Details for: HOXD3

Gene ID: 3232

Symbol: HOXD3

Ensembl ID: ENSG00000128652

Description: homeobox D3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 12.2214
    Cell Significance Index: -5.7700
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 2.3825
    Cell Significance Index: 27.7000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.2220
    Cell Significance Index: 59.5400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.9922
    Cell Significance Index: -4.3600
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.9204
    Cell Significance Index: 9.3400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.2938
    Cell Significance Index: 79.3200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.9591
    Cell Significance Index: 13.7400
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.9265
    Cell Significance Index: 11.9700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.6657
    Cell Significance Index: 8.5300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.6176
    Cell Significance Index: 14.9600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.3060
    Cell Significance Index: 7.0700
  • Cell Name: endothelial stalk cell (CL0002671)
    Fold Change: 0.3043
    Cell Significance Index: 3.4100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2282
    Cell Significance Index: 22.5800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2005
    Cell Significance Index: 181.0500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1869
    Cell Significance Index: 35.5700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1554
    Cell Significance Index: 5.4000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1519
    Cell Significance Index: 3.1500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1496
    Cell Significance Index: 3.1900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1312
    Cell Significance Index: 3.7800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1307
    Cell Significance Index: 21.2700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1133
    Cell Significance Index: 12.3300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1031
    Cell Significance Index: 18.5900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0768
    Cell Significance Index: 4.6100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0611
    Cell Significance Index: 2.7700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0544
    Cell Significance Index: 3.7600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0317
    Cell Significance Index: 4.3500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0313
    Cell Significance Index: 1.1000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0124
    Cell Significance Index: 0.3100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0047
    Cell Significance Index: 1.3400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0003
    Cell Significance Index: -0.2300
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0014
    Cell Significance Index: -0.0200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0025
    Cell Significance Index: -0.1300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0036
    Cell Significance Index: -6.7000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0048
    Cell Significance Index: -8.8700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0059
    Cell Significance Index: -9.0300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0081
    Cell Significance Index: -4.5400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0083
    Cell Significance Index: -0.1800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0089
    Cell Significance Index: -6.6100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0122
    Cell Significance Index: -7.7800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0133
    Cell Significance Index: -0.6700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0137
    Cell Significance Index: -7.4900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0169
    Cell Significance Index: -1.7300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0179
    Cell Significance Index: -8.1300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0181
    Cell Significance Index: -0.2900
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.0199
    Cell Significance Index: -0.2500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0220
    Cell Significance Index: -0.4600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0271
    Cell Significance Index: -3.3300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0277
    Cell Significance Index: -5.4900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0327
    Cell Significance Index: -6.5600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0364
    Cell Significance Index: -6.2100
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0377
    Cell Significance Index: -0.3400
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: -0.0405
    Cell Significance Index: -0.3200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0456
    Cell Significance Index: -0.7800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0477
    Cell Significance Index: -0.9300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0500
    Cell Significance Index: -6.4600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0523
    Cell Significance Index: -7.6100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0574
    Cell Significance Index: -1.8400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0576
    Cell Significance Index: -6.6000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0624
    Cell Significance Index: -0.9900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0666
    Cell Significance Index: -6.9400
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.0680
    Cell Significance Index: -0.6200
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0729
    Cell Significance Index: -0.6200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0785
    Cell Significance Index: -6.2200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0798
    Cell Significance Index: -3.7200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0861
    Cell Significance Index: -6.4200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0875
    Cell Significance Index: -2.3000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0950
    Cell Significance Index: -2.5900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1003
    Cell Significance Index: -7.7000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1020
    Cell Significance Index: -6.8600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1192
    Cell Significance Index: -3.5100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1234
    Cell Significance Index: -5.8000
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.1302
    Cell Significance Index: -1.4600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1388
    Cell Significance Index: -3.9800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1388
    Cell Significance Index: -7.7900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.1449
    Cell Significance Index: -2.5600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1471
    Cell Significance Index: -4.1100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1583
    Cell Significance Index: -4.0700
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.1628
    Cell Significance Index: -1.8900
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1670
    Cell Significance Index: -2.1100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1819
    Cell Significance Index: -8.0500
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.1890
    Cell Significance Index: -1.4500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1924
    Cell Significance Index: -3.2200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1933
    Cell Significance Index: -6.7700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1971
    Cell Significance Index: -2.9700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2106
    Cell Significance Index: -6.9000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2108
    Cell Significance Index: -5.6400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2128
    Cell Significance Index: -8.0600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2154
    Cell Significance Index: -6.8600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2193
    Cell Significance Index: -8.0500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2198
    Cell Significance Index: -5.8700
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: -0.2247
    Cell Significance Index: -2.1400
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.2469
    Cell Significance Index: -3.3900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2610
    Cell Significance Index: -6.6500
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: -0.2655
    Cell Significance Index: -2.8100
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: -0.2676
    Cell Significance Index: -2.8900
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.2698
    Cell Significance Index: -2.6100
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.2729
    Cell Significance Index: -1.9600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2778
    Cell Significance Index: -3.0200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2822
    Cell Significance Index: -7.0400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2843
    Cell Significance Index: -4.2600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Anterior-Posterior Pattern Specification:** HOXD3 is involved in the regulation of anterior-posterior patterning during embryonic development, particularly in the hindbrain and skull formation. 2. **Cell-Matrix Adhesion:** HOXD3 interacts with other genes to regulate cell-matrix adhesion, which is essential for tissue morphogenesis and immune cell migration. 3. **Transcriptional Regulation:** HOXD3 acts as a transcriptional regulator, influencing the expression of target genes involved in various developmental processes, including immune system development and function. 4. **Dna-Binding Transcription Activator Activity:** HOXD3 possesses a unique dna-binding transcription activator activity, allowing it to regulate gene expression at the transcriptional level. **Pathways and Functions:** 1. **Notch Signaling Pathway:** HOXD3 is involved in the regulation of the Notch signaling pathway, which plays a critical role in cell differentiation, proliferation, and death in the immune system. 2. **Dna-Polymerase II-Dependent Transcription:** HOXD3 acts as a positive regulator of transcription by dna-polymerase II, influencing the expression of target genes involved in immune system development and function. 3. **Aggresome Formation:** HOXD3 is involved in the regulation of aggresome formation, a process critical for the clearance of protein aggregates and the maintenance of cellular homeostasis. 4. **Thyroid Gland Development:** HOXD3 is required for the proper development and function of the thyroid gland, highlighting its role in endocrine system development. **Clinical Significance:** 1. **Immune System Disorders:** Alterations in HOXD3 expression have been linked to various immune system disorders, including autoimmune diseases and immunodeficiency syndromes. 2. **Cancer Development:** HOXD3 is involved in the regulation of cell proliferation and differentiation, making it a potential target for cancer therapy. 3. **Neurological Disorders:** HOXD3 expression has been linked to neurological disorders, including autism spectrum disorder and schizophrenia, highlighting its role in brain development and function. 4. **Developmental Abnormalities:** Mutations in HOXD3 have been associated with developmental abnormalities, including craniofacial defects and skeletal dysplasias. In conclusion, the HOXD3 gene is a critical regulator of developmental processes and tissue homeostasis, with significant implications for immune system development and function. Further studies are necessary to fully elucidate the mechanisms by which HOXD3 influences immune responses and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 2946202524

Symbol: HXD3_HUMAN

Name: Homeobox protein Hox-D3

UniProtKB Accession Codes:

P31249 Q99955 Q9BSC5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 3 ExpressionAtlas 1 GO 22 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 8 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1358204

Title: Cloning and sequencing of the human homeobox gene HOX4A.

PubMed ID: 1358204

DOI: 10.1016/0167-4781(92)90173-w

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2576652

Title: Organization of human class I homeobox genes.

PubMed ID: 2576652

DOI: 10.1139/g89-133

Sequence Information:

  • Length: 432
  • Mass: 45730
  • Checksum: BC962D2AA076B87B
  • Sequence:
    • MLFEQGQQAL ELPECTMQKA AYYENPGLFG GYGYSKTTDT YGYSTPHQPY PPPAAASSLD 
TDYPGSACSI QSSAPLRAPA HKGAELNGSC MRPGTGNSQG GGGGSQPPGL NSEQQPPQPP 
PPPPTLPPSS PTNPGGGVPA KKPKGGPNAS SSSATISKQI FPWMKESRQN SKQKNSCATA 
GESCEDKSPP GPASKRVRTA YTSAQLVELE KEFHFNRYLC RPRRVEMANL LNLTERQIKI 
WFQNRRMKYK KDQKAKGILH SPASQSPERS PPLGGAAGHV AYSGQLPPVP GLAYDAPSPP 
AFAKSQPNMY GLAAYTAPLS SCLPQQKRYA APEFEPHPMA SNGGGFASAN LQGSPVYVGG 
NFVESMAPAS GPVFNLGHLS HPSSASVDYS CAAQIPGNHH HGPCDPHPTY TDLSAHHSSQ 
GRLPEAPKLT HL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.