Details for: AGFG2

Gene ID: 3268

Symbol: AGFG2

Ensembl ID: ENSG00000106351

Description: ArfGAP with FG repeats 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 63.5828
    Cell Significance Index: -9.8900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 45.6547
    Cell Significance Index: -11.5800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 26.0426
    Cell Significance Index: -10.5800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 9.3596
    Cell Significance Index: -11.5400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.2644
    Cell Significance Index: -8.7500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.2395
    Cell Significance Index: -9.9500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.0017
    Cell Significance Index: -11.8500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.1918
    Cell Significance Index: 102.1900
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 1.7655
    Cell Significance Index: 36.8200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.7041
    Cell Significance Index: 338.1800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1686
    Cell Significance Index: 1055.1700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8599
    Cell Significance Index: 93.5300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7928
    Cell Significance Index: 128.9400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.6742
    Cell Significance Index: 78.5800
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: 0.5816
    Cell Significance Index: 5.8200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.5690
    Cell Significance Index: 25.1700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.4836
    Cell Significance Index: 18.3100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.4636
    Cell Significance Index: 7.8100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4590
    Cell Significance Index: 31.7500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4470
    Cell Significance Index: 89.6600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4302
    Cell Significance Index: 5.8700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3779
    Cell Significance Index: 17.1300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.3129
    Cell Significance Index: 21.0400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3104
    Cell Significance Index: 30.7100
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.3039
    Cell Significance Index: 4.2500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2862
    Cell Significance Index: 8.2500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2816
    Cell Significance Index: 6.1000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2772
    Cell Significance Index: 14.4000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2568
    Cell Significance Index: 6.8800
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.2350
    Cell Significance Index: 0.8900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2174
    Cell Significance Index: 41.3800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1862
    Cell Significance Index: 33.5800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1725
    Cell Significance Index: 4.8200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1412
    Cell Significance Index: 50.6500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1098
    Cell Significance Index: 75.9700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0970
    Cell Significance Index: 7.4500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0961
    Cell Significance Index: 1.4400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0764
    Cell Significance Index: 9.3900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0427
    Cell Significance Index: 1.5000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0420
    Cell Significance Index: 26.6800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0395
    Cell Significance Index: 1.2700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0383
    Cell Significance Index: 16.9300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0364
    Cell Significance Index: 1.0400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0323
    Cell Significance Index: 17.6400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0232
    Cell Significance Index: 35.7200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0216
    Cell Significance Index: 2.9600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0206
    Cell Significance Index: 0.5600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0153
    Cell Significance Index: 28.9000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0136
    Cell Significance Index: 0.2900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0136
    Cell Significance Index: 25.1100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0018
    Cell Significance Index: 0.8000
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0003
    Cell Significance Index: -0.4000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0080
    Cell Significance Index: -6.0600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0097
    Cell Significance Index: -7.1400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0105
    Cell Significance Index: -7.8100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0118
    Cell Significance Index: -1.7100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0124
    Cell Significance Index: -1.4200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0125
    Cell Significance Index: -0.6500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0125
    Cell Significance Index: -1.6000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0201
    Cell Significance Index: -11.3500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0221
    Cell Significance Index: -13.8200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0271
    Cell Significance Index: -0.2500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0320
    Cell Significance Index: -3.7800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0345
    Cell Significance Index: -9.9300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0348
    Cell Significance Index: -4.5000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0358
    Cell Significance Index: -6.1200
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.0431
    Cell Significance Index: -0.4100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0551
    Cell Significance Index: -1.4500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0586
    Cell Significance Index: -5.9900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0642
    Cell Significance Index: -1.0300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0643
    Cell Significance Index: -13.5500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0649
    Cell Significance Index: -3.4100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0791
    Cell Significance Index: -4.4400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0833
    Cell Significance Index: -1.2300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0939
    Cell Significance Index: -1.5800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0969
    Cell Significance Index: -10.0900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1012
    Cell Significance Index: -1.7500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1046
    Cell Significance Index: -7.4000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1102
    Cell Significance Index: -5.1800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1103
    Cell Significance Index: -6.9500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1132
    Cell Significance Index: -8.4400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1144
    Cell Significance Index: -3.3600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1307
    Cell Significance Index: -10.3500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1585
    Cell Significance Index: -9.7400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1590
    Cell Significance Index: -10.2600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1603
    Cell Significance Index: -9.8300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1692
    Cell Significance Index: -3.9100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1812
    Cell Significance Index: -4.5300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1832
    Cell Significance Index: -3.1400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2025
    Cell Significance Index: -2.9000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2037
    Cell Significance Index: -4.4600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2171
    Cell Significance Index: -10.9700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2292
    Cell Significance Index: -7.3000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2452
    Cell Significance Index: -9.0000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2468
    Cell Significance Index: -8.0800
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.2512
    Cell Significance Index: -3.6000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2522
    Cell Significance Index: -5.3900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2529
    Cell Significance Index: -8.8600
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -0.2845
    Cell Significance Index: -2.8700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The AGFG2 gene exhibits a wide range of expression patterns, with significantly high levels detected in cells of the salivary gland, astrocytes in the cerebral cortex, and endothelial cells in various organs. This suggests that AGFG2 plays a critical role in maintaining tissue homeostasis and function in these cells. The protein encoded by this gene, AGFG2_HUMAN, contains both Arf-GAP domain and FG repeats, which are thought to be essential for its biological activity. The Arf-GAP domain is typically associated with GTPase activation, while the FG repeats may contribute to protein-protein interactions and regulation of signaling pathways. **Pathways and Functions:** The AGFG2 gene is implicated in several critical cellular processes, including GTPase activation, metal ion binding, and molecular function. The Arf-GAP domain of AGFG2_HUMAN is thought to play a key role in regulating the activity of GTPases, which are essential for various cellular signaling pathways. These pathways include those involved in cell migration, adhesion, and proliferation. The FG repeats in AGFG2_HUMAN may also contribute to protein-protein interactions, which could regulate the activity of downstream effectors and influence cellular behavior. Furthermore, AGFG2 has been shown to be involved in the regulation of metal ion binding, which is critical for maintaining cellular homeostasis. This function is particularly relevant in cells exposed to oxidative stress, such as endothelial cells. The molecular function of AGFG2 is thought to be mediated by its ability to interact with other proteins and regulate signaling pathways. **Clinical Significance:** Despite its widespread expression and potential biological functions, the clinical significance of AGFG2 remains poorly understood. However, alterations in AGFG2 expression have been observed in various diseases, including cancer, cardiovascular disease, and neurological disorders. For example, studies have shown that AGFG2 is overexpressed in certain types of cancer, suggesting a potential role in tumor progression and metastasis. Moreover, AGFG2 has been implicated in the regulation of immune cell function, with some studies suggesting that it may play a role in the development of autoimmune diseases. Further research is necessary to elucidate the precise mechanisms by which AGFG2 influences disease pathogenesis and to explore its potential as a therapeutic target. In conclusion, AGFG2 is a gene with multifaceted functions in various tissues, and its precise role in maintaining tissue homeostasis and regulating cellular processes remains poorly understood. Further research is necessary to elucidate the clinical significance of AGFG2 and to explore its potential as a therapeutic target in various diseases.

Genular Protein ID: 492651221

Symbol: AGFG2_HUMAN

Name: Arf-GAP domain and FG repeat-containing protein 2

UniProtKB Accession Codes:

O95081 O75429 Q96AB9 Q96GL4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 NIAGADS 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9303539

Title: Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module.

PubMed ID: 9303539

DOI: 10.1101/gad.11.17.2239

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9799793

Title: Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes.

PubMed ID: 9799793

DOI: 10.1101/gr.8.10.1060

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 481
  • Mass: 48963
  • Checksum: A89202A0F0924FE2
  • Sequence:
    • MVMAAKKGPG PGGGVSGGKA EAEAASEVWC RRVRELGGCS QAGNRHCFEC AQRGVTYVDI 
TVGSFVCTTC SGLLRGLNPP HRVKSISMTT FTEPEVVFLQ SRGNEVCRKI WLGLFDARTS 
LVPDSRDPQK VKEFLQEKYE KKRWYVPPDQ VKGPTYTKGS ASTPVQGSIP EGKPLRTLLG 
DPAPSLSVAA STSSQPVSQS HARTSQARST QPPPHSSVKK ASTDLLADIG GDPFAAPQMA 
PAFAAFPAFG GQTPSQGGFA NFDAFSSGPS SSVFGSLPPA GQASFQAQPT PAGSSQGTPF 
GATPLAPASQ PNSLADVGSF LGPGVPAAGV PSSLFGMAGQ VPPLQSVTMG GGGGSSTGLA 
FGAFTNPFTA PAAQSPLPST NPFQPNGLAP GPGFGMSSAG PGFPQAVPPT GAFASSFPAP 
LFPPQTPLVQ QQNGSSFGDL GSAKLGQRPL SQPAGISTNP FMTGPSSSPF ASKPPTTNPF 
L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.