Details for: HPRT1
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 34.86rCSI 31.48%PRS 62.19
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CSI 18.98rCSI 15.35%PRS 66.86
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CSI 16.87rCSI 12.67%PRS 70.93
-
CSI 15.84rCSI 27.92%PRS 61.83
-
CSI 15.36rCSI 19.28%PRS 75.64
-
CSI 12.06rCSI 34.43%PRS 75.81
-
CSI 10.75rCSI 8.34%PRS 67.93
-
CSI 9.22rCSI 40.02%PRS 76.59
-
CSI 8.7rCSI 6.05%PRS 76.48
-
CSI 8.43rCSI 20.48%PRS 45.14
-
CSI 7.86rCSI 12.08%PRS 74.42
-
CSI 7.21rCSI 17.25%PRS 52.27
-
CSI 6.99rCSI 4.87%PRS 80.43
-
CSI 6.68rCSI 24.05%PRS 44.97
-
CSI 6.53rCSI 5.19%PRS 85.65
-
CSI 6.35rCSI 7.27%PRS 82.56
-
CSI 6.2rCSI 33.43%PRS 76.4
-
CSI 6.07rCSI 13.76%PRS 68.54
-
CSI 5.81rCSI 13.03%PRS 47.33
-
CSI 5.35rCSI 16.71%PRS 48.35
-
CSI 5.1rCSI 8.83%PRS 55.48
-
CSI 5.1rCSI 4.7%PRS 66.88
-
CSI 5.09rCSI 3.38%PRS 68.32
-
CSI 5.04rCSI 29.67%PRS 47.82
-
CSI 4.77rCSI 4.86%PRS 77.41
-
CSI 4.75rCSI 7.25%PRS 74.47
-
CSI 4.21rCSI 5.08%PRS 74.11
-
CSI 4.07rCSI 4.26%PRS 68.72
-
CSI 3.99rCSI 3.2%PRS 84.25
-
CSI 3.85rCSI 3.78%PRS 80.85
-
CSI 3.82rCSI 10.13%PRS 75.69
-
CSI 3.77rCSI 10.8%PRS 84.47
-
CSI 3.75rCSI 3.1%PRS 67.63
-
CSI 3.73rCSI 3.67%PRS 67.99
-
CSI 3.71rCSI 21.24%PRS 73.76
-
CSI 3.57rCSI 4.95%PRS 63.71
-
CSI 3.56rCSI 2.71%PRS 78.34
-
CSI 3.41rCSI 5.48%PRS 48.6
-
CSI 3.38rCSI 3.54%PRS 61.67
-
CSI 3.37rCSI 4.61%PRS 71.06
-
CSI 3.22rCSI 4.4%PRS 66.55
-
CSI 3.15rCSI 2.76%PRS 70.7
-
CSI 3.13rCSI 3.02%PRS 65.04
-
CSI 3.13rCSI 7.93%PRS 54.73
-
CSI 3.01rCSI 4.75%PRS 67.79
-
CSI 2.98rCSI 4.13%PRS 65.61
-
CSI 2.97rCSI 33.39%PRS 81.49
-
CSI 2.95rCSI 4.26%PRS 74.14
-
CSI 2.89rCSI 69.3%PRS 45.7
-
CSI 2.85rCSI 68.87%PRS 46.49
-
CSI 2.8rCSI 7.23%PRS 60.3
-
CSI 2.78rCSI 6.43%PRS 53.9
-
CSI 2.78rCSI 6.34%PRS 56.93
-
CSI 2.75rCSI 1.85%PRS 78.55
-
CSI 2.73rCSI 2.16%PRS 52.11
-
CSI 2.67rCSI 2.75%PRS 80.81
-
CSI 2.66rCSI 3.92%PRS 58.44
-
CSI 2.59rCSI 4.71%PRS 56.82
-
CSI 2.53rCSI 3.24%PRS 62.16
-
CSI 2.53rCSI 1.91%PRS 78.99
-
CSI 2.49rCSI 3.83%PRS 59.81
-
CSI 2.43rCSI 2.9%PRS 46.44
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CSI 2.43rCSI 1.89%PRS 82.49
-
CSI 2.43rCSI 3.71%PRS 80.31
-
CSI 2.42rCSI 2%PRS 64.77
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CSI 2.41rCSI 1.9%PRS 71.93
-
CSI 2.4rCSI 1.8%PRS 80.13
-
CSI 2.4rCSI 2.82%PRS 67.42
-
CSI 2.4rCSI 1.85%PRS 66.17
-
CSI 2.38rCSI 3.54%PRS 66.43
-
CSI 2.37rCSI 1.65%PRS 67.92
-
CSI 2.34rCSI 2.02%PRS 70.17
-
CSI 2.33rCSI 5.07%PRS 52.82
-
CSI 2.29rCSI 2.21%PRS 56.24
-
CSI 2.28rCSI 3.1%PRS 56.76
-
CSI 2.26rCSI 4.23%PRS 53.37
-
CSI 2.21rCSI 2.69%PRS 72.79
-
CSI 2.19rCSI 5%PRS 65.35
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CSI 2.17rCSI 9.88%PRS 89.8
-
CSI 2.15rCSI 17.46%PRS 58.73
-
CSI 2.11rCSI 5.03%PRS 65.77
-
CSI 2.04rCSI 7.66%PRS 57.14
-
CSI 2.04rCSI 2.04%PRS 58.7
-
CSI 2.03rCSI 4.07%PRS 54.25
-
CSI 2rCSI 2.14%PRS 65.13
-
CSI 1.98rCSI 1.72%PRS 75.98
-
CSI 1.97rCSI 2.21%PRS 81.28
-
CSI 1.96rCSI 2.62%PRS 73.92
-
CSI 1.89rCSI 2.6%PRS 83.72
-
CSI 1.86rCSI 2.14%PRS 58.11
-
CSI 1.82rCSI 1.9%PRS 63.18
-
CSI 1.81rCSI 1.93%PRS 74.42
-
CSI 1.81rCSI 1.35%PRS 81.27
-
CSI 1.81rCSI 2.64%PRS 70.32
-
CSI 1.75rCSI 1.3%PRS 78.5
-
CSI 1.71rCSI 1.58%PRS 83.86
-
CSI 1.7rCSI 2.41%PRS 61.67
-
CSI 1.7rCSI 4.53%PRS 54.46
-
CSI 1.68rCSI 2.56%PRS 61.57
-
CSI 1.67rCSI 2.65%PRS 57.69
-
CSI 0.3rCSI 3.8%PRS 89.6%
-
CSI 0.4rCSI 2.2%PRS 73.4%
-
CSI 0.4rCSI 3.3%PRS 87.8%
-
CSI 0.4rCSI 12.8%PRS 83.2%
-
CSI 0.5rCSI 1.6%PRS 53.7%
-
CSI 0.5rCSI 2.1%PRS 76.8%
-
CSI 0.6rCSI 1.9%PRS 50.7%
-
CSI 0.6rCSI 2.7%PRS 65.1%
-
CSI 0.7rCSI 2.4%PRS 73.1%
-
CSI 0.7rCSI 1.4%PRS 82.0%
-
CSI 0.7rCSI 1.0%PRS 69.2%
-
CSI 0.7rCSI 1.9%PRS 56.2%
-
CSI 0.7rCSI 15.1%PRS 57.2%
-
CSI 0.8rCSI 3.0%PRS 47.3%
-
CSI 0.8rCSI 3.2%PRS 84.6%
-
CSI 0.9rCSI 4.6%PRS 91.9%
-
CSI 0.9rCSI 1.7%PRS 68.2%
-
CSI 0.9rCSI 1.3%PRS 80.7%
-
CSI 0.9rCSI 3.1%PRS 77.2%
-
CSI 0.9rCSI 4.4%PRS 76.1%
-
CSI 0.9rCSI 1.2%PRS 71.6%
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CSI 0.9rCSI 1.6%PRS 73.7%
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CSI 1.0rCSI 2.5%PRS 62.1%
-
CSI 1.0rCSI 1.3%PRS 77.0%
-
CSI 1.0rCSI 6.5%PRS 81.4%
-
CSI 1.0rCSI 2.6%PRS 59.2%
-
CSI 1.0rCSI 1.6%PRS 69.6%
-
CSI 1.0rCSI 1.8%PRS 46.6%
-
CSI 1.1rCSI 2.9%PRS 72.1%
-
CSI 1.1rCSI 1.7%PRS 70.6%
-
CSI 1.1rCSI 3.5%PRS 52.0%
-
CSI 1.1rCSI 3.1%PRS 54.7%
-
CSI 1.1rCSI 1.7%PRS 63.7%
-
CSI 1.1rCSI 1.7%PRS 69.9%
-
CSI 1.1rCSI 3.8%PRS 50.1%
-
CSI 1.1rCSI 3.4%PRS 81.0%
-
CSI 1.1rCSI 2.2%PRS 89.2%
-
CSI 1.2rCSI 2.5%PRS 75.5%
-
CSI 1.2rCSI 23.8%PRS 55.7%
-
CSI 1.2rCSI 1.4%PRS 55.7%
-
CSI 1.2rCSI 2.6%PRS 69.2%
-
CSI 1.3rCSI 2.8%PRS 63.4%
-
CSI 1.3rCSI 3.3%PRS 68.4%
-
CSI 1.3rCSI 2.2%PRS 45.7%
-
CSI 1.3rCSI 3.2%PRS 63.8%
-
CSI 1.3rCSI 5.8%PRS 78.8%
-
CSI 1.3rCSI 3.8%PRS 76.4%
-
CSI 1.3rCSI 1.8%PRS 84.7%
-
CSI 1.4rCSI 2.4%PRS 57.3%
-
CSI 1.4rCSI 6.8%PRS 77.8%
-
CSI 1.4rCSI 1.9%PRS 71.2%
-
CSI 1.4rCSI 25.2%PRS 90.7%
-
CSI 1.4rCSI 3.1%PRS 73.1%
-
CSI 1.4rCSI 1.3%PRS 63.2%
-
CSI 1.4rCSI 2.5%PRS 64.6%
-
CSI 1.4rCSI 2.2%PRS 77.9%
-
CSI 1.4rCSI 7.4%PRS 85.6%
-
CSI 1.5rCSI 2.1%PRS 60.7%
-
CSI 1.5rCSI 15.4%PRS 63.2%
-
CSI 1.5rCSI 3.0%PRS 55.0%
-
CSI 1.5rCSI 1.3%PRS 69.2%
-
CSI 1.5rCSI 2.4%PRS 54.7%
-
CSI 1.5rCSI 2.2%PRS 75.4%
-
CSI 1.5rCSI 1.4%PRS 74.3%
-
CSI 1.5rCSI 2.9%PRS 75.7%
-
CSI 1.5rCSI 1.9%PRS 66.9%
-
CSI 1.5rCSI 3.4%PRS 51.2%
-
CSI 1.6rCSI 2.5%PRS 87.2%
-
CSI 1.6rCSI 5.7%PRS 84.1%
-
CSI 1.6rCSI 2.9%PRS 58.4%
-
CSI 1.6rCSI 2.0%PRS 44.8%
-
CSI 1.6rCSI 5.7%PRS 91.6%
-
CSI 1.6rCSI 1.4%PRS 53.1%
-
CSI 1.6rCSI 2.1%PRS 47.9%
-
CSI 1.6rCSI 2.6%PRS 54.3%
-
CSI 1.6rCSI 4.3%PRS 73.9%
-
CSI 1.6rCSI 6.7%PRS 58.9%
-
CSI 1.7rCSI 2.4%PRS 70.6%
-
CSI 1.7rCSI 2.7%PRS 57.7%
-
CSI 1.7rCSI 2.6%PRS 61.6%
-
CSI 1.7rCSI 4.5%PRS 54.5%
-
CSI 1.7rCSI 2.4%PRS 61.7%
-
CSI 1.7rCSI 1.6%PRS 83.9%
-
CSI 1.8rCSI 1.3%PRS 78.5%
-
CSI 1.8rCSI 2.6%PRS 70.3%
-
CSI 1.8rCSI 1.4%PRS 81.3%
-
CSI 1.8rCSI 1.9%PRS 74.4%
-
CSI 1.8rCSI 1.9%PRS 63.2%
-
CSI 1.9rCSI 2.1%PRS 58.1%
-
CSI 1.9rCSI 2.6%PRS 83.7%
-
CSI 2.0rCSI 2.6%PRS 73.9%
-
CSI 2.0rCSI 2.2%PRS 81.3%
-
CSI 2.0rCSI 1.7%PRS 76.0%
-
CSI 2.0rCSI 2.1%PRS 65.1%
-
CSI 2.0rCSI 4.1%PRS 54.3%
-
CSI 2.0rCSI 2.0%PRS 58.7%
-
CSI 2.0rCSI 7.7%PRS 57.1%
-
CSI 2.1rCSI 5.0%PRS 65.8%
-
CSI 2.2rCSI 17.5%PRS 58.7%
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CSI 2.2rCSI 9.9%PRS 89.8%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 2727652252
Symbol: HPRT_HUMAN
Name: Hypoxanthine-guanine phosphoribosyltransferase
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 6300847
Title: Isolation and characterization of a full-length expressible cDNA for human hypoxanthine phosphoribosyl transferase.
PubMed ID: 6300847
PubMed ID: 2341149
Title: Automated DNA sequencing of the human HPRT locus.
PubMed ID: 2341149
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15772651
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 7107641
Title: Human hypoxanthine-guanine phosphoribosyltransferase. Complete amino acid sequence of the erythrocyte enzyme.
PubMed ID: 7107641
PubMed ID: 3023844
Title: Fine structure of the human hypoxanthine phosphoribosyltransferase gene.
PubMed ID: 3023844
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25114211
Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.
PubMed ID: 25114211
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 8044844
Title: The crystal structure of human hypoxanthine-guanine phosphoribosyltransferase with bound GMP.
PubMed ID: 8044844
PubMed ID: 10360366
Title: The 2.0 A structure of human hypoxanthine-guanine phosphoribosyltransferase in complex with a transition-state analog inhibitor.
PubMed ID: 10360366
DOI: 10.1038/9376
PubMed ID: 10338013
Title: Ternary complex structure of human HGPRTase, PRPP, Mg2+, and the inhibitor HPP reveals the involvement of the flexible loop in substrate binding.
PubMed ID: 10338013
DOI: 10.1110/ps.8.5.1023
PubMed ID: 1487231
Title: A review of the molecular basis of hypoxanthine-guanine phosphoribosyltransferase (HPRT) deficiency.
PubMed ID: 1487231
DOI: 10.1007/bf00220062
PubMed ID: 15990111
Title: The crystal structure of free human hypoxanthine-guanine phosphoribosyltransferase reveals extensive conformational plasticity throughout the catalytic cycle.
PubMed ID: 15990111
PubMed ID: 19527031
Title: Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: a new class of antimalarial therapeutics.
PubMed ID: 19527031
DOI: 10.1021/jm900267n
PubMed ID: 6853490
Title: Human hypoxanthine-guanine phosphoribosyltransferase.
PubMed ID: 6853490
PubMed ID: 6853716
Title: Molecular basis of hypoxanthine-guanine phosphoribosyltransferase deficiency in a patient with the Lesch-Nyhan syndrome.
PubMed ID: 6853716
DOI: 10.1172/jci110884
PubMed ID: 6572373
Title: Human hypoxanthine (guanine) phosphoribosyltransferase: an amino acid substitution in a mutant form of the enzyme isolated from a patient with gout.
PubMed ID: 6572373
PubMed ID: 6706936
Title: Human hypoxanthine-guanine phosphoribosyltransferase. Structural alteration in a dysfunctional enzyme variant (HPRTMunich) isolated from a patient with gout.
PubMed ID: 6706936
PubMed ID: 3358423
Title: Resolution of a missense mutant in human genomic DNA by denaturing gradient gel electrophoresis and direct sequencing using in vitro DNA amplification: HPRT Munich.
PubMed ID: 3358423
PubMed ID: 3384338
Title: Genetic basis of hypoxanthine guanine phosphoribosyltransferase deficiency in a patient with the Lesch-Nyhan syndrome (HPRTFlint).
PubMed ID: 3384338
PubMed ID: 3265398
Title: Human hypoxanthine-guanine phosphoribosyltransferase: a single nucleotide substitution in cDNA clones isolated from a patient with Lesch-Nyhan syndrome (HPRTMidland).
PubMed ID: 3265398
PubMed ID: 2896620
Title: Identification of a single nucleotide change in a mutant gene for hypoxanthine-guanine phosphoribosyltransferase (HPRT Ann Arbor).
PubMed ID: 2896620
DOI: 10.1007/bf00291707
PubMed ID: 3198771
Title: Hypoxanthine-guanine phosphoribosyltransferase. Genetic evidence for identical mutations in two partially deficient subjects.
PubMed ID: 3198771
DOI: 10.1172/jci113839
PubMed ID: 3148064
Title: Biochemical basis of hypoxanthine-guanine phosphoribosyltransferase deficiency in nine families.
PubMed ID: 3148064
DOI: 10.1007/bf01800364
PubMed ID: 2572141
Title: Molecular analysis of hypoxanthine-guanine phosphoribosyltransferase mutations in five unrelated Japanese patients.
PubMed ID: 2572141
PubMed ID: 2909537
Title: Human hypoxanthine-guanine phosphoribosyltransferase deficiency. The molecular defect in a patient with gout (HPRTAshville).
PubMed ID: 2909537
PubMed ID: 2910902
Title: Identification of a single nucleotide change in the hypoxanthine-guanine phosphoribosyltransferase gene (HPRTYale) responsible for Lesch-Nyhan syndrome.
PubMed ID: 2910902
DOI: 10.1172/jci113846
PubMed ID: 2738157
Title: Molecular basis of hypoxanthine-guanine phosphoribosyltransferase deficiency in ten subjects determined by direct sequencing of amplified transcripts.
PubMed ID: 2738157
DOI: 10.1172/jci114160
PubMed ID: 2928313
Title: Identification of mutations leading to the Lesch-Nyhan syndrome by automated direct DNA sequencing of in vitro amplified cDNA.
PubMed ID: 2928313
PubMed ID: 2347587
Title: Multiplex DNA deletion detection and exon sequencing of the hypoxanthine phosphoribosyltransferase gene in Lesch-Nyhan families.
PubMed ID: 2347587
PubMed ID: 2358296
Title: Molecular analyses of a Lesch-Nyhan syndrome mutation (hprtMontreal) by use of T-lymphocyte cultures.
PubMed ID: 2358296
DOI: 10.1007/bf00276334
PubMed ID: 2246854
Title: Identification of a single nucleotide substitution in the coding sequence of in vitro amplified cDNA from a patient with partial HPRT deficiency (HPRTBRISBANE).
PubMed ID: 2246854
DOI: 10.1007/bf01799570
PubMed ID: 2018042
Title: Identification of 17 independent mutations responsible for human hypoxanthine-guanine phosphoribosyltransferase (HPRT) deficiency.
PubMed ID: 2018042
PubMed ID: 2071157
Title: Determination of the mutations responsible for the Lesch-Nyhan syndrome in 17 subjects.
PubMed ID: 2071157
PubMed ID: 1937471
Title: Hypoxanthine-guanine phosphoribosyltransferase deficiency: analysis of HPRT mutations by direct sequencing and allele-specific amplification.
PubMed ID: 1937471
DOI: 10.1007/bf00201727
PubMed ID: 1840476
Title: Identification of two independent Japanese mutant HPRT genes using the PCR technique.
PubMed ID: 1840476
PubMed ID: 1551676
Title: The point mutation of hypoxanthine-guanine phosphoribosyltransferase (HPRTEdinburgh) and detection by allele-specific polymerase chain reaction.
PubMed ID: 1551676
DOI: 10.1007/bf02265300
PubMed ID: 1301916
Title: Characterization of mutations in phenotypic variants of hypoxanthine phosphoribosyltransferase deficiency.
PubMed ID: 1301916
DOI: 10.1093/hmg/1.6.427
PubMed ID: 7987318
Title: Sequence, expression and characterization of HPRTMoose Jaw: a point mutation resulting in cooperativity and decreased substrate affinities.
PubMed ID: 7987318
DOI: 10.1093/hmg/3.8.1377
PubMed ID: 7627191
Title: Identification of a new missense mutation in exon 2 of the human hypoxanthine phosphoribosyltransferase gene (HPRTIsar): a further example of clinical heterogeneity in HPRT deficiencies.
PubMed ID: 7627191
PubMed ID: 9003484
Title: An asymptomatic germline missense base substitution in the hypoxanthine phosphoribosyltransferase (HPRT) gene that reduces the amount of enzyme in humans.
PubMed ID: 9003484
PubMed ID: 9452051
Title: The molecular basis of hypoxanthine-guanine phosphoribosyltransferase deficiency in French families; report of two novel mutations.
PubMed ID: 9452051
PubMed ID: 15571223
Title: Mutations in the hypoxanthine guanine phosphoribosyltransferase gene (HPRT1) in Asian HPRT deficient families.
PubMed ID: 15571223
PubMed ID: 17027311
Title: Molecular analysis of HPRT deficiencies: an update of the spectrum of Asian mutations with novel mutations.
PubMed ID: 17027311
PubMed ID: 20544509
Title: Molecular analysis of two enzyme genes, HPRT1 and PRPS1, causing X-linked inborn errors of purine metabolism.
PubMed ID: 20544509
PubMed ID: 24940672
Title: Hypoxanthine guanine phosphoribosyltransferase (HPRT) deficiencies: HPRT1 mutations in new Japanese families and PRPP concentration.
PubMed ID: 24940672
Sequence Information:
- Length: 218
- Mass: 24579
- Checksum: 1928EE69517CCB40
- Sequence:
MATRSPGVVI SDDEPGYDLD LFCIPNHYAE DLERVFIPHG LIMDRTERLA RDVMKEMGGH HIVALCVLKG GYKFFADLLD YIKALNRNSD RSIPMTVDFI RLKSYCNDQS TGDIKVIGGD DLSTLTGKNV LIVEDIIDTG KTMQTLLSLV RQYNPKMVKV ASLLVKRTPR SVGYKPDFVG FEIPDKFVVG YALDYNEYFR DLNHVCVISE TGKAKYKA