Details for: MRPL58

Gene ID: 3396

Symbol: MRPL58

Ensembl ID: ENSG00000167862

Description: mitochondrial ribosomal protein L58

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 51.2790
    Cell Significance Index: -24.2100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 46.5410
    Cell Significance Index: -23.9400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 36.1687
    Cell Significance Index: -24.2700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.5779
    Cell Significance Index: -20.3000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.8499
    Cell Significance Index: 111.0600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.8437
    Cell Significance Index: 29.5800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8509
    Cell Significance Index: 44.2000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.7998
    Cell Significance Index: 23.4900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.7959
    Cell Significance Index: 92.7500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.6423
    Cell Significance Index: 40.4900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6123
    Cell Significance Index: 42.3500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.5922
    Cell Significance Index: 8.0800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.5488
    Cell Significance Index: 4.6100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5254
    Cell Significance Index: 61.9600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4691
    Cell Significance Index: 33.1800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4548
    Cell Significance Index: 13.1100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4418
    Cell Significance Index: 20.6000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4200
    Cell Significance Index: 75.7200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4076
    Cell Significance Index: 222.6000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3863
    Cell Significance Index: 17.5100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3758
    Cell Significance Index: 166.1500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3551
    Cell Significance Index: 43.6600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.2809
    Cell Significance Index: 80.8200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2722
    Cell Significance Index: 37.3800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2330
    Cell Significance Index: 46.2300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1826
    Cell Significance Index: 18.0600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1719
    Cell Significance Index: 34.4800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1631
    Cell Significance Index: 10.5300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1511
    Cell Significance Index: 11.2700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.1235
    Cell Significance Index: 1.8500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1216
    Cell Significance Index: 1.1200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1086
    Cell Significance Index: 20.6700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1025
    Cell Significance Index: 2.7900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0902
    Cell Significance Index: 1.9200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0871
    Cell Significance Index: 11.2500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0810
    Cell Significance Index: 3.8100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0810
    Cell Significance Index: 2.1300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0646
    Cell Significance Index: 23.1600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0635
    Cell Significance Index: 8.1400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0435
    Cell Significance Index: 2.2000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0411
    Cell Significance Index: 28.4400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0105
    Cell Significance Index: 0.2800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0099
    Cell Significance Index: 7.5000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0094
    Cell Significance Index: 0.3300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0072
    Cell Significance Index: 6.4900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0023
    Cell Significance Index: 1.6900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0078
    Cell Significance Index: -14.6800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0112
    Cell Significance Index: -1.9100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0130
    Cell Significance Index: -24.0500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0152
    Cell Significance Index: -23.3300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0173
    Cell Significance Index: -1.7700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0184
    Cell Significance Index: -25.0500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0208
    Cell Significance Index: -0.3500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0238
    Cell Significance Index: -15.1400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0283
    Cell Significance Index: -20.9300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0374
    Cell Significance Index: -21.0900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0397
    Cell Significance Index: -4.5500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0409
    Cell Significance Index: -18.5800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0424
    Cell Significance Index: -26.4700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0693
    Cell Significance Index: -1.7700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0708
    Cell Significance Index: -2.4600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0810
    Cell Significance Index: -0.9200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0833
    Cell Significance Index: -6.4000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0878
    Cell Significance Index: -1.4700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0970
    Cell Significance Index: -14.1000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1265
    Cell Significance Index: -26.6500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1355
    Cell Significance Index: -5.5500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1887
    Cell Significance Index: -3.9500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1907
    Cell Significance Index: -10.0100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1928
    Cell Significance Index: -15.2700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2009
    Cell Significance Index: -12.3500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2041
    Cell Significance Index: -6.5400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2049
    Cell Significance Index: -4.7400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2064
    Cell Significance Index: -2.4600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2068
    Cell Significance Index: -11.6100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2207
    Cell Significance Index: -22.9800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3055
    Cell Significance Index: -18.7300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3165
    Cell Significance Index: -8.4700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3173
    Cell Significance Index: -3.2900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3623
    Cell Significance Index: -7.8500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3704
    Cell Significance Index: -3.0200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3846
    Cell Significance Index: -20.0400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.3974
    Cell Significance Index: -4.3200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4176
    Cell Significance Index: -18.4700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4510
    Cell Significance Index: -8.3400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4891
    Cell Significance Index: -14.0200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5010
    Cell Significance Index: -18.9700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.5043
    Cell Significance Index: -7.6000
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.5143
    Cell Significance Index: -7.3700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5258
    Cell Significance Index: -9.0100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5315
    Cell Significance Index: -15.6600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5386
    Cell Significance Index: -19.7700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5469
    Cell Significance Index: -19.1600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5481
    Cell Significance Index: -14.0900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6118
    Cell Significance Index: -20.0300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6135
    Cell Significance Index: -19.5400
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.6554
    Cell Significance Index: -7.4200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.6830
    Cell Significance Index: -17.0600
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.7003
    Cell Significance Index: -9.4500
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.7567
    Cell Significance Index: -9.7500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MRPL58 is a mitochondrial ribosomal protein that is significantly expressed in various cell types, including extravillous trophoblast, erythroid progenitor cell, myeloid dendritic cell, and neural progenitor cell. It is also encoded by a single gene, ENSG00000167862, which is highly conserved across species. MRPL58 is involved in the translation of proteins within the mitochondria, where it interacts with other mitochondrial ribosomal proteins to form the large ribosomal subunit. **Pathways and Functions:** MRPL58 is involved in several key pathways, including: 1. **Mitochondrial translation:** MRPL58 is a critical component of the mitochondrial large ribosomal subunit, which is responsible for the translation of proteins within the mitochondria. 2. **Mitochondrial translational termination:** MRPL58 is involved in the termination of protein synthesis within the mitochondria, where it interacts with the translation release factor. 3. **Mitochondrial translation elongation:** MRPL58 is also involved in the elongation of protein synthesis within the mitochondria, where it interacts with other mitochondrial ribosomal proteins. 4. **Rescue of stalled ribosome:** MRPL58 can rescue stalled ribosomes within the mitochondria, ensuring the proper termination of protein synthesis. **Clinical Significance:** Dysregulation of MRPL58 has been implicated in various diseases, including: 1. **Mitochondrial disorders:** Mutations in the ENSG00000167862 gene have been associated with mitochondrial disorders, such as MELAS syndrome and Kearns-Sayre syndrome. 2. **Cancer:** Overexpression of MRPL58 has been observed in certain types of cancer, including leukemia and lymphoma. 3. **Neurodegenerative diseases:** MRPL58 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 4. **Cardiovascular disease:** MRPL58 has also been implicated in cardiovascular disease, where it plays a role in the regulation of mitochondrial function in cardiac cells. In conclusion, MRPL58 is a critical component of mitochondrial translation and has significant implications in human health and disease. Further research is needed to fully understand the role of MRPL58 in various diseases and to develop therapeutic strategies to target this protein. **Protein: ICT1_HUMAN (Digestion substraction 1)** The protein ICT1_HUMAN is a digestive enzyme that plays a role in the breakdown of proteins. However, its relationship to MRPL58 is not well understood and requires further investigation. **Significantly expressed cells:** The significantly expressed cells listed in the article include: 1. Extravillous trophoblast 2. Erythroid progenitor cell 3. Myeloid dendritic cell 4. Proerythroblast 5. Tracheobronchial smooth muscle cell 6. Placental villous trophoblast 7. Neural progenitor cell 8. Primitive red blood cell 9. Skeletal muscle satellite cell 10. Oogonial cell These cells are involved in various physiological processes, including cell growth, differentiation, and survival, and may be influenced by the expression of MRPL58. **Pathways/Ontology:** The pathways and ontology listed in the article include: 1. Aminoacyl-trna hydrolase activity 2. Metabolism of proteins 3. Mitochondrial inner membrane 4. Mitochondrial large ribosomal subunit 5. Mitochondrial matrix 6. Mitochondrial translation 7. Mitochondrial translational termination 8. Mitochondrial translation elongation 9. Mitochondrial translation initiation 10. Mitochondrial translation termination 11. Mitochondrion 12. Nucleoplasm 13. Plasma membrane 14. Rescue of stalled ribosome 15. Translation 16. Translation release factor activity 17. Codon nonspecific These pathways and ontology are involved in various cellular processes, including protein synthesis, metabolism, and cell growth, and may be influenced by the expression of MRPL58.

Genular Protein ID: 2474507831

Symbol: ICT1_HUMAN

Name: Digestion substraction 1

UniProtKB Accession Codes:

Q14197 B2RAD1 Q53HM7 Q53Y11

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 5 ChiTaRS 1 ComplexPortal 1 DNASU 1 DisGeNET 1 EC 1 EMBL 6 EMDB 58 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 61 PDBsum 61 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 2 Rhea 4 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8575443

Title: Identification of mRNAs that show modulated expression during colon carcinoma cell differentiation.

PubMed ID: 8575443

DOI: 10.1111/j.1432-1033.1995.843_a.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20186120

Title: A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome.

PubMed ID: 20186120

DOI: 10.1038/emboj.2010.14

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23908630

Title: Identification and characterization of CHCHD1, AURKAIP1, and CRIF1 as new members of the mammalian mitochondrial ribosome.

PubMed ID: 23908630

DOI: 10.3389/fphys.2013.00183

PubMed ID: 24352605

Title: Codon-reading specificities of mitochondrial release factors and translation termination at non-standard stop codons.

PubMed ID: 24352605

DOI: 10.1038/ncomms3940

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27023846

Title: Structure and function of the mitochondrial ribosome.

PubMed ID: 27023846

DOI: 10.1146/annurev-biochem-060815-014343

PubMed ID: 35260756

Title: Mammalian HEMK1 methylates glutamine residue of the GGQ motif of mitochondrial release factors.

PubMed ID: 35260756

DOI: 10.1038/s41598-022-08061-y

PubMed ID: 37141370

Title: Molecular basis of translation termination at noncanonical stop codons in human mitochondria.

PubMed ID: 37141370

DOI: 10.1126/science.adf9890

PubMed ID: 25278503

Title: Structure of the large ribosomal subunit from human mitochondria.

PubMed ID: 25278503

DOI: 10.1126/science.1258026

PubMed ID: 25838379

Title: Ribosome. The structure of the human mitochondrial ribosome.

PubMed ID: 25838379

DOI: 10.1126/science.aaa1193

PubMed ID: 28892042

Title: Structures of the human mitochondrial ribosome in native states of assembly.

PubMed ID: 28892042

DOI: 10.1038/nsmb.3464

PubMed ID: 33878294

Title: Structural basis of translation termination, rescue, and recycling in mammalian mitochondria.

PubMed ID: 33878294

DOI: 10.1016/j.molcel.2021.03.042

PubMed ID: 35177605

Title: A late-stage assembly checkpoint of the human mitochondrial ribosome large subunit.

PubMed ID: 35177605

DOI: 10.1038/s41467-022-28503-5

Sequence Information:

  • Length: 206
  • Mass: 23630
  • Checksum: 663BF52443D41540
  • Sequence:
    • MAATRCLRWG LSRAGVWLLP PPARCPRRAL HKQKDGTEFK SIYSLDKLYP ESQGSDTAWR 
VPNGAKQADS DIPLDRLTIS YCRSSGPGGQ NVNKVNSKAE VRFHLATAEW IAEPVRQKIA 
ITHKNKINRL GELILTSESS RYQFRNLADC LQKIRDMITE ASQTPKEPTK EDVKLHRIRI 
ENMNRERLRQ KRIHSAVKTS RRVDMD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.