Details for: MRPL58

Gene ID: 3396

Symbol: MRPL58

Ensembl ID: ENSG00000167862

Description: mitochondrial ribosomal protein L58

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.83
    Marker Score: 1634
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 1.69
    Marker Score: 1762
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 1.57
    Marker Score: 954
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.44
    Marker Score: 974
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.4
    Marker Score: 409
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.3
    Marker Score: 5103.5
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.28
    Marker Score: 4947
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.23
    Marker Score: 923
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 1.21
    Marker Score: 811
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.2
    Marker Score: 1720
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.17
    Marker Score: 825
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.17
    Marker Score: 2462
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.15
    Marker Score: 787
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.12
    Marker Score: 1032
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.08
    Marker Score: 6910
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.08
    Marker Score: 1432
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 1.07
    Marker Score: 14259
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 1.06
    Marker Score: 484
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.02
    Marker Score: 1504
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.02
    Marker Score: 506
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71702
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47926
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30392
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.97
    Marker Score: 2295
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.96
    Marker Score: 8301
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2395
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 483
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.94
    Marker Score: 1008.5
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 438
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.92
    Marker Score: 771
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.92
    Marker Score: 667
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.91
    Marker Score: 2702
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5190
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.91
    Marker Score: 10554
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2698
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.9
    Marker Score: 501
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.88
    Marker Score: 883
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.88
    Marker Score: 2380
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.87
    Marker Score: 480
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.87
    Marker Score: 2130
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 311
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.86
    Marker Score: 5233
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.86
    Marker Score: 4218
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.86
    Marker Score: 908
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.86
    Marker Score: 1364
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.84
    Marker Score: 7333
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.83
    Marker Score: 1355
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.83
    Marker Score: 6449.5
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.81
    Marker Score: 2214.5
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.81
    Marker Score: 1412
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.81
    Marker Score: 846
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.8
    Marker Score: 322
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.79
    Marker Score: 1273
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.79
    Marker Score: 416
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.79
    Marker Score: 195
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.78
    Marker Score: 1639
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.78
    Marker Score: 1292
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.77
    Marker Score: 2845
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.77
    Marker Score: 3143.5
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 583.5
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.76
    Marker Score: 786
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.76
    Marker Score: 1721
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.75
    Marker Score: 415.5
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.75
    Marker Score: 292.5
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.75
    Marker Score: 766.5
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.75
    Marker Score: 940
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.75
    Marker Score: 5577
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.74
    Marker Score: 394
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.74
    Marker Score: 491
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.73
    Marker Score: 25388
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.73
    Marker Score: 1389
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.73
    Marker Score: 352
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 377
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.73
    Marker Score: 3491
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.73
    Marker Score: 209
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.72
    Marker Score: 205
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.71
    Marker Score: 764
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.71
    Marker Score: 228.5
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.71
    Marker Score: 2516.5
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.71
    Marker Score: 512
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.7
    Marker Score: 785
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.7
    Marker Score: 641
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.7
    Marker Score: 654
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.69
    Marker Score: 983
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.69
    Marker Score: 441
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.69
    Marker Score: 431.5
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.69
    Marker Score: 161
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.69
    Marker Score: 206
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2877
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.68
    Marker Score: 1339
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.68
    Marker Score: 452
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.68
    Marker Score: 317
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.68
    Marker Score: 688
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.68
    Marker Score: 1686
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.68
    Marker Score: 718
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.67
    Marker Score: 4394
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.67
    Marker Score: 440
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.66
    Marker Score: 487
  • Cell Name: centroblast (CL0009112)
    Fold Change: 0.66
    Marker Score: 326

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Other Information

**Key characteristics:** * MRPL58 is a mitochondrial ribosomal protein that is found in the inner membrane of mitochondria. * It is a key component of the mitochondrial translation machinery, and is involved in the initiation, elongation, and termination of protein synthesis. * It is also involved in the rescue of stalled ribosomes. **Pathways and functions:** * MRPL58 is involved in the translation of mitochondrial mRNAs. * It is a key component of the mitochondrial translation initiation complex, and is required for the initiation of protein synthesis. * It is also involved in the mitochondrial translation elongation complex, and is required for the elongation of polypeptide chains. * MRPL58 is also involved in the mitochondrial translation termination complex, and is required for the termination of protein synthesis. * It is involved in the rescue of stalled ribosomes, and is a key regulator of protein synthesis in the mitochondria. **Clinical significance:** * Mutations in MRPL58 have been linked to a number of human diseases, including mitochondrial disorders and cancer. * These diseases are characterized by the accumulation of abnormal proteins in the mitochondria, which can lead to cell death. * MRPL58 is a promising target for the treatment of these diseases, as it is a common protein that is involved in the mitochondria.

Genular Protein ID: 2474507831

Symbol: ICT1_HUMAN

Name: Digestion substraction 1

UniProtKB Accession Codes:

Q14197 B2RAD1 Q53HM7 Q53Y11

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 5 ChiTaRS 1 ComplexPortal 1 DNASU 1 DisGeNET 1 EC 1 EMBL 6 EMDB 57 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 66 PDBsum 59 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 2 Rhea 4 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8575443

Title: Identification of mRNAs that show modulated expression during colon carcinoma cell differentiation.

PubMed ID: 8575443

DOI: 10.1111/j.1432-1033.1995.843_a.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20186120

Title: A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome.

PubMed ID: 20186120

DOI: 10.1038/emboj.2010.14

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23908630

Title: Identification and characterization of CHCHD1, AURKAIP1, and CRIF1 as new members of the mammalian mitochondrial ribosome.

PubMed ID: 23908630

DOI: 10.3389/fphys.2013.00183

PubMed ID: 24352605

Title: Codon-reading specificities of mitochondrial release factors and translation termination at non-standard stop codons.

PubMed ID: 24352605

DOI: 10.1038/ncomms3940

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27023846

Title: Structure and function of the mitochondrial ribosome.

PubMed ID: 27023846

DOI: 10.1146/annurev-biochem-060815-014343

PubMed ID: 35260756

Title: Mammalian HEMK1 methylates glutamine residue of the GGQ motif of mitochondrial release factors.

PubMed ID: 35260756

DOI: 10.1038/s41598-022-08061-y

PubMed ID: 37141370

Title: Molecular basis of translation termination at noncanonical stop codons in human mitochondria.

PubMed ID: 37141370

DOI: 10.1126/science.adf9890

PubMed ID: 25278503

Title: Structure of the large ribosomal subunit from human mitochondria.

PubMed ID: 25278503

DOI: 10.1126/science.1258026

PubMed ID: 25838379

Title: Ribosome. The structure of the human mitochondrial ribosome.

PubMed ID: 25838379

DOI: 10.1126/science.aaa1193

PubMed ID: 28892042

Title: Structures of the human mitochondrial ribosome in native states of assembly.

PubMed ID: 28892042

DOI: 10.1038/nsmb.3464

PubMed ID: 33878294

Title: Structural basis of translation termination, rescue, and recycling in mammalian mitochondria.

PubMed ID: 33878294

DOI: 10.1016/j.molcel.2021.03.042

Sequence Information:

  • Length: 206
  • Mass: 23630
  • Checksum: 663BF52443D41540
  • Sequence:
    • MAATRCLRWG LSRAGVWLLP PPARCPRRAL HKQKDGTEFK SIYSLDKLYP ESQGSDTAWR 
VPNGAKQADS DIPLDRLTIS YCRSSGPGGQ NVNKVNSKAE VRFHLATAEW IAEPVRQKIA 
ITHKNKINRL GELILTSESS RYQFRNLADC LQKIRDMITE ASQTPKEPTK EDVKLHRIRI 
ENMNRERLRQ KRIHSAVKTS RRVDMD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.