL0000549)
    Fold Change: 15.5026
    Cell Significance Index: 7.0600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 7.9655
    Cell Significance Index: -7.6100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.9694
    Cell Significance Index: -7.3600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.1338
    Cell Significance Index: -8.4200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 1.7223
    Cell Significance Index: -5.2900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1010
    Cell Significance Index: 179.0700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0077
    Cell Significance Index: 191.7700
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 0.9447
    Cell Significance Index: 5.3700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8789
    Cell Significance Index: 95.6000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.7972
    Cell Significance Index: 94.0100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6494
    Cell Significance Index: 586.3300
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: 0.6273
    Cell Significance Index: 7.7900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.6264
    Cell Significance Index: 73.0000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4535
    Cell Significance Index: 31.3600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4200
    Cell Significance Index: 21.8200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.4105
    Cell Significance Index: 3.7800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.3955
    Cell Significance Index: 4.3000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.3594
    Cell Significance Index: 11.5100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3263
    Cell Significance Index: 64.7500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.2959
    Cell Significance Index: 7.5600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2648
    Cell Significance Index: 9.2000
  • Cell Name: colon endothelial cell (CL1001572)
    Fold Change: 0.2620
    Cell Significance Index: 0.2000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2497
    Cell Significance Index: 6.6900
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.2432
    Cell Significance Index: 2.0900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2392
    Cell Significance Index: 130.6600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2325
    Cell Significance Index: 23.0000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1961
    Cell Significance Index: 5.2500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.1768
    Cell Significance Index: 4.4100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1632
    Cell Significance Index: 4.5600
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.1486
    Cell Significance Index: 0.3400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1452
    Cell Significance Index: 6.5800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1396
    Cell Significance Index: 3.4900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1333
    Cell Significance Index: 3.8400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1192
    Cell Significance Index: 6.6900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0808
    Cell Significance Index: 1.7200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0626
    Cell Significance Index: 1.3100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0590
    Cell Significance Index: 36.8600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0448
    Cell Significance Index: 0.9700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0434
    Cell Significance Index: 30.0300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0433
    Cell Significance Index: 19.1600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0306
    Cell Significance Index: 5.5200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0299
    Cell Significance Index: 1.0500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0296
    Cell Significance Index: 0.7900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0259
    Cell Significance Index: 3.1900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0056
    Cell Significance Index: 1.1200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0048
    Cell Significance Index: 0.0800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0042
    Cell Significance Index: 0.1800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0040
    Cell Significance Index: 0.2500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0032
    Cell Significance Index: -6.1000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0036
    Cell Significance Index: -2.6900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0052
    Cell Significance Index: -9.5300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0067
    Cell Significance Index: -0.7700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0072
    Cell Significance Index: -11.0800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0077
    Cell Significance Index: -10.5000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0085
    Cell Significance Index: -4.8000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0095
    Cell Significance Index: -7.2000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0103
    Cell Significance Index: -3.6800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0112
    Cell Significance Index: -8.2200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0117
    Cell Significance Index: -2.4700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0119
    Cell Significance Index: -7.5800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0158
    Cell Significance Index: -4.5500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0201
    Cell Significance Index: -9.1300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0220
    Cell Significance Index: -3.7500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0226
    Cell Significance Index: -0.3500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0246
    Cell Significance Index: -1.5100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0285
    Cell Significance Index: -2.9100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0312
    Cell Significance Index: -4.2800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0409
    Cell Significance Index: -5.9400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0450
    Cell Significance Index: -5.7700
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.0533
    Cell Significance Index: -0.7400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0542
    Cell Significance Index: -6.2100
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0561
    Cell Significance Index: -0.5100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0601
    Cell Significance Index: -3.8800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0670
    Cell Significance Index: -8.6600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0691
    Cell Significance Index: -4.1500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0808
    Cell Significance Index: -2.3800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0809
    Cell Significance Index: -8.4200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0817
    Cell Significance Index: -1.1700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0851
    Cell Significance Index: -6.0200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0861
    Cell Significance Index: -6.6100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0927
    Cell Significance Index: -0.9600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1003
    Cell Significance Index: -2.0800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1058
    Cell Significance Index: -5.5100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1064
    Cell Significance Index: -8.4300
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1078
    Cell Significance Index: -0.6400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1139
    Cell Significance Index: -7.0000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1259
    Cell Significance Index: -9.3800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1309
    Cell Significance Index: -8.8100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1428
    Cell Significance Index: -6.7100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1451
    Cell Significance Index: -5.9500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1559
    Cell Significance Index: -4.9300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1605
    Cell Significance Index: -2.1900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1638
    Cell Significance Index: -4.2100
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1656
    Cell Significance Index: -1.1200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1682
    Cell Significance Index: -8.8300
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.1707
    Cell Significance Index: -2.1600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1856
    Cell Significance Index: -5.4500
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1882
    Cell Significance Index: -1.6000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cell Surface Receptor**: HMMR is a cell surface receptor that binds to hyaluronic acid (HA), a key component of the extracellular matrix. 2. **Motility Regulation**: The interaction between HMMR and HA regulates cellular motility, influencing processes such as cell migration, adhesion, and invasion. 3. **Hyaluronan Metabolism**: HMMR is involved in the uptake and degradation of hyaluronic acid, which is essential for maintaining tissue homeostasis and regulating cellular behavior. 4. **Significant Expression in Various Cell Types**: HMMR is expressed in a wide range of cell types, including immune cells, endothelial cells, neural cells, and epithelial cells. **Pathways and Functions:** 1. **Aurka Activation by Tpx2**: HMMR interacts with Aurora kinase A (Aurka) and its activator, Tpx2, to regulate cell cycle progression and mitotic spindle formation. 2. **Cargo Receptor Activity**: HMMR acts as a cargo receptor, facilitating the uptake of hyaluronic acid and other molecules into cells. 3. **Cell Cycle Regulation**: HMMR regulates cell cycle progression, particularly during the G2/M transition, influencing cell proliferation and survival. 4. **Glycosaminoglycan Metabolism**: HMMR is involved in the metabolism of glycosaminoglycans (GAGs), which are key components of the extracellular matrix. 5. **Hyaluronic Acid Binding**: HMMR binds to hyaluronic acid, regulating its uptake and degradation. **Clinical Significance:** 1. **Cancer Metastasis**: HMMR has been implicated in cancer metastasis, as it facilitates the migration and invasion of cancer cells. 2. **Immune Cell Regulation**: HMMR regulates the migration and function of immune cells, influencing immune responses and inflammation. 3. **Neurological Disorders**: HMMR has been linked to various neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 4. **Cardiovascular Disease**: HMMR has been implicated in cardiovascular disease, particularly in the context of endothelial cell function and atherosclerosis. In conclusion, HMMR is a multifunctional protein that plays a critical role in regulating cellular motility, metabolism, and cell cycle progression. Its involvement in various diseases, including cancer, immune disorders, and neurological disorders, highlights the importance of further research into the mechanisms of HMMR and its potential as a therapeutic target.

Genular Protein ID: 685149231

Symbol: HMMR_HUMAN

Name: Hyaluronan mediated motility receptor

UniProtKB Accession Codes:

O75330 A8K3G2 B4E114 D3DQK9 D3DQL0 E9PCS0 Q32N02 Q92767

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 10 Ensembl 4 ExpressionAtlas 1 GO 11 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 2 RefSeq 4 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8890751

Title: The characterization of a human RHAMM cDNA: conservation of the hyaluronan-binding domains.

PubMed ID: 8890751

DOI: 10.1016/0378-1119(96)00080-7

PubMed ID: 9601098

Title: The human hyaluronan receptor RHAMM is expressed as an intracellular protein in breast cancer cells.

PubMed ID: 9601098

DOI: 10.1242/jcs.111.12.1685

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22965910

Title: Dynein light chain 1 and a spindle-associated adaptor promote dynein asymmetry and spindle orientation.

PubMed ID: 22965910

DOI: 10.1083/jcb.201202112

PubMed ID: 22666460

Title: ANKRD26 and its interacting partners TRIO, GPS2, HMMR and DIPA regulate adipogenesis in 3T3-L1 cells.

PubMed ID: 22666460

DOI: 10.1371/journal.pone.0038130

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 724
  • Mass: 84100
  • Checksum: F2C3C0DBA863955F
  • Sequence:
    • MSFPKAPLKR FNDPSGCAPS PGAYDVKTLE VLKGPVSFQK SQRFKQQKES KQNLNVDKDT 
TLPASARKVK SSESKESQKN DKDLKILEKE IRVLLQERGA QDRRIQDLET ELEKMEARLN 
AALREKTSLS ANNATLEKQL IELTRTNELL KSKFSENGNQ KNLRILSLEL MKLRNKRETK 
MRGMMAKQEG MEMKLQVTQR SLEESQGKIA QLEGKLVSIE KEKIDEKSET EKLLEYIEEI 
SCASDQVEKY KLDIAQLEEN LKEKNDEILS LKQSLEENIV ILSKQVEDLN VKCQLLEKEK 
EDHVNRNREH NENLNAEMQN LKQKFILEQQ EREKLQQKEL QIDSLLQQEK ELSSSLHQKL 
CSFQEEMVKE KNLFEEELKQ TLDELDKLQQ KEEQAERLVK QLEEEAKSRA EELKLLEEKL 
KGKEAELEKS SAAHTQATLL LQEKYDSMVQ SLEDVTAQFE SYKALTASEI EDLKLENSSL 
QEKAAKAGKN AEDVQHQILA TESSNQEYVR MLLDLQTKSA LKETEIKEIT VSFLQKITDL 
QNQLKQQEED FRKQLEDEEG RKAEKENTTA ELTEEINKWR LLYEELYNKT KPFQLQLDAF 
EVEKQALLNE HGAAQEQLNK IRDSYAKLLG HQNLKQKIKH VVKLKDENSQ LKSEVSKLRC 
QLAKKKQSET KLQEELNKVL GIKHFDPSKA FHHESKENFA LKTPLKEGNT NCYRAPMECQ 
ESWK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.