Details for: DNAJB2

Gene ID: 3300

Symbol: DNAJB2

Ensembl ID: ENSG00000135924

Description: DnaJ heat shock protein family (Hsp40) member B2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.15
    Marker Score: 2595.5
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.97
    Marker Score: 4722
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.88
    Marker Score: 3818
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.88
    Marker Score: 1502
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.86
    Marker Score: 1753
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.6
    Marker Score: 5496
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.42
    Marker Score: 12216
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.42
    Marker Score: 53801
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.42
    Marker Score: 5474
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.33
    Marker Score: 889
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.23
    Marker Score: 5080
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.2
    Marker Score: 449
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.2
    Marker Score: 2542.5
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.19
    Marker Score: 1339
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.19
    Marker Score: 4401
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.18
    Marker Score: 2697
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.18
    Marker Score: 72288
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.17
    Marker Score: 12075
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.15
    Marker Score: 8848
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.15
    Marker Score: 17251
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.15
    Marker Score: 10952
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.15
    Marker Score: 42356
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.11
    Marker Score: 22032
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 1.1
    Marker Score: 349
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.09
    Marker Score: 3123
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.09
    Marker Score: 1806
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.08
    Marker Score: 2713
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.07
    Marker Score: 22857
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.07
    Marker Score: 9297
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.05
    Marker Score: 1547
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.05
    Marker Score: 690
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.05
    Marker Score: 236
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.03
    Marker Score: 8894
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.02
    Marker Score: 1573
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.01
    Marker Score: 7908
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.01
    Marker Score: 1049
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71664
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47888
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.98
    Marker Score: 330
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30386
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.98
    Marker Score: 310
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.97
    Marker Score: 290
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.97
    Marker Score: 1724
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2390
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.94
    Marker Score: 14711
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.93
    Marker Score: 1320
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.93
    Marker Score: 2489
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 474
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.92
    Marker Score: 533
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.91
    Marker Score: 927
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 429
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.91
    Marker Score: 209
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2713
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.9
    Marker Score: 8469
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.88
    Marker Score: 3444
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.87
    Marker Score: 204
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.86
    Marker Score: 3334
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.86
    Marker Score: 5217
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.86
    Marker Score: 911
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.85
    Marker Score: 468
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 305
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.83
    Marker Score: 4752
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.83
    Marker Score: 1396
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.83
    Marker Score: 295
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.83
    Marker Score: 2942
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.83
    Marker Score: 408
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.82
    Marker Score: 1142
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.82
    Marker Score: 709
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.82
    Marker Score: 1551
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.81
    Marker Score: 284
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.81
    Marker Score: 196
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.8
    Marker Score: 683
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.8
    Marker Score: 5105
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.8
    Marker Score: 204
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.8
    Marker Score: 533
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.79
    Marker Score: 409
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.78
    Marker Score: 4654
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.78
    Marker Score: 534
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1262
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 586
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.77
    Marker Score: 321
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.77
    Marker Score: 26041
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.76
    Marker Score: 306
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.76
    Marker Score: 362
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.76
    Marker Score: 7624
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.76
    Marker Score: 1239.5
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.75
    Marker Score: 685
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.75
    Marker Score: 257
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.74
    Marker Score: 302
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.74
    Marker Score: 779
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.74
    Marker Score: 213
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.73
    Marker Score: 2817
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.73
    Marker Score: 1655
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.73
    Marker Score: 174
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.73
    Marker Score: 375
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.73
    Marker Score: 234
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.73
    Marker Score: 1154
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.72
    Marker Score: 3018
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.72
    Marker Score: 1154
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 371

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Other Information

**Key characteristics:** * DNJB2 is a chaperone protein that can bind to misfolded or damaged proteins and prevent them from aggregation. * It is a key regulator of cell growth and proliferation by interacting with the Erad pathway, which is involved in cell cycle regulation. * DNJB2 also regulates protein folding and proteasomal ubiquitin-dependent protein catabolic process. **Pathways and functions:** * **Atpase activator activity:** DNJB2 is involved in the regulation of atpase activity, which is a key enzyme involved in lipid metabolism. * **Erad pathway:** DNJB2 is a key regulator of the Erad pathway, a signaling pathway that is involved in cell cycle regulation and apoptosis. * **Hsp70 protein binding:** DNJB2 can bind to the Hsp70 protein, which is a chaperone protein that helps to fold and refold proteins. * **Negative regulation of cell growth and proliferation:** DNJB2 binds to the E2F1 transcription factor, which is a key regulator of cell growth and proliferation. By binding to E2F1, DNJB2 inhibits its activity and prevents the expression of pro-proliferative genes. * **Negative regulation of cell population proliferation:** DNJB2 also binds to the p53 tumor suppressor protein, which is a key regulator of cell cycle regulation. By binding to p53, DNJB2 inhibits its activity and prevents the cell from entering mitosis. **Clinical significance:** DNJB2 mutations have been linked to a number of neurological disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. These mutations can lead to the accumulation of misfolded or damaged proteins, which can disrupt cellular function and contribute to the development of neurodegenerative diseases. Thus, DNJB2 is a promising target for the treatment of neurodegenerative diseases.

Genular Protein ID: 3258980752

Symbol: DNJB2_HUMAN

Name: N/A

UniProtKB Accession Codes:

P25686 A8K9P6 Q53QD7 Q8IUK1 Q8IUK2 Q96F52

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 34 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 4 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 2 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1599432

Title: Human homologues of the bacterial heat-shock protein DnaJ are preferentially expressed in neurons.

PubMed ID: 1599432

DOI: 10.1042/bj2840469

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7957263

Title: Regulation of 70-kDa heat-shock-protein ATPase activity and substrate binding by human DnaJ-like proteins, HSJ1a and HSJ1b.

PubMed ID: 7957263

DOI: 10.1111/j.1432-1033.1994.tb20030.x

PubMed ID: 12754272

Title: The chaperone environment at the cytoplasmic face of the endoplasmic reticulum can modulate rhodopsin processing and inclusion formation.

PubMed ID: 12754272

DOI: 10.1074/jbc.m212349200

PubMed ID: 15936278

Title: HSJ1 is a neuronal shuttling factor for the sorting of chaperone clients to the proteasome.

PubMed ID: 15936278

DOI: 10.1016/j.cub.2005.04.058

PubMed ID: 20889486

Title: Molecular chaperone-mediated rescue of mitophagy by a Parkin RING1 domain mutant.

PubMed ID: 20889486

DOI: 10.1093/hmg/ddq428

PubMed ID: 21719532

Title: The cytosolic chaperone Hsc70 promotes traffic to the cell surface of intracellular retained melanocortin-4 receptor mutants.

PubMed ID: 21719532

DOI: 10.1210/me.2011-1020

PubMed ID: 21625540

Title: Co-chaperone HSJ1a dually regulates the proteasomal degradation of ataxin-3.

PubMed ID: 21625540

DOI: 10.1371/journal.pone.0019763

PubMed ID: 22522442

Title: A rare recessive distal hereditary motor neuropathy with HSJ1 chaperone mutation.

PubMed ID: 22522442

DOI: 10.1002/ana.22684

PubMed ID: 22396390

Title: Suppression of protein aggregation by chaperone modification of high molecular weight complexes.

PubMed ID: 22396390

DOI: 10.1093/brain/aws022

PubMed ID: 24023695

Title: Molecular chaperone mediated late-stage neuroprotection in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis.

PubMed ID: 24023695

DOI: 10.1371/journal.pone.0073944

PubMed ID: 24627108

Title: Whole-exome sequencing in patients with inherited neuropathies: outcome and challenges.

PubMed ID: 24627108

DOI: 10.1007/s00415-014-7289-8

PubMed ID: 25274842

Title: HSJ1-related hereditary neuropathies: novel mutations and extended clinical spectrum.

PubMed ID: 25274842

DOI: 10.1212/wnl.0000000000000966

PubMed ID: 22219199

Title: The C-terminal helices of heat shock protein 70 are essential for J-domain binding and ATPase activation.

PubMed ID: 22219199

DOI: 10.1074/jbc.m111.294728

Sequence Information:

  • Length: 324
  • Mass: 35580
  • Checksum: 0154ED3E29F34B4A
  • Sequence:
    • MASYYEILDV PRSASADDIK KAYRRKALQW HPDKNPDNKE FAEKKFKEVA EAYEVLSDKH 
KREIYDRYGR EGLTGTGTGP SRAEAGSGGP GFTFTFRSPE EVFREFFGSG DPFAELFDDL 
GPFSELQNRG SRHSGPFFTF SSSFPGHSDF SSSSFSFSPG AGAFRSVSTS TTFVQGRRIT 
TRRIMENGQE RVEVEEDGQL KSVTINGVPD DLALGLELSR REQQPSVTSR SGGTQVQQTP 
ASCPLDSDLS EDEDLQLAMA YSLSEMEAAG KKPAGGREAQ HRRQGRPKAQ HQDPGLGGTQ 
EGARGEATKR SPSPEEKASR CLIL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.