Gene HOXD3 - ENSG00000128652 | NCBI Gene ID: 3232

Details for: HOXD3

Gene ID: 3232

Symbol: HOXD3

Ensembl ID: ENSG00000128652

Description: homeobox D3

Associated with

Activation of anterior hox genes in hindbrain development during early embryogenesis
(R-HSA-5617472)
Activation of hox genes during differentiation
(R-HSA-5619507)
Developmental biology
(R-HSA-1266738)
Aggresome
(GO:0016235)
Anterior/posterior pattern specification
(GO:0009952)
Cartilage development
(GO:0051216)
Cell-matrix adhesion
(GO:0007160)
Chromatin
(GO:0000785)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-templated transcription
(GO:0006351)
Embryonic skeletal system morphogenesis
(GO:0048704)
Glossopharyngeal nerve morphogenesis
(GO:0021615)
Notch signaling pathway
(GO:0007219)
Nuclear body
(GO:0016604)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of neuron differentiation
(GO:0045666)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Sequence-specific double-stranded dna binding
(GO:1990837)
Thyroid gland development
(GO:0030878)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: renal principal cell (CL0005009)
Fold Change: 2.54
Marker Score: 1954
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 2.18
Marker Score: 1506
Cell Name: taste receptor cell (CL0000209)
Fold Change: 1.94
Marker Score: 1678
Cell Name: granulosa cell (CL0000501)
Fold Change: 1.46
Marker Score: 14729
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.37
Marker Score: 866
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 1.33
Marker Score: 1491
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 1.18
Marker Score: 3225
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.14
Marker Score: 4801
Cell Name: goblet cell (CL0000160)
Fold Change: 1.07
Marker Score: 7094
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 1.02
Marker Score: 536
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71808.5
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48034
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30407
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.98
Marker Score: 505.5
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.98
Marker Score: 307
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.97
Marker Score: 459
Cell Name: Unknown (CL0002371)
Fold Change: 0.97
Marker Score: 1030
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.95
Marker Score: 644
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2412
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5344
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.93
Marker Score: 371
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.92
Marker Score: 380.5
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2736
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9
Marker Score: 323
Cell Name: B cell (CL0000236)
Fold Change: 0.88
Marker Score: 836
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5283
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 0.81
Marker Score: 1120
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.8
Marker Score: 208
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 0.8
Marker Score: 1542
Cell Name: mast cell (CL0000097)
Fold Change: 0.79
Marker Score: 460
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.78
Marker Score: 593
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.77
Marker Score: 1256
Cell Name: brush cell (CL0002204)
Fold Change: 0.77
Marker Score: 705
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 394
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.73
Marker Score: 1721
Cell Name: natural killer cell (CL0000623)
Fold Change: 0.73
Marker Score: 944
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.72
Marker Score: 1368
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 0.72
Marker Score: 688
Cell Name: plasma cell (CL0000786)
Fold Change: 0.71
Marker Score: 788.5
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 178
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 0.64
Marker Score: 685
Cell Name: neutrophil (CL0000775)
Fold Change: 0.63
Marker Score: 384
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.63
Marker Score: 11181
Cell Name: papillary tips cell (CL1000597)
Fold Change: 0.6
Marker Score: 121
Cell Name: Leydig cell (CL0000178)
Fold Change: 0.59
Marker Score: 637
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.58
Marker Score: 385
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 0.58
Marker Score: 816
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.56
Marker Score: 148
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 444
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 0.54
Marker Score: 1925
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.53
Marker Score: 3477
Cell Name: mesangial cell (CL0000650)
Fold Change: 0.53
Marker Score: 644
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.53
Marker Score: 340
Cell Name: chromaffin cell (CL0000166)
Fold Change: 0.5
Marker Score: 702
Cell Name: motor neuron (CL0000100)
Fold Change: 0.5
Marker Score: 296
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.49
Marker Score: 205
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.49
Marker Score: 472
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 0.49
Marker Score: 177
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.48
Marker Score: 489
Cell Name: gut endothelial cell (CL0000131)
Fold Change: 0.48
Marker Score: 171
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.47
Marker Score: 494
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.46
Marker Score: 275
Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 0.45
Marker Score: 205
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.42
Marker Score: 134
Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 0.42
Marker Score: 98
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.41
Marker Score: 182
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4
Marker Score: 292
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.39
Marker Score: 6147
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: 0.39
Marker Score: 242
Cell Name: podocyte (CL0000653)
Fold Change: 0.39
Marker Score: 142.5
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.38
Marker Score: 771
Cell Name: inhibitory motor neuron (CL0008015)
Fold Change: 0.38
Marker Score: 179
Cell Name: stromal cell (CL0000499)
Fold Change: 0.37
Marker Score: 430
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.37
Marker Score: 369
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.37
Marker Score: 116
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 0.36
Marker Score: 900
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 0.35
Marker Score: 699
Cell Name: secretory cell (CL0000151)
Fold Change: 0.34
Marker Score: 629
Cell Name: neural cell (CL0002319)
Fold Change: 0.34
Marker Score: 164
Cell Name: sympathetic neuron (CL0011103)
Fold Change: 0.34
Marker Score: 112
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.33
Marker Score: 298
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.31
Marker Score: 101
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.29
Marker Score: 293.5
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 0.29
Marker Score: 779
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.28
Marker Score: 170
Cell Name: enteric neuron (CL0007011)
Fold Change: 0.28
Marker Score: 148
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.28
Marker Score: 470
Cell Name: mesothelial cell (CL0000077)
Fold Change: 0.27
Marker Score: 108
Cell Name: germ cell (CL0000586)
Fold Change: 0.27
Marker Score: 469
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.27
Marker Score: 430
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 0.26
Marker Score: 162
Cell Name: oligodendrocyte (CL0000128)
Fold Change: 0.25
Marker Score: 610
Cell Name: ependymal cell (CL0000065)
Fold Change: 0.25
Marker Score: 87
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.24
Marker Score: 510
Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
Fold Change: 0.24
Marker Score: 73
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 0.24
Marker Score: 297
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.23
Marker Score: 111
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.23
Marker Score: 66
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.23
Marker Score: 104
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 0.23
Marker Score: 374

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**Key characteristics:** * HXD3 is a highly conserved gene with a conserved DNA sequence and a well-documented role in vertebrates. * It is a key regulator of neural tube formation and survival. * It is expressed in a variety of neural and non-neural cell types, including neural stem cells, oligodendrocytes, and neurons. * It is a key regulator of the specification of the anterior/posterior (A/P) axis in the developing brain. * It is also involved in the regulation of various developmental processes, including cell-matrix adhesion, embryonic skeletal system morphogenesis, and thyroid gland development. **Pathways and functions:** * HXD3 is a key activator of the anterior hox genes in hindbrain development. * It is also involved in the regulation of the Notch signaling pathway, which is essential for the specification of the A/P axis. * It is a key regulator of the development of the glossopharyngeal nerve, which is derived from the neural tube. * It is also involved in the regulation of other neural and non-neural processes, including cell-matrix adhesion, embryonic skeletal system morphogenesis, and thyroid gland development. **Clinical significance:** HOXD3 mutations have been linked to several human diseases, including lissencephaly, neural tube defects, and various developmental disorders. These mutations can lead to intellectual disability and other neurological symptoms. **Conclusion:** HOXD3 is a critical transcription factor that plays a vital role in the early development of the vertebrate neural tube. Its mutations have significant implications for human health, underscoring its importance in maintaining neural tube integrity and preventing the development of various neurological disorders.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Homeobox protein Hox-D3

Genular Protein ID: 2946202524

Symbol: HXD3_HUMAN

Name: Homeobox protein Hox-D3

UniProtKB Accession Codes:

P31249 Q99955 Q9BSC5

Database IDs:

Citations:

PubMed ID: 1358204

Title: Cloning and sequencing of the human homeobox gene HOX4A.

PubMed ID: 1358204

DOI: 10.1016/0167-4781(92)90173-w

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2576652

Title: Organization of human class I homeobox genes.

PubMed ID: 2576652

DOI: 10.1139/g89-133

Sequence Information:

Length: 432
Mass: 45730
Checksum: BC962D2AA076B87B
Sequence:

MLFEQGQQAL ELPECTMQKA AYYENPGLFG GYGYSKTTDT YGYSTPHQPY PPPAAASSLD 
TDYPGSACSI QSSAPLRAPA HKGAELNGSC MRPGTGNSQG GGGGSQPPGL NSEQQPPQPP 
PPPPTLPPSS PTNPGGGVPA KKPKGGPNAS SSSATISKQI FPWMKESRQN SKQKNSCATA 
GESCEDKSPP GPASKRVRTA YTSAQLVELE KEFHFNRYLC RPRRVEMANL LNLTERQIKI 
WFQNRRMKYK KDQKAKGILH SPASQSPERS PPLGGAAGHV AYSGQLPPVP GLAYDAPSPP 
AFAKSQPNMY GLAAYTAPLS SCLPQQKRYA APEFEPHPMA SNGGGFASAN LQGSPVYVGG 
NFVESMAPAS GPVFNLGHLS HPSSASVDYS CAAQIPGNHH HGPCDPHPTY TDLSAHHSSQ 
GRLPEAPKLT HL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: HOXD3

Associated with

Cells (max top 100)

Other Information

Cloning and sequencing of the human homeobox gene HOX4A. PubMed ID: 1358204

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Organization of human class I homeobox genes. PubMed ID: 2576652

Database document:

PubMed ID: 1358204

PubMed ID: 15815621

PubMed ID: 15489334

PubMed ID: 2576652