Details for: HMMR

Gene ID: 3161

Symbol: HMMR

Ensembl ID: ENSG00000072571

Description: hyaluronan mediated motility receptor

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 3.74
    Marker Score: 2451
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.64
    Marker Score: 1466
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 1.52
    Marker Score: 2183
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.27
    Marker Score: 3457.5
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.24
    Marker Score: 2344
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.02
    Marker Score: 764.5
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.02
    Marker Score: 322
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71820
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48044
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 504
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 458
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.94
    Marker Score: 738
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.91
    Marker Score: 1215
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2736
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5192
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.9
    Marker Score: 321
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5285
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.85
    Marker Score: 2509
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.81
    Marker Score: 12722
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.81
    Marker Score: 758
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.79
    Marker Score: 579
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.77
    Marker Score: 1813
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.76
    Marker Score: 251
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 571
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.73
    Marker Score: 292
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.72
    Marker Score: 656
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.69
    Marker Score: 343
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.68
    Marker Score: 338
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.67
    Marker Score: 2822.5
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.67
    Marker Score: 215
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.59
    Marker Score: 186
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.58
    Marker Score: 586
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.58
    Marker Score: 1175.5
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.58
    Marker Score: 828
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.54
    Marker Score: 582
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.53
    Marker Score: 336
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.5
    Marker Score: 210
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.5
    Marker Score: 1971
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.46
    Marker Score: 288
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.45
    Marker Score: 141
  • Cell Name: pre-conventional dendritic cell (CL0002010)
    Fold Change: 0.44
    Marker Score: 129
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.42
    Marker Score: 109
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.41
    Marker Score: 297
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.41
    Marker Score: 697
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.4
    Marker Score: 192
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.38
    Marker Score: 102
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.38
    Marker Score: 1041
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.38
    Marker Score: 105
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.38
    Marker Score: 238
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.37
    Marker Score: 106
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.37
    Marker Score: 463
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.36
    Marker Score: 176
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.36
    Marker Score: 756
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.36
    Marker Score: 349
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.36
    Marker Score: 162
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.36
    Marker Score: 205
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.34
    Marker Score: 183
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.33
    Marker Score: 354
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.33
    Marker Score: 345
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.33
    Marker Score: 161
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.32
    Marker Score: 338
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.32
    Marker Score: 1245
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.32
    Marker Score: 100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.31
    Marker Score: 129
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.31
    Marker Score: 10767
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.29
    Marker Score: 135
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.29
    Marker Score: 181
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.28
    Marker Score: 71
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.28
    Marker Score: 1157
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.28
    Marker Score: 670.5
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.28
    Marker Score: 81
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.28
    Marker Score: 168
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.28
    Marker Score: 657.5
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.28
    Marker Score: 123
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.28
    Marker Score: 113
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.27
    Marker Score: 150
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.27
    Marker Score: 94
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.27
    Marker Score: 321
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 88
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.25
    Marker Score: 237
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.25
    Marker Score: 61
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.25
    Marker Score: 2533
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.25
    Marker Score: 166
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.25
    Marker Score: 393
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.24
    Marker Score: 900
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.24
    Marker Score: 172
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.24
    Marker Score: 105
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.24
    Marker Score: 77
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.23
    Marker Score: 84
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.23
    Marker Score: 192
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.23
    Marker Score: 1346
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.23
    Marker Score: 113
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.23
    Marker Score: 78

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Other Information

**Key characteristics:** - HMMR is a type of cell surface receptor that is expressed on a variety of cell types. - It is a heterotrimer, which means it is composed of four different subunits that come together to form a functional receptor. - Each subunit of HMMR has a different specific binding domain that recognizes different ligands. - HMMR is a key regulator of cell migration and invasion. It is involved in the regulation of cell migration by binding to glycosaminoglycans, which are a type of extracellular matrix protein. - When HMMR binds to glycosaminoglycans, it activates a signaling cascade that leads to the phosphorylation of a number of downstream proteins. - These downstream proteins regulate the cell's migration and invasion. **Pathways and functions:** - HMMR is involved in the regulation of cell migration and invasion. - It is expressed in a variety of cell types, including T-helper 17 cells, extravillous trophoblast, respiratory basal cell, large pre-B-II cell, cardiac endothelial cell, primitive red blood cell, renal beta-intercalated cell, cerebral cortex GABAergic interneuron, forebrain radial glial cell, and absorptive cell. - When HMMR binds to glycosaminoglycans, it activates a signaling cascade that leads to the phosphorylation of a number of downstream proteins. - These downstream proteins regulate the cell's migration and invasion. **Clinical significance:** - Mutations in the HMMR gene have been linked to a number of human diseases, including cancer and fibrosis. - These diseases are characterized by the uncontrolled migration and invasion of cells. - Targeting HMMR has been investigated as a potential treatment for cancer and fibrosis.

Genular Protein ID: 685149231

Symbol: HMMR_HUMAN

Name: Hyaluronan mediated motility receptor

UniProtKB Accession Codes:

O75330 A8K3G2 B4E114 D3DQK9 D3DQL0 E9PCS0 Q32N02 Q92767

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 10 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 11 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 2 RefSeq 4 SAM 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8890751

Title: The characterization of a human RHAMM cDNA: conservation of the hyaluronan-binding domains.

PubMed ID: 8890751

DOI: 10.1016/0378-1119(96)00080-7

PubMed ID: 9601098

Title: The human hyaluronan receptor RHAMM is expressed as an intracellular protein in breast cancer cells.

PubMed ID: 9601098

DOI: 10.1242/jcs.111.12.1685

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22965910

Title: Dynein light chain 1 and a spindle-associated adaptor promote dynein asymmetry and spindle orientation.

PubMed ID: 22965910

DOI: 10.1083/jcb.201202112

PubMed ID: 22666460

Title: ANKRD26 and its interacting partners TRIO, GPS2, HMMR and DIPA regulate adipogenesis in 3T3-L1 cells.

PubMed ID: 22666460

DOI: 10.1371/journal.pone.0038130

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 724
  • Mass: 84100
  • Checksum: F2C3C0DBA863955F
  • Sequence:
    • MSFPKAPLKR FNDPSGCAPS PGAYDVKTLE VLKGPVSFQK SQRFKQQKES KQNLNVDKDT 
TLPASARKVK SSESKESQKN DKDLKILEKE IRVLLQERGA QDRRIQDLET ELEKMEARLN 
AALREKTSLS ANNATLEKQL IELTRTNELL KSKFSENGNQ KNLRILSLEL MKLRNKRETK 
MRGMMAKQEG MEMKLQVTQR SLEESQGKIA QLEGKLVSIE KEKIDEKSET EKLLEYIEEI 
SCASDQVEKY KLDIAQLEEN LKEKNDEILS LKQSLEENIV ILSKQVEDLN VKCQLLEKEK 
EDHVNRNREH NENLNAEMQN LKQKFILEQQ EREKLQQKEL QIDSLLQQEK ELSSSLHQKL 
CSFQEEMVKE KNLFEEELKQ TLDELDKLQQ KEEQAERLVK QLEEEAKSRA EELKLLEEKL 
KGKEAELEKS SAAHTQATLL LQEKYDSMVQ SLEDVTAQFE SYKALTASEI EDLKLENSSL 
QEKAAKAGKN AEDVQHQILA TESSNQEYVR MLLDLQTKSA LKETEIKEIT VSFLQKITDL 
QNQLKQQEED FRKQLEDEEG RKAEKENTTA ELTEEINKWR LLYEELYNKT KPFQLQLDAF 
EVEKQALLNE HGAAQEQLNK IRDSYAKLLG HQNLKQKIKH VVKLKDENSQ LKSEVSKLRC 
QLAKKKQSET KLQEELNKVL GIKHFDPSKA FHHESKENFA LKTPLKEGNT NCYRAPMECQ 
ESWK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.