Details for: IGF1R

Gene ID: 3480

Symbol: IGF1R

Ensembl ID: ENSG00000140443

Description: insulin like growth factor 1 receptor

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 7.79
    Marker Score: 138369
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 5.31
    Marker Score: 3994
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 4.73
    Marker Score: 15850
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 4.09
    Marker Score: 3625
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 4.05
    Marker Score: 21255
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 4.02
    Marker Score: 135721
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 4.01
    Marker Score: 3297
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 4
    Marker Score: 5385
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 3.88
    Marker Score: 4694
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 3.84
    Marker Score: 5397
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 3.7
    Marker Score: 4189
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 3.65
    Marker Score: 19605
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 3.61
    Marker Score: 7922.5
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 3.5
    Marker Score: 14662
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 3.39
    Marker Score: 1630
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 3.36
    Marker Score: 75036
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 3.34
    Marker Score: 4155
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 3.29
    Marker Score: 6323
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 3.28
    Marker Score: 1082
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 3.17
    Marker Score: 2198
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 3.1
    Marker Score: 1739
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 3.1
    Marker Score: 1634
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 3.09
    Marker Score: 1803
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 3.01
    Marker Score: 1676
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.95
    Marker Score: 1761
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 2.95
    Marker Score: 1713
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 2.94
    Marker Score: 2544
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 2.92
    Marker Score: 2250
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.88
    Marker Score: 909
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 2.87
    Marker Score: 6606.5
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.86
    Marker Score: 836
  • Cell Name: granule cell (CL0000120)
    Fold Change: 2.86
    Marker Score: 21559
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.84
    Marker Score: 60537
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.58
    Marker Score: 1511
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 2.53
    Marker Score: 8991.5
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.5
    Marker Score: 19179
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.49
    Marker Score: 94677
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 2.49
    Marker Score: 1287
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 2.48
    Marker Score: 786
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.47
    Marker Score: 49137
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 2.46
    Marker Score: 710
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.45
    Marker Score: 1026
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 2.42
    Marker Score: 5805
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 2.4
    Marker Score: 1582
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.37
    Marker Score: 35481
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.37
    Marker Score: 10942
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.36
    Marker Score: 8396
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.31
    Marker Score: 85322
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 2.3
    Marker Score: 834.5
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.27
    Marker Score: 9416
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.25
    Marker Score: 2487
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.22
    Marker Score: 852
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.14
    Marker Score: 8275
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 2.14
    Marker Score: 8911.5
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.13
    Marker Score: 19994
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.1
    Marker Score: 2419
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.07
    Marker Score: 1974
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.05
    Marker Score: 125951
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 2.04
    Marker Score: 1105
  • Cell Name: podocyte (CL0000653)
    Fold Change: 2.02
    Marker Score: 748
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 2.02
    Marker Score: 996
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.99
    Marker Score: 2142
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.9
    Marker Score: 18093
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.9
    Marker Score: 19591
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.89
    Marker Score: 1243
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.85
    Marker Score: 15849
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.84
    Marker Score: 1299
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.84
    Marker Score: 1867
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.83
    Marker Score: 501
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.82
    Marker Score: 4474
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.81
    Marker Score: 1941
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.78
    Marker Score: 557
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.75
    Marker Score: 28115
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.75
    Marker Score: 2181
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.74
    Marker Score: 4094
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.73
    Marker Score: 7031
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.72
    Marker Score: 2883
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.7
    Marker Score: 2962
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.68
    Marker Score: 4797
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.67
    Marker Score: 426
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.67
    Marker Score: 4466
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.66
    Marker Score: 2052
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.66
    Marker Score: 1746
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.63
    Marker Score: 5620
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.62
    Marker Score: 2359
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.62
    Marker Score: 419
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.6
    Marker Score: 2474
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.56
    Marker Score: 738
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.51
    Marker Score: 1826
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.48
    Marker Score: 1284
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.46
    Marker Score: 498
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 166992
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.43
    Marker Score: 12448.5
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.42
    Marker Score: 2012
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.41
    Marker Score: 48902
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.41
    Marker Score: 2493
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.41
    Marker Score: 453
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.38
    Marker Score: 1779
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.36
    Marker Score: 21342
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.35
    Marker Score: 273

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Other Information

**Key characteristics:** * The IGF1R is a single-pass transmembrane protein with a molecular weight of approximately 125 kDa. * It is a member of the IGF1 receptor family of cell surface receptors. * The IGF1R is activated by the binding of IGF-1 to its receptor. * Activation of the IGF1R leads to the phosphorylation of its cytoplasmic domain by IGF-1 receptor-associated protein kinase (IGF-1R-AK). * Phosphorylation of the IGF1R by IGF-1R-AK leads to the dimerization of the IGF1R and its associated protein, leading to the activation of downstream signaling pathways. **Pathways and functions:** The IGF1R signaling pathway is involved in a variety of cellular processes, including: * Cell growth and differentiation * Proliferation * Survival * Migration * Differentiation * Tumor growth **Clinical significance:** The IGF1R gene is a tumor suppressor gene. Mutations in the IGF1R gene have been linked to the development of a number of human cancers, including breast cancer, lung cancer, and prostate cancer. **Additional information:** * The IGF1R is a key regulator of cell growth and metabolism. * It is also involved in inflammation and apoptosis. * The IGF1R pathway is a potential target for cancer therapy.

Genular Protein ID: 1449590405

Symbol: IGF1R_HUMAN

Name: Insulin-like growth factor 1 receptor

UniProtKB Accession Codes:

P08069 B1B5Y2 Q14CV2 Q9UCC0

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CORUM 1 CPTAC 2 CTD 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 29 DrugCentral 1 EC 2 EMBL 10 EMDB 7 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 77 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 16 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 57 PDBsum 44 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 5 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 4 RefSeq 2 Rhea 3 SAM 1 SASBDB 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2877871

Title: Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity.

PubMed ID: 2877871

DOI: 10.1002/j.1460-2075.1986.tb04528.x

PubMed ID: 1316909

Title: Insulin-like growth factor I receptor gene structure.

PubMed ID: 1316909

DOI: 10.1016/s0021-9258(19)50083-7

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1711844

Title: Analysis of the human type I insulin-like growth factor receptor promoter region.

PubMed ID: 1711844

DOI: 10.1016/0006-291x(91)90654-p

PubMed ID: 8257688

Title: Characterization of human placental insulin-like growth factor-I/insulin hybrid receptors by protein microsequencing and purification.

PubMed ID: 8257688

DOI: 10.1021/bi00212a019

PubMed ID: 8247543

Title: A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes.

PubMed ID: 8247543

PubMed ID: 1846292

Title: Interaction of the alpha beta dimers of the insulin-like growth factor I receptor is required for receptor autophosphorylation.

PubMed ID: 1846292

DOI: 10.1021/bi00215a008

PubMed ID: 8452530

Title: Purified hybrid insulin/insulin-like growth factor-I receptors bind insulin-like growth factor-I, but not insulin, with high affinity.

PubMed ID: 8452530

DOI: 10.1042/bj2900419

PubMed ID: 7679099

Title: Role of tyrosine kinase activity in signal transduction by the insulin-like growth factor-I (IGF-I) receptor. Characterization of kinase-deficient IGF-I receptors and the action of an IGF-I-mimetic antibody (alpha IR-3).

PubMed ID: 7679099

DOI: 10.1016/s0021-9258(18)53824-2

PubMed ID: 7541045

Title: Non-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor I receptor.

PubMed ID: 7541045

DOI: 10.1074/jbc.270.26.15639

PubMed ID: 9355755

Title: Insulin receptor/IGF-I receptor hybrids are widely distributed in mammalian tissues: quantification of individual receptor species by selective immunoprecipitation and immunoblotting.

PubMed ID: 9355755

DOI: 10.1042/bj3270209

PubMed ID: 9581554

Title: 14-3-3 proteins interact with the insulin-like growth factor receptor but not the insulin receptor.

PubMed ID: 9581554

DOI: 10.1042/bj3270765

PubMed ID: 9202395

Title: Distribution of insulin/insulin-like growth factor-I hybrid receptors in human tissues.

PubMed ID: 9202395

DOI: 10.1016/s0303-7207(97)04050-1

PubMed ID: 9727029

Title: Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor.

PubMed ID: 9727029

DOI: 10.1074/jbc.273.37.24095

PubMed ID: 9822622

Title: beta-arrestins regulate mitogenic signaling and clathrin-mediated endocytosis of the insulin-like growth factor I receptor.

PubMed ID: 9822622

DOI: 10.1074/jbc.273.48.31640

PubMed ID: 10579905

Title: The IGF-I receptor in cancer research.

PubMed ID: 10579905

DOI: 10.1006/excr.1999.4667

PubMed ID: 10454568

Title: Grb10, a positive, stimulatory signaling adapter in platelet-derived growth factor BB-, insulin-like growth factor I-, and insulin-mediated mitogenesis.

PubMed ID: 10454568

DOI: 10.1128/mcb.19.9.6217

PubMed ID: 11071852

Title: Suppressor of cytokine signaling (SOCS)-3 protein interacts with the insulin-like growth factor-I receptor.

PubMed ID: 11071852

DOI: 10.1006/bbrc.2000.3762

PubMed ID: 11162456

Title: Autophosphorylation of the insulin-like growth factor I receptor cytoplasmic domain.

PubMed ID: 11162456

DOI: 10.1006/bbrc.2000.4046

PubMed ID: 10747872

Title: Mechanism of STAT3 activation by insulin-like growth factor I receptor.

PubMed ID: 10747872

DOI: 10.1074/jbc.m000089200

PubMed ID: 12019176

Title: Expression of the type 1 insulin-like growth factor receptor is up-regulated in primary prostate cancer and commonly persists in metastatic disease.

PubMed ID: 12019176

PubMed ID: 12138094

Title: Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved.

PubMed ID: 12138094

DOI: 10.1074/jbc.m202766200

PubMed ID: 11884618

Title: RACK1, an insulin-like growth factor I (IGF-I) receptor-interacting protein, modulates IGF-I-dependent integrin signaling and promotes cell spreading and contact with extracellular matrix.

PubMed ID: 11884618

DOI: 10.1128/mcb.22.7.2345-2365.2002

PubMed ID: 12556535

Title: Type 1 insulin-like growth factor receptor (IGF-IR) signaling inhibits apoptosis signal-regulating kinase 1 (ASK1).

PubMed ID: 12556535

DOI: 10.1074/jbc.m211398200

PubMed ID: 12821780

Title: Mdm2-dependent ubiquitination and degradation of the insulin-like growth factor 1 receptor.

PubMed ID: 12821780

DOI: 10.1073/pnas.1431613100

PubMed ID: 14729630

Title: Cyclolignans as inhibitors of the insulin-like growth factor-1 receptor and malignant cell growth.

PubMed ID: 14729630

DOI: 10.1158/0008-5472.can-03-2522

PubMed ID: 15878855

Title: {beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase.

PubMed ID: 15878855

DOI: 10.1074/jbc.m501129200

PubMed ID: 15998644

Title: JAK/STAT3 pathway is involved in survival of neurons in response to insulin-like growth factor and negatively regulated by suppressor of cytokine signaling-3.

PubMed ID: 15998644

DOI: 10.1074/jbc.m501316200

PubMed ID: 16831875

Title: Hybrid receptors formed by insulin receptor (IR) and insulin-like growth factor I receptor (IGF-IR) have low insulin and high IGF-1 affinity irrespective of the IR splice variant.

PubMed ID: 16831875

DOI: 10.1074/jbc.m605189200

PubMed ID: 17524361

Title: The insulin-like growth factor 1 (IGF-1) receptor is a substrate for gamma-secretase-mediated intramembrane proteolysis.

PubMed ID: 17524361

DOI: 10.1016/j.bbrc.2007.05.062

PubMed ID: 17624760

Title: The insulin-like growth factor 1 receptor in cancer: old focus, new future.

PubMed ID: 17624760

DOI: 10.1016/j.ejca.2007.05.021

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19578119

Title: The direct binding of insulin-like growth factor-1 (IGF-1) to integrin alphavbeta3 is involved in IGF-1 signaling.

PubMed ID: 19578119

DOI: 10.1074/jbc.m109.013201

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20596523

Title: Development and validation of a method for profiling post-translational modification activities using protein microarrays.

PubMed ID: 20596523

DOI: 10.1371/journal.pone.0011332

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21994939

Title: Polyubiquitination of insulin-like growth factor I receptor (IGF-IR) activation loop promotes antibody-induced receptor internalization and down-regulation.

PubMed ID: 21994939

DOI: 10.1074/jbc.m111.288514

PubMed ID: 22351760

Title: Cross-talk between integrin alpha6beta4 and insulin-like growth factor-1 receptor (IGF1R) through direct alpha6beta4 binding to IGF1 and subsequent alpha6beta4-IGF1-IGF1R ternary complex formation in anchorage-independent conditions.

PubMed ID: 22351760

DOI: 10.1074/jbc.m111.304170

PubMed ID: 26692333

Title: Loss of the proteostasis factor AIRAPL causes myeloid transformation by deregulating IGF-1 signaling.

PubMed ID: 26692333

DOI: 10.1038/nm.4013

PubMed ID: 32494007

Title: IGF1R is an entry receptor for respiratory syncytial virus.

PubMed ID: 32494007

DOI: 10.1038/s41586-020-2369-7

PubMed ID: 9690478

Title: Crystal structure of the first three domains of the type-1 insulin-like growth factor receptor.

PubMed ID: 9690478

DOI: 10.1038/28668

PubMed ID: 11694888

Title: Structure and autoregulation of the insulin-like growth factor 1 receptor kinase.

PubMed ID: 11694888

DOI: 10.1038/nsb721

PubMed ID: 11591350

Title: Crystal structure of bisphosphorylated IGF-1 receptor kinase: insight into domain movements upon kinase activation.

PubMed ID: 11591350

DOI: 10.1016/s0969-2126(01)00655-4

PubMed ID: 12138114

Title: Crystal structure of the Apo, unactivated insulin-like growth factor-1 receptor kinase. Implication for inhibitor specificity.

PubMed ID: 12138114

DOI: 10.1074/jbc.m205580200

PubMed ID: 14501110

Title: Structure of apo, unactivated insulin-like growth factor-1 receptor kinase at 1.5 A resolution.

PubMed ID: 14501110

DOI: 10.1107/s0907444903015415

PubMed ID: 17317169

Title: Discovery and initial SAR of 3-(1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-ones as inhibitors of insulin-like growth factor 1-receptor (IGF-1R).

PubMed ID: 17317169

DOI: 10.1016/j.bmcl.2007.01.102

PubMed ID: 18501599

Title: Lead identification to generate isoquinolinedione inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment.

PubMed ID: 18501599

DOI: 10.1016/j.bmcl.2008.04.044

PubMed ID: 18566589

Title: Small-molecule inhibition and activation-loop trans-phosphorylation of the IGF1 receptor.

PubMed ID: 18566589

DOI: 10.1038/emboj.2008.116

PubMed ID: 19041240

Title: Lead identification to generate 3-cyanoquinoline inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment.

PubMed ID: 19041240

DOI: 10.1016/j.bmcl.2008.11.037

PubMed ID: 19778024

Title: Discovery of a 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitor (BMS-754807) of insulin-like growth factor receptor (IGF-1R) kinase in clinical development.

PubMed ID: 19778024

DOI: 10.1021/jm900786r

Title: Allosteric IGF-1R Inhibitors.

DOI: 10.1021/ml100044h

PubMed ID: 20675137

Title: Proline isosteres in a series of 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitors of IGF-1R kinase and IR kinase.

PubMed ID: 20675137

DOI: 10.1016/j.bmcl.2010.07.045

PubMed ID: 20545947

Title: Design of potent IGF1-R inhibitors related to bis-azaindoles.

PubMed ID: 20545947

DOI: 10.1111/j.1747-0285.2010.00991.x

PubMed ID: 21441024

Title: Discovery of the first non-ATP competitive IGF-1R kinase inhibitors: advantages in comparison with competitive inhibitors.

PubMed ID: 21441024

DOI: 10.1016/j.bmcl.2011.03.003

PubMed ID: 21414779

Title: Discovery of 2,4-bis-arylamino-1,3-pyrimidines as insulin-like growth factor-1 receptor (IGF-1R) inhibitors.

PubMed ID: 21414779

DOI: 10.1016/j.bmcl.2011.02.075

PubMed ID: 14657428

Title: IGF-I receptor mutations resulting in intrauterine and postnatal growth retardation.

PubMed ID: 14657428

DOI: 10.1056/nejmoa010107

PubMed ID: 15928254

Title: Mutation at cleavage site of insulin-like growth factor receptor in a short-stature child born with intrauterine growth retardation.

PubMed ID: 15928254

DOI: 10.1210/jc.2004-1947

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 25040157

Title: Three novel IGF1R mutations in microcephalic patients with prenatal and postnatal growth impairment.

PubMed ID: 25040157

DOI: 10.1111/cen.12555

Sequence Information:

  • Length: 1367
  • Mass: 154793
  • Checksum: AE8A735F87F745C8
  • Sequence:
    • MKSGSGGGSP TSLWGLLFLS AALSLWPTSG EICGPGIDIR NDYQQLKRLE NCTVIEGYLH 
ILLISKAEDY RSYRFPKLTV ITEYLLLFRV AGLESLGDLF PNLTVIRGWK LFYNYALVIF 
EMTNLKDIGL YNLRNITRGA IRIEKNADLC YLSTVDWSLI LDAVSNNYIV GNKPPKECGD 
LCPGTMEEKP MCEKTTINNE YNYRCWTTNR CQKMCPSTCG KRACTENNEC CHPECLGSCS 
APDNDTACVA CRHYYYAGVC VPACPPNTYR FEGWRCVDRD FCANILSAES SDSEGFVIHD 
GECMQECPSG FIRNGSQSMY CIPCEGPCPK VCEEEKKTKT IDSVTSAQML QGCTIFKGNL 
LINIRRGNNI ASELENFMGL IEVVTGYVKI RHSHALVSLS FLKNLRLILG EEQLEGNYSF 
YVLDNQNLQQ LWDWDHRNLT IKAGKMYFAF NPKLCVSEIY RMEEVTGTKG RQSKGDINTR 
NNGERASCES DVLHFTSTTT SKNRIIITWH RYRPPDYRDL ISFTVYYKEA PFKNVTEYDG 
QDACGSNSWN MVDVDLPPNK DVEPGILLHG LKPWTQYAVY VKAVTLTMVE NDHIRGAKSE 
ILYIRTNASV PSIPLDVLSA SNSSSQLIVK WNPPSLPNGN LSYYIVRWQR QPQDGYLYRH 
NYCSKDKIPI RKYADGTIDI EEVTENPKTE VCGGEKGPCC ACPKTEAEKQ AEKEEAEYRK 
VFENFLHNSI FVPRPERKRR DVMQVANTTM SSRSRNTTAA DTYNITDPEE LETEYPFFES 
RVDNKERTVI SNLRPFTLYR IDIHSCNHEA EKLGCSASNF VFARTMPAEG ADDIPGPVTW 
EPRPENSIFL KWPEPENPNG LILMYEIKYG SQVEDQRECV SRQEYRKYGG AKLNRLNPGN 
YTARIQATSL SGNGSWTDPV FFYVQAKTGY ENFIHLIIAL PVAVLLIVGG LVIMLYVFHR 
KRNNSRLGNG VLYASVNPEY FSAADVYVPD EWEVAREKIT MSRELGQGSF GMVYEGVAKG 
VVKDEPETRV AIKTVNEAAS MRERIEFLNE ASVMKEFNCH HVVRLLGVVS QGQPTLVIME 
LMTRGDLKSY LRSLRPEMEN NPVLAPPSLS KMIQMAGEIA DGMAYLNANK FVHRDLAARN 
CMVAEDFTVK IGDFGMTRDI YETDYYRKGG KGLLPVRWMS PESLKDGVFT TYSDVWSFGV 
VLWEIATLAE QPYQGLSNEQ VLRFVMEGGL LDKPDNCPDM LFELMRMCWQ YNPKMRPSFL 
EIISSIKEEM EPGFREVSFY YSEENKLPEP EELDLEPENM ESVPLDPSAS SSSLPLPDRH 
SGHKAENGPG PGVLVLRASF DERQPYAHMN GGRKNERALP LPQSSTC

Genular Protein ID: 3394930756

Symbol: C9J5X1_HUMAN

Name: N/A

UniProtKB Accession Codes:

C9J5X1

Database IDs:

ARBA 11 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChEBI 10 ChiTaRS 1 DNASU 1 EC 1 EMBL 4 EPD 2 Ensembl 2 ExpressionAtlas 1 GO 9 Gene3D 3 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 IntAct 1 InterPro 16 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 2 PRINTS 1 PROSITE 7 PROSITE-ProRule 1 Pfam 4 Proteomes 2 ProteomicsDB 1 RefSeq 1 Rhea 3 RuleBase 1 SAM 3 SMART 3 SMR 1 SUPFAM 4 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.M800588-MCP200

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

Sequence Information:

  • Length: 1366
  • Mass: 154791
  • Checksum: EFC88F7D7718D938
  • Sequence:
    • MKSGSGGGSP TSLWGLLFLS AALSLWPTSG EICGPGIDIR NDYQQLKRLE NCTVIEGYLH 
ILLISKAEDY RSYRFPKLTV ITEYLLLFRV AGLESLGDLF PNLTVIRGWK LFYNYALVIF 
EMTNLKDIGL YNLRNITRGA IRIEKNADLC YLSTVDWSLI LDAVSNNYIV GNKPPKECGD 
LCPGTMEEKP MCEKTTINNE YNYRCWTTNR CQKMCPSTCG KRACTENNEC CHPECLGSCS 
APDNDTACVA CRHYYYAGVC VPACPPNTYR FEGWRCVDRD FCANILSAES SDSEGFVIHD 
GECMQECPSG FIRNGSQSMY CIPCEGPCPK VCEEEKKTKT IDSVTSAQML QGCTIFKGNL 
LINIRRGNNI ASELENFMGL IEVVTGYVKI RHSHALVSLS FLKNLRLILG EEQLEGNYSF 
YVLDNQNLQQ LWDWDHRNLT IKAGKMYFAF NPKLCVSEIY RMEEVTGTKG RQSKGDINTR 
NNGERASCES DVLHFTSTTT SKNRIIITWH RYRPPDYRDL ISFTVYYKEA PFKNVTEYDG 
QDACGSNSWN MVDVDLPPNK DVEPGILLHG LKPWTQYAVY VKAVTLTMVE NDHIRGAKSE 
ILYIRTNASV PSIPLDVLSA SNSSSQLIVK WNPPSLPNGN LSYYIVRWQR QPQDGYLYRH 
NYCSKDKIPI RKYADGTIDI EEVTENPKTE VCGGEKGPCC ACPKTEAEKQ AEKEEAEYRK 
VFENFLHNSI FVPRPERKRR DVMQVANTTM SSRSRNTTAA DTYNITDPEE LETEYPFFES 
RVDNKERTVI SNLRPFTLYR IDIHSCNHEA EKLGCSASNF VFARTMPAEG ADDIPGPVTW 
EPRPENSIFL KWPEPENPNG LILMYEIKYG SQVEDQRECV SRQEYRKYGG AKLNRLNPGN 
YTARIQATSL SGNGSWTDPV FFYVQAKRYE NFIHLIIALP VAVLLIVGGL VIMLYVFHRK 
RNNSRLGNGV LYASVNPEYF SAADVYVPDE WEVAREKITM SRELGQGSFG MVYEGVAKGV 
VKDEPETRVA IKTVNEAASM RERIEFLNEA SVMKEFNCHH VVRLLGVVSQ GQPTLVIMEL 
MTRGDLKSYL RSLRPEMENN PVLAPPSLSK MIQMAGEIAD GMAYLNANKF VHRDLAARNC 
MVAEDFTVKI GDFGMTRDIY ETDYYRKGGK GLLPVRWMSP ESLKDGVFTT YSDVWSFGVV 
LWEIATLAEQ PYQGLSNEQV LRFVMEGGLL DKPDNCPDML FELMRMCWQY NPKMRPSFLE 
IISSIKEEME PGFREVSFYY SEENKLPEPE ELDLEPENME SVPLDPSASS SSLPLPDRHS 
GHKAENGPGP GVLVLRASFD ERQPYAHMNG GRKNERALPL PQSSTC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.