Details for: HNMT

Gene ID: 3176

Symbol: HNMT

Ensembl ID: ENSG00000150540

Description: histamine N-methyltransferase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 272.7342
    Cell Significance Index: -42.4200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 165.1531
    Cell Significance Index: -41.8900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 113.2668
    Cell Significance Index: -46.6600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 101.6351
    Cell Significance Index: -41.2900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 95.9073
    Cell Significance Index: -45.2800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 91.3129
    Cell Significance Index: -46.9700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 34.4051
    Cell Significance Index: -42.4200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.5827
    Cell Significance Index: -41.7600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.7813
    Cell Significance Index: -17.0300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.0892
    Cell Significance Index: 414.6000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.0775
    Cell Significance Index: 107.9200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.9721
    Cell Significance Index: 18.1600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.6444
    Cell Significance Index: 24.6400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.4890
    Cell Significance Index: 1344.4900
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.1213
    Cell Significance Index: 13.8700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.0012
    Cell Significance Index: 15.4900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.9303
    Cell Significance Index: 127.7500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9220
    Cell Significance Index: 166.2000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.8674
    Cell Significance Index: 16.9300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.7608
    Cell Significance Index: 12.8200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.6588
    Cell Significance Index: 11.0800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.6530
    Cell Significance Index: 48.6700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.6444
    Cell Significance Index: 82.6100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.6003
    Cell Significance Index: 16.3400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5433
    Cell Significance Index: 296.7300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5174
    Cell Significance Index: 11.2100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4755
    Cell Significance Index: 58.4700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4303
    Cell Significance Index: 86.3200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.3939
    Cell Significance Index: 7.2800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3509
    Cell Significance Index: 45.3400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3334
    Cell Significance Index: 119.6000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3085
    Cell Significance Index: 136.4100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3018
    Cell Significance Index: 208.7300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2440
    Cell Significance Index: 7.0300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.2153
    Cell Significance Index: 10.8800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1983
    Cell Significance Index: 9.3200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1428
    Cell Significance Index: 3.5700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1234
    Cell Significance Index: 23.4800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1201
    Cell Significance Index: 5.6000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0940
    Cell Significance Index: 3.0100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0717
    Cell Significance Index: 2.5200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0618
    Cell Significance Index: 6.1200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0398
    Cell Significance Index: 6.8000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0338
    Cell Significance Index: 2.3900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0049
    Cell Significance Index: 3.7000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0043
    Cell Significance Index: 0.1000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0069
    Cell Significance Index: -0.7000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0127
    Cell Significance Index: -9.3200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0133
    Cell Significance Index: -24.5600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0165
    Cell Significance Index: -31.0500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0193
    Cell Significance Index: -29.7200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0244
    Cell Significance Index: -15.2600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0333
    Cell Significance Index: -0.7100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0337
    Cell Significance Index: -24.9900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0355
    Cell Significance Index: -48.2100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0386
    Cell Significance Index: -1.7500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0540
    Cell Significance Index: -34.2900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0589
    Cell Significance Index: -33.2100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0737
    Cell Significance Index: -33.4400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1270
    Cell Significance Index: -36.5500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1513
    Cell Significance Index: -17.3300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1668
    Cell Significance Index: -35.1400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1770
    Cell Significance Index: -2.6100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2016
    Cell Significance Index: -23.4900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2023
    Cell Significance Index: -29.4100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2052
    Cell Significance Index: -3.4400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2292
    Cell Significance Index: -14.0900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3475
    Cell Significance Index: -39.6700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4060
    Cell Significance Index: -42.2700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4086
    Cell Significance Index: -48.1900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4154
    Cell Significance Index: -27.9300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4333
    Cell Significance Index: -34.3200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4788
    Cell Significance Index: -29.3600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4839
    Cell Significance Index: -37.1400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5170
    Cell Significance Index: -13.8300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.5236
    Cell Significance Index: -5.4200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.5697
    Cell Significance Index: -15.9200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.5801
    Cell Significance Index: -4.7300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6384
    Cell Significance Index: -18.3000
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.7204
    Cell Significance Index: -10.3500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.7258
    Cell Significance Index: -40.7300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.7381
    Cell Significance Index: -47.6200
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.7596
    Cell Significance Index: -4.6800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.7829
    Cell Significance Index: -40.7800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.7890
    Cell Significance Index: -49.7300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.8690
    Cell Significance Index: -38.4400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.8769
    Cell Significance Index: -46.0400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.8956
    Cell Significance Index: -26.3800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.9161
    Cell Significance Index: -34.6900
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.9268
    Cell Significance Index: -11.6700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.0080
    Cell Significance Index: -25.9100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -1.0191
    Cell Significance Index: -8.5600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.0325
    Cell Significance Index: -27.1500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -1.0448
    Cell Significance Index: -21.8700
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -1.0476
    Cell Significance Index: -15.2100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.0783
    Cell Significance Index: -30.7700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.0839
    Cell Significance Index: -34.5200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.0907
    Cell Significance Index: -40.0400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.1426
    Cell Significance Index: -37.4100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HNMT is a cytosolic enzyme, primarily expressed in cells of the immune system, including alveolar macrophages, Kupffer cells, and hepatoblasts. The enzyme exhibits high specificity, with a preference for histamine as its substrate. HNMT is also involved in the catabolism of histidine, and its activity is crucial for the regulation of histamine levels in the body. The enzyme's expression is tightly regulated, with its levels varying depending on the physiological context. **Pathways and Functions:** HNMT is involved in several metabolic pathways, including the histamine catabolic process, histamine metabolic process, and methylation. The enzyme's primary function is to methylate histamine, converting it into N-methylhistamine, which is then excreted or inactivated. This process is essential for regulating histamine levels and preventing excessive histamine release, which can lead to allergic reactions and inflammation. HNMT also plays a role in the regulation of histidine catabolism, and its activity is influenced by various factors, including pH, temperature, and metal ions. **Clinical Significance:** HNMT has significant implications in various clinical contexts, including: 1. **Allergic diseases:** HNMT's role in regulating histamine levels makes it a potential target for the treatment of allergic diseases, such as asthma and allergic rhinitis. 2. **Inflammatory disorders:** The enzyme's involvement in histamine metabolism suggests that HNMT may play a role in the pathogenesis of inflammatory disorders, such as atherosclerosis and rheumatoid arthritis. 3. **Neurological disorders:** HNMT's expression in the brain and its involvement in histamine metabolism suggest that the enzyme may be involved in the pathogenesis of neurological disorders, such as Parkinson's disease and schizophrenia. 4. **Cancer:** HNMT's role in histamine metabolism and its expression in various cancer types suggest that the enzyme may be involved in the development and progression of cancer. In conclusion, HNMT is a crucial enzyme in the histamine metabolic pathway, playing a pivotal role in regulating histamine levels and immune homeostasis. Its clinical significance extends to various diseases, including allergic disorders, inflammatory disorders, neurological disorders, and cancer. Further research is needed to fully elucidate the enzyme's role in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 663709023

Symbol: HNMT_HUMAN

Name: Histamine N-methyltransferase

UniProtKB Accession Codes:

P50135 B2R9J3 Q546Z6 Q7Z7I2 Q8IU56 Q8WW98 Q9BRW6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEBI 10 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 7 DrugCentral 1 EC 1 EMBL 21 Ensembl 5 EvolutionaryTrace 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PDB 7 PDBsum 7 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 2 RefSeq 3 Rhea 1 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7943261

Title: Structure and function of human histamine N-methyltransferase: critical enzyme in histamine metabolism in airway.

PubMed ID: 7943261

DOI: 10.1152/ajplung.1994.267.3.l342

PubMed ID: 8145732

Title: Human histamine N-methyltransferase pharmacogenetics: cloning and expression of kidney cDNA.

PubMed ID: 8145732

PubMed ID: 8605025

Title: Human histamine N-methyltransferase gene: structural characterization and chromosomal location.

PubMed ID: 8605025

DOI: 10.1006/bbrc.1996.0271

PubMed ID: 14667820

Title: Characterization of a new mRNA species from the human histamine N-methyltransferase gene.

PubMed ID: 14667820

DOI: 10.1016/s0888-7543(03)00236-2

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 11566133

Title: Two polymorphic forms of human histamine methyltransferase: structural, thermal, and kinetic comparisons.

PubMed ID: 11566133

DOI: 10.1016/s0969-2126(01)00643-8

PubMed ID: 9547362

Title: Human histamine N-methyltransferase pharmacogenetics: common genetic polymorphisms that alter activity.

PubMed ID: 9547362

DOI: 10.1124/mol.53.4.708

PubMed ID: 10803682

Title: Histamine N-methyltransferase pharmacogenetics: association of a common functional polymorphism with asthma.

PubMed ID: 10803682

DOI: 10.1097/00008571-200004000-00007

PubMed ID: 26206890

Title: Mutations in the histamine N-methyltransferase gene, HNMT, are associated with nonsyndromic autosomal recessive intellectual disability.

PubMed ID: 26206890

DOI: 10.1093/hmg/ddv286

Sequence Information:

  • Length: 292
  • Mass: 33295
  • Checksum: 9CCADD1EE0CCB653
  • Sequence:
    • MASSMRSLFS DHGKYVESFR RFLNHSTEHQ CMQEFMDKKL PGIIGRIGDT KSEIKILSIG 
GGAGEIDLQI LSKVQAQYPG VCINNEVVEP SAEQIAKYKE LVAKTSNLEN VKFAWHKETS 
SEYQSRMLEK KELQKWDFIH MIQMLYYVKD IPATLKFFHS LLGTNAKMLI IVVSGSSGWD 
KLWKKYGSRF PQDDLCQYIT SDDLTQMLDN LGLKYECYDL LSTMDISDCF IDGNENGDLL 
WDFLTETCNF NATAPPDLRA ELGKDLQEPE FSAKKEGKVL FNNTLSFIVI EA

Genular Protein ID: 2590533656

Symbol: B4DWC1_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DWC1

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChEBI 5 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 2 Gene3D 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PROSITE 1 PeptideAtlas 1 Pfam 1 RefSeq 1 Rhea 1 SUPFAM 1

Sequence Information:

  • Length: 161
  • Mass: 18435
  • Checksum: 470FA49DA28FDE1C
  • Sequence:
    • MASSMRSLFS DHGKYVESFR RFLNHSTEHQ CMQEFMDKKL PGIIGRIGDT KSEIKILSIG 
GGAGEIDLQI LSKVQAQYPG VCINNEVVEP SAEQIAKYKE LVAKTSNLEN VKFAWHKETS 
SEYQSRMLEK KELQKWDFIH MIQVNENLLI SNFTSDHDLP K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.