Details for: HNMT

Gene ID: 3176

Symbol: HNMT

Ensembl ID: ENSG00000150540

Description: histamine N-methyltransferase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.39
    Marker Score: 61112
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.28
    Marker Score: 2279
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 2.25
    Marker Score: 1239
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 2
    Marker Score: 6558
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.94
    Marker Score: 561
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.91
    Marker Score: 2815
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.88
    Marker Score: 6670
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.87
    Marker Score: 2145
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.83
    Marker Score: 7895
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.78
    Marker Score: 3257
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.7
    Marker Score: 848
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.62
    Marker Score: 1681
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.58
    Marker Score: 816
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.58
    Marker Score: 3944
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.58
    Marker Score: 3750
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.57
    Marker Score: 8272
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.52
    Marker Score: 85201
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.52
    Marker Score: 2962
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.5
    Marker Score: 383
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 1.47
    Marker Score: 789
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.46
    Marker Score: 8856
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.46
    Marker Score: 1012
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.44
    Marker Score: 2380
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.42
    Marker Score: 402
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.41
    Marker Score: 6072
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.41
    Marker Score: 1642.5
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.4
    Marker Score: 2848
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.39
    Marker Score: 3508
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.39
    Marker Score: 8912
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.37
    Marker Score: 435
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.35
    Marker Score: 746
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.35
    Marker Score: 1460
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.34
    Marker Score: 7179
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 1.33
    Marker Score: 1735
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.33
    Marker Score: 3442
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.33
    Marker Score: 496.5
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.31
    Marker Score: 3521
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.28
    Marker Score: 1303
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.28
    Marker Score: 4942
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.28
    Marker Score: 1357
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.28
    Marker Score: 1065.5
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 1.27
    Marker Score: 507
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.26
    Marker Score: 706
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.26
    Marker Score: 290
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.25
    Marker Score: 3937
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.25
    Marker Score: 987
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.24
    Marker Score: 465
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.23
    Marker Score: 609
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.22
    Marker Score: 3189
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.2
    Marker Score: 2724
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.2
    Marker Score: 2814
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.19
    Marker Score: 4946
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.17
    Marker Score: 4613
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.17
    Marker Score: 1035
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.15
    Marker Score: 1232
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.13
    Marker Score: 1130
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.13
    Marker Score: 326
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.13
    Marker Score: 8390
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.13
    Marker Score: 1735
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.11
    Marker Score: 2705
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 1.1
    Marker Score: 459
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.1
    Marker Score: 979
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.08
    Marker Score: 12151
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.06
    Marker Score: 1710
  • Cell Name: macrophage (CL0000235)
    Fold Change: 1.06
    Marker Score: 1180
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.05
    Marker Score: 1299
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.04
    Marker Score: 245
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.04
    Marker Score: 519
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251710
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.03
    Marker Score: 1983.5
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.03
    Marker Score: 479
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.03
    Marker Score: 388
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.02
    Marker Score: 230
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.02
    Marker Score: 729
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.01
    Marker Score: 1429
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1
    Marker Score: 288
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71729
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47954
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.99
    Marker Score: 510
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.98
    Marker Score: 4721
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30398
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.98
    Marker Score: 1731
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.98
    Marker Score: 935
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 501
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.97
    Marker Score: 563
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 456
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.96
    Marker Score: 33389
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.96
    Marker Score: 1531
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.96
    Marker Score: 918
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.96
    Marker Score: 1120
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.95
    Marker Score: 2305
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.95
    Marker Score: 1794
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2408
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.95
    Marker Score: 191
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.94
    Marker Score: 233
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.94
    Marker Score: 644
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5329
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.93
    Marker Score: 12494
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.93
    Marker Score: 1686
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.92
    Marker Score: 1490

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Other Information

**Key characteristics:** * The protein is a transmembrane protein with a molecular weight of approximately 120 kDa. * It is a member of the cytochrome P450 family of enzymes. * It is responsible for the N-methylation of histamine, which is a critical step in its degradation. * It is also involved in the metabolism of other molecules, including histidine, selenoamino acids, and amino acids. **Pathways and functions:** * The main pathway for histamine degradation involves the N-methylation of histamine by HNMT. This process is part of the histamine catabolic process and the metabolism of other amino acids. * HNMT also participates in the regulation of inflammation and immune responses. * It is involved in the regulation of the immune response to allergens and pathogens. * It is also involved in the regulation of the respiratory system, including the regulation of mucus production and inflammation. **Clinical significance:** * Mutations in the HNMT gene have been linked to several human diseases, including asthma, allergies, and inflammatory bowel disease. * Inhibition of HNMT has been shown to have anti-inflammatory effects in animal models. * Therefore, HNMT is a promising target for the treatment of inflammatory diseases. **Additional notes:** * The gene is also involved in the regulation of cell growth, differentiation, and survival. * It is a highly conserved protein, with similar genes found in other mammals. * The expression of HNMT is regulated by various factors, including growth factors, cytokines, and hormones.

Genular Protein ID: 663709023

Symbol: HNMT_HUMAN

Name: Histamine N-methyltransferase

UniProtKB Accession Codes:

P50135 B2R9J3 Q546Z6 Q7Z7I2 Q8IU56 Q8WW98 Q9BRW6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEBI 10 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 7 DrugCentral 1 EC 1 EMBL 21 EPD 1 Ensembl 5 EvolutionaryTrace 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PDB 9 PDBsum 7 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 2 RefSeq 3 Rhea 1 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7943261

Title: Structure and function of human histamine N-methyltransferase: critical enzyme in histamine metabolism in airway.

PubMed ID: 7943261

DOI: 10.1152/ajplung.1994.267.3.l342

PubMed ID: 8145732

Title: Human histamine N-methyltransferase pharmacogenetics: cloning and expression of kidney cDNA.

PubMed ID: 8145732

PubMed ID: 8605025

Title: Human histamine N-methyltransferase gene: structural characterization and chromosomal location.

PubMed ID: 8605025

DOI: 10.1006/bbrc.1996.0271

PubMed ID: 14667820

Title: Characterization of a new mRNA species from the human histamine N-methyltransferase gene.

PubMed ID: 14667820

DOI: 10.1016/s0888-7543(03)00236-2

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 11566133

Title: Two polymorphic forms of human histamine methyltransferase: structural, thermal, and kinetic comparisons.

PubMed ID: 11566133

DOI: 10.1016/s0969-2126(01)00643-8

PubMed ID: 9547362

Title: Human histamine N-methyltransferase pharmacogenetics: common genetic polymorphisms that alter activity.

PubMed ID: 9547362

DOI: 10.1124/mol.53.4.708

PubMed ID: 10803682

Title: Histamine N-methyltransferase pharmacogenetics: association of a common functional polymorphism with asthma.

PubMed ID: 10803682

DOI: 10.1097/00008571-200004000-00007

PubMed ID: 26206890

Title: Mutations in the histamine N-methyltransferase gene, HNMT, are associated with nonsyndromic autosomal recessive intellectual disability.

PubMed ID: 26206890

DOI: 10.1093/hmg/ddv286

Sequence Information:

  • Length: 292
  • Mass: 33295
  • Checksum: 9CCADD1EE0CCB653
  • Sequence:
    • MASSMRSLFS DHGKYVESFR RFLNHSTEHQ CMQEFMDKKL PGIIGRIGDT KSEIKILSIG 
GGAGEIDLQI LSKVQAQYPG VCINNEVVEP SAEQIAKYKE LVAKTSNLEN VKFAWHKETS 
SEYQSRMLEK KELQKWDFIH MIQMLYYVKD IPATLKFFHS LLGTNAKMLI IVVSGSSGWD 
KLWKKYGSRF PQDDLCQYIT SDDLTQMLDN LGLKYECYDL LSTMDISDCF IDGNENGDLL 
WDFLTETCNF NATAPPDLRA ELGKDLQEPE FSAKKEGKVL FNNTLSFIVI EA

Genular Protein ID: 2590533656

Symbol: B4DWC1_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DWC1

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChEBI 5 DNASU 1 EC 1 EMBL 2 GO 2 Gene3D 1 GenomeRNAi 1 InterPro 2 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PROSITE 1 PeptideAtlas 1 Pfam 1 RefSeq 1 Rhea 1 SUPFAM 1

Sequence Information:

  • Length: 161
  • Mass: 18435
  • Checksum: 470FA49DA28FDE1C
  • Sequence:
    • MASSMRSLFS DHGKYVESFR RFLNHSTEHQ CMQEFMDKKL PGIIGRIGDT KSEIKILSIG 
GGAGEIDLQI LSKVQAQYPG VCINNEVVEP SAEQIAKYKE LVAKTSNLEN VKFAWHKETS 
SEYQSRMLEK KELQKWDFIH MIQVNENLLI SNFTSDHDLP K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.