Details for: HOXD9

Gene ID: 3235

Symbol: HOXD9

Ensembl ID: ENSG00000128709

Description: homeobox D9

Associated with

  • Adult locomotory behavior
    (GO:0008344)
  • Anterior/posterior pattern specification
    (GO:0009952)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Dna-templated transcription
    (GO:0006351)
  • Embryonic forelimb morphogenesis
    (GO:0035115)
  • Embryonic skeletal system morphogenesis
    (GO:0048704)
  • Hindlimb morphogenesis
    (GO:0035137)
  • Mammary gland development
    (GO:0030879)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleolus
    (GO:0005730)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Peripheral nervous system neuron development
    (GO:0048935)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Proximal/distal pattern formation
    (GO:0009954)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Single fertilization
    (GO:0007338)
  • Skeletal muscle tissue development
    (GO:0007519)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 3.14
    Marker Score: 1653
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 2.95
    Marker Score: 1674
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 2.18
    Marker Score: 3965
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.7
    Marker Score: 4623
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.65
    Marker Score: 3288
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.46
    Marker Score: 611
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.44
    Marker Score: 1525
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 869
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.23
    Marker Score: 1302
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.18
    Marker Score: 11886
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.15
    Marker Score: 7677
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.15
    Marker Score: 2912
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.15
    Marker Score: 834
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4809
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.13
    Marker Score: 266
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.06
    Marker Score: 1146
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251802
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.01
    Marker Score: 686.5
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71820
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48045
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 509
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 463
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 375
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5317
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 327
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.91
    Marker Score: 1013
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.87
    Marker Score: 5674
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5285
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.87
    Marker Score: 2331
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.86
    Marker Score: 1218
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.85
    Marker Score: 495
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.85
    Marker Score: 1438
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.83
    Marker Score: 551
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.82
    Marker Score: 1707
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 593.5
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1258
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.77
    Marker Score: 951
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.74
    Marker Score: 569
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.63
    Marker Score: 403
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.61
    Marker Score: 621
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.6
    Marker Score: 993
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.58
    Marker Score: 706
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 464
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 150
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.54
    Marker Score: 468
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.54
    Marker Score: 515
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.53
    Marker Score: 221
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.52
    Marker Score: 1007
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.52
    Marker Score: 348
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.52
    Marker Score: 495
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.51
    Marker Score: 349
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 476
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.49
    Marker Score: 118
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.49
    Marker Score: 857
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 279
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.44
    Marker Score: 273.5
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.43
    Marker Score: 740
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.42
    Marker Score: 133
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.42
    Marker Score: 82
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.41
    Marker Score: 367.5
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.4
    Marker Score: 669
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.39
    Marker Score: 628
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.39
    Marker Score: 363
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.38
    Marker Score: 268.5
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 373
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.36
    Marker Score: 4041
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.34
    Marker Score: 129
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.34
    Marker Score: 394
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.33
    Marker Score: 353
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.32
    Marker Score: 161
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.31
    Marker Score: 329
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.31
    Marker Score: 276
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.3
    Marker Score: 566
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.3
    Marker Score: 78
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.29
    Marker Score: 293
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.29
    Marker Score: 550
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.28
    Marker Score: 112
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.27
    Marker Score: 1153
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.26
    Marker Score: 53
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.26
    Marker Score: 377
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 0.25
    Marker Score: 329
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.25
    Marker Score: 72
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.25
    Marker Score: 609.5
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.24
    Marker Score: 62
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.23
    Marker Score: 105
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.22
    Marker Score: 65
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.21
    Marker Score: 71
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.21
    Marker Score: 65
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.2
    Marker Score: 52
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.2
    Marker Score: 113
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.2
    Marker Score: 73.5
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.2
    Marker Score: 50
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.19
    Marker Score: 45

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Other Information

**Key characteristics:** * HOXD9 is a transcription factor that is involved in the regulation of gene expression. * It is a member of the Hox family of transcription factors, which are known for their ability to control the development of the body along the anterior/posterior axis. * HOXD9 is a key regulator of embryonic forelimb morphogenesis, skeletal muscle tissue development, and mammary gland development. * It is also involved in the regulation of the peripheral nervous system, the development of the proximal/distal pattern, and the development of the female reproductive tract. **Pathways and functions:** * HOXD9 is involved in the regulation of cell proliferation, differentiation, and survival. * It is essential for the development of the hematopoietic system, the skeletal muscle tissue, the mammary gland, and the developing female reproductive tract. * It is also involved in the regulation of the peripheral nervous system, the development of the proximal/distal pattern, and the development of the female reproductive tract. **Clinical significance:** * Mutations in the HOXD9 gene have been linked to a number of human diseases, including leukemia, breast cancer, and coronary artery disease. * HOXD9 inhibitors are being investigated as a potential treatment for these diseases.

Genular Protein ID: 54322379

Symbol: HXD9_HUMAN

Name: Homeobox protein Hox-D9

UniProtKB Accession Codes:

P28356 Q86ST1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 GO 24 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1756725

Title: HOX4 genes encode transcription factors with potential auto- and cross-regulatory capacities.

PubMed ID: 1756725

DOI: 10.1002/j.1460-2075.1991.tb04996.x

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2568311

Title: Complementary homeo protein gradients in developing limb buds.

PubMed ID: 2568311

DOI: 10.1101/gad.3.5.641

PubMed ID: 2574852

Title: The human HOX gene family.

PubMed ID: 2574852

DOI: 10.1093/nar/17.24.10385

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 11857506

Title: Complete mutation analysis panel of the 39 human HOX genes.

PubMed ID: 11857506

DOI: 10.1002/tera.10009

Sequence Information:

  • Length: 352
  • Mass: 36495
  • Checksum: ECBFE68B48C0F532
  • Sequence:
    • MLGGSAGRLK MSSSGTLSNY YVDSLIGHEG DEVFAARFGP PGPGAQGRPA GVADGPAATA 
AEFASCSFAP RSAVFSASWS AVPSQPPAAA AMSGLYHPYV PPPPLAASAS EPGRYVRSWM 
EPLPGFPGGA GGGGGGGGGG PGRGPSPGPS GPANGRHYGI KPETRAAPAP ATAASTTSSS 
STSLSSSSKR TECSVARESQ GSSGPEFSCN SFLQEKAAAA TGGTGPGAGI GAATGTGGSS 
EPSACSDHPI PGCSLKEEEK QHSQPQQQQL DPNNPAANWI HARSTRKKRC PYTKYQTLEL 
EKEFLFNMYL TRDRRYEVAR ILNLTERQVK IWFQNRRMKM KKMSKEKCPK GD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.