Details for: HOXD9

Gene ID: 3235

Symbol: HOXD9

Ensembl ID: ENSG00000128709

Description: homeobox D9

Associated with

  • Adult locomotory behavior
    (GO:0008344)
  • Anterior/posterior pattern specification
    (GO:0009952)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Dna-templated transcription
    (GO:0006351)
  • Embryonic forelimb morphogenesis
    (GO:0035115)
  • Embryonic skeletal system morphogenesis
    (GO:0048704)
  • Hindlimb morphogenesis
    (GO:0035137)
  • Mammary gland development
    (GO:0030879)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleolus
    (GO:0005730)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Peripheral nervous system neuron development
    (GO:0048935)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Proximal/distal pattern formation
    (GO:0009954)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Single fertilization
    (GO:0007338)
  • Skeletal muscle tissue development
    (GO:0007519)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 8.9582
    Cell Significance Index: 76.1400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 6.6706
    Cell Significance Index: 234.4000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 4.5863
    Cell Significance Index: 132.1400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 3.5487
    Cell Significance Index: 73.6200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 3.5102
    Cell Significance Index: 87.7500
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 3.3206
    Cell Significance Index: 16.1500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.1043
    Cell Significance Index: 45.5900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.7711
    Cell Significance Index: 20.1200
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.2250
    Cell Significance Index: 7.6700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.1389
    Cell Significance Index: 216.7400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.1139
    Cell Significance Index: 14.2700
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.7477
    Cell Significance Index: 12.0000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.6835
    Cell Significance Index: 23.7500
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.5919
    Cell Significance Index: 6.6200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5228
    Cell Significance Index: 51.7200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4693
    Cell Significance Index: 423.7700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4145
    Cell Significance Index: 18.7900
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.3996
    Cell Significance Index: 4.6500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2968
    Cell Significance Index: 6.3200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2861
    Cell Significance Index: 46.5300
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.2345
    Cell Significance Index: 3.0400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2337
    Cell Significance Index: 25.4200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1991
    Cell Significance Index: 5.3400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1651
    Cell Significance Index: 22.6700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1319
    Cell Significance Index: 9.1200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1281
    Cell Significance Index: 7.6900
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.1228
    Cell Significance Index: 1.2200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0132
    Cell Significance Index: 9.7000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0113
    Cell Significance Index: 2.0400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0064
    Cell Significance Index: -4.7100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0065
    Cell Significance Index: -0.4000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0180
    Cell Significance Index: -0.9100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0181
    Cell Significance Index: -2.2300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0183
    Cell Significance Index: -10.3400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0207
    Cell Significance Index: -0.3200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0219
    Cell Significance Index: -0.9000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0228
    Cell Significance Index: -12.4300
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.0232
    Cell Significance Index: -0.1800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0262
    Cell Significance Index: -0.8300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0263
    Cell Significance Index: -0.9200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0296
    Cell Significance Index: -13.4300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0403
    Cell Significance Index: -5.1700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0558
    Cell Significance Index: -11.0800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0582
    Cell Significance Index: -11.6800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0609
    Cell Significance Index: -10.4000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0879
    Cell Significance Index: -1.8400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0894
    Cell Significance Index: -9.1300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0981
    Cell Significance Index: -11.2400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1065
    Cell Significance Index: -2.8000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1108
    Cell Significance Index: -14.3100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1182
    Cell Significance Index: -9.3700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1204
    Cell Significance Index: -1.9100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1263
    Cell Significance Index: -4.0500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1275
    Cell Significance Index: -6.6300
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.1533
    Cell Significance Index: -1.9800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1684
    Cell Significance Index: -4.7100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1806
    Cell Significance Index: -5.3200
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1811
    Cell Significance Index: -2.6300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1881
    Cell Significance Index: -4.6900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1908
    Cell Significance Index: -14.2200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1925
    Cell Significance Index: -5.2400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.2026
    Cell Significance Index: -3.5800
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.2276
    Cell Significance Index: -3.8900
  • Cell Name: surface ectodermal cell (CL0000114)
    Fold Change: -0.2319
    Cell Significance Index: -1.8300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2359
    Cell Significance Index: -11.0000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2612
    Cell Significance Index: -2.8400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2727
    Cell Significance Index: -12.8200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2797
    Cell Significance Index: -12.1600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2979
    Cell Significance Index: -5.8900
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.3158
    Cell Significance Index: -4.3300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3221
    Cell Significance Index: -8.6200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3358
    Cell Significance Index: -5.6200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3451
    Cell Significance Index: -12.6700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.3905
    Cell Significance Index: -9.9500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4221
    Cell Significance Index: -12.1000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.4280
    Cell Significance Index: -6.4500
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.4359
    Cell Significance Index: -6.2000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4423
    Cell Significance Index: -11.8100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.4578
    Cell Significance Index: -9.1300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.4600
    Cell Significance Index: -11.4900
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: -0.4686
    Cell Significance Index: -3.8300
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.4711
    Cell Significance Index: -4.2500
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: -0.4711
    Cell Significance Index: -2.3500
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.4713
    Cell Significance Index: -4.5600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.4767
    Cell Significance Index: -7.7200
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.4936
    Cell Significance Index: -5.6800
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.5171
    Cell Significance Index: -5.9500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.5295
    Cell Significance Index: -12.9200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.5315
    Cell Significance Index: -12.2800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.5316
    Cell Significance Index: -11.6400
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.5318
    Cell Significance Index: -5.5600
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.5368
    Cell Significance Index: -7.5300
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.5440
    Cell Significance Index: -7.7300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5885
    Cell Significance Index: -12.4900
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.5910
    Cell Significance Index: -6.0000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.6007
    Cell Significance Index: -12.0600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.6041
    Cell Significance Index: -11.7900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.6333
    Cell Significance Index: -9.4900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.6363
    Cell Significance Index: -12.4400
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.6415
    Cell Significance Index: -8.8100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** HOXD9 is widely expressed in various tissues, including hematopoietic stem cells, megakaryocytes, microglial cells, and endothelial cells of the uterus. 2. **Function:** HOXD9 acts as a transcription factor, regulating the expression of genes involved in developmental processes, immune function, and cell differentiation. 3. **Conservation:** HOXD9 is conserved across species, suggesting its importance in evolutionarily conserved processes. 4. **Cellular Localization:** HOXD9 is primarily localized to the nucleus, where it regulates transcriptional activity. **Pathways and Functions:** 1. **Developmental Processes:** HOXD9 plays a crucial role in the specification of the anterior-posterior axis, hindlimb morphogenesis, and embryonic skeletal system morphogenesis. 2. **Immune Function:** HOXD9 regulates the expression of genes involved in hematopoiesis, including megakaryocyte-erythroid progenitor cell development and granulocyte-monocyte progenitor cell development. 3. **Cell Differentiation:** HOXD9 promotes the differentiation of microglial cells and endothelial cells of the uterus. 4. **Transcriptional Regulation:** HOXD9 acts as a transcriptional repressor or activator, depending on the context, and regulates the expression of genes involved in various cellular processes. **Clinical Significance:** 1. **Hematological Disorders:** Alterations in HOXD9 expression have been linked to various hematological disorders, including leukemia, lymphoma, and myelodysplastic syndromes. 2. **Immune-Mediated Diseases:** HOXD9 has been implicated in the pathogenesis of immune-mediated diseases, such as rheumatoid arthritis and multiple sclerosis. 3. **Cancer:** HOXD9 is overexpressed in various types of cancer, including breast cancer, lung cancer, and colon cancer, suggesting its role in tumorigenesis. 4. **Neurological Disorders:** HOXD9 has been linked to neurological disorders, including autism spectrum disorder and schizophrenia, highlighting its role in brain development and function. In conclusion, the HOXD9 gene is a multifaceted regulator of developmental processes and immune function. Its dysregulation has significant implications for human health, and further research is needed to elucidate the mechanisms underlying its clinical significance.

Genular Protein ID: 54322379

Symbol: HXD9_HUMAN

Name: Homeobox protein Hox-D9

UniProtKB Accession Codes:

P28356 Q86ST1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 GO 24 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1756725

Title: HOX4 genes encode transcription factors with potential auto- and cross-regulatory capacities.

PubMed ID: 1756725

DOI: 10.1002/j.1460-2075.1991.tb04996.x

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2568311

Title: Complementary homeo protein gradients in developing limb buds.

PubMed ID: 2568311

DOI: 10.1101/gad.3.5.641

PubMed ID: 2574852

Title: The human HOX gene family.

PubMed ID: 2574852

DOI: 10.1093/nar/17.24.10385

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 11857506

Title: Complete mutation analysis panel of the 39 human HOX genes.

PubMed ID: 11857506

DOI: 10.1002/tera.10009

Sequence Information:

  • Length: 352
  • Mass: 36495
  • Checksum: ECBFE68B48C0F532
  • Sequence:
    • MLGGSAGRLK MSSSGTLSNY YVDSLIGHEG DEVFAARFGP PGPGAQGRPA GVADGPAATA 
AEFASCSFAP RSAVFSASWS AVPSQPPAAA AMSGLYHPYV PPPPLAASAS EPGRYVRSWM 
EPLPGFPGGA GGGGGGGGGG PGRGPSPGPS GPANGRHYGI KPETRAAPAP ATAASTTSSS 
STSLSSSSKR TECSVARESQ GSSGPEFSCN SFLQEKAAAA TGGTGPGAGI GAATGTGGSS 
EPSACSDHPI PGCSLKEEEK QHSQPQQQQL DPNNPAANWI HARSTRKKRC PYTKYQTLEL 
EKEFLFNMYL TRDRRYEVAR ILNLTERQVK IWFQNRRMKM KKMSKEKCPK GD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.