Details for: DNAJB2

Gene ID: 3300

Symbol: DNAJB2

Ensembl ID: ENSG00000135924

Description: DnaJ heat shock protein family (Hsp40) member B2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 207.1423
    Cell Significance Index: -32.2200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 141.1430
    Cell Significance Index: -35.8000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 73.1378
    Cell Significance Index: -34.5300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 68.8357
    Cell Significance Index: -27.9700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 63.1239
    Cell Significance Index: -32.4700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 27.3651
    Cell Significance Index: -33.7400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.3725
    Cell Significance Index: -34.9300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.9674
    Cell Significance Index: -29.3800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.3004
    Cell Significance Index: -36.7000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 4.0374
    Cell Significance Index: 66.5300
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 2.4378
    Cell Significance Index: 18.7900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.9116
    Cell Significance Index: 132.2000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.7155
    Cell Significance Index: 90.0700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0513
    Cell Significance Index: 210.9000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.0466
    Cell Significance Index: 14.2800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8808
    Cell Significance Index: 143.2600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.8781
    Cell Significance Index: 40.9400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8472
    Cell Significance Index: 303.8900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.8033
    Cell Significance Index: 50.6300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.7584
    Cell Significance Index: 9.0400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7528
    Cell Significance Index: 45.2000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.6737
    Cell Significance Index: 86.3700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.6189
    Cell Significance Index: 29.0900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5888
    Cell Significance Index: 106.1500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5498
    Cell Significance Index: 28.5600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5375
    Cell Significance Index: 53.1800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5206
    Cell Significance Index: 14.1700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3879
    Cell Significance Index: 47.7000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3610
    Cell Significance Index: 10.4000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3511
    Cell Significance Index: 155.2300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3275
    Cell Significance Index: 14.8500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3189
    Cell Significance Index: 8.5500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3010
    Cell Significance Index: 41.3400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2518
    Cell Significance Index: 137.5100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2316
    Cell Significance Index: 17.2600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2209
    Cell Significance Index: 42.0400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2207
    Cell Significance Index: 13.5700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2108
    Cell Significance Index: 27.2400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1954
    Cell Significance Index: 38.7700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1662
    Cell Significance Index: 10.7300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1036
    Cell Significance Index: 12.2200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0585
    Cell Significance Index: 10.0000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0398
    Cell Significance Index: 1.4000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0025
    Cell Significance Index: 4.6300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0105
    Cell Significance Index: -7.9400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0111
    Cell Significance Index: -7.0600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0137
    Cell Significance Index: -25.2600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0143
    Cell Significance Index: -10.4900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0155
    Cell Significance Index: -1.0400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0180
    Cell Significance Index: -27.7800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0186
    Cell Significance Index: -25.3300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0359
    Cell Significance Index: -26.6200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0428
    Cell Significance Index: -19.4100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0461
    Cell Significance Index: -4.7100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0520
    Cell Significance Index: -3.9900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0583
    Cell Significance Index: -32.8900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0652
    Cell Significance Index: -40.7200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0768
    Cell Significance Index: -2.0500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0974
    Cell Significance Index: -1.6700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1032
    Cell Significance Index: -2.5800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1043
    Cell Significance Index: -12.1500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1056
    Cell Significance Index: -2.9500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1065
    Cell Significance Index: -30.6500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1446
    Cell Significance Index: -4.6300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1611
    Cell Significance Index: -23.4200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1634
    Cell Significance Index: -3.4800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1640
    Cell Significance Index: -4.7000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1680
    Cell Significance Index: -11.8800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1838
    Cell Significance Index: -38.7200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2038
    Cell Significance Index: -3.4100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2111
    Cell Significance Index: -24.1900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2251
    Cell Significance Index: -5.9200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2376
    Cell Significance Index: -6.7800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2510
    Cell Significance Index: -6.0200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2563
    Cell Significance Index: -2.3600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3047
    Cell Significance Index: -24.1300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3390
    Cell Significance Index: -11.7800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3457
    Cell Significance Index: -36.0000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3478
    Cell Significance Index: -7.5400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4108
    Cell Significance Index: -9.0000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.4157
    Cell Significance Index: -3.3900
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.4569
    Cell Significance Index: -1.0300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4689
    Cell Significance Index: -28.7500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5170
    Cell Significance Index: -26.9300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.5549
    Cell Significance Index: -13.5400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5696
    Cell Significance Index: -31.9700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.5795
    Cell Significance Index: -12.1300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.6208
    Cell Significance Index: -7.7000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.6754
    Cell Significance Index: -10.1200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6805
    Cell Significance Index: -30.1000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7211
    Cell Significance Index: -23.6100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.7223
    Cell Significance Index: -15.3300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7347
    Cell Significance Index: -21.6400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.7357
    Cell Significance Index: -14.7700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.7380
    Cell Significance Index: -27.0900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7388
    Cell Significance Index: -23.5300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.7537
    Cell Significance Index: -22.1400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.7821
    Cell Significance Index: -27.4000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.7888
    Cell Significance Index: -21.1000
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.8063
    Cell Significance Index: -11.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Molecular Chaperone Function:** DNAJB2 acts as a molecular chaperone, binding to unfolded or misfolded proteins and facilitating their proper folding. 2. **Hsp40 Family Member:** DNAJB2 is a member of the Hsp40 family of heat shock proteins, which are characterized by their ability to activate ATPase activity in other proteins. 3. **Cellular Localization:** DNAJB2 is primarily found in the cytosol and endoplasmic reticulum membrane, where it interacts with other proteins to regulate protein folding and ubiquitination. 4. **Regulation of Cellular Processes:** DNAJB2 regulates various cellular processes, including protein folding, ubiquitination, cell growth, and negative regulation of cell population proliferation. **Pathways and Functions:** 1. **Chaperone-Mediated Protein Folding:** DNAJB2 interacts with other proteins to facilitate proper protein folding, preventing protein aggregation and maintaining cellular homeostasis. 2. **Erad Pathway:** DNAJB2 is involved in the ER-associated degradation (ERAD) pathway, which regulates the ubiquitination and degradation of misfolded proteins. 3. **Protein Binding and Refolding:** DNAJB2 binds to unfolded or misfolded proteins, facilitating their proper refolding and preventing protein aggregation. 4. **Regulation of Ubiquitination:** DNAJB2 regulates the ubiquitination of proteins, which is essential for protein degradation and cellular homeostasis. 5. **Negative Regulation of Cell Growth:** DNAJB2 negatively regulates cell growth, which is essential for preventing cancer and other diseases. **Clinical Significance:** Dysregulation of DNAJB2 has been implicated in several neurodegenerative diseases, including: 1. **Amyotrophic Lateral Sclerosis (ALS):** Mutations in DNAJB2 have been associated with ALS, a progressive neurodegenerative disease characterized by motor neuron degeneration. 2. **Frontotemporal Dementia (FTD):** Dysregulation of DNAJB2 has also been linked to FTD, a group of neurodegenerative diseases characterized by progressive cognitive and behavioral decline. 3. **Neurodegenerative Diseases:** DNAJB2 dysregulation has been implicated in other neurodegenerative diseases, including Parkinson's disease, Huntington's disease, and Alzheimer's disease. In conclusion, DNAJB2 plays a critical role in maintaining cellular homeostasis and responding to unfolded proteins. Its dysregulation has been implicated in several neurodegenerative diseases, highlighting the importance of this molecular chaperone in preventing disease. Further research is needed to fully understand the mechanisms by which DNAJB2 regulates cellular processes and to develop novel therapeutic strategies for the treatment of neurodegenerative diseases.

Genular Protein ID: 3258980752

Symbol: DNJB2_HUMAN

Name: N/A

UniProtKB Accession Codes:

P25686 A8K9P6 Q53QD7 Q8IUK1 Q8IUK2 Q96F52

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 37 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1599432

Title: Human homologues of the bacterial heat-shock protein DnaJ are preferentially expressed in neurons.

PubMed ID: 1599432

DOI: 10.1042/bj2840469

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7957263

Title: Regulation of 70-kDa heat-shock-protein ATPase activity and substrate binding by human DnaJ-like proteins, HSJ1a and HSJ1b.

PubMed ID: 7957263

DOI: 10.1111/j.1432-1033.1994.tb20030.x

PubMed ID: 12754272

Title: The chaperone environment at the cytoplasmic face of the endoplasmic reticulum can modulate rhodopsin processing and inclusion formation.

PubMed ID: 12754272

DOI: 10.1074/jbc.m212349200

PubMed ID: 15936278

Title: HSJ1 is a neuronal shuttling factor for the sorting of chaperone clients to the proteasome.

PubMed ID: 15936278

DOI: 10.1016/j.cub.2005.04.058

PubMed ID: 20889486

Title: Molecular chaperone-mediated rescue of mitophagy by a Parkin RING1 domain mutant.

PubMed ID: 20889486

DOI: 10.1093/hmg/ddq428

PubMed ID: 21719532

Title: The cytosolic chaperone Hsc70 promotes traffic to the cell surface of intracellular retained melanocortin-4 receptor mutants.

PubMed ID: 21719532

DOI: 10.1210/me.2011-1020

PubMed ID: 21625540

Title: Co-chaperone HSJ1a dually regulates the proteasomal degradation of ataxin-3.

PubMed ID: 21625540

DOI: 10.1371/journal.pone.0019763

PubMed ID: 22522442

Title: A rare recessive distal hereditary motor neuropathy with HSJ1 chaperone mutation.

PubMed ID: 22522442

DOI: 10.1002/ana.22684

PubMed ID: 22396390

Title: Suppression of protein aggregation by chaperone modification of high molecular weight complexes.

PubMed ID: 22396390

DOI: 10.1093/brain/aws022

PubMed ID: 24023695

Title: Molecular chaperone mediated late-stage neuroprotection in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis.

PubMed ID: 24023695

DOI: 10.1371/journal.pone.0073944

PubMed ID: 24627108

Title: Whole-exome sequencing in patients with inherited neuropathies: outcome and challenges.

PubMed ID: 24627108

DOI: 10.1007/s00415-014-7289-8

PubMed ID: 25274842

Title: HSJ1-related hereditary neuropathies: novel mutations and extended clinical spectrum.

PubMed ID: 25274842

DOI: 10.1212/wnl.0000000000000966

PubMed ID: 22219199

Title: The C-terminal helices of heat shock protein 70 are essential for J-domain binding and ATPase activation.

PubMed ID: 22219199

DOI: 10.1074/jbc.m111.294728

Sequence Information:

  • Length: 324
  • Mass: 35580
  • Checksum: 0154ED3E29F34B4A
  • Sequence:
    • MASYYEILDV PRSASADDIK KAYRRKALQW HPDKNPDNKE FAEKKFKEVA EAYEVLSDKH 
KREIYDRYGR EGLTGTGTGP SRAEAGSGGP GFTFTFRSPE EVFREFFGSG DPFAELFDDL 
GPFSELQNRG SRHSGPFFTF SSSFPGHSDF SSSSFSFSPG AGAFRSVSTS TTFVQGRRIT 
TRRIMENGQE RVEVEEDGQL KSVTINGVPD DLALGLELSR REQQPSVTSR SGGTQVQQTP 
ASCPLDSDLS EDEDLQLAMA YSLSEMEAAG KKPAGGREAQ HRRQGRPKAQ HQDPGLGGTQ 
EGARGEATKR SPSPEEKASR CLIL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.