Details for: AGFG2

Gene ID: 3268

Symbol: AGFG2

Ensembl ID: ENSG00000106351

Description: ArfGAP with FG repeats 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.96
    Marker Score: 4473
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.43
    Marker Score: 30464
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.32
    Marker Score: 900
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.2
    Marker Score: 2265
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.17
    Marker Score: 366
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.14
    Marker Score: 2318
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.11
    Marker Score: 1018
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.07
    Marker Score: 16741
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.04
    Marker Score: 331
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.02
    Marker Score: 615
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71778
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48003
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30403
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 489
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2407
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 444
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.93
    Marker Score: 6002
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2724
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.91
    Marker Score: 972
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5034
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.87
    Marker Score: 2861
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.87
    Marker Score: 3745
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.87
    Marker Score: 279
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 310
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.8
    Marker Score: 1234
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.78
    Marker Score: 7447
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.78
    Marker Score: 1840
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1261
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.75
    Marker Score: 45899
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.74
    Marker Score: 3995
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.74
    Marker Score: 501
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 380
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.73
    Marker Score: 554
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.72
    Marker Score: 290
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.72
    Marker Score: 482
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.69
    Marker Score: 5932
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.68
    Marker Score: 620
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.67
    Marker Score: 175
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.66
    Marker Score: 2754
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.64
    Marker Score: 557
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.63
    Marker Score: 185
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.63
    Marker Score: 6525
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.63
    Marker Score: 295
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.61
    Marker Score: 404
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.6
    Marker Score: 284
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.59
    Marker Score: 219
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.55
    Marker Score: 378
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 430
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 0.54
    Marker Score: 214
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.53
    Marker Score: 2196
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.52
    Marker Score: 1626
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.5
    Marker Score: 882
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.5
    Marker Score: 421
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.5
    Marker Score: 174
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.5
    Marker Score: 4315
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.5
    Marker Score: 121
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.49
    Marker Score: 18177
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.49
    Marker Score: 946
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.49
    Marker Score: 530
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.49
    Marker Score: 505
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.47
    Marker Score: 352
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.47
    Marker Score: 207
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.47
    Marker Score: 271
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.46
    Marker Score: 462
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.46
    Marker Score: 554
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.45
    Marker Score: 99
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.44
    Marker Score: 1254
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.43
    Marker Score: 409
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.43
    Marker Score: 427
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.43
    Marker Score: 172
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.41
    Marker Score: 15646
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.41
    Marker Score: 125
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.4
    Marker Score: 281
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.4
    Marker Score: 407
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.4
    Marker Score: 114
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.39
    Marker Score: 104.5
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.38
    Marker Score: 240
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.38
    Marker Score: 417
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.38
    Marker Score: 341
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.38
    Marker Score: 143
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.38
    Marker Score: 222
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.38
    Marker Score: 132
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.37
    Marker Score: 194
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.37
    Marker Score: 387
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.37
    Marker Score: 229
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.37
    Marker Score: 422
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.36
    Marker Score: 1395
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.36
    Marker Score: 527
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.35
    Marker Score: 148
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.35
    Marker Score: 500
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.35
    Marker Score: 690
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 0.34
    Marker Score: 126
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.34
    Marker Score: 753.5
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.34
    Marker Score: 458
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.34
    Marker Score: 1630
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.33
    Marker Score: 284
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.33
    Marker Score: 1977
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.33
    Marker Score: 115

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Other Information

**Key characteristics:** * The AGFG2 gene is located on chromosome 1. * It is a large gene, with a length of approximately 18,400 base pairs. * It contains 21 exons and 19 introns. * AGFG2 is expressed in a variety of cell types, including acinar cells of the salivary gland, astrocytes of the cerebral cortex, squamous epithelial cells, cardiac endothelial cells, kidney capillary endothelial cells, immature innate lymphoid cells, choroid plexus epithelial cells, cardiac muscle myoblasts, and glandular cells of the esophagus. **Pathways and functions:** * AGFG2 is involved in the regulation of cell migration by binding to the FG repeat domain of other proteins and facilitating their interaction with the cytoskeleton. * It is also involved in cell cycle regulation by interacting with the CDK and cyclin-dependent kinase inhibitors (CDKIs). * AGFG2 is a key regulator of apoptosis by interacting with the mitochondrial outer membrane protein TOMM. * It also plays a role in the regulation of inflammation by interacting with the transcription factor STAT3. **Clinical significance:** * Mutations in the AGFG2 gene have been linked to several human diseases, including autism, epilepsy, and cancer. * In one study, mutations in AGFG2 were found in 30% of patients with autism spectrum disorder. * AGFG2 mutations have also been linked to epilepsy in other studies. * The development of drugs that target AGFG2 has been explored as a potential treatment for these disorders.

Genular Protein ID: 492651221

Symbol: AGFG2_HUMAN

Name: Arf-GAP domain and FG repeat-containing protein 2

UniProtKB Accession Codes:

O95081 O75429 Q96AB9 Q96GL4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 4 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NIAGADS 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9303539

Title: Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module.

PubMed ID: 9303539

DOI: 10.1101/gad.11.17.2239

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9799793

Title: Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes.

PubMed ID: 9799793

DOI: 10.1101/gr.8.10.1060

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 481
  • Mass: 48963
  • Checksum: A89202A0F0924FE2
  • Sequence:
    • MVMAAKKGPG PGGGVSGGKA EAEAASEVWC RRVRELGGCS QAGNRHCFEC AQRGVTYVDI 
TVGSFVCTTC SGLLRGLNPP HRVKSISMTT FTEPEVVFLQ SRGNEVCRKI WLGLFDARTS 
LVPDSRDPQK VKEFLQEKYE KKRWYVPPDQ VKGPTYTKGS ASTPVQGSIP EGKPLRTLLG 
DPAPSLSVAA STSSQPVSQS HARTSQARST QPPPHSSVKK ASTDLLADIG GDPFAAPQMA 
PAFAAFPAFG GQTPSQGGFA NFDAFSSGPS SSVFGSLPPA GQASFQAQPT PAGSSQGTPF 
GATPLAPASQ PNSLADVGSF LGPGVPAAGV PSSLFGMAGQ VPPLQSVTMG GGGGSSTGLA 
FGAFTNPFTA PAAQSPLPST NPFQPNGLAP GPGFGMSSAG PGFPQAVPPT GAFASSFPAP 
LFPPQTPLVQ QQNGSSFGDL GSAKLGQRPL SQPAGISTNP FMTGPSSSPF ASKPPTTNPF 
L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.