Details for: IGF1R

Gene ID: 3480

Symbol: IGF1R

Ensembl ID: ENSG00000140443

Description: insulin like growth factor 1 receptor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 608.6333
    Cell Significance Index: -94.6700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 378.0899
    Cell Significance Index: -95.9000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 202.5533
    Cell Significance Index: -95.6300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 182.3476
    Cell Significance Index: -74.0800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 142.6331
    Cell Significance Index: -95.7100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 77.8617
    Cell Significance Index: -96.0000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 77.6020
    Cell Significance Index: -74.0900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 34.6304
    Cell Significance Index: -92.7700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 27.1454
    Cell Significance Index: -59.4100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 24.5258
    Cell Significance Index: -96.7800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 9.9574
    Cell Significance Index: 558.7600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 4.9655
    Cell Significance Index: 138.7700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 4.6509
    Cell Significance Index: 356.9100
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 4.6200
    Cell Significance Index: 41.0100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 4.4235
    Cell Significance Index: 118.5300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 3.5637
    Cell Significance Index: 219.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 3.4239
    Cell Significance Index: 6446.8600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.7299
    Cell Significance Index: 547.6100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.4777
    Cell Significance Index: 888.7100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 2.4022
    Cell Significance Index: 57.6100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.0829
    Cell Significance Index: 216.8800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.0185
    Cell Significance Index: 27.5400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.9450
    Cell Significance Index: 86.0300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.8117
    Cell Significance Index: 68.6100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.6846
    Cell Significance Index: 42.1100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.6535
    Cell Significance Index: 35.3500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.6075
    Cell Significance Index: 1111.8100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.3501
    Cell Significance Index: 26.3500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.2308
    Cell Significance Index: 1894.8100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.1343
    Cell Significance Index: 2091.9800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.1013
    Cell Significance Index: 699.4200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9923
    Cell Significance Index: 122.0200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.9430
    Cell Significance Index: 63.4100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.9198
    Cell Significance Index: 417.4700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8714
    Cell Significance Index: 157.1000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8461
    Cell Significance Index: 92.0300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7911
    Cell Significance Index: 432.0600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7851
    Cell Significance Index: 155.8000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7533
    Cell Significance Index: 122.5100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.6341
    Cell Significance Index: 16.3000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5262
    Cell Significance Index: 100.1400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.4430
    Cell Significance Index: 6.5400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.3927
    Cell Significance Index: 6.7300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.3921
    Cell Significance Index: 533.1600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3754
    Cell Significance Index: 10.8200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.2584
    Cell Significance Index: 3.7100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2430
    Cell Significance Index: 107.4300
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 0.2333
    Cell Significance Index: 2.4300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1473
    Cell Significance Index: 10.1900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1146
    Cell Significance Index: 3.0600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0483
    Cell Significance Index: 6.6300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0397
    Cell Significance Index: 0.2400
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.0099
    Cell Significance Index: -0.1500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.0114
    Cell Significance Index: -0.0700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0183
    Cell Significance Index: -0.8600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0205
    Cell Significance Index: -2.9800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0420
    Cell Significance Index: -30.8300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0476
    Cell Significance Index: -8.1200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0668
    Cell Significance Index: -49.5100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0819
    Cell Significance Index: -51.1600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1110
    Cell Significance Index: -3.9000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1231
    Cell Significance Index: -69.4100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.1325
    Cell Significance Index: -100.3100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1454
    Cell Significance Index: -6.7800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1630
    Cell Significance Index: -20.8900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1654
    Cell Significance Index: -7.5000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1691
    Cell Significance Index: -4.8300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2805
    Cell Significance Index: -80.7100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3153
    Cell Significance Index: -66.4200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3419
    Cell Significance Index: -17.8100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.3874
    Cell Significance Index: -38.3200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3929
    Cell Significance Index: -20.4100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4445
    Cell Significance Index: -51.8000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4740
    Cell Significance Index: -10.3800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.5371
    Cell Significance Index: -69.3900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.5394
    Cell Significance Index: -55.1000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.5753
    Cell Significance Index: -42.8800
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.5938
    Cell Significance Index: -7.4100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.6734
    Cell Significance Index: -13.9700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.6773
    Cell Significance Index: -77.6000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.7800
    Cell Significance Index: -49.1600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.7969
    Cell Significance Index: -93.9800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.8161
    Cell Significance Index: -93.1600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.8385
    Cell Significance Index: -12.0600
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -1.0213
    Cell Significance Index: -12.8900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -1.0274
    Cell Significance Index: -72.6600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.0298
    Cell Significance Index: -81.5600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.0634
    Cell Significance Index: -34.0600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -1.0669
    Cell Significance Index: -29.0400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -1.1158
    Cell Significance Index: -7.5600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.1982
    Cell Significance Index: -73.4600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.2254
    Cell Significance Index: -64.3400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -1.2813
    Cell Significance Index: -82.6600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.3363
    Cell Significance Index: -43.7500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.3547
    Cell Significance Index: -29.3500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.3859
    Cell Significance Index: -44.1400
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: -1.5147
    Cell Significance Index: -9.3500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.5511
    Cell Significance Index: -33.0400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -1.6512
    Cell Significance Index: -32.6500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.7543
    Cell Significance Index: -46.1300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure:** IGF1R is a transmembrane receptor with an extracellular domain that binds IGF-1, a ligand that activates the receptor. 2. **Tyrosine Kinase Activity:** IGF1R is a protein tyrosine kinase that phosphorylates tyrosine residues on downstream substrates, initiating signaling cascades. 3. **Signaling Pathways:** IGF1R activates multiple signaling pathways, including the PI3K/AKT, MAPK, and JNK cascades, which regulate various cellular processes. 4. **Cellular Expression:** IGF1R is expressed in various tissues, including the adrenal gland, prostate, and brain, and is also found in immune cells and neurons. **Pathways and Functions:** 1. **Cell Growth and Survival:** IGF1R regulates cell growth and survival by activating the PI3K/AKT pathway, which promotes cell proliferation and inhibits apoptosis. 2. **Differentiation:** IGF1R is involved in regulating cellular differentiation, particularly in the development of the brain and prostate. 3. **Neuroprotection:** IGF1R has neuroprotective effects, and its dysregulation has been implicated in neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Cancer:** IGF1R is overexpressed in various types of cancer, including breast, prostate, and colon cancer, and its signaling pathways contribute to tumorigenesis and metastasis. 5. **Immune Response:** IGF1R is involved in regulating immune responses, particularly in the context of viral infections and autoimmune diseases. **Clinical Significance:** 1. **Cancer Therapy:** Targeting IGF1R has emerged as a promising strategy for cancer therapy, with several IGF1R inhibitors currently in clinical trials. 2. **Neurodegenerative Diseases:** IGF1R signaling pathways have been implicated in the pathogenesis of neurodegenerative diseases, and targeting these pathways may provide therapeutic benefits. 3. **Metabolic Disorders:** IGF1R is involved in regulating glucose and lipid metabolism, and its dysregulation has been implicated in metabolic disorders, such as insulin resistance and type 2 diabetes. 4. **Cardiovascular Disease:** IGF1R is also involved in regulating cardiovascular function, and its dysregulation has been implicated in cardiovascular disease. In conclusion, the Insulin-like Growth Factor 1 Receptor (IGF1R) is a critical regulator of various cellular processes, including cell growth, survival, differentiation, and development. Its dysregulation has been implicated in several diseases, including cancer, neurodegenerative disorders, and metabolic disorders. Targeting IGF1R signaling pathways holds promise for the development of novel therapeutic strategies for these diseases.

Genular Protein ID: 1449590405

Symbol: IGF1R_HUMAN

Name: Insulin-like growth factor 1 receptor

UniProtKB Accession Codes:

P08069 B1B5Y2 Q14CV2 Q9UCC0

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CORUM 1 CPTAC 2 CTD 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 29 DrugCentral 1 EC 2 EMBL 10 EMDB 8 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 77 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 17 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 45 PDBsum 45 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 5 RefSeq 2 Rhea 3 SASBDB 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2877871

Title: Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity.

PubMed ID: 2877871

DOI: 10.1002/j.1460-2075.1986.tb04528.x

PubMed ID: 1316909

Title: Insulin-like growth factor I receptor gene structure.

PubMed ID: 1316909

DOI: 10.1016/s0021-9258(19)50083-7

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1711844

Title: Analysis of the human type I insulin-like growth factor receptor promoter region.

PubMed ID: 1711844

DOI: 10.1016/0006-291x(91)90654-p

PubMed ID: 8257688

Title: Characterization of human placental insulin-like growth factor-I/insulin hybrid receptors by protein microsequencing and purification.

PubMed ID: 8257688

DOI: 10.1021/bi00212a019

PubMed ID: 8247543

Title: A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes.

PubMed ID: 8247543

PubMed ID: 1846292

Title: Interaction of the alpha beta dimers of the insulin-like growth factor I receptor is required for receptor autophosphorylation.

PubMed ID: 1846292

DOI: 10.1021/bi00215a008

PubMed ID: 8452530

Title: Purified hybrid insulin/insulin-like growth factor-I receptors bind insulin-like growth factor-I, but not insulin, with high affinity.

PubMed ID: 8452530

DOI: 10.1042/bj2900419

PubMed ID: 7679099

Title: Role of tyrosine kinase activity in signal transduction by the insulin-like growth factor-I (IGF-I) receptor. Characterization of kinase-deficient IGF-I receptors and the action of an IGF-I-mimetic antibody (alpha IR-3).

PubMed ID: 7679099

DOI: 10.1016/s0021-9258(18)53824-2

PubMed ID: 7541045

Title: Non-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor I receptor.

PubMed ID: 7541045

DOI: 10.1074/jbc.270.26.15639

PubMed ID: 9355755

Title: Insulin receptor/IGF-I receptor hybrids are widely distributed in mammalian tissues: quantification of individual receptor species by selective immunoprecipitation and immunoblotting.

PubMed ID: 9355755

DOI: 10.1042/bj3270209

PubMed ID: 9581554

Title: 14-3-3 proteins interact with the insulin-like growth factor receptor but not the insulin receptor.

PubMed ID: 9581554

DOI: 10.1042/bj3270765

PubMed ID: 9202395

Title: Distribution of insulin/insulin-like growth factor-I hybrid receptors in human tissues.

PubMed ID: 9202395

DOI: 10.1016/s0303-7207(97)04050-1

PubMed ID: 9727029

Title: Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor.

PubMed ID: 9727029

DOI: 10.1074/jbc.273.37.24095

PubMed ID: 9822622

Title: beta-arrestins regulate mitogenic signaling and clathrin-mediated endocytosis of the insulin-like growth factor I receptor.

PubMed ID: 9822622

DOI: 10.1074/jbc.273.48.31640

PubMed ID: 10579905

Title: The IGF-I receptor in cancer research.

PubMed ID: 10579905

DOI: 10.1006/excr.1999.4667

PubMed ID: 10454568

Title: Grb10, a positive, stimulatory signaling adapter in platelet-derived growth factor BB-, insulin-like growth factor I-, and insulin-mediated mitogenesis.

PubMed ID: 10454568

DOI: 10.1128/mcb.19.9.6217

PubMed ID: 11071852

Title: Suppressor of cytokine signaling (SOCS)-3 protein interacts with the insulin-like growth factor-I receptor.

PubMed ID: 11071852

DOI: 10.1006/bbrc.2000.3762

PubMed ID: 11162456

Title: Autophosphorylation of the insulin-like growth factor I receptor cytoplasmic domain.

PubMed ID: 11162456

DOI: 10.1006/bbrc.2000.4046

PubMed ID: 10747872

Title: Mechanism of STAT3 activation by insulin-like growth factor I receptor.

PubMed ID: 10747872

DOI: 10.1074/jbc.m000089200

PubMed ID: 12019176

Title: Expression of the type 1 insulin-like growth factor receptor is up-regulated in primary prostate cancer and commonly persists in metastatic disease.

PubMed ID: 12019176

PubMed ID: 12138094

Title: Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved.

PubMed ID: 12138094

DOI: 10.1074/jbc.m202766200

PubMed ID: 11884618

Title: RACK1, an insulin-like growth factor I (IGF-I) receptor-interacting protein, modulates IGF-I-dependent integrin signaling and promotes cell spreading and contact with extracellular matrix.

PubMed ID: 11884618

DOI: 10.1128/mcb.22.7.2345-2365.2002

PubMed ID: 12556535

Title: Type 1 insulin-like growth factor receptor (IGF-IR) signaling inhibits apoptosis signal-regulating kinase 1 (ASK1).

PubMed ID: 12556535

DOI: 10.1074/jbc.m211398200

PubMed ID: 12821780

Title: Mdm2-dependent ubiquitination and degradation of the insulin-like growth factor 1 receptor.

PubMed ID: 12821780

DOI: 10.1073/pnas.1431613100

PubMed ID: 14729630

Title: Cyclolignans as inhibitors of the insulin-like growth factor-1 receptor and malignant cell growth.

PubMed ID: 14729630

DOI: 10.1158/0008-5472.can-03-2522

PubMed ID: 15878855

Title: {beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase.

PubMed ID: 15878855

DOI: 10.1074/jbc.m501129200

PubMed ID: 15998644

Title: JAK/STAT3 pathway is involved in survival of neurons in response to insulin-like growth factor and negatively regulated by suppressor of cytokine signaling-3.

PubMed ID: 15998644

DOI: 10.1074/jbc.m501316200

PubMed ID: 16831875

Title: Hybrid receptors formed by insulin receptor (IR) and insulin-like growth factor I receptor (IGF-IR) have low insulin and high IGF-1 affinity irrespective of the IR splice variant.

PubMed ID: 16831875

DOI: 10.1074/jbc.m605189200

PubMed ID: 17524361

Title: The insulin-like growth factor 1 (IGF-1) receptor is a substrate for gamma-secretase-mediated intramembrane proteolysis.

PubMed ID: 17524361

DOI: 10.1016/j.bbrc.2007.05.062

PubMed ID: 17624760

Title: The insulin-like growth factor 1 receptor in cancer: old focus, new future.

PubMed ID: 17624760

DOI: 10.1016/j.ejca.2007.05.021

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19578119

Title: The direct binding of insulin-like growth factor-1 (IGF-1) to integrin alphavbeta3 is involved in IGF-1 signaling.

PubMed ID: 19578119

DOI: 10.1074/jbc.m109.013201

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20596523

Title: Development and validation of a method for profiling post-translational modification activities using protein microarrays.

PubMed ID: 20596523

DOI: 10.1371/journal.pone.0011332

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21994939

Title: Polyubiquitination of insulin-like growth factor I receptor (IGF-IR) activation loop promotes antibody-induced receptor internalization and down-regulation.

PubMed ID: 21994939

DOI: 10.1074/jbc.m111.288514

PubMed ID: 22351760

Title: Cross-talk between integrin alpha6beta4 and insulin-like growth factor-1 receptor (IGF1R) through direct alpha6beta4 binding to IGF1 and subsequent alpha6beta4-IGF1-IGF1R ternary complex formation in anchorage-independent conditions.

PubMed ID: 22351760

DOI: 10.1074/jbc.m111.304170

PubMed ID: 26692333

Title: Loss of the proteostasis factor AIRAPL causes myeloid transformation by deregulating IGF-1 signaling.

PubMed ID: 26692333

DOI: 10.1038/nm.4013

PubMed ID: 32494007

Title: IGF1R is an entry receptor for respiratory syncytial virus.

PubMed ID: 32494007

DOI: 10.1038/s41586-020-2369-7

PubMed ID: 9690478

Title: Crystal structure of the first three domains of the type-1 insulin-like growth factor receptor.

PubMed ID: 9690478

DOI: 10.1038/28668

PubMed ID: 11694888

Title: Structure and autoregulation of the insulin-like growth factor 1 receptor kinase.

PubMed ID: 11694888

DOI: 10.1038/nsb721

PubMed ID: 11591350

Title: Crystal structure of bisphosphorylated IGF-1 receptor kinase: insight into domain movements upon kinase activation.

PubMed ID: 11591350

DOI: 10.1016/s0969-2126(01)00655-4

PubMed ID: 12138114

Title: Crystal structure of the Apo, unactivated insulin-like growth factor-1 receptor kinase. Implication for inhibitor specificity.

PubMed ID: 12138114

DOI: 10.1074/jbc.m205580200

PubMed ID: 14501110

Title: Structure of apo, unactivated insulin-like growth factor-1 receptor kinase at 1.5 A resolution.

PubMed ID: 14501110

DOI: 10.1107/s0907444903015415

PubMed ID: 17317169

Title: Discovery and initial SAR of 3-(1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-ones as inhibitors of insulin-like growth factor 1-receptor (IGF-1R).

PubMed ID: 17317169

DOI: 10.1016/j.bmcl.2007.01.102

PubMed ID: 18501599

Title: Lead identification to generate isoquinolinedione inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment.

PubMed ID: 18501599

DOI: 10.1016/j.bmcl.2008.04.044

PubMed ID: 18566589

Title: Small-molecule inhibition and activation-loop trans-phosphorylation of the IGF1 receptor.

PubMed ID: 18566589

DOI: 10.1038/emboj.2008.116

PubMed ID: 19041240

Title: Lead identification to generate 3-cyanoquinoline inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment.

PubMed ID: 19041240

DOI: 10.1016/j.bmcl.2008.11.037

PubMed ID: 19778024

Title: Discovery of a 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitor (BMS-754807) of insulin-like growth factor receptor (IGF-1R) kinase in clinical development.

PubMed ID: 19778024

DOI: 10.1021/jm900786r

Title: Allosteric IGF-1R Inhibitors.

DOI: 10.1021/ml100044h

PubMed ID: 20675137

Title: Proline isosteres in a series of 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitors of IGF-1R kinase and IR kinase.

PubMed ID: 20675137

DOI: 10.1016/j.bmcl.2010.07.045

PubMed ID: 20545947

Title: Design of potent IGF1-R inhibitors related to bis-azaindoles.

PubMed ID: 20545947

DOI: 10.1111/j.1747-0285.2010.00991.x

PubMed ID: 21441024

Title: Discovery of the first non-ATP competitive IGF-1R kinase inhibitors: advantages in comparison with competitive inhibitors.

PubMed ID: 21441024

DOI: 10.1016/j.bmcl.2011.03.003

PubMed ID: 21414779

Title: Discovery of 2,4-bis-arylamino-1,3-pyrimidines as insulin-like growth factor-1 receptor (IGF-1R) inhibitors.

PubMed ID: 21414779

DOI: 10.1016/j.bmcl.2011.02.075

PubMed ID: 14657428

Title: IGF-I receptor mutations resulting in intrauterine and postnatal growth retardation.

PubMed ID: 14657428

DOI: 10.1056/nejmoa010107

PubMed ID: 15928254

Title: Mutation at cleavage site of insulin-like growth factor receptor in a short-stature child born with intrauterine growth retardation.

PubMed ID: 15928254

DOI: 10.1210/jc.2004-1947

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 25040157

Title: Three novel IGF1R mutations in microcephalic patients with prenatal and postnatal growth impairment.

PubMed ID: 25040157

DOI: 10.1111/cen.12555

Sequence Information:

  • Length: 1367
  • Mass: 154793
  • Checksum: AE8A735F87F745C8
  • Sequence:
    • MKSGSGGGSP TSLWGLLFLS AALSLWPTSG EICGPGIDIR NDYQQLKRLE NCTVIEGYLH 
ILLISKAEDY RSYRFPKLTV ITEYLLLFRV AGLESLGDLF PNLTVIRGWK LFYNYALVIF 
EMTNLKDIGL YNLRNITRGA IRIEKNADLC YLSTVDWSLI LDAVSNNYIV GNKPPKECGD 
LCPGTMEEKP MCEKTTINNE YNYRCWTTNR CQKMCPSTCG KRACTENNEC CHPECLGSCS 
APDNDTACVA CRHYYYAGVC VPACPPNTYR FEGWRCVDRD FCANILSAES SDSEGFVIHD 
GECMQECPSG FIRNGSQSMY CIPCEGPCPK VCEEEKKTKT IDSVTSAQML QGCTIFKGNL 
LINIRRGNNI ASELENFMGL IEVVTGYVKI RHSHALVSLS FLKNLRLILG EEQLEGNYSF 
YVLDNQNLQQ LWDWDHRNLT IKAGKMYFAF NPKLCVSEIY RMEEVTGTKG RQSKGDINTR 
NNGERASCES DVLHFTSTTT SKNRIIITWH RYRPPDYRDL ISFTVYYKEA PFKNVTEYDG 
QDACGSNSWN MVDVDLPPNK DVEPGILLHG LKPWTQYAVY VKAVTLTMVE NDHIRGAKSE 
ILYIRTNASV PSIPLDVLSA SNSSSQLIVK WNPPSLPNGN LSYYIVRWQR QPQDGYLYRH 
NYCSKDKIPI RKYADGTIDI EEVTENPKTE VCGGEKGPCC ACPKTEAEKQ AEKEEAEYRK 
VFENFLHNSI FVPRPERKRR DVMQVANTTM SSRSRNTTAA DTYNITDPEE LETEYPFFES 
RVDNKERTVI SNLRPFTLYR IDIHSCNHEA EKLGCSASNF VFARTMPAEG ADDIPGPVTW 
EPRPENSIFL KWPEPENPNG LILMYEIKYG SQVEDQRECV SRQEYRKYGG AKLNRLNPGN 
YTARIQATSL SGNGSWTDPV FFYVQAKTGY ENFIHLIIAL PVAVLLIVGG LVIMLYVFHR 
KRNNSRLGNG VLYASVNPEY FSAADVYVPD EWEVAREKIT MSRELGQGSF GMVYEGVAKG 
VVKDEPETRV AIKTVNEAAS MRERIEFLNE ASVMKEFNCH HVVRLLGVVS QGQPTLVIME 
LMTRGDLKSY LRSLRPEMEN NPVLAPPSLS KMIQMAGEIA DGMAYLNANK FVHRDLAARN 
CMVAEDFTVK IGDFGMTRDI YETDYYRKGG KGLLPVRWMS PESLKDGVFT TYSDVWSFGV 
VLWEIATLAE QPYQGLSNEQ VLRFVMEGGL LDKPDNCPDM LFELMRMCWQ YNPKMRPSFL 
EIISSIKEEM EPGFREVSFY YSEENKLPEP EELDLEPENM ESVPLDPSAS SSSLPLPDRH 
SGHKAENGPG PGVLVLRASF DERQPYAHMN GGRKNERALP LPQSSTC

Genular Protein ID: 3394930756

Symbol: C9J5X1_HUMAN

Name: N/A

UniProtKB Accession Codes:

C9J5X1

Database IDs:

ARBA 11 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChEBI 10 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 4 Ensembl 2 ExpressionAtlas 1 GO 8 Gene3D 3 GeneTree 1 HGNC 1 HOGENOM 1 IntAct 1 InterPro 17 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 2 PRINTS 1 PROSITE 7 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 3 Proteomes 2 ProteomicsDB 2 RefSeq 1 Rhea 3 RuleBase 1 SAM 3 SMART 3 SMR 1 SUPFAM 4 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.M800588-MCP200

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

Sequence Information:

  • Length: 1366
  • Mass: 154791
  • Checksum: EFC88F7D7718D938
  • Sequence:
    • MKSGSGGGSP TSLWGLLFLS AALSLWPTSG EICGPGIDIR NDYQQLKRLE NCTVIEGYLH 
ILLISKAEDY RSYRFPKLTV ITEYLLLFRV AGLESLGDLF PNLTVIRGWK LFYNYALVIF 
EMTNLKDIGL YNLRNITRGA IRIEKNADLC YLSTVDWSLI LDAVSNNYIV GNKPPKECGD 
LCPGTMEEKP MCEKTTINNE YNYRCWTTNR CQKMCPSTCG KRACTENNEC CHPECLGSCS 
APDNDTACVA CRHYYYAGVC VPACPPNTYR FEGWRCVDRD FCANILSAES SDSEGFVIHD 
GECMQECPSG FIRNGSQSMY CIPCEGPCPK VCEEEKKTKT IDSVTSAQML QGCTIFKGNL 
LINIRRGNNI ASELENFMGL IEVVTGYVKI RHSHALVSLS FLKNLRLILG EEQLEGNYSF 
YVLDNQNLQQ LWDWDHRNLT IKAGKMYFAF NPKLCVSEIY RMEEVTGTKG RQSKGDINTR 
NNGERASCES DVLHFTSTTT SKNRIIITWH RYRPPDYRDL ISFTVYYKEA PFKNVTEYDG 
QDACGSNSWN MVDVDLPPNK DVEPGILLHG LKPWTQYAVY VKAVTLTMVE NDHIRGAKSE 
ILYIRTNASV PSIPLDVLSA SNSSSQLIVK WNPPSLPNGN LSYYIVRWQR QPQDGYLYRH 
NYCSKDKIPI RKYADGTIDI EEVTENPKTE VCGGEKGPCC ACPKTEAEKQ AEKEEAEYRK 
VFENFLHNSI FVPRPERKRR DVMQVANTTM SSRSRNTTAA DTYNITDPEE LETEYPFFES 
RVDNKERTVI SNLRPFTLYR IDIHSCNHEA EKLGCSASNF VFARTMPAEG ADDIPGPVTW 
EPRPENSIFL KWPEPENPNG LILMYEIKYG SQVEDQRECV SRQEYRKYGG AKLNRLNPGN 
YTARIQATSL SGNGSWTDPV FFYVQAKRYE NFIHLIIALP VAVLLIVGGL VIMLYVFHRK 
RNNSRLGNGV LYASVNPEYF SAADVYVPDE WEVAREKITM SRELGQGSFG MVYEGVAKGV 
VKDEPETRVA IKTVNEAASM RERIEFLNEA SVMKEFNCHH VVRLLGVVSQ GQPTLVIMEL 
MTRGDLKSYL RSLRPEMENN PVLAPPSLSK MIQMAGEIAD GMAYLNANKF VHRDLAARNC 
MVAEDFTVKI GDFGMTRDIY ETDYYRKGGK GLLPVRWMSP ESLKDGVFTT YSDVWSFGVV 
LWEIATLAEQ PYQGLSNEQV LRFVMEGGLL DKPDNCPDML FELMRMCWQY NPKMRPSFLE 
IISSIKEEME PGFREVSFYY SEENKLPEPE ELDLEPENME SVPLDPSASS SSLPLPDRHS 
GHKAENGPGP GVLVLRASFD ERQPYAHMNG GRKNERALPL PQSSTC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.